LOCUS       NM_178399               3187 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus vexin (Vxn), mRNA.
ACCESSION   NM_178399
VERSION     NM_178399.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Moore,K.B., Logan,M.A., Aldiri,I., Roberts,J.M., Steele,M. and
            Vetter,M.L.
  TITLE     C8orf46 homolog encodes a novel protein Vexin that is required for
            neurogenesis in Xenopus laevis
  JOURNAL   Dev Biol 437 (1), 27-40 (2018)
   PUBMED   29518376
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC103620.12.
            
            On May 2, 2007 this sequence version replaced NM_178399.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043759.1, AK043576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               AC103620.12        92689-93072
            385-440             AC103620.12        98396-98451
            441-603             AC103620.12        104734-104896
            604-665             AC103620.12        111258-111319
            666-757             AC103620.12        114015-114106
            758-3187            AC103620.12        116135-118564
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     gene            1..3187
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /note="vexin"
                     /db_xref="GeneID:76982"
                     /db_xref="MGI:MGI:1924232"
     exon            1..384
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..941
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /note="uncharacterized protein C8orf46 homolog"
                     /codon_start=1
                     /product="vexin"
                     /protein_id="NP_848486.1"
                     /db_xref="CCDS:CCDS14813.1"
                     /db_xref="GeneID:76982"
                     /db_xref="MGI:MGI:1924232"
                     /translation="MHQIYSCSDENIEVFTTVIPSKVSSSSRRRVKSSHHLLAKNVVI
                     ESDLYPPPRPLELLPQRCERRDTGDRRWLQTGRLQTARPPGAHPTKTPSRPVGISEPK
                     TSNLCGNRAYGKSLIPPVARISVKAPAGAEVAAKGSEHGAVLGRGSRHLKKIAEEYPA
                     LPQGAEASLPLTGSTSCGVPGILRKMWTRHKKKSEYVGATNSAFEAD"
     exon            385..440
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            441..603
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..665
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            666..757
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..3187
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3145
                     /gene="Vxn"
                     /gene_synonym="3110035E14Rik"
ORIGIN      
        1 tcactgcggc agacactgga aaataaaatt gttaagtaca tcctagctga gagggagaga
       61 cggaaggctc cgtgttcaat caaaggtttg caataatagg agtcatttaa gaaagaaaga
      121 aagaaagaaa aaaaaaaaga cagatgggat taggaaatgt tgctgcggtg agactgtcat
      181 gagaggcaca ggcagcctgc cttttgtgga cctgcacaat gatcacagag ccagactggc
      241 ttaggagacc ctgggactag ggctccagag agaggccacg ggctcccgga caccctgcag
      301 ggcagggggc tgagaccatg catcagatct acagctgcag tgatgagaat attgaagttt
      361 tcaccacggt gattccttcc aaggtgtcca gttcatccag gagaagagtc aagagctctc
      421 accacctctt ggccaagaat gtggtgatcg agtccgacct gtacccgcca ccaaggcccc
      481 tggagctact gcctcaacgc tgtgagcgca gggacacagg tgaccgcaga tggttgcaga
      541 ctggccggct gcagactgcc aggccacccg gggcgcatcc caccaaaacg ccctccagac
