LOCUS       NM_027462               5028 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus tryptophanyl tRNA synthetase 2 (mitochondrial)
            (Wars2), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_027462
VERSION     NM_027462.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5028)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5028)
  AUTHORS   Muso,M., Bentley,L., Vizor,L., Yon,M., Burling,K., Barker,P.,
            Zolkiewski,L.A.K., Cox,R.D. and Dumbell,R.
  TITLE     A Wars2 mutant mouse shows a sex and diet specific change in fat
            distribution, reduced food intake and depot-specific upregulation
            of WAT browning
  JOURNAL   Front Physiol 13, 953199 (2022)
   PUBMED   36091365
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5028)
  AUTHORS   Agnew,T., Goldsworthy,M., Aguilar,C., Morgan,A., Simon,M.,
            Hilton,H., Esapa,C., Wu,Y., Cater,H., Bentley,L., Scudamore,C.,
            Poulton,J., Morten,K.J., Thompson,K., He,L., Brown,S.D.M.,
            Taylor,R.W., Bowl,M.R. and Cox,R.D.
  TITLE     A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and
            Activation of Tissue-Specific Stress Response Pathways
  JOURNAL   Cell Rep 25 (12), 3315-3328 (2018)
   PUBMED   30566859
  REMARK    GeneRIF: the characterization of a mouse model harboring a mutation
            in the tryptophanyl-tRNA synthetase 2 (Wars2) gene, encoding the
            mitochondrial-localized WARS2 protein, is reported.
REFERENCE   4  (bases 1 to 5028)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 5028)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5028)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5028)
  AUTHORS   Wakasugi,K.
  TITLE     Species-specific differences in the regulation of the
            aminoacylation activity of mammalian tryptophanyl-tRNA synthetases
  JOURNAL   FEBS Lett 584 (1), 229-232 (2010)
   PUBMED   19941862
REFERENCE   8  (bases 1 to 5028)
  AUTHORS   Banin,E., Dorrell,M.I., Aguilar,E., Ritter,M.R., Aderman,C.M.,
            Smith,A.C., Friedlander,J. and Friedlander,M.
  TITLE     T2-TrpRS inhibits preretinal neovascularization and enhances
            physiological vascular regrowth in OIR as assessed by a new method
            of quantification
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 2125-2134 (2006)
   PUBMED   16639024
REFERENCE   9  (bases 1 to 5028)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080018.14.
            
            On Mar 27, 2023 this sequence version replaced NM_027462.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042964.1, AK042715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC080018.14        142950-143048       c
            100-357             AC080018.14        96400-96657         c
            358-438             AC080018.14        79522-79602         c
            439-524             AC080018.14        78828-78913         c
            525-643             AC080018.14        69364-69482         c
            644-5028            AC080018.14        63295-67679         c
FEATURES             Location/Qualifiers
     source          1..5028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.03 cM"
     gene            1..5028
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="tryptophanyl tRNA synthetase 2 (mitochondrial)"
                     /db_xref="GeneID:70560"
                     /db_xref="MGI:MGI:1917810"
     exon            1..99
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1092
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /EC_number="6.1.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tryptophanyl-tRNA synthetase, mitochondrial; (Mt)TrpRS;
                     tryptophan--tRNA ligase, mitochondrial"
                     /codon_start=1
                     /product="tryptophan--tRNA ligase, mitochondrial isoform
                     1"
                     /protein_id="NP_081738.2"
                     /db_xref="CCDS:CCDS17672.1"
                     /db_xref="GeneID:70560"
                     /db_xref="MGI:MGI:1917810"
