LOCUS       NM_018765               3452 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WW domain binding protein 4 (Wbp4), mRNA.
ACCESSION   NM_018765
VERSION     NM_018765.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3452)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   2  (bases 1 to 3452)
  AUTHORS   Yadav,N., Lee,J., Kim,J., Shen,J., Hu,M.C., Aldaz,C.M. and
            Bedford,M.T.
  TITLE     Specific protein methylation defects and gene expression
            perturbations in coactivator-associated arginine methyltransferase
            1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (11), 6464-6468 (2003)
   PUBMED   12756295
REFERENCE   3  (bases 1 to 3452)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
REFERENCE   4  (bases 1 to 3452)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151994.3.
            
            On Jan 30, 2007 this sequence version replaced NM_018765.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135215.1, AK159522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC151994.3         145238-145575       c
            339-411             AC151994.3         144680-144752       c
            412-474             AC151994.3         141349-141411       c
            475-604             AC151994.3         141110-141239       c
            605-778             AC151994.3         136659-136832       c
            779-825             AC151994.3         134994-135040       c
            826-901             AC151994.3         134412-134487       c
            902-1092            AC151994.3         131580-131770       c
            1093-1259           AC151994.3         130490-130656       c
            1260-3452           AC151994.3         124244-126436       c
FEATURES             Location/Qualifiers
     source          1..3452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.66 cM"
     gene            1..3452
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="WW domain binding protein 4"
                     /db_xref="GeneID:22380"
                     /db_xref="MGI:MGI:109568"
     exon            1..338
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1467
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="formin binding protein 21; WBP-4; WW
                     domain-containing-binding protein 4"
                     /codon_start=1
                     /product="WW domain-binding protein 4"
                     /protein_id="NP_061235.2"
                     /db_xref="CCDS:CCDS27300.1"
                     /db_xref="GeneID:22380"
                     /db_xref="MGI:MGI:109568"
                     /translation="MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVARRI
                     SEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLPLPSDISEPTVSPVIST
                     VQPTPTSNQQKEKKKKKKKKEASKGGWVEGVTADGHCYYYDLITGASQWEKPEGFQGN
                     LKKTAAKAVWVEGLSEDGYTYYYNTETGESKWEKPEDFIPHGGDVLSSKDSGKLPDTL
                     EDAKSSDSHSDSEGEQKKAGEASTETKKLIIKFKEKNKSTEKRIGPEIQKEKSTPKQN
                     PSNTNEEKPKTLKKSTNPYGEWQEIKQEAESQEEVDLELPSTEGECLSTSEAGVGEIK
                     VVFKEKTVSSLGVAADGVAPVFKKRRLENGKSRNLRQRGDDE"
     exon            339..411
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            412..474
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            475..604
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            605..778
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            779..825
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            826..901
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1092
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1259
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..3452
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="hexamer: AATAAA"
     polyA_site      1643
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="major polyA site"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="hexamer: ATTAAA"
     polyA_site      2456
                     /gene="Wbp4"
                     /gene_synonym="FBP21"
                     /note="major polyA site"
ORIGIN      
        1 gaggttctgg atcccgggag gcgtgaggac cgcgggatgg agcctgggtc ggacgctcgg