      601 ctgtggggat ttctgaaccc aaaacatcaa atctgtgtgg gaatcgagca tatgggaagt
      661 cgttgattcc tccagtggct aggatctcgg tgaaagctcc agcaggggcg gaggtggcag
      721 ccaagggctc agaacatgga gctgttctgg gaagaggatc cagacacctc aagaagatag
      781 cagaagagta cccagccctt ccccagggag cagaagcctc cctgccatta acaggcagta
      841 cttcctgtgg cgtccctggc atcctacgaa aaatgtggac caggcacaag aagaagtctg
      901 aatatgtggg agccaccaac agcgcctttg aagccgacta aactcgacat ttcatgggca
      961 ccttgcattg gtcaaggttc ggaggaagat agaagagttg aggactggga ctgagccacc
     1021 ctcccctctg ctggttgctg gtccaaacac atcatcattc cttatactct gacatggggc
     1081 atggaaagta acatcctcag aaggcaagaa agctgttcct cagaactgct aaagccattg
     1141 gtcttaaagt cgtattggtc aattacaaag gttatatacc tacttttagg caaagctata
     1201 ccaaaagcaa actttcctgg cctgtttaaa agcctccaag gaaaacagaa ggcagttgat
     1261 ctgtcttctt tgtgagtttt cccaaaacgt atggtttctg gtgtaaatgt aaaagtttga
     1321 ttctgaggta ctcagaacac aacagttctt acttttccca tcccatgtct gttttccctt
     1381 gatgaaatac aaaatgcttc atctttgctt tgttctaata tctacttaac agcaaccatt
     1441 gccaatctgc tttgctaatc atgggcatga ctgcatgagc tctctctctt ctttaggtgc
     1501 attcttgtct atagaaaagc acttaaaatc ccaatgttaa ttttaatgtc taatattttg
     1561 tgatgtggtg caattgacaa gctttgtata gtgactttaa tccagagagc attctcccat
     1621 cattgtctct tctcaccatt acaaaccctc tgataagaaa gcactgtggt ccccaaccta
     1681 cagattggga cactagagca tctggatggc agtatgtgac ttaacagcag cttgtgggac
     1741 tgtcaccagg tctgagcatc tctaaaataa ctgatttaag aaagtcttta aatggagaga
     1801 agaatctgac aatgttggaa caaagaagtg attcgaatga aatacatcat tgtgtattag
     1861 ataattaaga cgggtgcaga gaacagggac cccaacacgt aaagaggttc agacaggagg
     1921 atcacatgtt tgggacatgc ctggacagcc tagcaatatc ctgtctcaaa aacaaaacaa
     1981 atcatgcatg gacacacaca caaacagaga gggagagaga ttatgcatag atgaaaccag
     2041 aagaaatcgc catttttgta ggttgaaaca gctgaaaatc aatttcctgt ggctcaaact
     2101 aatatttact atcatttaaa aatgatcatg taagaaataa tggtaatcaa agctatcatt
     2161 tgttaaatgc ctacctgcct tgtgctgagc acagtgttga acaccacgca tgaattaagc
     2221 tattctttct aacaactaac ttgggtggat tttctcactg tatatgttga tactaattca
     2281 aaaaagttaa gtgattagat tgaagtcgcc taactctagg tgtctaactt taatgcccat
     2341 attgtatctt ctccttcaca caaaataagg aaaagggaag gatggaaatc agcaaaacgt
     2401 cttcctctgc aatggcctgg gaagaggcta cctggagcac agcgtggaga tgaggtatca
     2461 gagtgcagag actggttagt ggtatctgcc tgtgaagtgg tcggtaacat agaccttata
     2521 tatttctcat ctgtggctta aattctgccc cccggaagtc ttgttcccta attaagaggt
     2581 ttaaattaat ccgaccttct taatgaaagc agaaactccg tggtaaactc taccctaagg
     2641 ttatgttgag actccgcagg tgttggcaca agcacgagtt tgaactgttt gggtatcagg
     2701 cttgcttctg ctgttctgtg gattctgctt tcctgttcct gatgctctgg ataaactgaa
     2761 acatggcggt aagtcaaacc cagacttcca ggctcttgcc ttgctgattg ctgccctccc
     2821 acctctgctt tagaccctga gcatctgacc ctcatgtcca aacatagtct ggacacttgg
     2881 gcatcaagtg ctttgtccca gtgaaccatc taatgtcata tacaatatta agttggaatc
     2941 cagaacaaag ttagggataa aacatgtcac agagtctcca acgattgaat ttatttaact
     3001 taaaattgat gtcttaaatg tgtgtgtgtg gctcctggag atttatttta tatgtagact
     3061 gggactcatt tatttatctt taatttaaat atttaatggt gaaatgtttg ccttctgtag
     3121 aacatttcat tcaaataaaa ataaaggatg ccttgttagt gacattaata aaccacttga
     3181 agattgt
//
