LOCUS       NM_001111279            4566 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus WD repeat and FYVE domain containing 1 (Wdfy1),
            transcript variant 1, mRNA.
ACCESSION   NM_001111279
VERSION     NM_001111279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Doherty,R., MacLeod,B.L., Nelson,M.M., Ibrahim,M.M.H., Borges,B.C.,
            Jaradat,N.W., Finneran,M.C., Giger,R.J. and Corfas,G.
  TITLE     Identification of in vivo roles of ErbB4-JMa and its direct nuclear
            signaling using a novel isoform-specific knock out mouse
  JOURNAL   Sci Rep 12 (1), 17267 (2022)
   PUBMED   36241655
  REMARK    Erratum:[Sci Rep. 2022 Dec 1;12(1):20748. doi:
            10.1038/s41598-022-25021-8.. PMID: 36456684]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4566)
  AUTHORS   Lv,C., Xiong,M., Guo,S., Gui,Y., Liu,X., Wang,X., Wu,Y., Feng,S.,
            Zhang,J., Zhang,Y., Liu,Y., Qin,W. and Yuan,S.
  TITLE     WDFY1, a WD40 repeat protein, is not essential for spermatogenesis
            and male fertility in mice
  JOURNAL   Biochem Biophys Res Commun 596, 71-75 (2022)
   PUBMED   35121371
  REMARK    GeneRIF: WDFY1, a WD40 repeat protein, is not essential for
            spermatogenesis and male fertility in mice.
REFERENCE   4  (bases 1 to 4566)
  AUTHORS   Rahman,S., Vandewalle,J., van Hamersveld,P.H.P., Verseijden,C.,
            Welting,O., Jongejan,A., Casanova,P., Meijer,S.L., Libert,C.,
            Hakvoort,T.B.M., de Jonge,W.J. and Heinsbroek,S.E.M.
  TITLE     miR-511 Deficiency Protects Mice from Experimental Colitis by
            Reducing TLR3 and TLR4 Responses via WD Repeat and
            FYVE-Domain-Containing Protein 1
  JOURNAL   Cells 11 (1), 58 (2021)
   PUBMED   35011620
  REMARK    GeneRIF: miR-511 Deficiency Protects Mice from Experimental Colitis
            by Reducing TLR3 and TLR4 Responses via WD Repeat and
            FYVE-Domain-Containing Protein 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4566)
  AUTHORS   Boschen,K.E., Ptacek,T.S., Berginski,M.E., Simon,J.M. and
            Parnell,S.E.
  TITLE     Transcriptomic analyses of gastrulation-stage mouse embryos with
            differential susceptibility to alcohol
  JOURNAL   Dis Model Mech 14 (6) (2021)
   PUBMED   34137816
REFERENCE   6  (bases 1 to 4566)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4566)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4566)
  AUTHORS   Boettger-Tong,H.L., Rohozinski,J., Agoulnik,A.I., Dohmae,K.,
            Nishimune,Y., Levy,N. and Bishop,C.E.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
REFERENCE   9  (bases 1 to 4566)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4566)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007215.1, AK220391.1, AK159710.1, AK165554.1, AC083910.9 and
            BQ031098.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165554.1, AK159710.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164134
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AK007215.1         2-67
            67-441              AK220391.1         1-375
            442-1894            AK159710.1         413-1865
            1895-2813           AK165554.1         1867-2785
            2814-4183           AC083910.9         45901-47270
            4184-4566           BQ031098.1         1-383               c
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.94 cM"
     gene            1..4566
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /note="WD repeat and FYVE domain containing 1"
                     /db_xref="GeneID:69368"
                     /db_xref="MGI:MGI:1916618"
     exon            1..206
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1302
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /note="isoform 1 is encoded by transcript variant 1; WD40
                     and FYVE domain containing 1; WD40- and FYVE
