LOCUS       NM_001379453            2718 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus WASP family, member 1 (Wasf1), transcript variant 3,
            mRNA.
ACCESSION   NM_001379453 XM_006512932
VERSION     NM_001379453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2718)
  AUTHORS   Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
            Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
  TITLE     Neurodevelopmental disorder-associated CYFIP2 regulates
            membraneless organelles and eIF2alpha phosphorylation via protein
            interactors and actin cytoskeleton
  JOURNAL   Hum Mol Genet 33 (19), 1671-1687 (2024)
   PUBMED   38981622
REFERENCE   2  (bases 1 to 2718)
  AUTHORS   Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
            Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   3  (bases 1 to 2718)
  AUTHORS   Zhang,Y., Kang,H., Lee,Y., Kim,Y., Lee,B., Kim,J.Y., Jin,C.,
            Kim,S., Kim,H. and Han,K.
  TITLE     Smaller Body Size, Early Postnatal Lethality, and Cortical
            Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null
            Embryonic Mice
  JOURNAL   Front Mol Neurosci 11, 482 (2019)
   PUBMED   30687000
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2718)
  AUTHORS   Chen,Y., Milenkovic,M., Horsfall,W., Salahpour,A., Soderling,S.H.
            and Ramsey,A.J.
  TITLE     Restoring striatal WAVE-1 improves maze exploration performance of
            GluN1 knockdown mice
  JOURNAL   PLoS One 13 (10), e0199341 (2018)
   PUBMED   30352064
  REMARK    GeneRIF: WAVE-1 restoration improves maze exploration performance
            of GluN1 knockdown mice
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2718)
  AUTHORS   Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    GeneRIF: Data indicate a molecular protocadherin alpha
            (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family
            (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from
            protocadherin cell-surface receptors to actin cytoskeletal dynamics
            in cortical neuron migration and dendrite morphogenesis in mouse
            brain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2718)
  AUTHORS   Soderling,S.H., Langeberg,L.K., Soderling,J.A., Davee,S.M.,
            Simerly,R., Raber,J. and Scott,J.D.
  TITLE     Loss of WAVE-1 causes sensorimotor retardation and reduced learning
            and memory in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003)
   PUBMED   12578964
  REMARK    GeneRIF: role in causing sensorimotor retardation and reduced
            learning and memory in mice
REFERENCE   7  (bases 1 to 2718)
  AUTHORS   Benachenhou,N., Massy,I. and Vacher,J.
  TITLE     Characterization and expression analyses of the mouse
            Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar
  JOURNAL   Gene 290 (1-2), 131-140 (2002)
   PUBMED   12062808
REFERENCE   8  (bases 1 to 2718)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   9  (bases 1 to 2718)
  AUTHORS   Westphal,R.S., Soderling,S.H., Alto,N.M., Langeberg,L.K. and
            Scott,J.D.
  TITLE     Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an
            actin-associated multi-kinase scaffold
  JOURNAL   EMBO J 19 (17), 4589-4600 (2000)
   PUBMED   10970852
REFERENCE   10 (bases 1 to 2718)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC174452.2.
            
            On Apr 3, 2020 this sequence version replaced XM_006512932.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4262466.1,
                                           SRR7652917.988268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC174452.2         112685-112928       c
            245-405             AC174452.2         76347-76507         c
            406-540             AC174452.2         70137-70271         c
            541-694             AC174452.2         65971-66124         c
            695-812             AC174452.2         64722-64839         c
            813-985             AC174452.2         63470-63642         c
            986-1165            AC174452.2         62099-62278         c
            1166-1794           AC174452.2         60017-60645         c
            1795-2718           AC174452.2         58186-59109         c
FEATURES             Location/Qualifiers
     source          1..2718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.07 cM"
     gene            1..2718
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="WASP family, member 1"
                     /db_xref="GeneID:83767"
                     /db_xref="MGI:MGI:1890563"
     exon            1..244
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..405
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1952
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     wiskott-Aldrich syndrome protein family member 1; protein
                     WAVE-1; WASP family protein member 1; WASP family 1; WAS
                     protein family, member 1; actin-binding protein WASF1"
                     /codon_start=1
