LOCUS       NP_001104749             410 aa            linear   ROD 10-FEB-2025
DEFINITION  WD repeat and FYVE domain-containing protein 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001104749
VERSION     NP_001104749.1
DBSOURCE    REFSEQ: accession NM_001111279.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 410)
  AUTHORS   Doherty,R., MacLeod,B.L., Nelson,M.M., Ibrahim,M.M.H., Borges,B.C.,
            Jaradat,N.W., Finneran,M.C., Giger,R.J. and Corfas,G.
  TITLE     Identification of in vivo roles of ErbB4-JMa and its direct nuclear
            signaling using a novel isoform-specific knock out mouse
  JOURNAL   Sci Rep 12 (1), 17267 (2022)
   PUBMED   36241655
  REMARK    Erratum:[Sci Rep. 2022 Dec 1;12(1):20748. doi:
            10.1038/s41598-022-25021-8.. PMID: 36456684]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 410)
  AUTHORS   Lv,C., Xiong,M., Guo,S., Gui,Y., Liu,X., Wang,X., Wu,Y., Feng,S.,
            Zhang,J., Zhang,Y., Liu,Y., Qin,W. and Yuan,S.
  TITLE     WDFY1, a WD40 repeat protein, is not essential for spermatogenesis
            and male fertility in mice
  JOURNAL   Biochem Biophys Res Commun 596, 71-75 (2022)
   PUBMED   35121371
  REMARK    GeneRIF: WDFY1, a WD40 repeat protein, is not essential for
            spermatogenesis and male fertility in mice.
REFERENCE   4  (residues 1 to 410)
  AUTHORS   Rahman,S., Vandewalle,J., van Hamersveld,P.H.P., Verseijden,C.,
            Welting,O., Jongejan,A., Casanova,P., Meijer,S.L., Libert,C.,
            Hakvoort,T.B.M., de Jonge,W.J. and Heinsbroek,S.E.M.
  TITLE     miR-511 Deficiency Protects Mice from Experimental Colitis by
            Reducing TLR3 and TLR4 Responses via WD Repeat and
            FYVE-Domain-Containing Protein 1
  JOURNAL   Cells 11 (1), 58 (2021)
   PUBMED   35011620
  REMARK    GeneRIF: miR-511 Deficiency Protects Mice from Experimental Colitis
            by Reducing TLR3 and TLR4 Responses via WD Repeat and
            FYVE-Domain-Containing Protein 1.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 410)
  AUTHORS   Boschen,K.E., Ptacek,T.S., Berginski,M.E., Simon,J.M. and
            Parnell,S.E.
  TITLE     Transcriptomic analyses of gastrulation-stage mouse embryos with
            differential susceptibility to alcohol
  JOURNAL   Dis Model Mech 14 (6) (2021)
   PUBMED   34137816
REFERENCE   6  (residues 1 to 410)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (residues 1 to 410)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 410)
  AUTHORS   Boettger-Tong,H.L., Rohozinski,J., Agoulnik,A.I., Dohmae,K.,
            Nishimune,Y., Levy,N. and Bishop,C.E.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
REFERENCE   9  (residues 1 to 410)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 410)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007215.1, AK220391.1, AK159710.1, AK165554.1, AC083910.9 and
            BQ031098.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165554.1, AK159710.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164134
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.94 cM"
     Protein         1..410
                     /product="WD repeat and FYVE domain-containing protein 1
                     isoform 1"
                     /note="WD40 and FYVE domain containing 1; WD40- and FYVE
                     domain-containing protein 1; WD repeat and FYVE
                     domain-containing protein 1"
                     /calculated_mol_wt=46087
     Region          <16..272
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..61
                     /region_name="WD 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          28..67
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..105
                     /region_name="WD 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          71..111
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..150
                     /region_name="WD 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          118..153
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..192
                     /region_name="WD 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          158..196
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          197..236
                     /region_name="WD 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          202..239
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..279
                     /region_name="WD 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          245..269
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          279..354
                     /region_name="FYVE_WDFY1"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein 1 (WDFY1) and similar proteins;
                     cd15756"
                     /db_xref="CDD:277295"
     Site            order(281,285,310..315,317..318,342..344)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277295"
     Region          364..403
                     /region_name="WD 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q4P1.1)"
     Region          369..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Site            408
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (E9Q4P1.1)"
     CDS             1..410
                     /gene="Wdfy1"
                     /gene_synonym="1700013B03Rik; 1700120F24Rik; FENS-1; Jr1;
                     mKIAA1435; WDF1; ZFYVE17"
                     /coded_by="NM_001111279.1:70..1302"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48296.1"
                     /db_xref="GeneID:69368"
                     /db_xref="MGI:MGI:1916618"
ORIGIN      
        1 maaeihsrpq ssrpvllski eghqdavtaa llipkedgvi tasedrtirv wlkrdsgqyw
       61 psiyhtmasp csamayhhds rrifvgqdng avmefhvsed fnkmnfikty pahqnrvsai
      121 ifslaaewvi stghdkcvsw mctrsgnmlg rhffsswasc lqydldtqha fvgdysgqit
      181 llkleqntcs vittlkgheg siaclwwdpi qrllfsgasd nsvimwdigg rkgrtlllqg
      241 hhdrvqslcy lqltrqlvsc sadggiavwn mdvsreeapq wlesdscqkc eqpffwnikq
      301 mwdtktlglr qhhcrkcgqa vcgkcsskrs sypvmgfefq vrvcdscyds ikdedrtsla
      361 tfhegkhnis hmsmdiargl mvtcgtdrvv kiwdmtpvvg cslatgfsph
//
