LOCUS       NM_011708               8834 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus Von Willebrand factor (Vwf), mRNA.
ACCESSION   NM_011708
VERSION     NM_011708.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8834)
  AUTHORS   Santoro,M.L., Sachetto,A.T.A., Rosa,J.G., Torquato,R.J.S.,
            Andrade-Silva,D., Trevisan-Silva,D., de Albuquerque,C.Z.,
            Serrano,S.M.T., de Moura Mattaraia,V.G., Tanaka,A.S. and
            Peichoto,M.E.
  TITLE     Jararaca GPIb-binding protein causes thrombocytopenia during
            Bothrops jararaca envenomation
  JOURNAL   Sci Rep 14 (1), 31769 (2024)
   PUBMED   39738271
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8834)
  AUTHORS   Heger,L.A., Schommer,N., Van Bruggen,S., Sheehy,C.E., Chan,W. and
            Wagner,D.D.
  TITLE     Neutrophil NLRP3 promotes cardiac injury following acute myocardial
            infarction through IL-1beta production, VWF release and NET
            deposition in the myocardium
  JOURNAL   Sci Rep 14 (1), 14524 (2024)
   PUBMED   38914598
  REMARK    GeneRIF: Neutrophil NLRP3 promotes cardiac injury following acute
            myocardial infarction through IL-1beta production, VWF release and
            NET deposition in the myocardium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8834)
  AUTHORS   Jongejan,Y.K., Linthorst,N.A., Schrader Echeverri,E., Laan,S.N.J.,
            Dirven,R.J., Dahlman,J.E., van Vlijmen,B.J.M., Denis,C.V. and
            Eikenboom,J.C.J.
  TITLE     Impact of allele-selective silencing of von Willebrand factor in
            mice based on a single nucleotide allelic difference in von
            Willebrand factor
  JOURNAL   Thromb Res 236, 201-208 (2024)
   PUBMED   38461614
  REMARK    GeneRIF: Impact of allele-selective silencing of von Willebrand
            factor in mice based on a single nucleotide allelic difference in
            von Willebrand factor.
REFERENCE   4  (bases 1 to 8834)
  AUTHORS   Sisak,S., Chae,R.C., Nelson,K.E., Schuster,R.M., Perez,E.C.,
            England,L.G., Caldwell,C.C., Lentsch,A.B., Goodman,M.D. and
            Pritts,T.A.
  TITLE     Microvesicles from stored red blood cells induce P-selectin and von
            Willebrand factor release from endothelial cells via a protein
            kinase C-dependent mechanism
  JOURNAL   Transfus Apher Sci 63 (2), 103890 (2024)
   PUBMED   38355315
  REMARK    GeneRIF: Microvesicles from stored red blood cells induce
            P-selectin and von Willebrand factor release from endothelial cells
            via a protein kinase C-dependent mechanism.
REFERENCE   5  (bases 1 to 8834)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8834)
  AUTHORS   Chakraborty,I., Das,S.K. and Dey,S.K.
  TITLE     Differential expression of vascular endothelial growth factor and
            its receptor mRNAs in the mouse uterus around the time of
            implantation
  JOURNAL   J Endocrinol 147 (2), 339-352 (1995)
   PUBMED   7490564
REFERENCE   7  (bases 1 to 8834)
  AUTHORS   Korhonen,J., Partanen,J., Armstrong,E., Vaahtokari,A., Elenius,K.,
            Jalkanen,M. and Alitalo,K.
  TITLE     Enhanced expression of the tie receptor tyrosine kinase in
            endothelial cells during neovascularization
  JOURNAL   Blood 80 (10), 2548-2555 (1992)
   PUBMED   1384789
REFERENCE   8  (bases 1 to 8834)
  AUTHORS   Dumont,D.J., Yamaguchi,T.P., Conlon,R.A., Rossant,J. and
            Breitman,M.L.
  TITLE     tek, a novel tyrosine kinase gene located on mouse chromosome 4, is
            expressed in endothelial cells and their presumptive precursors
  JOURNAL   Oncogene 7 (8), 1471-1480 (1992)
   PUBMED   1630810
REFERENCE   9  (bases 1 to 8834)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   10 (bases 1 to 8834)
  AUTHORS   Coffin,J.D., Harrison,J., Schwartz,S. and Heimark,R.