                     /translation="MALFSVRKARECWRFIRALHKGPAATLAPQKESGERVFSGIQPT
                     GILHLGNYLGAIESWVNLQEEYDTVIYSIVDLHSITVPQDPTVLQQSILDMTAVLLAC
                     GINPEKSILFQQSKVSEHTQLSWILTCMVRLPRLQHLHQWKAKAAKQKHDGTVGLLTY
                     PVLQAADILCYKSTHVPVGEDQVQHMELVQDLARSFNQKYGEFFPLPKSILTSMKKVK
                     SLRDPSSKMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYEPDSRAGVSNMV
                     AIHAAVSGLSVEEVVRSSAGLDTARYKLLVADAVIEKFAPIRKEIEKLKMDKDHLRKV
                     LLVGSAKAKELASPVFEEVKKLVGIL"
     exon            100..357
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     exon            358..438
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     exon            439..524
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     exon            525..643
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     exon            644..5028
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1420..1425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="hexamer: CATAAA"
     polyA_site      1443
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="major polyA site"
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="hexamer: AATAAA"
     polyA_site      2543
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="major polyA site"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="hexamer: AATAAA"
     polyA_site      2663
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
     polyA_site      3047
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
     regulatory      5009..5014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="hexamer: AATAAA"
     polyA_site      5028
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /note="major polyA site"
ORIGIN      
        1 cttctcaaga tggcgctgtt ctctgtgcgg aaggcccgtg agtgctggcg cttcatccgg
       61 gcacttcaca aaggacccgc agcaactctg gctccccaga aggagagtgg agagcgagtg
      121 ttttctggca ttcagcctac aggaatcctc cacctgggaa attaccttgg agccatcgag
      181 agctgggtga acttacagga ggaatatgac acagtgatat acagcatcgt ggacctccac
      241 tccatcactg tcccccaaga ccccaccgtc ctccagcaga gcatcctgga catgactgct
      301 gtgcttcttg cctgtggcat aaacccagag aaaagtatcc ttttccagca gtctaaggtg
      361 tctgaacaca ctcagttaag ttggatcctc acctgcatgg tgagactgcc tcgattgcag
      421 catttacacc agtggaaggc aaaggctgcg aagcagaagc atgatgggac cgtaggcctg
      481 ctcacatacc ctgtactcca ggcagcagac atcctgtgct acaagtccac acacgttcct
      541 gtcggggagg atcaagtcca gcacatggaa ctagttcagg atctagctcg aagtttcaac
      601 caaaagtatg gggagttctt tccattgccc aagtccattc tcacatccat gaagaaagtg
      661 aaatctcttc gagacccttc ttccaagatg tcaaaatcgg accctgacaa actcgccact
      721 gttcgaataa cagacagccc agaggagatt gtacagaaat tccgcaaggc tgtgacagac
      781 ttcacgtcag aggtcaccta cgagccggac agcagagctg gtgtttccaa catggtggcg
      841 atccacgcgg ccgtgtcggg cctctcggtg gaggaggtgg tgcgcagtag cgcaggcttg
      901 gacactgcac gctacaagct gctagtggcc gatgctgtga ttgagaaatt tgctccaatc
      961 aggaaggaga ttgagaaatt gaaaatggat aaggaccact taagaaaggt tttacttgtt
     1021 ggatctgcaa aagccaaaga attggcctct cctgtgttcg aggaggtgaa gaagttggtg
     1081 gggattctgt agcaaggtca gccagtcact gcactcaagt caaggcagct ttcctcccac
     1141 agattttagc ctgtccaaat tcaattgagt gtgatgatca gctgcatttg atgactgctg
     1201 tcaattgagc aacgttccaa tccctgaggc aggcacagct cttccactcc agttcaatga
     1261 cacacagttt tttggtctga agtattcccg aaaacgtgaa caattactga gccatggcgt
     1321 gtgcttgctt gtgcagtatt tactgtgcag gtgcactttg tctgtgttgt gcagacaggt
     1381 cctatgctgc aatcctgaat ccagtgggta tttgcagttc ataaagagag gttcattctt
     1441 gcagctcatg tgatgatgat gtgatgatgt ttatcctcat gtattggaat gacttgactt
     1501 gtgctagcaa ggtggctcgg gctcaaggta cctgctgcca agctgaatag ctggagctca
     1561 atccacaggg ccagcatggt ggaaggagaa actgactggc aggttgtcct ctgacctccg
     1621 cttgtctgcc atggtatgag tacacacaca cacacacatg cgcgcctaag taaaaataca
     1681 ataacctact tgtttcttaa aaggcacaca ctgacttact tatttcagca aatgtctgta
     1741 cttaagtgat ccaggaggtc attggagagc attatattgc ttcagttcca tctatttatt
