LOCUS       NM_001419443            5728 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus WASP family, member 2 (Wasf2), transcript variant 2,
            mRNA.
ACCESSION   NM_001419443
VERSION     NM_001419443.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5728)
  AUTHORS   Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
            Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
  TITLE     Neurodevelopmental disorder-associated CYFIP2 regulates
            membraneless organelles and eIF2alpha phosphorylation via protein
            interactors and actin cytoskeleton
  JOURNAL   Hum Mol Genet 33 (19), 1671-1687 (2024)
   PUBMED   38981622
REFERENCE   2  (bases 1 to 5728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5728)
  AUTHORS   Nguyen,M.T., Ly,Q.K., Kim,H.J. and Lee,W.
  TITLE     WAVE2 Is a Vital Regulator in Myogenic Differentiation of
            Progenitor Cells through the Mechanosensitive MRTFA-SRF Axis
  JOURNAL   Cells 13 (1), 9 (2023)
   PUBMED   38201213
  REMARK    GeneRIF: WAVE2 Is a Vital Regulator in Myogenic Differentiation of
            Progenitor Cells through the Mechanosensitive MRTFA-SRF Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5728)
  AUTHORS   Ahn,H.R., Baek,G.O., Yoon,M.G., Son,J.A., Yoon,J.H., Cheong,J.Y.,
            Cho,H.J., Kang,H.C., Eun,J.W. and Kim,S.S.
  TITLE     Hypomethylation-mediated upregulation of the WASF2 promoter region
            correlates with poor clinical outcomes in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 158 (2022)
   PUBMED   35477411
  REMARK    GeneRIF: Hypomethylation-mediated upregulation of the WASF2
            promoter region correlates with poor clinical outcomes in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5728)
  AUTHORS   Liu,M., Zhang,J., Pinder,B.D., Liu,Q., Wang,D., Yao,H., Gao,Y.,
            Toker,A., Gao,J., Peterson,A., Qu,J. and Siminovitch,K.A.
  TITLE     WAVE2 suppresses mTOR activation to maintain T cell homeostasis and
            prevent autoimmunity
  JOURNAL   Science 371 (6536) (2021)
   PUBMED   33766857
REFERENCE   6  (bases 1 to 5728)
  AUTHORS   Dahl,J.P., Wang-Dunlop,J., Gonzales,C., Goad,M.E., Mark,R.J. and
            Kwak,S.P.
  TITLE     Characterization of the WAVE1 knock-out mouse: implications for CNS
            development
  JOURNAL   J Neurosci 23 (8), 3343-3352 (2003)
   PUBMED   12716942
REFERENCE   7  (bases 1 to 5728)
  AUTHORS   Sun,P., Yamamoto,H., Suetsugu,S., Miki,H., Takenawa,T. and Endo,T.
  TITLE     Small GTPase Rah/Rab34 is associated with membrane ruffles and
            macropinosomes and promotes macropinosome formation
  JOURNAL   J Biol Chem 278 (6), 4063-4071 (2003)
   PUBMED   12446704
REFERENCE   8  (bases 1 to 5728)
  AUTHORS   Magdalena,J., Millard,T.H., Etienne-Manneville,S., Launay,S.,
            Warwick,H.K. and Machesky,L.M.