  TITLE     Angioblast differentiation and morphogenesis of the vascular
            endothelium in the mouse embryo
  JOURNAL   Dev Biol 148 (1), 51-62 (1991)
   PUBMED   1936575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153580.19, AY208897.1, BF662502.1 and BI133662.1.
            
            On Jun 2, 2012 this sequence version replaced NM_011708.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. A downstream
            translational start codon is selected for this RefSeq based on its
            better conservation in mammalian species. An upstream in-frame
            start codon is also present but is only present in mouse; use of
            the upstream start codon would result in a protein that is 3 aa
            longer. Leaky scanning by ribosomes may allow translation
            initiation at the downstream start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ355287.1, AY208897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AC153580.19        2708-2899           c
            193-8729            AY208897.1         1-8537
            8730-8832           BF662502.1         1-103               c
            8833-8834           BI133662.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..8834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..8834
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /note="Von Willebrand factor"
                     /db_xref="GeneID:22371"
                     /db_xref="MGI:MGI:98941"
     exon            1..252
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..8694
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /note="Von Willebrand factor homolog"
                     /codon_start=1
                     /product="von Willebrand factor precursor"
                     /protein_id="NP_035838.3"
                     /db_xref="CCDS:CCDS20552.1"
                     /db_xref="GeneID:22371"
                     /db_xref="MGI:MGI:98941"
                     /translation="MNPFRYEICLLVLALTWPGTLCTEKPRDRPSTARCSLFGDDFIN
                     TFDETMYSFAGGCSYLLAGDCQKRSFSILGNFQDGKRMSLSVYLGEFFDIHLFANGTV
                     TQGDQSISMPYASQGLYLEREAGYYKLSSETFGFAARIDGNGNFQVLMSDRHFNKTCG
                     LCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSEEQRCKRASPPSRNCESSSGDMH
                     QAMWEQCQLLKTASVFARCHPLVDPESFVALCEKILCTCATGPECACPVLLEYARTCA
                     QEGMVLYGWTDHSACRPACPAGMEYKECVSPCPRTCQSLSINEVCQQQCVDGCSCPEG
                     ELLDEDRCVQSSDCPCVHAGKRYPPGTSLSQDCNTCICRNSLWICSNEECPGECLVTG
                     QSHFKSFDNRYFTFSGICQYLLARDCEDHTFSIVIETMQCADDPDAVCTRSVSVRLSA
                     LHNSLVKLKHGGAVGIDGQDVQLPFLQGDLRIQHTVMASVRLSYAEDLQMDWDGRGRL
                     LVKLSPVYSGKTCGLCGNYNGNKGDDFLTPAGLVEPLVVDFGNAWKLQGDCSDLRRQH
                     SDPCSLNPRLTRFAEEACALLTSSKFEACHHAVSPLPYLQNCRYDVCSCSDSRDCLCN
                     AVANYAAECARKGVHIGWREPGFCALGCPQGQVYLQCGNSCNLTCRSLSLPDEECSEV
                     CLEGCYCPPGLYQDERGDCVPKAQCPCYYDGELFQPADIFSDHHTMCYCEDGFMHCTT
                     SGTLGSLLPDTVLSSPLSHRSKRSLSCRPPMVKLVCPADNPRAQGLECAKTCQNYDLE
                     CMSLGCVSGCLCPPGMVRHENKCVALERCPCFHQGAEYAPGDTVKIGCNTCVCRERKW
                     NCTNHVCDATCSAIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFQILVGNEGC
