LOCUS       NM_145425               2443 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus WD repeat containing planar cell polarity effector
            (Wdpcp), transcript variant 1, mRNA.
ACCESSION   NM_145425
VERSION     NM_145425.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Langousis,G., Cavadini,S., Boegholm,N., Lorentzen,E., Kempf,G. and
            Matthias,P.
  TITLE     Structure of the ciliogenesis-associated CPLANE complex
  JOURNAL   Sci Adv 8 (15), eabn0832 (2022)
   PUBMED   35427153
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Langhans,M.T., Gao,J., Tang,Y., Wang,B., Alexander,P. and Tuan,R.S.
  TITLE     Wdpcp regulates cellular proliferation and differentiation in the
            developing limb via hedgehog signaling
  JOURNAL   BMC Dev Biol 21 (1), 10 (2021)
   PUBMED   34225660
  REMARK    GeneRIF: Wdpcp regulates cellular proliferation and differentiation
            in the developing limb via hedgehog signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Liu,X., Wang,Y., Liu,F., Zhang,M., Song,H., Zhou,B., Lo,C.W.,
            Tong,S., Hu,Z. and Zhang,Z.
  TITLE     Wdpcp promotes epicardial EMT and epicardium-derived cell migration
            to facilitate coronary artery remodeling
  JOURNAL   Sci Signal 11 (519) (2018)
   PUBMED   29487191
  REMARK    GeneRIF: Data suggest that the WD repeat containing planar cell
            polarity effector (Wdpcp) mutant mice will be a useful tool to
            dissect the molecular mechanisms that govern the remodeling of the
            primitive plexus during coronary development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2443)
  AUTHORS   Toriyama,M., Lee,C., Taylor,S.P., Duran,I., Cohn,D.H., Bruel,A.L.,
            Tabler,J.M., Drew,K., Kelly,M.R., Kim,S., Park,T.J., Braun,D.A.,
            Pierquin,G., Biver,A., Wagner,K., Malfroot,A., Panigrahi,I.,
            Franco,B., Al-Lami,H.A., Yeung,Y., Choi,Y.J., Duffourd,Y.,
            Faivre,L., Riviere,J.B., Chen,J., Liu,K.J., Marcotte,E.M.,
            Hildebrandt,F., Thauvin-Robinet,C., Krakow,D., Jackson,P.K. and
            Wallingford,J.B.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     The ciliopathy-associated CPLANE proteins direct basal body
            recruitment of intraflagellar transport machinery
  JOURNAL   Nat Genet 48 (6), 648-656 (2016)
   PUBMED   27158779
  REMARK    Erratum:[Nat Genet. 2016 Jul 27;48(8):970. doi:
            10.1038/ng0816-970b.. PMID: 27463398]
REFERENCE   6  (bases 1 to 2443)
  AUTHORS   Cui,C., Chatterjee,B., Lozito,T.P., Zhang,Z., Francis,R.J.,
            Yagi,H., Swanhart,L.M., Sanker,S., Francis,D., Yu,Q., San
            Agustin,J.T., Puligilla,C., Chatterjee,T., Tansey,T., Liu,X.,
            Kelley,M.W., Spiliotis,E.T., Kwiatkowski,A.V., Tuan,R.,
            Pazour,G.J., Hukriede,N.A. and Lo,C.W.
  TITLE     Wdpcp, a PCP protein required for ciliogenesis, regulates
            directional cell migration and cell polarity by direct modulation
            of the actin cytoskeleton
  JOURNAL   PLoS Biol 11 (11), e1001720 (2013)
   PUBMED   24302887
  REMARK    GeneRIF: Wdpcp is required for Sept2 recruitment to actin
            filaments.
REFERENCE   7  (bases 1 to 2443)
  AUTHORS   Schmitt-John,T., Drepper,C., Mussmann,A., Hahn,P., Kuhlmann,M.,
            Thiel,C., Hafner,M., Lengeling,A., Heimann,P., Jones,J.M.,
            Meisler,M.H. and Jockusch,H.
