LOCUS       NM_029066               1318 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WBP2 N-terminal like (Wbp2nl), mRNA.
ACCESSION   NM_029066 XM_001001745 XM_905693 XM_987274
VERSION     NM_029066.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Satouh,Y., Nozawa,K. and Ikawa,M.
  TITLE     Sperm postacrosomal WW domain-binding protein is not required for
            mouse egg activation
  JOURNAL   Biol Reprod 93 (4), 94 (2015)
   PUBMED   26377222
  REMARK    GeneRIF: PAWP does not play an essential role in mouse
            fertilization
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Nomikos,M., Sanders,J.R., Theodoridou,M., Kashir,J., Matthews,E.,
            Nounesis,G., Lai,F.A. and Swann,K.
  TITLE     Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does
            not cause Ca2+ release in mouse oocytes
  JOURNAL   Mol Hum Reprod 20 (10), 938-947 (2014)
   PUBMED   25057041
  REMARK    GeneRIF: The data suggest that sperm-derived PAWP is not involved
            in triggering Ca(2+) oscillations at fertilization in mammalian
            oocytes.
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Aarabi,M., Balakier,H., Bashar,S., Moskovtsev,S.I., Sutovsky,P.,
            Librach,C.L. and Oko,R.
  TITLE     Sperm-derived WW domain-binding protein, PAWP, elicits calcium
            oscillations and oocyte activation in humans and mice
  JOURNAL   FASEB J 28 (10), 4434-4440 (2014)
   PUBMED   24970390
REFERENCE   5  (bases 1 to 1318)
  AUTHORS   Nourashrafeddin,S., Aarabi,M., Miryounesi,M.,
            Ebrahimzadeh-Vesal,R., Zarghami,N., Modarressi,M.H. and Nouri,M.
  TITLE     Expression analysis of PAWP during mouse embryonic stem cell-based
            spermatogenesis in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (5), 475-481 (2014)
   PUBMED   24381051
  REMARK    GeneRIF: These results indicate that PAWP plays a role in
            spermatogenesis and germ cell development. Moreover, we suggest
            PAWP as one of the markers that could be looked in ESC studies as a
            confirmed testis-specific gene
REFERENCE   6  (bases 1 to 1318)
  AUTHORS   Wu,A.T., Sutovsky,P., Xu,W., van der Spoel,A.C., Platt,F.M. and
            Oko,R.
  TITLE     The postacrosomal assembly of sperm head protein, PAWP, is
            independent of acrosome formation and dependent on microtubular
            manchette transport
  JOURNAL   Dev Biol 312 (2), 471-483 (2007)
   PUBMED   17988661
  REMARK    GeneRIF: The postacrosomal assembly of sperm head protein, PAWP, is
            independent of acrosome formation and dependent on microtubular
            manchette transport
REFERENCE   7  (bases 1 to 1318)
  AUTHORS   Wu,A.T., Sutovsky,P., Manandhar,G., Xu,W., Katayama,M., Day,B.N.,
            Park,K.W., Yi,Y.J., Xi,Y.W., Prather,R.S. and Oko,R.
  TITLE     PAWP, a sperm-specific WW domain-binding protein, promotes meiotic
            resumption and pronuclear development during fertilization
  JOURNAL   J Biol Chem 282 (16), 12164-12175 (2007)
   PUBMED   17289678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC119520.2.
            
            On or before Nov 9, 2006 this sequence version replaced
            XM_905693.2, XM_987274.1, XM_001001745.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119520.2, AK015863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.56 cM"
     gene            1..1318
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /note="WBP2 N-terminal like"
                     /db_xref="GeneID:74716"
                     /db_xref="MGI:MGI:1921966"
     exon            1..85
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1103
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /note="WW domain-binding protein 2-like"
                     /codon_start=1
                     /product="postacrosomal sheath WW domain-binding protein"
                     /protein_id="NP_083342.1"
                     /db_xref="CCDS:CCDS37158.1"
                     /db_xref="GeneID:74716"
                     /db_xref="MGI:MGI:1921966"
                     /translation="MAVNQNHTVDRRWAAIPHGESLLKKCSEVDLSFPQSPPGSNLFS
                     GTKRGALFLTSYRVIFVTSRADNDPMFSFTMPFHLMNNCTVEQPIFGANYIKGTIQAA
                     PDGGWEGSATFKIVFRKGGAIDFAQLMAKAASAAAQGVPLRVASFWMGPLGIYVITGD
                     RNMYAPQAYQVAYGAPPAGYGASPVGYGVPSAGYGAPPAGYGAPPVGYVAPSPGYDVL
                     PPGYGAVRYGSPPPLYVATPMGYGVPPPGYGPPPVRYGSPPPGYEAPTMEYGAQPPRY
                     GTTPMGSGSPPPRYEAPPMGYGTPPSGRESIPPGSRATSVAQEAPPAGSEAGHPMSVA
                     VQNPEFQASFPSTSSSQVHSPRSKM"
     exon            86..194
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            195..336
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            337..429
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            430..534
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1318
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1127
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
                     /note="major polyA site"
     polyA_site      1182
                     /gene="Wbp2nl"
                     /gene_synonym="4930521I23Rik; PAWP"
ORIGIN      
        1 ggcgggagga gacctagagc aagatggcag tgaaccagaa ccatacagtg gaccgccgtt
       61 gggccgccat ccctcatggt gaaagtctct tgaagaaatg ttcagaagtg gacctctcct
      121 tcccccagtc accgccaggc tccaacctct ttagtggtac aaagaggggg gctctgtttc
      181 tcacctcata ccgggtgatt tttgtgactt cgcgtgcaga caacgatccc atgttttctt
      241 ttacgatgcc atttcatcta atgaataact gcactgttga acaaccaatc tttggtgcaa
      301 actacattaa agggacaatt caggcagctc cagacggtgg ctgggaaggt tctgctactt
      361 ttaaaatagt cttccggaaa ggaggtgcta tcgactttgc ccagttgatg gccaaagctg
      421 cctctgcggc tgcccaagga gttccactac gagttgcaag cttctggatg ggccctctag
      481 gaatttatgt catcactggg gacaggaaca tgtatgcccc acaggcatac caagttgcct
      541 atggagcccc acctgcggga tatggggcct cacccgtggg atacggagtc ccatctgcag
      601 ggtatggagc cccacctgcg gggtacggag ccccgccagt gggttatgta gccccatctc
      661 ccggatacga tgtcctgcct cctggatacg gagctgtgag atatggctcc cctcctcctc
      721 tatatgtagc taccccaatg ggctatggag ttccacctcc tggatatgga cctccacctg
      781 tgagatacgg atccccacct cctggatatg aagcccccac tatggagtat ggagcccaac
      841 ctcccagata cggaactaca cctatgggat ccggttcccc acctcccaga tatgaagccc
      901 cgcctatggg gtatggaact cctccttcag ggcgtgagtc catacctcct ggatcaaggg
      961 ccacgtctgt agcacaggaa gctccacctg ctgggtctga agcaggccat cccatgtctg
     1021 tggcagtcca gaatcctgaa ttccaggcat cttttccctc tacctcgtcc tcacaagtcc
     1081 actctccccg ctctaagatg taaaccttga agtttcacca agcaaaacag caccctaatg
     1141 ttgaagtcaa gataacccgg aacacttagg tatctgatca cagacctgtt ctaggtagtt
     1201 tgtttccctc cttgggagtt tagtcacagg gtggaaccaa atcttatctc catgtcttgc
     1261 ttgtagaagc agtgtgaatt cttggttagc tggataaaga agggacagcg tcagaggg
//