                     /product="actin-binding protein WASF1 isoform 1"
                     /protein_id="NP_001366382.1"
                     /db_xref="GeneID:83767"
                     /db_xref="MGI:MGI:1890563"
                     /translation="MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSL
                     SKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFR
                     SSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDL
                     WKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDA
                     DLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPH
                     EPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSA
                     LSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPP
                     LVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAH
                     PPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKG
                     IQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
     exon            406..540
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..694
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..812
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..985
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1165
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1794
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2718
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2695..2700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="hexamer: AATAAA"
     polyA_site      2718
                     /gene="Wasf1"
                     /gene_synonym="Scar; WAVE; WAVE-1"
                     /note="major polyA site"
ORIGIN      
        1 agggcagcgg ctgctcgcgg tgttgttcgc tcgcgcgtcg agcgcaccgc ggctcgggcg
       61 agcagtgggc gcccccggcg gcattcccgg cggcccggcg cctcagccag tgcccggcgc
      121 ggcttccatc ccgcagcccg acgctcccga ggggctcctg gtggcgcccc agtgcggagc
      181 cggaccggcg gcagccgccg aagcatgtag aaggggtacg gcgcgagccc cccacggttt
      241 cgcggtgagc tggttcagtg gctgagctca agatgccgtt ggtgaaaaga aacatcgacc
      301 ctcggcactt gtgccacaca gcactgccca ggggcattaa gaacgaactg gaatgtgtaa
      361 ccaacatttc cctggcaaat ataattagac aactgagtag cctaagtaag tatgctgaag
      421 acatatttgg agaattattc aatgaagcac acagtttttc cttcagagtt aactcgttgc
      481 aagagcgcgt ggaccgattg tctgttagtg tcacacagct tgatcctaag gaggaagaac
      541 tgtctttgca agatataacg atgagaaagg ctttccggag ctccacaatt caagatcagc
      601 agcttttcga ccgcaagacg ttgcctattc cattgcaaga aacatacgat gtgtgtgagc
      661 aacctccgcc tctcaatatc ctcacccctt acagggatga tggtaaggaa gggctgaagt
      721 tttataccaa tccttcatat ttctttgatc tgtggaaaga aaagatgttg caagatacag
      781 aggacaagag gaaggaaaag agaaagcaga agcagaaaaa tctagaccgt cctcatgaac
      841 cagagaaagt gccaagagca cctcatgaca ggcggcggga atggcagaag ctggcccaag
      901 gtccagagct ggctgaggat gacgctgacc tcctacacaa gcatattgaa gttgccaatg
      961 gcccagcctc tcattatgag acaaggccac agacatacgt ggatcatatg gacggatcgt
     1021 actcactctc tgccttgcca ttcagtcaga tgagtgaact tctgaccaga gctgaggaga
     1081 gggtcttagt cagaccccat gaacctcctc cgcctccacc aatgcatgga gcaggagatg
     1141 caaagcccac acccacctgt atcagttctg ctacaggttt gatagagaat cgcccccagt
     1201 ccccagctgc aggcagaaca cctgtgtttg tgagccccac tcccccacct cctcccccac
     1261 ctcttccgtc tgccttgtcc acttcttcac taagagcttc aatgacctca actcctcccc
     1321 caccagtccc tcctccgcct cctcccccag ccactgcttt gcaggcccca gcagtgcccc
     1381 cacctccggc tcctcttcag attgcccctg gtgttcttca cccagctcct cctccaattg
     1441 ctcctcctct agtgcagccc tctcccccag tagctcgagc tgccccagta tgcgagactg
     1501 tgccagttca cccactcccg caaggtgaag tgcaggggct gcctccaccc ccaccaccgc
     1561 ctcctctacc tccgcctggc atccggccat catctcctgt cgcagttgca gctcttgctc
     1621 atcctccctc tgggctccat ccagcaccat ctactgcccc gggtccccat gctccattaa
     1681 tgcctccatc tcctccatca caagttctac ctgcctctga gccaaagcgc catccatcca
     1741 ccctgcctgt aatcagtgac gcaaggagtg tgctgctgga agccatccga aaaggtattc
     1801 agcttcgcaa agtggaagag cagcgtgaac aggaagcaaa acacgagcgg attgaaaacg
     1861 acgtggccac catcctgtct cgccgcattg ctgtggagta tagcgactcg gaagatgact
     1921 cggagttcga tgaagtagac tggctggagt aagaaagcca cagtgacttg gaagatgact
     1981 cggagttcga tgaagtagac tggatggagt aagacagccg ccttgctctg tattgcaagg
     2041 ctgaatgcac atgtccctcg tggcgcttgt tctttgaaaa tgttcggtca ttctagtgtt
     2101 ttgcttccta ttcctcataa tgaataaccc ttttcctcca ttatttttga tttctatgaa
     2161 aagtattagc atatatttca aactaaatat tttgtggctt accttaattt ttccccctgg
     2221 aaaaatataa tttggtccaa taaactacta agtattaagc atggaaagcc gttattagag
     2281 tagcagattc agtttttgat attccttaat tgtgcacttt gtgatttttt tttttttttt
     2341 taaatttgaa gaacgcaact gagactggaa tcttgaaggc agctgtgtct gggaacgagc
     2401 cttattccgt ttcttgatgt tttaaatgaa gaaacactgc ctcgattata tgaatacact
     2461 cagaaggaac atgtagcttg tagtgttgaa ttctcttaaa ggaatggtta gctttggtta
     2521 tcattttgtt gtttttgaat acttgcctta tttgaacgtt tagcagaacc ccttcccact
     2581 tatatattgt gtggtacagt tttgcttgcc tatagaagtt taaatttttc catgtgaaat
     2641 actcagaata agcatatgtg tgacttacat aatgtgagaa ttacaatctg atgtaataaa
     2701 cggttcattt taaaggct
//
