LOCUS       NM_016852               1828 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WW domain binding protein 2 (Wbp2), transcript variant
            1, mRNA.
ACCESSION   NM_016852
VERSION     NM_016852.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1828)
  AUTHORS   Zheng,Z., Li,Y., Fan,S., An,J., Luo,X., Liang,M., Zhu,F. and
            Huang,K.
  TITLE     WW domain-binding protein 2 overexpression prevents diet-induced
            liver steatosis and insulin resistance through AMPKbeta1
  JOURNAL   Cell Death Dis 12 (3), 228 (2021)
   PUBMED   33658485
  REMARK    GeneRIF: WW domain-binding protein 2 overexpression prevents
            diet-induced liver steatosis and insulin resistance through
            AMPKbeta1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1828)
  AUTHORS   Field,N.S., Elbulok,O.A., Dybas,J.M., Moser,E.K., Dar,A.A.,
            Spruce,L.A., Fazelinia,H., Seeholzer,S.H. and Oliver,P.M.
  TITLE     Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2
            protein stability
  JOURNAL   Eur J Immunol 50 (10), 1468-1483 (2020)
   PUBMED   32459862
REFERENCE   4  (bases 1 to 1828)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1828)
  AUTHORS   Walko,G., Woodhouse,S., Pisco,A.O., Rognoni,E., Liakath-Ali,K.,
            Lichtenberger,B.M., Mishra,A., Telerman,S.B., Viswanathan,P.,
            Logtenberg,M., Renz,L.M., Donati,G., Quist,S.R. and Watt,F.M.
  TITLE     A genome-wide screen identifies YAP/WBP2 interplay conferring
            growth advantage on human epidermal stem cells
  JOURNAL   Nat Commun 8, 14744 (2017)
   PUBMED   28332498
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1828)
  AUTHORS   Buniello,A., Ingham,N.J., Lewis,M.A., Huma,A.C., Martinez-Vega,R.,
            Varela-Nieto,I., Vizcay-Barrena,G., Fleck,R.A., Houston,O.,
            Bardhan,T., Johnson,S.L., White,J.K., Yuan,H., Marcotti,W. and
            Steel,K.P.
  TITLE     Wbp2 is required for normal glutamatergic synapses in the cochlea
            and is crucial for hearing
  JOURNAL   EMBO Mol Med 8 (3), 191-207 (2016)
   PUBMED   26881968
REFERENCE   7  (bases 1 to 1828)
  AUTHORS   Lim,S.K., Orhant-Prioux,M., Toy,W., Tan,K.Y. and Lim,Y.P.
  TITLE     Tyrosine phosphorylation of transcriptional coactivator WW-domain
            binding protein 2 regulates estrogen receptor alpha function in
            breast cancer via the Wnt pathway
  JOURNAL   FASEB J 25 (9), 3004-3018 (2011)
   PUBMED   21642474
  REMARK    GeneRIF: This study established WBP2 as a tyrosine phosphorylation
            target of estrogen signaling via EGFR crosstalk.
REFERENCE   8  (bases 1 to 1828)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   9  (bases 1 to 1828)
  AUTHORS   Chen,H.I. and Sudol,M.
  TITLE     The WW domain of Yes-associated protein binds a proline-rich ligand
            that differs from the consensus established for Src homology
            3-binding modules
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7819-7823 (1995)
   PUBMED   7644498
REFERENCE   10 (bases 1 to 1828)
  AUTHORS   Sudol,M., Chen,H.I., Bougeret,C., Einbond,A. and Bork,P.
  TITLE     Characterization of a novel protein-binding module--the WW domain
  JOURNAL   FEBS Lett 369 (1), 67-71 (1995)
   PUBMED   7641887
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607108.17.