                     SYPSVKCRKRVTILVDGGELELFDGEVNVKRPLRDESHFEVVESGRYVILLLGQALSV
                     VWDHHLSISVVLKHTYQEQVCGLCGNFDGIQNNDFTTSSLQVEEDPVNFGNSWKVSSQ
                     CADTRKLSLDVSPATCHNNIMKQTMVDSACRILTSDVFQGCNRLVDPEPYLDICIYDT
                     CSCESIGDCACFCDTIAAYAHVCAQHGQVVAWRTPTLCPQSCEEKNVRENGYECEWRY
                     NSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGRILDELLQTCVDPQDCPVCEVAGR
                     RLAPGKKITLSPDDPAHCQNCHCDGVNLTCEACQEPGGLVAPPTDAPVSSTTPYVEDT
                     PEPPLHNFYCSKLLDLVFLLDGSSMLSEAEFEVLKAFVVGMMERLHISQKRIRVAVVE
                     YHDGSRAYLELKARKRPSELRRITSQIKYTGSQVASTSEVLKYTLFQIFGKIDRPEAS
                     HITLLLTASQEPPRMARNLVRYVQGLKKKKVIVIPVGIGPHASLKQIRLIEKQAPENK
                     AFLLSGVDELEQRRDEIVSYLCDLAPEAPAPTQPPQVAHVTVSPGIAGISSPGPKRKS
                     MVLDVVFVLEGSDEVGEANFNKSKEFVEEVIQRMDVSPDATRISVLQYSYTVTMEYAF
                     NGAQSKEEVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDRVEAPNLVYMVTGN
                     PASDEIKRLPGDIQVVPIGVGPHANMQELERISRPIAPIFIRDFETLPREAPDLVLQT
                     CCSKEGLQLPTLPPLPDCSQPLDVVLLLDGSSSLPESSFDKMKSFAKAFISKANIGPH
                     LTQVSVIQYGSINTIDVPWNVVQEKAHLQSLVDLMQQEGGPSQIGDALAFAVRYVTSQ
                     IHGARPGASKAVVIIIMDTSLDPVDTAADAARSNRVAVFPVGVGDRYDEAQLRILAGP
                     GASSNVVKLQQVEDLSTMATLGNSFFHKLCSGFSGVCVDEDGNEKRPGDVWTLPDQCH
                     TVTCLANGQTLLQSHRVNCDHGPRPSCANSQSPVRVEETCGCRWTCPCVCTGSSTRHI
                     VTFDGQNFKLTGSCSYVIFQNKEQDLEVLLHNGACSPGAKQACMKSIEIKHAGVSAEL
                     HSNMEMAVDGRLVLAPYVGENMEVSIYGAIMYEVRFTHLGHILTYTPQNNEFQLQLSP
                     KTFASKMHGLCGICDENGANDFTLRDGTVTTDWKRLVQEWTVQQPGYTCQAVPEEQCP
                     VSDSSHCQVLLSASFAECHKVIAPATFHTICQQDSCHQERVCEVIASYAHLCRTSGVC
                     VDWRTTDFCAMSCPPSLVYNHCERGCPRHCDGNTSFCGDHPSEGCFCPQHQVFLEGSC
                     VPEEACTQCVGEDGVRHQFLETWVPDHQPCQICMCLSGRKINCTAQPCPTARAPTCGP
                     CEVARLKQSTNLCCPEYECVCDLFNCNLPPVPPCEGGLQPTLTNPGECRPTFTCACRK
                     EECKRVSPPSCPPHRTPTLRKTQCCDEYECACSCVNSTLSCPLGYLASATTNDCGCTT
                     TTCLPDKVCVHRGTVYPVGQFWEEGCDTCTCTDMEDTVVGLRVVQCSQRPCEDSCQPG
                     FSYVLHEGECCGRCLPSACKVVAGSLRGDSHSSWKSVGSRWAVPENPCLVNECVRVED
                     AVFVQQRNISCPQLAVPTCPTGFQLNCETSECCPSCHCEPVEACLLNGTIIGPGKSVM
                     VDLCTTCRCIVQTDAISRFKLECRKTTCEACPMGYREEKSQGECCGRCLPTACTIQLR
                     GGRIMTLKQDETFQDGCDSHLCRVNERGEYIWEKRVTGCPPFDEHKCLAEGGKIVKIP
                     GTCCDTCEEPDCKDITAKVQYIKVGDCKSQEEVDIHYCQGKCASKAVYSIDIEDVQEQ
                     CSCCLPSRTEPMRVPLHCTNGSVVYHEVINAMQCRCSPRNCSK"
     exon            253..307
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            308..472
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            473..575
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            576..784
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            785..909
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1126
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1249
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1361
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1408
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1545
