LOCUS       NM_175546               2011 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat and FYVE domain containing 2 (Wdfy2), mRNA.
ACCESSION   NM_175546
VERSION     NM_175546.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Zhang,L., Li,X., Zhang,N., Yang,X., Hou,T., Fu,W., Yuan,F.,
            Wang,L., Wen,H., Tian,Y., Zhang,H., Lu,X. and Zhu,W.G.
  TITLE     WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls
            Endosomal Localization of the Insulin Receptor and IRS1/2
  JOURNAL   Diabetes 69 (9), 1887-1902 (2020)
   PUBMED   32641353
  REMARK    GeneRIF: WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls
            Endosomal Localization of the Insulin Receptor and IRS1/2.
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Fritzius,T. and Moelling,K.
  TITLE     Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes
            adipogenesis
  JOURNAL   EMBO J 27 (9), 1399-1410 (2008)
   PUBMED   18388859
  REMARK    GeneRIF: Data show that ProF binds to Foxo1, a negative regulator
            of insulin action and adipogenesis, and facilitates the
            phosphorylation and thus inactivation of Foxo1 by Akt.
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Fritzius,T., Frey,A.D., Schweneker,M., Mayer,D. and Moelling,K.
  TITLE     WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein
            kinase Czeta
  JOURNAL   FEBS J 274 (6), 1552-1566 (2007)
   PUBMED   17313651
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Fritzius,T., Burkard,G., Haas,E., Heinrich,J., Schweneker,M.,
            Bosse,M., Zimmermann,S., Frey,A.D., Caelers,A., Bachmann,A.S. and
            Moelling,K.
  TITLE     A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
  JOURNAL   Biochem J 399 (1), 9-20 (2006)
   PUBMED   16792529
  REMARK    GeneRIF: The ProF protein partially co-localizes with EEA1 on
            vesicular structures and binds to the protein kinases Akt and
            PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat
            propeller.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086275.1, AK151817.1 and CB520148.1.
            
            On Jul 21, 2009 this sequence version replaced NM_175546.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131958.1, AK151817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK086275.1         14-58
            46-1732             AK151817.1         2-1688
            1733-2011           CB520148.1         458-736
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.23 cM"
     gene            1..2011
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /note="WD repeat and FYVE domain containing 2"
                     /db_xref="GeneID:268752"
                     /db_xref="MGI:MGI:2442811"
     exon            1..368
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1434
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /note="propeller-FYVE protein; WD40- and FYVE
                     domain-containing protein 2"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 2"
                     /protein_id="NP_780755.2"
                     /db_xref="CCDS:CCDS27192.1"
                     /db_xref="GeneID:268752"
                     /db_xref="MGI:MGI:2442811"
                     /translation="MAAEIQPQPLTRKPILLQRVEGSQEVVNMAVIVPKEEGVISVSE
                     DRTVRVWLKRDSGQYWPSIYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYN
                     KMTPVKNYQAHQSRVTMVLFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASG
                     LQFDVETRHVFIGDHSGQVTILKLEQENCTLLTSFRGHTGGVTALCWDPVQRVLFSGS
                     SDHSVIMWDIGGRKGTAIELQGHNDKVQALSYAQHTRQLISCGGDGGIVVWNMDVERQ
                     ETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPL
                     MGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKL
                     WDMTPVVS"
     exon            369..436
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            437..510
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            511..565
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            566..716
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            717..829
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            830..956
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1062
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1164
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1295
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1404
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..2011
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1733
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /note="major polyA site"
     polyA_site      1801
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /note="major polyA site"
ORIGIN      
        1 ctgctccccg ccccctactc tcttaggtgg cgccggcttg cggctagtgt ggcggcggtg
       61 ttggttttgg aagccagagc gggcacattc cctggacagg cggcagggct atggtcgctg
      121 gctcccaaag gcccgctccg cttcgcagcc cgatcctgag cgcaagcctg agcgttctct
      181 tcagccaagt cccccggcgc gttcggctgc tccccgggcg cgccccctcc gatggcggcg
      241 gagatccagc cccagccact gacccgcaag ccgatcctgc tgcagcgggt cgaggggtcg
      301 caggaggtgg tcaacatggc ggtgattgta cctaaagaag agggtgtcat cagcgtctcg
      361 gaggacagga cagttcgtgt ttggttaaag agggacagtg gacagtactg gccaagcatc
      421 taccatgcaa tgccttctcc atgttcatgc atgtctttta acccggaaac aagaagactg
      481 tccataggtc tagacaatgg tacaatctca gagtttattt tgtctgaaga ttataacaag
      541 atgacacctg tgaaaaacta tcaagcacat cagagcagag taacgatggt cctgtttgtt
      601 ctggaactgg agtgggtgct gagcacagga caggacaagc agttcgcctg gcactgctct
      661 gagagtggac agcgcctggg aggttaccgc accagtgctg tggcctcagg cctgcaattt
      721 gatgttgaaa cccgtcatgt gtttattggc gatcactcgg gccaagtaac catcctcaaa
      781 ctggaacaag aaaactgcac actgctcaca tccttcagag ggcacacagg aggggtgaca
      841 gcactctgct gggacccggt gcagcgcgtg ctattctcag gcagttccga tcactctgtc
      901 atcatgtggg acatcggtgg gagaaaaggc acggccatcg aactccaagg acacaatgac
      961 aaagtccagg ccctctccta tgcacagcac acacgacagc tcatctcatg tggcggtgac
     1021 ggtggcattg tcgtctggaa catggatgtg gaaaggcagg agacccctga gtggttggac
     1081 agtgactcct gccaaaagtg tgaccagcct ttcttctgga acttcaagca aatgtgggac
     1141 agtaagaaaa ttggactaag acagcaccac tgccggaagt gtgggaaggc cgtgtgcggc
     1201 aagtgtagct ccaagcgctc ttccatccca ctcatgggct ttgagtttga agtgcgggtc
     1261 tgcgacagct gccacgaggc catcacagat gaagaacgcg cccccacagc caccttccat
     1321 gacagtaagc ataacattgt gcatgtgcat ttcgatgcaa ccaggggatg gttactgact
     1381 tctggaactg acaaggtaat taagctgtgg gacatgaccc cagtggtgtc atgatgactc
     1441 gcccagggac taggagacag tgtccctgaa gaagcacttg agtccagcat cctcccggga
     1501 ggaggaaaga gagcttctgg atgagcaaga agagagaccg aggctcccag cgagtgtggg
     1561 tcctccgcca ctgttaccgc aatctagtga aagccattcc ctcccaggac tcttcagtcg
     1621 tccataccac agaaaagaag atattttttt atcaaatggt ttatacagcc tggctgtgct
     1681 gcattcatta ttttgagtat attggaaaat ctgtgtggat gtttacgctt ctatatttca
     1741 gctgtgtgtt gtgttcattg ctttctctgt cagaaaaaga gagaaacatc tgttgaaggt
     1801 attgcgttct cgtcaagcgg tctcctcgtt cttgcctcag catgtacaga cagtccttct
     1861 cgtttctcga gacttccacc accggcctcg cttgcctctt gccacagagg atgatcacag
     1921 tttgtgccgt gtttctcttt catggcttgg gataagagtt ggaaaaccat gcgtgtccaa
     1981 cagctggcct cttgagtcac ctggagggag c
//
