LOCUS       NP_780755                400 aa            linear   ROD 28-APR-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 [Mus musculus].
ACCESSION   NP_780755
VERSION     NP_780755.2
DBSOURCE    REFSEQ: accession NM_175546.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Zhang,L., Li,X., Zhang,N., Yang,X., Hou,T., Fu,W., Yuan,F.,
            Wang,L., Wen,H., Tian,Y., Zhang,H., Lu,X. and Zhu,W.G.
  TITLE     WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls
            Endosomal Localization of the Insulin Receptor and IRS1/2
  JOURNAL   Diabetes 69 (9), 1887-1902 (2020)
   PUBMED   32641353
  REMARK    GeneRIF: WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls
            Endosomal Localization of the Insulin Receptor and IRS1/2.
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 400)
  AUTHORS   Fritzius,T. and Moelling,K.
  TITLE     Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes
            adipogenesis
  JOURNAL   EMBO J 27 (9), 1399-1410 (2008)
   PUBMED   18388859
  REMARK    GeneRIF: Data show that ProF binds to Foxo1, a negative regulator
            of insulin action and adipogenesis, and facilitates the
            phosphorylation and thus inactivation of Foxo1 by Akt.
REFERENCE   4  (residues 1 to 400)
  AUTHORS   Fritzius,T., Frey,A.D., Schweneker,M., Mayer,D. and Moelling,K.
  TITLE     WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein
            kinase Czeta
  JOURNAL   FEBS J 274 (6), 1552-1566 (2007)
   PUBMED   17313651
REFERENCE   5  (residues 1 to 400)
  AUTHORS   Fritzius,T., Burkard,G., Haas,E., Heinrich,J., Schweneker,M.,
            Bosse,M., Zimmermann,S., Frey,A.D., Caelers,A., Bachmann,A.S. and
            Moelling,K.
  TITLE     A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda
  JOURNAL   Biochem J 399 (1), 9-20 (2006)
   PUBMED   16792529
  REMARK    GeneRIF: The ProF protein partially co-localizes with EEA1 on
            vesicular structures and binds to the protein kinases Akt and
            PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat
            propeller.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086275.1, AK151817.1 and CB520148.1.
            
            On Jul 21, 2009 this sequence version replaced NP_780755.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131958.1, AK151817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.23 cM"
     Protein         1..400
                     /product="WD repeat and FYVE domain-containing protein 2"
                     /note="propeller-FYVE protein; WD40- and FYVE
                     domain-containing protein 2"
                     /calculated_mol_wt=44963
     Region          <16..272
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..61
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          27..64
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..105
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          72..111
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..150
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          117..153
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..192
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          159..197
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          197..236
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          203..240
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..279
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          245..283
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          279..348
                     /region_name="FYVE_WDFY1_like"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein WDFY1 and WDFY2, and similar
                     proteins; cd15718"
                     /db_xref="CDD:277258"
     Site            order(281,285,310..315,317..318,342..344)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277258"
     Region          321..363
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          364..399
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BUB4.2)"
     Region          369..395
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..400
                     /gene="Wdfy2"
                     /gene_synonym="5830485M08; B130024L21Rik; ProF; ZFYVE22"
                     /coded_by="NM_175546.4:232..1434"
                     /db_xref="CCDS:CCDS27192.1"
                     /db_xref="GeneID:268752"
                     /db_xref="MGI:MGI:2442811"
ORIGIN      
        1 maaeiqpqpl trkpillqrv egsqevvnma vivpkeegvi svsedrtvrv wlkrdsgqyw
       61 psiyhampsp cscmsfnpet rrlsigldng tisefilsed ynkmtpvkny qahqsrvtmv
      121 lfvlelewvl stgqdkqfaw hcsesgqrlg gyrtsavasg lqfdvetrhv figdhsgqvt
      181 ilkleqenct lltsfrghtg gvtalcwdpv qrvlfsgssd hsvimwdigg rkgtaielqg
      241 hndkvqalsy aqhtrqlisc ggdggivvwn mdverqetpe wldsdscqkc dqpffwnfkq
      301 mwdskkiglr qhhcrkcgka vcgkcsskrs siplmgfefe vrvcdschea itdeerapta
      361 tfhdskhniv hvhfdatrgw lltsgtdkvi klwdmtpvvs
//