  TITLE     Mutation of Vps54 causes motor neuron disease and defective
            spermiogenesis in the wobbler mouse
  JOURNAL   Nat Genet 37 (11), 1213-1215 (2005)
   PUBMED   16244655
REFERENCE   8  (bases 1 to 2443)
  AUTHORS   Yu,Q., Shen,Y., Chatterjee,B., Siegfried,B.H., Leatherbury,L.,
            Rosenthal,J., Lucas,J.F., Wessels,A., Spurney,C.F., Wu,Y.J.,
            Kirby,M.L., Svenson,K. and Lo,C.W.
  TITLE     ENU induced mutations causing congenital cardiovascular anomalies
  JOURNAL   Development 131 (24), 6211-6223 (2004)
   PUBMED   15548583
REFERENCE   9  (bases 1 to 2443)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083042.1.
            
            On Apr 6, 2007 this sequence version replaced NM_145425.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083042.1, SRR1660817.111247.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2443              AK083042.1         2-2444
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 13.9 cM"
     gene            1..2443
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /note="WD repeat containing planar cell polarity effector"
                     /db_xref="GeneID:216560"
                     /db_xref="MGI:MGI:2144467"
     exon            1..90
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            91..175
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2283
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein C2orf86 homolog; WD
                     repeat-containing and planar cell polarity effector
                     protein fritz homolog; mFrtz"
                     /codon_start=1
                     /product="WD repeat-containing and planar cell polarity
                     effector protein fritz homolog isoform 1"
                     /protein_id="NP_663400.2"
                     /db_xref="CCDS:CCDS24467.1"
                     /db_xref="GeneID:216560"
                     /db_xref="MGI:MGI:2144467"
                     /translation="MSFCLTELHLWSLKSTLHIADRDIGVYQYYDKKDPSVSATEHGN
                     LEEKQRLAESRDYPWTLKNRRPEKLRDSLKELEELMQSSPCVLSKWKSKYICQLLFGS
                     GVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTK
                     KMDSLDGNKRLEKLSALDLKISYYDIPGPANRTIDRHLAVNSTQDLVVCWWPLVSDDV
                     WPWTPVSSEKDRANMLLLGFTQGGLEVLSFVRTEWSPLDVHFGTKQPYQVFTVECSVS
                     VDKEPMADSCIYESVRNKLHCVSVTRIPLRSKAISCCRNSTEDKLIVGCEDSSVILYE
                     AHRGVTLLAQAELRPSLISCHPSGAILLVGSNQGELQIFDIALSPINIQLLAEDYSPK
                     ETLQFKKFFDVSSSLVQMQWMAPPVVFQKPKRGEICDLLFLRFNKGPLGVLLFKLGIL
                     TRGQLGLVDLILQYIHYSEVYEAISILRSMDWDTLGQQCLIGMGTIVNHLLRQRLTPE
                     REAQLEASLGTFYAPTRPLLDTTILEYREPVSKYARRLFHHLLRYKRFEKAFLLAVDI
                     GARDLFMDIHYLALDMGELALAEVARRRAHDIDVESVSSGVELLGPLDRRDMLNEGFA
                     SSALMPEGENKFPGLLPSIGSTHMQTLQQKIPNGPSSRWAIERRTEEEEEEEEEEEEE
                     LCTDSSGATTWNAEGELKEDQRKQDIGDVGSLRMVHFGLV"
     exon            176..223
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            224..274
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            275..345
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            346..405
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            406..520
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            521..654
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            655..846
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1456
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1645
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1769