  TITLE     Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in
            scratch wound models
  JOURNAL   Mol Biol Cell 14 (2), 670-684 (2003)
   PUBMED   12589062
  REMARK    GeneRIF: Scar2 and the Arp2/3 complex appear to be involved in the
            establishment and maintenance of Golgi polarity during directed
            migration
REFERENCE   9  (bases 1 to 5728)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5728)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671858.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.984773.1,
                                           SRR13422600.1524519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AL671858.6         19602-19767
            167-310             AL671858.6         44161-44304
            311-482             AL671858.6         65480-65651
            483-617             AL671858.6         74008-74142
            618-771             AL671858.6         74638-74791
            772-889             AL671858.6         78117-78234
            890-1020            AL671858.6         79168-79298
            1021-1176           AL671858.6         81144-81299
            1177-1688           AL671858.6         83435-83946
            1689-5728           AL671858.6         84756-88795
FEATURES             Location/Qualifiers
     source          1..5728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.22 cM"
     gene            1..5728
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /note="WASP family, member 2"
                     /db_xref="GeneID:242687"
                     /db_xref="MGI:MGI:1098641"
     exon            1..166
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            167..310
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..482
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1846
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /note="wiskott-Aldrich syndrome protein family member 2;
                     protein WAVE-2; WASP family protein member 2; WAS protein
                     family, member 2"
                     /codon_start=1
                     /product="actin-binding protein WASF2"
                     /protein_id="NP_001406372.1"
                     /db_xref="GeneID:242687"
                     /db_xref="MGI:MGI:1098641"
                     /translation="MPLVTRNIEPRHLCRQTLPSDTSELECRTNITLANVIRQLGSLS
                     KYAEDIFGEICTQASAFASRVNSLAERVDRVQVKVTQLDPKEEEVSLQGINTRKAFRS
                     STTQDQKLFDRNSLPVPVLETYNSCDAPPPLNNLSPYRDDGKEALKFYTNPSYFFDLW
                     KEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKER
                     LGPSGYSSTLVYQNGSIGSVENVDAASYPPPPQSDSASSPSPSFSEDNLPPPPAEFSY
                     PADNQRGSVLAGPKRTSMVSPSHPPPAPPLSSPPGPKPGFAPPPAPPPPPPMSVPPPL
                     PSMGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPMPPPPLSQPSGGAPPPPP
                     PPPPPGPPPLPFSGADGQPAAPPPPPPSEATKPKSSLPAVSDARSDLLSAIRQGFQLR
                     RVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD"
     exon            483..617
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..771
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..889
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1020
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1176
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1688
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..5728
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /note="hexamer: AAGAAA"
     polyA_site      1966
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
     regulatory      5702..5707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /note="hexamer: GATAAA"
     polyA_site      5728