            
            On Mar 19, 2018 this sequence version replaced NM_016852.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031908.1, AK043037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AL607108.17        103224-103352       c
            130-238             AL607108.17        100196-100304       c
            239-374             AL607108.17        98633-98768         c
            375-467             AL607108.17        97589-97681         c
            468-602             AL607108.17        96903-97037         c
            603-725             AL607108.17        96579-96701         c
            726-802             AL607108.17        96065-96141         c
            803-1828            AL607108.17        94928-95953         c
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..1828
                     /gene="Wbp2"
                     /note="WW domain binding protein 2"
                     /db_xref="GeneID:22378"
                     /db_xref="MGI:MGI:104709"
     exon            1..129
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..856
                     /gene="Wbp2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     WBP-2"
                     /codon_start=1
                     /product="WW domain-binding protein 2 isoform 1"
                     /protein_id="NP_058548.1"
                     /db_xref="CCDS:CCDS25657.1"
                     /db_xref="GeneID:22378"
                     /db_xref="MGI:MGI:104709"
                     /translation="MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKG
                     TKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANFIKGIVKAEAGG
                     GWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPNGAYGYPYMPSGAYVFPPPVA
                     NGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPSAPATPA
                     AEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ"
     exon            130..238
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..374
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..467
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..602
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..725
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..802
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1828
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wbp2"
                     /note="hexamer: AGTAAA"
     polyA_site      1826
                     /gene="Wbp2"
                     /note="major polyA site"
ORIGIN      
        1 actagaggcg ggccaaagac cagcgcaagc gcagagcgtt gcgagtctcg ggaccccagt
       61 gggagagact atggcgctca acaagaatca ctcagagggc ggcggagtga tcgtcaacaa
      121 cactgagagc atcctaatgt cctatgatca tgtggagctt accttcaacg acatgaagaa
      181 tgtgccagag gccttcaaag ggaccaagaa aggcaccgtc taccttactc cgtaccgggt
      241 catctttctg tctaagggga aggacgccat gcagtccttc atgatgccct tttacctgat
      301 gaaggactgt gagattaagc agccggtgtt tggtgcgaac ttcattaagg gaatagtgaa
      361 ggctgaagca ggaggtggct gggaaggctc cgcctcctac aagctgacct tcacagcagg
      421 gggcgccatt gagtttgggc agaggatgct ccaggtggca tctcaagcct ccagaggtga
      481 agtccccaat ggagcctatg ggtaccctta catgcccagc ggggcctatg tctttccccc
      541 gccagtcgcc aatggaatgt acccctgccc tcctggctac ccctatccac cacccccacc
      601 cgagttctat ccaggacctc ccatgatgga tggggccatg ggctatgtac agcccccacc
      661 accaccctat cctgggccca tggagcctcc ggtcagcggc cccagtgccc ccgctactcc
      721 tgcagccgag gccaaggctg cagaagccgc tgccagtgcc tattacaacc caggcaaccc
      781 acacaatgtc tacatgccca cgagccagcc tccaccacca ccctactacc ccccagaaga
      841 caagaagacc cagtagaccc tgcccacttc ccgcctctta cccagagacc ccttcctggg
      901 cctcccgtgg ggctgcatct gggattccag gaggccaggg agggccctgt tcttccccag
      961 gcctgagtat aaagttagca ggagctagcc ctgatagaaa ggtggaactc ctggcctctg
     1021 agaggcacgt cccagcttct cgccctagct cagctcacag cgctcttctt cccagcttcc
     1081 ctttcaccat ctctggagct cgcaggagca cggggtgacc ctcgttcctc atgatactag
     1141 cccccaccca tacagaggga ctctctggcc actcctcact gctgcccagc cccttcagcc
     1201 tggtgaccat tgttcttcat ctcttgggct cctaagacca gccatgtgtc tccccaacag
     1261 gccctgccaa accctgttca cattccttac ccctggtgtg ctcctggctc tggaaggccg
     1321 ctgtcccagc agactgtcag tccagtcaca cttacccggc caccttgttc tttgtgagag
     1381 cttccaggga ttttgctggg cgcttccagt ggctggcatc agaggtgaag ccactgtgtt
     1441 acagaggaag cccctctgcc cctatgctac tgtttctggg aattattcgc ctcctctcct
     1501 ctccccttta cagggggctg ctctgcagga gggatagaga atgcatgtct gtcccgccag
     1561 gccctttgat ctgggactga ggccttccaa ctatgtgacc tctaacctgc agtctgcccc
     1621 tctgtaagct tcacgccccc tggatgcact aagaattgct cttgttcgtt cctggtccag
     1681 acacaaaatg aggagatggt tatttaaaga gaattcctat ttatttgaca caaaatgtcc
     1741 agttaatata ttaatgtgaa ataaaccctg tttgcacctt gatttgtttg ctacaactgt
     1801 gaaatagtaa aaacgaagtg actggagg
//