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1833
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1936
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2099
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2203
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2232
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2443
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="Wdpcp"
                     /gene_synonym="Frtz; homolog-13"
                     /note="major polyA site"
ORIGIN      
        1 agcttcaccg ttgctaggcg acgaggcagc ctcacctgag cgctctccag accaagagct
       61 tgtggagctg tgttctcacg tcccaggctg gacagagatt tcctctgctg tcagatgtct
      121 ttctgcttga ctgaactaca cctgtggtct ctgaaaagca ccttacacat tgcggataga
      181 gacatcggcg tctaccagta ctatgacaag aaagatccat cagtatcagc aacagagcat
      241 ggtaacttag aagaaaaaca aaggctggca gaatcacgag attatccttg gacactcaaa
      301 aatagacgcc cagaaaaact tcgagattca ctgaaggagt tggaggaact gatgcaaagc
      361 agtccgtgtg tgctgagcaa atggaagagc aaatacatct gccagctcct gtttggttca
      421 ggtgtgctgg tgtccctaag tctttctggg cctcagctgg agaaagtggt gattgacaga
      481 agcctggtgg ggaagctcat ctcagacacc atcagtgatg ctctccttac agacagtttc
      541 atcatcttat catttctggc acaaaacaaa ctatgtttta ttcagtttac aaagaaaatg
      601 gattctcttg atggaaacaa gaggctggag aaactctcag ccttggacct taagatttcc
      661 tattatgaca tacctggccc agccaacagg acaatagatc gtcacttagc tgtcaactcc
      721 actcaggatc tagttgtttg ttggtggccg ctggtcagtg atgatgtttg gccttggact
      781 ccagtttctt ctgagaagga cagagccaat atgctgttgc tgggctttac tcaaggagga
      841 ttggaggttc taagttttgt tcgcacagaa tggagtcccc tggatgttca cttcggcacc
      901 aaacaacctt atcaggtgtt cacagtggag tgctccgtca gtgtagacaa ggagcccatg
      961 gctgacagct gtatttatga atctgtccgg aacaaactcc actgcgtgtc agttaccaga
     1021 ataccactaa gatcgaaggc catcagctgc tgcaggaact ctacggaaga caaactgatc
     1081 gtgggctgtg aagactcttc agtaattctc tatgaagctc accgtggtgt gactctcctg
     1141 gcccaggctg aacttaggcc ttcattgata agctgccacc caagtggcgc cattcttctg
     1201 gttggcagca accaagggga gctacaaatt tttgatattg ctctgtcccc tatcaacatc
     1261 cagctcttgg cagaagatta ctcaccgaag gagactctgc aattcaagaa gttctttgat
     1321 gtttcaagca gtcttgttca aatgcagtgg atggctcctc ctgttgtttt ccagaagcct
     1381 aaaagaggag aaatctgtga tcttctcttc ctcaggttca acaaaggacc tttgggtgtg
     1441 ctactgttta aacttggcat cctcacacga ggacaactgg gcctggtaga cctcatctta
     1501 cagtacattc actacagtga ggtatatgag gccatcagca tcctgcgcag catggactgg
     1561 gacaccctgg gccagcagtg tttgatcggc atgggcacca tcgtgaacca tcttcttaga
     1621 cagaggctca caccagagag agaagcacag cttgaggcga gccttggaac cttctatgct
     1681 ccaacaagac cacttctgga tacaactatt ttggaatata gagagccagt cagcaagtat
     1741 gccaggaggc tcttccacca cctgctcagg tacaagagat ttgaaaaggc ctttcttcta
     1801 gctgttgaca ttggagctcg tgacctgttc atggacattc attaccttgc tctagatatg
     1861 ggtgaactgg cactggctga agtggcaaga agaagggcgc atgatattga tgttgagtca
     1921 gtatcctctg gagtcgagct cctggggccc ttggacagaa gagacatgct gaatgaaggt
     1981 tttgccagct cagctctcat gcctgaagga gaaaacaagt ttccaggcct tcttccttcc
     2041 attggttcaa cacacatgca aactcttcaa cagaaaatac caaatggccc ttcaagcaga
     2101 tgggcaattg agagaaggac tgaggaagaa gaggaggagg aggaggagga agaggaggag
     2161 ttatgcactg actcttcagg ggccaccacc tggaatgcag aaggagaact gaaagaagac
     2221 caaaggaaac aggacattgg agatgttggt tctctcagaa tggttcactt tggtttggtg
     2281 taaatcatcc gaaacaccaa aaagaaagct gcccttttca tttcttttct attgacctga
     2341 tcaataaaaa tcttcacgtg tggattttaa tagaaggaaa gatagtagta catgtagcat
     2401 tgcataagtg accctcaata aaagttccga aacaattgtt ttc
//