                     /gene="Wasf2"
                     /gene_synonym="D4Ertd13e; WAVE2"
                     /note="major polyA site"
ORIGIN      
        1 gtaatggcgg actcaggccg gtggagtgcg gctgggggcg tagcgcgctg aggggggcgt
       61 ccggctgagt agcagcccgc gaagcagtag gctggagcgt tctccgtggg gacgcggacc
      121 ggctgcccag cccttcatgt cgctgagggc gactgcgcga ggtcaggact agggttgtga
      181 ctcagcctgc aggaagctct ggatttgatc cccactacca cagattgccg tggtgcaccc
      241 cgcgatccag ctctcgagga gaggcgagaa gatctgaagt tcaaggttat tgttgactgc
      301 acagagagag gtttttttca tcattgagaa cctcgcctga agcaggtcca ctatgccgtt
      361 agtaaccagg aacatcgagc caaggcacct gtgccgtcag acgttgccta gcgatacaag
      421 cgagctggaa tgcaggacca acatcaccct ggcaaatgtc atccgacagc tgggcagcct
      481 gagtaagtat gcagaggaca ttttcggaga gatttgtact caggcaagtg cctttgcctc
      541 ccgagtaaac tcccttgctg agcgggttga ccgagtacaa gttaaagtca ctcagctgga
      601 tcccaaggaa gaagaagtgt cactacaagg aatcaacact cggaaggcct tcagaagttc
      661 taccacccaa gaccagaagc tctttgacag gaactctctc ccggtgcccg tcttagagac
      721 ctataacagc tgtgacgctc ctccccctct taacaatctc agtccttaca gggacgatgg
      781 aaaagaggca ctcaaattct acaccaaccc ctcatacttc tttgatcttt ggaaggagaa
      841 gatgctgcag gacaccaagg atatcatgaa agagaagaga aagcatagga aagaaaagaa
      901 agataatcca aatagaggga atgtgaaccc acgtaaaatc aagacacgca aggaagagtg
      961 ggagaagatg aaaatgggac aagaatttgt agagtccaag gagaggctgg ggccttctgg
     1021 gtattcgtcc accttggtgt accagaatgg cagcattggc tctgttgaaa atgtggatgc
     1081 ggccagctac ccaccaccac cacagtcgga ctctgcctcc tcaccttccc cttcattctc
     1141 tgaagacaac ttgcctcccc cgccagcaga attcagctac cctgcagaca accaaagagg
     1201 atctgtcttg gctggaccca aaagaaccag catggtcagc ccaagccatc cacccccagc
     1261 tcctcctctg agctctccgc caggtcccaa gcctggcttc gctcctccac ctgcccctcc
     1321 acctccacct cccatgagtg tgccacctcc actaccatcg atgggattcg ggtctcctgg
     1381 gacccctcca cccccatcac ctccatcttt ccctcctcac cctgattttg ctgctcctcc
     1441 accacctccc ccaccaccag cagctgacta cccaatgcca ccacctcctt tgtcccaacc
     1501 gtctggaggt gctcctccgc ctcctcctcc ccctccccct ccagggcccc cgcctctccc
     1561 cttcagcggt gctgatggcc agcctgctgc accaccacca ccaccacctt ctgaggccac
     1621 caagcccaag tcttcattgc ctgctgtgag tgacgcgcgc agtgacctgc tttctgccat
     1681 tcgccaaggc tttcagctgc gaagggttga agagcaacgg gagcaagaga agcgtgatgt
     1741 ggtgggcaat gatgtggcca ccatcctgtc ccgtcggatc gctgttgagt acagcgactc
     1801 ggaagatgat tcttctgaat ttgatgaaga cgactggtcg gattaactcc gcctgctgcc
     1861 cacattcctc tttctagtcc tcccacctgc cttcctccat acaaactaac agtctcatgg
     1921 ggggaagaaa gcaagggaca aagaactgca aggggccaaa gccaaagatc tatccgagtg
     1981 cttccttcaa ctgaccatat gcttcttcct cgtgtctgcc tgcgggctcc tgagggtcca
     2041 cagctgagct gatccatctt tccctcaagt gaccgtatct agtgacagga agggagaacc
     2101 ctacagtaga tccctctgct tgggtttcaa ctggagatag tgccttcccc tgataaccat
     2161 tttaacccat ggccttcgtc aaaacccttt catttagcta cttcaaataa tgttatccac
     2221 ctcctgtctc acagcagtgg gtacagcctg tgtgggcgca ggtggtccct tttctgtgcc
     2281 ctgacaagta gactggcaca ctcctgcccc acactcagcc ttctgcagca ggtaggcttg
     2341 cttctgttag ctctgcctgg atgcctttgt tccagaaggc atcaggcctc taaagactgt
     2401 ctcacaagtg atgcccttct ggagactgag ggtgtggcct tcctcccatg ctctctctgg
     2461 gtgagtgtgg ggtctgggtg tcctttgcat tcccctcctc accccaggtg ccttaagaca
     2521 gcccagttct aacctgatat tcatgaccaa actagccctg acactcaggg acctgggcct
     2581 ctgctgactg tcaggagcaa aacttgaagg tgtggcaccg caggactgga agagagtgga
     2641 acaccttggg tcctgcctgt tcagggtact gaggccaaga tgagaagtga ctctctcaag
     2701 gtcacacaga tagtgataga acaagagccc aggcttcctg tttccaagtc acctgtgttt
     2761 cctgggacca aataatgagc acctgctgga gtctgggcag agcagcctgg ctcccttcta
