LOCUS       NP_081738                360 aa            linear   ROD 14-FEB-2025
DEFINITION  tryptophan--tRNA ligase, mitochondrial isoform 1 [Mus musculus].
ACCESSION   NP_081738
VERSION     NP_081738.2
DBSOURCE    REFSEQ: accession NM_027462.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Muso,M., Bentley,L., Vizor,L., Yon,M., Burling,K., Barker,P.,
            Zolkiewski,L.A.K., Cox,R.D. and Dumbell,R.
  TITLE     A Wars2 mutant mouse shows a sex and diet specific change in fat
            distribution, reduced food intake and depot-specific upregulation
            of WAT browning
  JOURNAL   Front Physiol 13, 953199 (2022)
   PUBMED   36091365
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Agnew,T., Goldsworthy,M., Aguilar,C., Morgan,A., Simon,M.,
            Hilton,H., Esapa,C., Wu,Y., Cater,H., Bentley,L., Scudamore,C.,
            Poulton,J., Morten,K.J., Thompson,K., He,L., Brown,S.D.M.,
            Taylor,R.W., Bowl,M.R. and Cox,R.D.
  TITLE     A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and
            Activation of Tissue-Specific Stress Response Pathways
  JOURNAL   Cell Rep 25 (12), 3315-3328 (2018)
   PUBMED   30566859
  REMARK    GeneRIF: the characterization of a mouse model harboring a mutation
            in the tryptophanyl-tRNA synthetase 2 (Wars2) gene, encoding the
            mitochondrial-localized WARS2 protein, is reported.
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Wakasugi,K.
  TITLE     Species-specific differences in the regulation of the
            aminoacylation activity of mammalian tryptophanyl-tRNA synthetases
  JOURNAL   FEBS Lett 584 (1), 229-232 (2010)
   PUBMED   19941862
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Banin,E., Dorrell,M.I., Aguilar,E., Ritter,M.R., Aderman,C.M.,
            Smith,A.C., Friedlander,J. and Friedlander,M.
  TITLE     T2-TrpRS inhibits preretinal neovascularization and enhances
            physiological vascular regrowth in OIR as assessed by a new method
            of quantification
  JOURNAL   Invest Ophthalmol Vis Sci 47 (5), 2125-2134 (2006)
   PUBMED   16639024
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080018.14.
            
            On Jun 9, 2003 this sequence version replaced NP_081738.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042964.1, AK042715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.03 cM"
     Protein         1..360
                     /product="tryptophan--tRNA ligase, mitochondrial isoform
                     1"
                     /EC_number="6.1.1.2"
                     /note="tryptophanyl-tRNA synthetase, mitochondrial;
                     (Mt)TrpRS; tryptophan--tRNA ligase, mitochondrial"
                     /calculated_mol_wt=37930
     transit_peptide 1..18
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9CYK1.2)"
                     /calculated_mol_wt=2241
     mat_peptide     19..360
                     /product="Tryptophan--tRNA ligase, mitochondrial.
                     /id=PRO_0000035829"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CYK1.2)"
                     /calculated_mol_wt=37930
     Region          35..360
                     /region_name="PRK00927"
                     /note="tryptophanyl-tRNA synthetase; Reviewed"
                     /db_xref="CDD:234866"
     CDS             1..360
                     /gene="Wars2"
                     /gene_synonym="5730427B17Rik; 9430020O07Rik; TrpRS"
                     /coded_by="NM_027462.5:10..1092"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17672.1"
                     /db_xref="GeneID:70560"
                     /db_xref="MGI:MGI:1917810"
ORIGIN      
        1 malfsvrkar ecwrfiralh kgpaatlapq kesgervfsg iqptgilhlg nylgaieswv
       61 nlqeeydtvi ysivdlhsit vpqdptvlqq sildmtavll acginpeksi lfqqskvseh
      121 tqlswiltcm vrlprlqhlh qwkakaakqk hdgtvgllty pvlqaadilc yksthvpvge
      181 dqvqhmelvq dlarsfnqky geffplpksi ltsmkkvksl rdpsskmsks dpdklatvri
      241 tdspeeivqk frkavtdfts evtyepdsra gvsnmvaiha avsglsveev vrssagldta
      301 rykllvadav iekfapirke ieklkmdkdh lrkvllvgsa kakelaspvf eevkklvgil
//
