LOCUS       NM_011709                562 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus whey acidic protein (Wap), mRNA.
ACCESSION   NM_011709
VERSION     NM_011709.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 562)
  AUTHORS   Stratikopoulos,E.E., Kiess,N., Szabolcs,M., Pegno,S., Kakit,C.,
            Wu,X., Poulikakos,P.I., Cheung,P., Schmidt,H. and Parsons,R.
  TITLE     Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen
            are heterogeneously dependent on estrogen and undergo BIM-dependent
            apoptosis with BH3 and PI3K agents
  JOURNAL   Oncogene 38 (1), 47-59 (2019)
   PUBMED   30076411
REFERENCE   2  (bases 1 to 562)
  AUTHORS   Reczek,C.R., Shakya,R., Miteva,Y., Szabolcs,M., Ludwig,T. and
            Baer,R.
  TITLE     The DNA resection protein CtIP promotes mammary tumorigenesis
  JOURNAL   Oncotarget 7 (22), 32172-32183 (2016)
   PUBMED   27058754
REFERENCE   3  (bases 1 to 562)
  AUTHORS   Stratikopoulos,E.E., Dendy,M., Szabolcs,M., Khaykin,A.J.,
            Lefebvre,C., Zhou,M.M. and Parsons,R.
  TITLE     Kinase and BET Inhibitors Together Clamp Inhibition of PI3K
            Signaling and Overcome Resistance to Therapy
  JOURNAL   Cancer Cell 27 (6), 837-851 (2015)
   PUBMED   26058079
REFERENCE   4  (bases 1 to 562)
  AUTHORS   Stellas,D., Szabolcs,M., Koul,S., Li,Z., Polyzos,A.,
            Anagnostopoulos,C., Cournia,Z., Tamvakopoulos,C., Klinakis,A. and
            Efstratiadis,A.
  TITLE     Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer
  JOURNAL   J Natl Cancer Inst 106 (12) (2014)
   PUBMED   25306215
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 562)
  AUTHORS   Elias,S., Thion,M.S., Yu,H., Sousa,C.M., Lasgi,C., Morin,X. and
            Humbert,S.
  TITLE     Huntingtin regulates mammary stem cell division and differentiation
  JOURNAL   Stem Cell Reports 2 (4), 491-506 (2014)
   PUBMED   24749073
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 562)
  AUTHORS   Schoenenberger,C.A., Andres,A.C., Groner,B., van der Valk,M.,
            LeMeur,M. and Gerlinger,P.
  TITLE     Targeted c-myc gene expression in mammary glands of transgenic mice
            induces mammary tumours with constitutive milk protein gene
            transcription
  JOURNAL   EMBO J 7 (1), 169-175 (1988)
   PUBMED   2834201
REFERENCE   7  (bases 1 to 562)
  AUTHORS   Campbell,S.M., Rosen,J.M., Hennighausen,L.G., Strech-Jurk,U. and
            Sippel,A.E.
  TITLE     Comparison of the whey acidic protein genes of the rat and mouse
  JOURNAL   Nucleic Acids Res 12 (22), 8685-8697 (1984)
   PUBMED   6095207
REFERENCE   8  (bases 1 to 562)
  AUTHORS   Hennighausen,L.G. and Sippel,A.E.
  TITLE     Characterization and cloning of the mRNAs specific for the
            lactating mouse mammary gland
  JOURNAL   Eur J Biochem 125 (1), 131-141 (1982)
   PUBMED   6896688
REFERENCE   9  (bases 1 to 562)
  AUTHORS   Hennighausen,L.G. and Sippel,A.E.
  TITLE     Mouse whey acidic protein is a novel member of the family of
            'four-disulfide core' proteins
  JOURNAL   Nucleic Acids Res 10 (8), 2677-2684 (1982)
   PUBMED   6896234
REFERENCE   10 (bases 1 to 562)
  AUTHORS   Gupta,P., Rosen,J.M., D'Eustachio,P. and Ruddle,F.H.
  TITLE     Localization of the casein gene family to a single mouse chromosome
  JOURNAL   J Cell Biol 93 (1), 199-204 (1982)
   PUBMED   6896059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603787.8.
            
            On Apr 28, 2007 this sequence version replaced NM_011709.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164735.1, CJ065887.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL603787.8         51952-52066         c
            116-250             AL603787.8         50607-50741         c
            251-415             AL603787.8         50127-50291         c
            416-562             AL603787.8         48900-49046         c
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.61 cM"
     gene            1..562
                     /gene="Wap"
                     /note="whey acidic protein"
                     /db_xref="GeneID:22373"
                     /db_xref="MGI:MGI:98943"
     exon            1..115
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..432
                     /gene="Wap"
                     /codon_start=1
                     /product="whey acidic protein precursor"
                     /protein_id="NP_035839.3"
                     /db_xref="CCDS:CCDS24424.1"
                     /db_xref="GeneID:22373"
                     /db_xref="MGI:MGI:98943"
                     /translation="MRCLISLVLGLLALEVALAQNLEEQVFNSVQSMFPKASPIEGTE
                     CIICQTNEECAQNAMCCPGSCGRTRKTPVNIGVPKAGFCPWNLLQMISSTGPCPMKIE
                     CSSDRECSGNMKCCNVDCVMTCTPPVPVITLQ"
     exon            116..250
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     exon            251..415
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     exon            416..562
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagtcact tgcctgacac cggtaccatg cgttgcctca tcagccttgt tcttggcctg
       61 ctggccctgg aggtggccct cgctcagaac ctagaggaac aagtcttcaa ctcagttcag
      121 tccatgttcc caaaagccag ccccattgag ggcacagagt gtatcatctg ccaaaccaac
      181 gaggagtgtg cccagaatgc catgtgctgt cccggttcct gtggtaggac ccgcaaaact
      241 cctgtcaaca ttggtgttcc gaaagctggc ttctgccctt ggaatctact ccaaatgatc
      301 agtagtaccg ggccgtgccc aatgaagata gaatgctcca gcgaccgtga gtgttctggc
      361 aacatgaaat gctgcaacgt cgactgtgtc atgacatgta cacccccagt gccagtgata
      421 acccttcagt gagcagccgg ccctggcatc cctgcctgtc gggagtgacc agcccaagtc
      481 tatacagcaa gacccttcac tcctggatcc agagagaaca taatgctttc aatctgctgc
      541 taataaaaat ccatttggct tt
//