     2821 ccccagagct cccaaatgcc ggccttgcat ttggagggtt catggcctgt gcggggaggt
     2881 gggggggggg ggctctccgg tgcagcttta actgcagccg ctctggtaag ccgctcttat
     2941 ttccccttct gtctgcagcc agtcatgtgg catgggagct gtgctgggga ggcagtgtag
     3001 agaggagctg tggggcagcc agccttggca ggtgcagttt gcagttcact gcagctccct
     3061 cccccttttg tttcctcaat ttaagcagag gttgtgccag ctgtagaaac ttcagtccct
     3121 caggctggca gccgctgcag gtacctgcct gggggggcct ggcagccatg gagaaggctg
     3181 agaggcagaa ggacacgggg tcttcctgcc tcaccacctt gctgtgcatg atgatgctga
     3241 cccaccccct ttacctccct tcccagaact gatacacggg tgttattatt caggaaaaaa
     3301 actgagcagc tctggccagc agcaaggttt cttctctact gccccaacta ttgtgtggcc
     3361 tcttgtgctg aaatctctgg cttcagagcc tgaaacaaag agaaacagga tctgtctcta
     3421 cccagcacag caaatggttg tagtaattgc caaagccctc ataaacccct ccggcttgag
     3481 gagagtgcaa tcatggctct gctgcctgca cttgctgggt tcctcccctc tgcctccttt
     3541 cttgaactca gaggtaggga ctaagcacca ggtgccagca ggccctcctg ctgtggccac
     3601 tccagagtgc tccgtgtctc catgtgtccg tggcctgccc cccccccaac cccccaaatc
     3661 cagtgtctgg caccgggttt ggcagtcaac tccatgctgt gcatgtttcc caccccgtgc
     3721 cttagaagct gaaggtgctt tttcatcaga accttaacat ggctgttgat ggtaccctgg
     3781 ctgcagccca gcgggggctg gagaggcagg ggagggcagt ggtccttcca aatagaagtc
     3841 ctggggcctg gccaggccag ggtttgggcc taatggtttt tactaaatta ctcccctcct
     3901 gctctccgag aaaggggagc cagagccgct cactgtggtt ctgttccgac cttgaagggg
     3961 cggtattggc ctggcttctg gaatggacag agtccaccag gaaagactgg gggcgggagg
     4021 agctggggag gggccctgtc tgcggaaggt aggattagat cattagctca gtgacctcct
     4081 agggtttcga tgtgctgtgt tctcatccta cagctggttt ggtaatgatc tgcaagtccc
     4141 ggagagcaac agcacagctc cgcctgacgc tctcattaaa atccatgcag ccaagctctg
     4201 cgctttgtag cagccggcct tgcagagcct cctcagcttg gggggctggg gacccagtca
     4261 gctgagaggt cctctaggct ctacttaggc atatgtgtac ccaaaaaaaa aatttttttt
     4321 taagcatgct tcttttaaac ccagagccct ttaaaataat aaagaaccca gtgcaggtgg
     4381 gtgtgtttgt ggaatcccgt aagcgtagaa taccaagttt agtgactatt taaactgggc
     4441 tgaggctggt aagactataa agcagtggcc cataaggact cttaagcgtg aggccaagga
     4501 gccacgtccc ttcccagtct gcctggccca ggggggctgc ccccattcct ggagcccagg
     4561 ggcccagctt gcaattgcta gtgtcaggag tgacttgtag ctttgccttg gttgtgaaat
     4621 gatttcattc caggggaggg ggcgggggat cccttggagg ctcagagcag ctggcccaag
     4681 ctgcagctcg tctccagtgg aggcttgaat gccctcagaa acgaccctgg ccaatgtcac
     4741 cgcagagccg aggcggtgtt gtcagggcta atgtgaaatc tcttcccgtg gcgccgatcc
     4801 tctgactcta tagcgccagc ttggacagat tgaggtctct gtggctttgg tgaccctgct
     4861 taagcattcc caccgtgtcc ctgttctgcg ctagcactgc ctcctgctgc agcccctgac
     4921 ttgacctcag ggcctgggga gggaagcacc ataccagggc caggagctcc aactccgacg
     4981 tgtcagcctc tgggggaggg gggattaagc cttgagcttg gctggtgccc attggacctg
     5041 ggaccaggtg ttacccagag aggtgcctct gctgtgcttc ctgcctccat cactttccta
     5101 gggcctccgt gagggctgag aacagctctg ctctgctcct gtattattaa cttgcttcag
     5161 ttaactgact tgagaaacta accaattttt accttctgcc tagaatgatg tacacatagg
     5221 agagaaagct atcatgttcc cgaagtgcct tgttttctct gatagaaata tatttataag
     5281 gacctattcc aataggctct tggtgtttcc catatcaaga tttctgctag ctaatgcata
     5341 gagggaatac tgtctaaaaa tagacccttt cttcccaaag gttgggaggt gggacctgag
     5401 cagtggagtg aagccacacc ccacaatttt ttatttattt ttttattttt agatagggtt
     5461 tcaggtagat ctgcaggcct tgaccttact atatagttga agatggcctt gacctcctga
     5521 cccctgcctc agccatgcct ggctaggaca gccaaattgt tgttgtttca agtctggttt
     5581 catttgcttc cctgccgggt ttattgtgtg taccccattt gtactcccaa taacctgaag
     5641 attccatgta actcttatgt acgcgcatga atactttaaa tgccaacctt ttcaatcatt
     5701 tgataaagtc tttgtagtca ctcagtca
//