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1684
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1785
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1981
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2197
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2438
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2533
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2694
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2798
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2937
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3072
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3219
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3360
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3474
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3631
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3790
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3926
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..5305
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5422
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5563
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5564..5707
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..5872
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5873..5916
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5917..6094
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6095..6315
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6316..6508
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6509..6850
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6851..7050
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7051..7153
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7154..7228
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7229..7333
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7334..7539
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7540..7689
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7690..7800
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7801..7981
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7982..8022
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8023..8139
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8140..8238
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8239..8367
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8368..8407
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8408..8505
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8506..8834
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8806..8811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /note="hexamer: AATAAA"
     polyA_site      8830
                     /gene="Vwf"
                     /gene_synonym="6820430P06Rik; B130011O06Rik; C630030D09;
                     F8VWF; VWD"
                     /note="major polyA site"
ORIGIN      
        1 gggctctgtg gtggcaactt ggagctattg caggcagagg aatgggctgg ggcacagctt
       61 gggttttctc tccctggctc tgaggacttt gaagcccctg gacaacttga cagcaggtcg
      121 gctcagagtc tgagcagatc catccagcag ttgcgcagga aaatggctta ggagtgagag
      181 gtggcaccac tgagtagcgg ctgggtttcc tcaagggacc ttggagatac agcccctgtt
      241 tgtatgggca agatgaaccc tttcaggtat gagatctgcc tgcttgttct ggccctcacc
      301 tggccaggga ccctctgcac agaaaagccc cgtgacaggc cgtcgacggc ccgatgcagc