                     domain-containing protein 1; WD repeat and FYVE
                     domain-containing protein 1"
                     /codon_start=1
                     /product="WD repeat and FYVE domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001104749.1"
                     /db_xref="CCDS:CCDS48296.1"
                     /db_xref="GeneID:69368"
                     /db_xref="MGI:MGI:1916618"
                     /translation="MAAEIHSRPQSSRPVLLSKIEGHQDAVTAALLIPKEDGVITASE
                     DRTIRVWLKRDSGQYWPSIYHTMASPCSAMAYHHDSRRIFVGQDNGAVMEFHVSEDFN
                     KMNFIKTYPAHQNRVSAIIFSLAAEWVISTGHDKCVSWMCTRSGNMLGRHFFSSWASC
                     LQYDLDTQHAFVGDYSGQITLLKLEQNTCSVITTLKGHEGSIACLWWDPIQRLLFSGA
                     SDNSVIMWDIGGRKGRTLLLQGHHDRVQSLCYLQLTRQLVSCSADGGIAVWNMDVSRE
                     EAPQWLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPV
                     MGFEFQVRVCDSCYDSIKDEDRTSLATFHEGKHNISHMSMDIARGLMVTCGTDRVVKI
                     WDMTPVVGCSLATGFSPH"
     exon            207..274
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            275..348
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            349..403
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            404..554
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            555..667
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            668..794
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            795..900
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1002
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1133
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1242
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..4551
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /note="hexamer: AATAAA"
     polyA_site      3769
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /note="hexamer: AATAAA"
     polyA_site      4551
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /note="major polyA site"
ORIGIN      
        1 aagcaaccgg cgcgtccccg cccggcggtc agctgatggg ccgcccgcgg gggaggccgc
       61 ggctcgaaca tggcggcgga gatccactcc aggcctcaga gcagccgccc ggtgctgctg
      121 agcaagatag agggccacca ggacgccgtc accgccgcgc tgctcatccc caaggaggac
      181 ggcgtgatca ccgctagcga ggacagaacc atccgagtat ggctgaaaag agacagcggc
      241 cagtactggc ccagcatcta ccacacaatg gcctcccctt gctctgccat ggcataccac
      301 cacgacagca ggcggatatt tgtgggccag gataatgggg ctgtgatgga atttcacgtt
      361 tctgaagatt ttaataaaat gaattttatc aagacctatc cagcccacca gaaccgcgtg
      421 tctgctatca tcttcagcct ggctgccgag tgggtgatca gcactggcca cgacaagtgt
      481 gtgagctgga tgtgcacgcg cagcgggaat atgcttggcc gccacttctt ctcgtcgtgg
      541 gcttcctgtt tgcagtatga tctggacact cagcacgcct ttgttggcga ttactcggga
      601 cagatcaccc tgctgaagct ggagcagaac acttgttcag ttatcacgac cctcaaggga
      661 catgaaggta gcatcgcctg cctttggtgg gaccctatcc aacggttact cttctcggga
      721 gcatccgaca acagcgtcat catgtgggac atcgggggac ggaaaggccg gacactcctc
      781 cttcaaggcc accatgacag agtgcagtca ctgtgctacc tgcagctcac gaggcagctc
      841 gtctcctgct cggcagatgg tggcattgca gtgtggaaca tggatgttag cagagaagag
      901 gctcctcagt ggttagaaag cgactcctgt cagaagtgtg agcagccctt cttctggaat
      961 ataaaacaga tgtgggacac aaagaccctg ggcttgaggc agcatcactg caggaagtgt
     1021 gggcaggccg tctgtgggaa gtgcagcagc aagcggtcca gttaccccgt catgggtttt
     1081 gagttccagg ttcgagtttg tgattcctgt tacgactcca tcaaagatga ggaccggact
     1141 tctctagcaa catttcatga aggaaaacat aacatttccc atatgtccat ggacattgca
     1201 aggggactga tggtgacctg tgggacagat cgtgttgtga agatatggga tatgactcct
     1261 gtggtgggct gcagcctggc aactggattt tctccacact gatcccagag ctgggtgatg
     1321 tctgctacac gtgatgcata gcatcctcca tgaatggaga cccttcatgt agctcaacag
     1381 ccactgtcgt gtaaatggac attagacgcc taaaaaaaca aatcaatatt ttttaaaaga
     1441 aaaaaatcta tataaaggtg tgtttggggg tatttgtgga aattgtctaa aaggtctgtc