     1801 atacagggcc tgtgttcctg gttgtattca taataagcac ttctattttt acattcatct
     1861 cagtttagtc tcaccaaacc ctacctctgt ggaacacata ggaactgagg ggtagaacat
     1921 ggaattagct gtacagtgtc actaagtaaa taagaagcaa gtccaagagt gaaggcctag
     1981 ctcccctgct tccaagactg gtgcttttta agacttctcc caaagctctg agggccaaag
     2041 ttttggacct ctaaacattc cagtattcag tttggatact gaaaagataa aggctgaaat
     2101 actgattttt gtttatgtga actcagctaa tggttgtgta ttttaaatct ggatccagcc
     2161 acctctggtc acacttacct ttcaaaaccc caaaaatggg tcccatggcc tcacttccaa
     2221 attcatgctg gagatgcctg cttgtctcgg ccagattcca gtgggagcga agtctaaagc
     2281 atctgacgtt tccagtgaag ggaagcttcc cgtctcagcc tgcctcaggc tctgtgaaat
     2341 cacagagtat agctctgcac gtccatgttc acagctgaaa cgaatggcag tcctggctta
     2401 catcccaagg cctgtatcaa gattgatttt gcagggccag caagatggct cagcagaaaa
     2461 gggctccttt tgtgaagcaa gcctgactat gtgagttcaa tccctgagat ccatgtgata
     2521 aataaaggag agaaccaact cctcaacgtt gtactgtgac ttacacacac acacacacac
     2581 acacacacac acacacacac cacaatgaaa tgcacaggac tacccacaca caaaaataaa
     2641 taaatgttta cttttaatgt taaggttgag ttcacctcga ttgtcacata gaattggaag
     2701 taggagacac tgtatcccag agtccagatt aaaacaccaa ctaggttcgg gaaaagggta
     2761 cattttactt ttgggggggg tgcatgttgt tttcttaatt catttattta ttagtgtatg
     2821 tgtttgaatg ggtgagatca tgctaaggtg tgtctgtcac ggttggagga tgattagtgg
     2881 ggtccggttc tctccttcca ccacgtaggt tctgggactc gagctcaggt catcaggcac
     2941 actttcccgt tgggccagtt agttttatct tttgcacctt agtgggagat gtctgcagtc
     3001 tgagagcatc actgagtgta tttcttttaa agatcttttt tactttcctt tcgttttatc
     3061 tgtttgcatt tgtgtgtgta tgtgtgcgcg cgcgcacgtg cgcatgcatg catgccacaa
     3121 aacatgtgtg atgtcagagg acagtgcaaa agctggcttt cttccaccag gtagattcca
     3181 gggttcaaac tcaggctgtc cggcttagca gcaggcaccc ctgcctactg aggcagccca
     3241 ccagtacctt ttcaccttcc ttttaaagaa atctattagg aatactggga attgtatcta
     3301 ccaggccaat tgcctgttta gctctgtggt ctctacctcc tagcaatgct tctgtctagc
     3361 aagaactaaa ggcaatagga aaagatctcc aaaaaaaaag aaaaagtgta aaagagaggg
     3421 ggagggaaca aaaaacacaa aaacactaga acaggataac gtctaaggaa cagggtcagt
     3481 gcattctgtt atgtaagact cttactgcag aaaatctaaa tttgccatat aattaagatt
     3541 cttgctcaat caatgtatta aagttcccca gggaaacaag cccaatagga cacatagaaa
     3601 caaaagagag tgggctgaag agatggctca ggggttaaga gcattagctg ctcttccagt
     3661 ggtcatgagt tcaattccta gcaaccacat ggtggctcac aaccatctgt aatggaatct
     3721 gatgccctct tctggtgtgt ctgaagagag caacagtata ctcacataca taaaataaat
     3781 aaataaatgg taagttctga gagacagaga gacagagagg agaggaagtt agtttaccag
     3841 gggctggagc atggctcagt gaccaatggc atgaagtttt tttcccagca ctcatgttgg
     3901 gcagcccaca actgcctgca aatgccagca ctaaggggtc agatatctct ggctttagca
     3961 tgcacctgta ttcacataac taaaaattac acacttaaaa taataacaat ttgccatatg
     4021 gattgggtca cactattaca aggactggga gaaaacatag catgctgtct ttaacctgga
     4081 gactcaggac agcagcgtaa tccagaccag acttaaaggc taacttgtca gtggtgcata
     4141 gtcagttcaa ggaattcaga gccaagagac tggacaggga ctcctgtgca agtcccggag
     4201 tctgggaacc ataaactatg acattccaag atgggtcagc tcaaggaaag aacaaactgg
     4261 cctttcccac atttttgagg cggccccttg atggattggt taggacctgc taacattgac
     4321 aaggataagt cttcatttac tgactcagtg tccaatcttt tctagaaata ccctcagaca
     4381 acccccctga aaaaaagtaa aattaaaaaa gaaaaggttt cactagctat ctgttacacc
     4441 ctgtcgcctc agaagctgag agcaaaggct gcatacagcc tagtgtgcct cttcacccct
     4501 tcccattgtt gtttacaggc ccagcaggtt gtttttttct tgagacaggg gctctacata
     4561 acccaggctg tactggtcta ctgtgtagac caggttagct ttgaactgat agagctcctc
     4621 tgccttctgg atgctgagat taatggagtg taccaccatg ctggcccaag aataaataaa
     4681 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta gagttagaaa tacaaacaac
     4741 tgacaactat ggttgacttc aaaaggaaaa ttttattgtt atttcctatt agctctatag
     4801 agaatggaaa tgtaaaaata tttcaaatga taatgttata gcagtcaggc agcatggtgc
     4861 ctgtaactgt gcctcctgac aaatcccact gcacactacc ttgtccaact agaccctctc
     4921 cacagtgagt aggttcatct tcattggttt atctttttga tatatgatag ttatcagagt
     4981 attaccagaa aatgtgctag agacttctaa taaagtgtga ttccccca
//