      361 ctctttgggg acgacttcat caacacgttt gatgagacca tgtacagctt tgcagggggc
      421 tgcagttatc tcctggctgg ggactgccag aaacgttcct tctccattct cgggaacttc
      481 caagatggca agagaatgag cctgtctgtg tatcttgggg agttttttga catccatttg
      541 tttgccaatg gcaccgtaac gcagggtgac caaagcatct ccatgcccta cgcctcccaa
      601 ggactctacc tagaacgcga ggctgggtac tataagctct ccagtgagac ctttggcttt
      661 gcggccagaa tcgatggcaa tggcaacttc caagtcctga tgtcagacag acacttcaac
      721 aagacctgtg ggctgtgcgg tgattttaac atcttcgcgg aagatgattt taggacgcag
      781 gaggggacct tgacctcaga cccctatgat tttgccaact cctgggccct gagcagtgag
      841 gaacagcggt gtaaacgggc atctcctccc agcaggaact gcgagagctc ttctggggac
      901 atgcatcagg ccatgtggga gcaatgccag ctactgaaga cggcatcggt gtttgcccgc
      961 tgccaccctc tggtggatcc cgagtccttt gtggctctgt gtgagaagat tttgtgtacg
     1021 tgtgctacgg ggccagagtg cgcatgtcct gtactccttg agtatgcccg aacctgcgcc
     1081 caggaaggga tggtgctgta cggctggact gaccacagtg cctgtcgtcc agcttgccca
     1141 gctggcatgg aatataagga gtgtgtgtct ccttgcccca gaacctgcca gagcctgtct
     1201 atcaatgaag tgtgtcagca gcaatgtgta gacggctgta gctgccctga gggagagctc
     1261 ttggatgaag accgatgtgt gcagagctcc gactgtcctt gcgtgcacgc tgggaagcgg
     1321 taccctcctg gcacctccct ctctcaggac tgcaacactt gtatctgcag aaacagccta
     1381 tggatctgca gcaatgagga atgcccaggg gagtgtcttg tcacaggcca atcgcacttc
     1441 aagagcttcg acaacaggta cttcaccttc agtgggatct gccaatatct gctggcccgg
     1501 gactgcgagg atcacacttt ctccattgtc atagagacca tgcagtgtgc cgatgaccct
     1561 gatgctgtct gcacccgctc ggtcagtgtg cggctctctg ccctgcacaa cagcctggtg
     1621 aaactgaagc acgggggagc agtgggcatc gatggtcagg atgtccagct ccccttcctg
     1681 caaggtgacc tccgcatcca gcacacagtg atggcttctg tacgcctcag ctatgcggag
     1741 gacctgcaga tggactggga tggccgtggg cggctactgg ttaagctgtc cccagtctat
     1801 tctgggaaga cctgtggctt gtgtgggaat tacaacggca acaagggaga cgacttcctc
     1861 acgccggccg gcttggtgga gcccctggtg gtagacttcg gaaacgcctg gaagcttcaa
     1921 ggggactgtt cggacctgcg caggcaacac agcgacccct gcagcctgaa tccacgcttg
     1981 accaggtttg cagaggaggc ttgtgcgctc ctgacgtcct ccaagttcga ggcctgccac
     2041 cacgcagtca gccctctgcc ctatctgcag aactgccgtt atgatgtttg ctcctgctcc
     2101 gacagccggg attgcctgtg taacgcagta gctaactatg ctgccgagtg tgcccgaaaa
     2161 ggcgtgcaca tcgggtggcg ggagcctggc ttctgtgctc tgggctgtcc acagggccag
     2221 gtgtacctgc agtgtgggaa ttcctgcaac ctgacctgcc gctccctctc cctcccggat
     2281 gaagaatgca gtgaagtctg tcttgaaggc tgctactgcc caccagggct ctaccaggat
     2341 gaaagagggg actgtgtgcc caaggcccag tgcccctgct actacgatgg tgagctcttc
     2401 cagcctgcgg acattttctc agaccaccat accatgtgtt actgtgaaga tggcttcatg
     2461 cactgtacca caagtggcac cctggggagc ctgttgcctg acactgtcct cagcagtccc
     2521 ctgtctcacc gtagcaaaag gagcctttcc tgccggccac ccatggtcaa gctggtgtgt
     2581 cctgctgaca acccacgggc tcaagggctg gagtgtgcta agacgtgcca gaactacgac
     2641 ctggagtgta tgagcctggg ctgtgtgtct ggctgcctct gtcccccagg catggtccgg
     2701 cacgaaaaca agtgtgtggc cttggagcgg tgtccctgct tccatcaggg tgcagagtac
     2761 gccccgggag acacagtgaa gattggctgc aacacctgtg tctgccggga gcggaagtgg
     2821 aactgcacga accatgtgtg tgacgccact tgctctgcca ttggtatggc ccactacctc
     2881 accttcgatg gactcaagta cctgttcccg ggggagtgcc agtatgttct ggtgcaggat