     1501 cacaacggac tcctaaggag tagaatttcc tcagcaaaac tgcctcatga acattgaacc
     1561 agtgggtaag gagggaacaa tgaagggttt agaaggaaaa atttttaaat gaaaaaggtt
     1621 agtgcttaga acttcttaaa tgcaaaccca tgagcacaca tggagtctcc cgagagggtc
     1681 cttgaggccc ctgagagtac tcagatacac aaccaggggc tgggggagag ctttctgtct
     1741 ttcttcaggg gaggtggcca gatgtgagaa acctatgctt gccatacaaa tgtcctctac
     1801 accgagttac tgataaacct catcaaggta cctgttctgt caggtggtgt cctaatctgc
     1861 tcttgggttt ggctcactct agttgtttct gtcccagcca gtgtcccctg ggtgaacctt
     1921 tacagctgtc atataacaag acagagcaca ttcatctcct tctcccaaac ctgccctgtg
     1981 gacaaagctt tcttttatgg tgctgatgta caagcctcct gacatttttt ttctttgtag
     2041 ctagtcatga cccatggcaa actcagctac caccatggtg gtgatgcgtg ccagcagcct
     2101 actccatgga acagcccagt cttgctaact gatacatttg tttgtagtcc caagaccaag
     2161 cccttgttat atggtagcaa gttatgcccc tcagaagtac tctggcgctt ctgtattatg
     2221 ttgtagctgt gaccagtgtt agtcatgtgt catagaaaga aattggtggc ccattgctaa
     2281 aattatcagt caggtcttgt acagtaatcc ctaacctgca aatcacttac atagcattta
     2341 gaaaagctgt tgtatgaaat gtgttgtcca atttttggcc agattaccaa gagatgtttg
     2401 tgtgtgtttg tgtaaacaga aagtagcaca tgaactattc cagtagaacc gtgggagcct
     2461 gctgcttgcc ggtaggaaag gcctactgct ttaacggatg aataatgact acctacagca
     2521 tccgtgtgac tcttgctaat gggtatggat ttaaaatctc actgtagcac tgtgttgggt
     2581 tacatcaaga tcaaggccat tctgccagag aggactaagg ctttatcact ttaccaacat
     2641 ggctaacaag gaggtggcgc acgcctttaa tcccagcact cgggaggcag aggcaggcag
     2701 ttttatgagt tcgaggccag cctggtctac aaactgagtt ccaggacagc cagggctaca
     2761 cagagaaacc ctgtctcaaa aaaacaaaaa acaaaaaaaa aaaaaaaaaa aaaaacaggc
     2821 agaaaagcta tggggtcaca atggataaaa cacaaacaat gaggaaagga aaggcagcca
     2881 ggcataatgg gctctgtatt tacagagagc tcttgacttg agaaataaga ccaaaggatg
     2941 ttttgccccc tttatgtttt atgtagcgtc acttttaact gctggttttt cattggattc
     3001 cccttacact atacaagatg tggattgctc cagtgctttg gacaagagag tgggtgacgt
     3061 cgtgaaacca caatgtagaa tgctctcctc gctgcttggt ttagctcagc ctgtggttct
     3121 gcccacgcaa gggaaacaga ccatggcgga gtcattgccc tgtggaatag tgctgagcca
     3181 ggcgtgggtt tattttctta aaagcatctg taaaatgtga cttttggata tctgtggtag
     3241 atcaaactga atattccctc tcctttttaa agcctcctga tagaaaaccc cgtgcctcat
     3301 agagagcatg tagtggttgg tttgagcctt ttaagaggct attagaaatc aaggaggaaa
     3361 aattatattt aaagaagaat tagagggagg gaccttagga gggaatgcag gctgaatgca
     3421 cttcgctcct cacttgagcc tgtggtcaca tctcctttca aaaacgtgct tgccaggctc
     3481 ccctatgtgt caggtagcaa agggggccat attttttata gagggtgaag attatattct
     3541 caagtttact gactgaaggg acaataaggc tcaggctttt tgccttattt ggattctgtt
     3601 gctaaacaca tcacttaaga gagttcctca agtaacaact atgtcctttc catcccagaa
     3661 ttctcaagct aatttgtaca gacaaggatc aagaagtaga gggtgttaga caagagtctt
     3721 gaacttagat ctagtatgta ataaagtgat gccgagtctt tattctcaat gtgttcttta
     3781 ctggtccttt attagttggt cctagtgata gcaataggcc tgtatgttgg tagaaaccac
     3841 ttcttattca ctagactgta attgtttact atgtcccagt tttaacttgc tgcctagtgg
     3901 gcagcaatag acactgttgc tgtagactat gctttgttct cccgcaccag tgattcagtt
     3961 tgttaacatc tatatttatt aaacttgtca aaattgataa atagagtagc agctcagacc
     4021 caagaagata tttttgaaaa tcagggtttc attaaaagta ctttctaata tctcctaaat
     4081 gacaagcatc aagttactgt taatgacagt gatctgctca ttctacatgg gaggcttaac
     4141 aaataagtaa tatatgctga cttctgcaag tgtctgttgc ttaattgtta attgtgagca
     4201 gattattgaa tgcctcatct attttctgca gtttactaca caataactct ttgaataagt
     4261 tgaagtttaa tcgtgcaaca aatttctatc agagaacaat gtaaagtatt ttactctgta
     4321 gccttttttt gttttttgac ttgggaagca aaaggtgaca ttaagtaagt caatgtgtcc
     4381 ttgtacaact gtgtttccat agagtaggat gccttgtgta tccgagagac gctgcaaatt
     4441 tttgttcttt ctacttgtgg gttccatttt tgtgggcttt tttattttat ttttagtttt
     4501 agttttgaga atacacatat aacaataaaa taccccttgc ttgttcctta aaaaaaaaaa
     4561 aaaaaa
//