       61 ggcccgcggc tccggtcccg tcgcgctttc gtcccttctg ggtgacctca acccctttat
      121 accgacccca cctctcaggc gccgcgagta ccgccccgtg ggggagggga agaggcggtg
      181 acaaccgcgc gcgcgggttg ggccgtcgcg gccgccgtag tccacccgtg gaaacgccgt
      241 acccgggggg gacgccgaga ccgagaggtc ctggcttgag ccaccggcgg acatcagtga
      301 gcgggatcgc gggctgcccg cggagctgcc gccgtcatgg ccgactactg gaagtcacaa
      361 ccaaagaaat tctgtgatta ctgcaagtgc tggatagcag acaataggcc tagtgttgag
      421 tttcatgaaa gaggaaagaa tcacaaggaa aatgtggcca ggaggatcag tgagattaaa
      481 cagaaaagct tggataaggc aaaggaagaa gaaaaggcat ccaaggagtt tgctgccatg
      541 gaggcagccg ccctgaaggc gtaccaagag gatctgaaaa ggctcggctt acccctaccc
      601 tcagacattt cagagccaac tgtatcacca gtcatcagca ctgtccaacc cacccctacg
      661 tcaaatcaac agaaagagaa gaaaaagaag aagaagaaga aagaagcttc aaagggtgga
      721 tgggtggaag gcgtgacagc cgacggccac tgctactatt atgatctcat cacaggagca
      781 tctcaatggg agaagccaga aggatttcaa gggaatttga aaaagacagc agcaaaggcc
      841 gtttgggtag aaggcttaag tgaagacggc tacacctatt attataatac agaaacagga
      901 gaatccaaat gggaaaagcc tgaagatttc atcccacatg gcggggatgt gctttctagt
      961 aaggacagtg gaaagttgcc cgacacccta gaagacgcca agtcctccga ttctcacagt
     1021 gattccgaag gggaacagaa gaaagctgga gaggcctcca cagagaccaa gaagctaatc
     1081 ataaagttta aggagaaaaa taaaagtact gagaaaagaa ttggcccaga aatacaaaaa
     1141 gaaaaaagta ctccaaaaca gaatccatca aatacaaatg aagaaaaacc caaaactctt
     1201 aagaaatcga caaaccctta tggggaatgg caagaaatta aacaggaggc tgagtctcaa
     1261 gaagaagttg atttggaact tccaagcact gaaggggaat gtctatcaac ttcagaagct
     1321 ggcgttgggg aaatcaaagt ggtatttaaa gagaaaacag tttcttctct gggagttgca
     1381 gcagatggag tggccccagt cttcaaaaag agaagacttg aaaatggaaa atctcgaaac
     1441 ttaagacagc gaggtgacga cgagtgactg tgaagctatg gatggaaggg gtgtcctttc
     1501 caagctgctc tgtgctctgt gaagctgtgg agaggaggtg tgtcctttcc aagctcctgt
     1561 gctttgaata ctgtagtgct gcattttaca tttatgctaa atatatttta tgtgaatcaa
     1621 aataaatctt ttttcatgtg aaatttattt ttgttcctta agtggtagcc taccacattg
     1681 cattgtaata cagtgtatta tgttcaatgt ctaaaattgc taattatata ataatttaag
     1741 atgctatgta tctgttattt aaaacatggg gaagaccttt gctctgttct tacttataaa
     1801 catatttatt ctgcattgaa aatgcattat ttccatatgc tgaaattaac ttgttacctg
     1861 agaagtaaga aatcagacac agccccaaga caatgtggtt ttgacagtcc tttctgaagc
     1921 ctggatgtag aaaactgcag atcggcttgt cttactccat ttaggacgga agaccaggag
     1981 aaggacgcac ctgagcactg acgtgcagag tgacagctgg accaagggtt gaaacctgtg
     2041 cttgcctcag atcagctgat agctgtagta tcttacaacc attttaacat ggggccaagc
     2101 cttggggggc ttgagataga ggggcagcct ctgccctacc attggttacg ttctggcaca
     2161 gccctttccc agtccggcat ccttttcata gccctggatc cgttggaagg tttacctaag
     2221 ttaactgcaa aaggcttgaa ctgaaatagg ttgtgttgtc cacttagatg ttccccattt
     2281 tctggttcca tttcttcaaa tagaagtttc atattctatt tgaagtactt ccctttatta
     2341 cttttgaata tttttaatca tttttcttaa gttgtacagt accttttggt agcaaatgtc
     2401 tttttacaat tgttagtgta catgtaagaa tagcttatta aaaaccataa agtaaatatc
     2461 ggggtctctt tttcttctaa tatgcatcaa agttacctta acattgacaa aacagtattt
     2521 gaagtattag tcttgacaat cactcaggct gaaactctgt attttgcggt attttaattt
     2581 ttgttttgtt aagagttttg ctgtgttgcc cttgaagact aacctcaagt ccagatcctc
     2641 tggcctaaga gtactcaaga acactggaat taaggactgg tgagccggct caagtgtgta
     2701 agagcactga ctgctctact aaaggtcctg agtttaaatc ccagcaacca catggtggct
     2761 cacaatcacc cataatgaga gctgacaccc tcttctggtg tgtctgaagt cagctgcagt
     2821 gtgcttatgt ataataataa atctttaaaa gaaaaagaat attaatgggt ataccatgat
     2881 acctgactga tagttgagta gtctttgact agggtggcca aggcctcacc atgcatatct
     2941 ggctgccttc aaacttgcag ttaccctcct gcctaaaacc ttagttctgg gattgttggc
     3001 gtgagccaac acaccccact ggtttattgg gggtttttgt agttgattgg gttctgcttt
     3061 tatttagtta gttggcttgg tttgatgggg gggggcgagt attgttggtt ttgttttgtt
     3121 tgagaccctc ttgtctgcca ggctagtctg gaacaactcc ctcctaaagt agcttggctg
     3181 aagatgacct taaacttgtg actctcctgt tttccacttc cccagagcta caggtgtgtg
     3241 ctaccctccc agtttctggg gtgctagact gagcaagcac caatggagcc atgatctgtt
     3301 tttcagtttt taataggcca tttgttatgt ctctgaggaa tatatatcag tccttgattc
     3361 ttttcaagtt ggaaaatact aaaagtggaa ccagtgcttt tatattttat ccacatttag
     3421 ctcctataaa ataaaatatt gaagacatat gc
//