     2941 tactgtggca gtaaccctgg gacctttcag atcctggtgg gaaatgaggg ttgcagctat
     3001 ccctcggtga agtgcaggaa gcgggtgacc atcctggtgg atggagggga gcttgaactg
     3061 tttgacggag aggtgaacgt taagaggccc ctgagagatg aatctcactt tgaggtggtg
     3121 gagtcgggcc ggtacgtcat cctgctgctg ggtcaggccc tttctgtggt ctgggaccac
     3181 cacctcagca tctctgtggt cctgaagcac acataccagg aacaggtgtg tggcctctgc
     3241 gggaactttg atggcatcca gaacaatgac ttcaccacta gcagcctcca ggtggaggaa
     3301 gaccccgtca actttgggaa ctcctggaaa gtgagctcac agtgtgctga cacgagaaag
     3361 ctgtcactag atgtttcccc tgccacttgc cacaacaaca tcatgaaaca gacgatggtg
     3421 gactcagcct gcagaatcct taccagtgac gtcttccagg gctgcaacag gctggtggac
     3481 cctgagccat acctggacat ctgtatttat gacacttgct cctgtgagtc catcggggac
     3541 tgcgcctgtt tctgtgacac cattgctgcc tatgcccacg tgtgtgccca gcatggccag
     3601 gtggtagcct ggaggacacc cacactgtgc ccccagagct gtgaagaaaa gaatgttcgg
     3661 gaaaatggct atgagtgtga gtggcgttat aacagctgtg cgcctgcttg cccagtcacg
     3721 tgtcagcacc ctgagcctct ggcttgccct gtgcagtgtg tggagggttg tcatgcacat
     3781 tgccctccag ggagaatcct ggatgaactt ctgcagacct gcgtagaccc ccaagactgc
     3841 cccgtgtgtg aggtggctgg tcggcgcttg gctcctggaa agaaaatcac cttgagtcct
     3901 gatgaccctg cacactgtca gaattgtcac tgtgatggtg tgaaccttac gtgtgaagcc
     3961 tgccaagagc ccggaggcct ggtggcaccc ccaactgatg ccccagtcag ctctaccacc
     4021 ccatatgttg aggatacccc cgagcccccc ctgcacaact tctactgcag caagctgctg
     4081 gatcttgtct tcctgctgga tggctcctct atgttgtccg aggctgagtt tgaagtgctc
     4141 aaagcttttg tggtgggcat gatggagagg ttacacatct ctcagaagcg catccgcgtg
     4201 gcagtggtag agtaccatga tggctcccgt gcctaccttg agctcaaggc ccggaagcga
     4261 ccctcagagc ttcggcgcat caccagccag attaagtata caggcagcca ggtggcctct
     4321 accagtgagg ttttgaagta cacactgttc cagatctttg gcaaaattga ccgccctgaa
     4381 gcctcccata tcactctgct cctgactgct agccaggagc ccccacggat ggctaggaat
     4441 ttggtccgct atgtccaagg tctgaagaag aagaaggtta tcgtgatccc tgtgggcatt
     4501 gggccccacg ccagcctcaa acagatccgc ctcatcgaga agcaggcccc tgaaaacaag
     4561 gcttttctgc tcagtggggt ggatgagctg gagcagagaa gagatgagat agtcagctac
     4621 ctctgtgacc ttgctcccga ggccccagcc ccaactcagc ctccacaggt agcccacgtc
     4681 accgtgagtc cagggatcgc tgggatctcg tcaccgggac caaaacggaa gtccatggtt
     4741 ctggatgtgg tgtttgtcct ggaggggtca gacgaagttg gtgaagccaa cttcaataag
     4801 agcaaggagt tcgtggagga ggtaatccag cgcatggacg tgagcccgga tgcaacgcgc
     4861 atctcagtac tgcagtattc ctacacggta accatggagt atgccttcaa tggggcccag
     4921 tccaaggagg aggtgctgcg gcacgtgcga gagatccgct accagggcgg caataggaca
     4981 aacactgggc aggccctgca gtacctttct gagcacagct tctctcccag ccaaggggac
     5041 cgggtagagg cacctaacct ggtctacatg gtcacgggga accccgcctc tgatgagatc
     5101 aagaggttgc ctggagacat ccaggtggta cccattgggg tgggccccca tgccaacatg
     5161 caggaactgg agaggatcag caggcccatc gctcccatct tcatccggga ctttgagaca
     5221 cttccccgag aggctcctga cctggtcctg cagacatgtt gctccaagga gggtctgcaa
     5281 ctgcccaccc tcccccctct ccctgactgc agccaacccc tggatgtggt cctgctcctg
     5341 gatggctcct ctagcttgcc agagtcttcc tttgataaaa tgaagagttt tgccaaggct
     5401 ttcatttcaa aggccaacat tgggccccac ctcacacagg tgtccgtgat acagtatgga
     5461 agcatcaata ccattgatgt accatggaat gtggttcagg agaaagccca tctacagagt
