LOCUS       NP_068360                641 aa            linear   ROD 01-JUN-2024
DEFINITION  WW domain-binding protein 11 [Mus musculus].
ACCESSION   NP_068360
VERSION     NP_068360.4
DBSOURCE    REFSEQ: accession NM_021714.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 641)
  AUTHORS   Martin,E.M.M.A., Enriquez,A., Sparrow,D.B., Humphreys,D.T.,
            McInerney-Leo,A.M., Leo,P.J., Duncan,E.L., Iyer,K.R., Greasby,J.A.,
            Ip,E., Giannoulatou,E., Sheng,D., Wohler,E., Dimartino,C.,
            Amiel,J., Capri,Y., Lehalle,D., Mory,A., Wilnai,Y., Lebenthal,Y.,
            Gharavi,A.G., Krzemien,G.G., Miklaszewska,M., Steiner,R.D.,
            Raggio,C., Blank,R., Baris Feldman,H., Milo Rasouly,H.,
            Sobreira,N.L.M., Jobling,R., Gordon,C.T., Giampietro,P.F.,
            Dunwoodie,S.L. and Chapman,G.
  TITLE     Heterozygous loss of WBP11 function causes multiple congenital
            defects in humans and mice
  JOURNAL   Hum Mol Genet 29 (22), 3662-3678 (2020)
   PUBMED   33276377
REFERENCE   2  (residues 1 to 641)
  AUTHORS   Llorian,M., Beullens,M., Lesage,B., Nicolaescu,E., Beke,L.,
            Landuyt,W., Ortiz,J.M. and Bollen,M.
  TITLE     Nucleocytoplasmic shuttling of the splicing factor SIPP1
  JOURNAL   J Biol Chem 280 (46), 38862-38869 (2005)
   PUBMED   16162498
  REMARK    GeneRIF: SIPP1 is a positive regulator of pre-mRNA splicing that is
            regulated by nucleocytoplasmic shuttling
REFERENCE   3  (residues 1 to 641)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   4  (residues 1 to 641)
  AUTHORS   Llorian,M., Beullens,M., Andres,I., Ortiz,J.M. and Bollen,M.
  TITLE     SIPP1, a novel pre-mRNA splicing factor and interactor of protein
            phosphatase-1
  JOURNAL   Biochem J 378 (Pt 1), 229-238 (2004)
   PUBMED   14640981
  REMARK    GeneRIF: Identification of SIPP1 as a pre-mRNA splicing factor and
            a binding partner of protein phosphatase-1.
REFERENCE   5  (residues 1 to 641)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   6  (residues 1 to 641)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122804.4 and AK041079.1.
            
            On Nov 13, 2009 this sequence version replaced NP_068360.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006600.1, AK153044.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     Protein         1..641
                     /product="WW domain-binding protein 11"
                     /note="Npw38-binding protein; WBP-11; splicing factor that
                     interacts with PQBP-1 and PP1"
                     /calculated_mol_wt=69744
     Region          1..45
                     /region_name="Required for nuclear import"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          1..37
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          12..92
                     /region_name="Wbp11"
                     /note="WW domain binding protein 11; pfam09429"
                     /db_xref="CDD:462795"
     Site            13
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            181
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          188..213
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            192
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W2; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          217..221
                     /region_name="Interaction with PP1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          236..550
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            236
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            237
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            279
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W2; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W2; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          306..310
                     /region_name="Interaction with PP1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            353
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            361
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            364
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          455..466
                     /region_name="PGR"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            565
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          588..620
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     Site            600
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2W2; propagated from
                     UniProtKB/Swiss-Prot (Q923D5.2)"
     Region          633..641
                     /region_name="Required for nuclear export"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923D5.2)"
     CDS             1..641
                     /gene="Wbp11"
                     /gene_synonym="2510026P17Rik; D6Wsu113e; Npwbp; SIPP1"
                     /coded_by="NM_021714.4:243..2168"
                     /db_xref="CCDS:CCDS20655.1"
                     /db_xref="GeneID:60321"
                     /db_xref="MGI:MGI:1891823"
ORIGIN      
        1 mgrrstsstk sgkfmnptdq arkearkrel kknkkqrmmv raavlkmkdp kqiirdmekl
       61 demefnpvqq pqlnekvlkd krkklretfe rilrlyeken pdiykelrkl eveyeqkraq
      121 lsqyfdavkn aqhvevesip lpdmphapsn iliqdiplpg aqppsilkkt saygpparav
      181 silpllghgv prlppgrkpp gpppgppppq vlqmygrkvg faldlpprrr dedmlyspel
      241 aqrghdddms stseddgype dmdqdkhdds tedsdtdrsd aesdgdefgh redserdnte
      301 ekksglsvrf admpgksrkk kknmkeltpl qammlrmagq eipeegreve efseeedadd
      361 sddseaekqs qkqhkddghs dstaaassqq qappqsapas qiqappmpgp pplgpppapp
      421 lrppgpptgl ppgpppgapp flrppgmpgi rgplprllpp gpppgrppgp ppgpppglpp
      481 gppprgpppr lpppappgip pprpgmmrpp lvpplgpapp glfppaplpn pgvlsappsl
      541 iqrpkaddas aatiekkata tisakpqitn pkaevtrfvp talrvrrenk gatavpqrrs
      601 eddsavpvak aaprsgpsva vsvqtkddvy eafmkemegl l
//