     5521 ttggtggacc tcatgcagca ggagggtggc cccagccaga ttggggatgc tctggccttt
     5581 gccgtgcgct atgtaacttc acaaatccac ggagccaggc ctggggcctc caaagcagtg
     5641 gtcatcatca tcatggatac ctccttggat cccgtggaca cagcagcaga tgctgccaga
     5701 tccaaccgag tggcagtgtt tcccgttggg gttggggatc ggtatgatga agcccagctg
     5761 aggatcttgg caggccctgg ggccagctcc aatgtggtaa agctccagca agttgaagac
     5821 ctctccacca tggccaccct gggcaactcc ttcttccaca aactgtgttc tgggttttct
     5881 ggagtttgtg tggatgaaga tgggaatgag aagaggcctg gggatgtctg gaccttgccg
     5941 gatcagtgcc acacagtgac ttgcttggca aatggccaga ccttgctgca gagtcatcgt
     6001 gtcaattgtg accatggacc ccggccttca tgtgccaaca gccagtctcc tgttcgggtg
     6061 gaggagacgt gtggctgccg ctggacctgc ccttgtgtgt gcacgggcag ttccactcgg
     6121 cacatcgtca ccttcgatgg gcagaatttc aagcttactg gtagctgctc ctatgtcatc
     6181 tttcaaaaca aggagcagga cctggaagtg ctcctccaca atggggcctg cagccccggg
     6241 gcaaaacaag cctgcatgaa gtccattgag attaagcatg ctggcgtctc tgctgagctg
     6301 cacagtaaca tggagatggc agtggatggg agactggtcc ttgccccgta cgttggtgaa
     6361 aacatggaag tcagcatcta cggcgctatc atgtatgaag tcaggtttac ccatcttggc
     6421 cacatcctca catacacgcc acaaaacaac gagttccaac tgcagcttag ccccaagacc
     6481 tttgcttcga agatgcatgg tctttgcgga atctgtgatg aaaacggggc caatgacttc
     6541 acgttgcgag atggcacggt caccacagac tggaaaaggc ttgtccagga atggacggtg
     6601 cagcagccag ggtacacatg ccaggctgtt cccgaggagc agtgtcccgt ctctgacagc
     6661 tcccactgcc aggtcctcct ctcagcgtcg tttgctgaat gccacaaggt catcgctcca
     6721 gccacattcc ataccatctg ccagcaagac agttgccacc aggagcgagt gtgtgaggtg
     6781 attgcttctt acgcccatct ctgtcggacc agtggggtct gtgttgattg gaggacaact
     6841 gatttctgtg ctatgtcatg cccaccgtcc ctggtgtata accactgtga gcgtggctgc
     6901 cctcggcact gcgatgggaa cactagcttc tgtggggacc atccctcaga aggctgcttc
     6961 tgtccccaac accaagtttt tctggaaggc agctgtgtcc ccgaggaggc ctgcactcag
     7021 tgtgttggcg aggatggagt tcgacatcag ttcctggaga cctgggtccc agaccatcag
     7081 ccctgtcaga tctgtatgtg cctcagtggg agaaagatta actgcactgc ccagccgtgt
     7141 cccacagccc gagctcccac gtgtggccca tgtgaagtgg ctcgcctcaa gcagagcaca
     7201 aacctgtgct gcccagagta tgagtgtgtg tgtgacctgt tcaactgcaa cttgcctcca
     7261 gtgcctccgt gtgaaggagg gctccagcca accctgacca accctggaga atgcagaccc
     7321 acctttacct gtgcctgcag gaaagaagag tgcaaaagag tgtccccacc ctcctgcccc
     7381 cctcaccgga cacccactct ccggaagacc cagtgctgtg atgaatacga gtgtgcttgc
     7441 agctgtgtca actccacgct gagctgccca cttggctacc tggcctcagc cactaccaat
     7501 gactgtggct gcaccacgac cacctgtctc cctgacaagg tttgtgtcca ccgaggcacc
     7561 gtctaccctg tgggccagtt ctgggaggag ggctgtgaca cgtgcacctg tacggacatg
     7621 gaggatactg tcgtgggcct gcgtgtggtc cagtgctctc aaaggccctg tgaagacagc
     7681 tgtcagccag gtttttctta tgttctccac gaaggcgagt gctgtggaag gtgcctgccc
     7741 tctgcttgca aggtggtggc tggctcactg cggggcgatt cccactcttc ctggaaaagt
     7801 gttggatctc ggtgggctgt tcctgagaac ccctgcctcg tcaacgagtg tgtccgcgtg
     7861 gaggatgcag tgtttgtgca gcagaggaac atctcctgcc cacagctggc tgtccctacc
     7921 tgtcccacag gcttccaact gaactgtgag acctcagagt gctgtcctag ctgccactgt
     7981 gagcctgtgg aggcctgcct gctcaatggc accatcattg ggcccgggaa gagtgtgatg
     8041 gttgacctat gcacgacctg ccgctgcatc gtgcagacag acgccatctc cagattcaag
     8101 ctggagtgca ggaagactac ctgtgaggcc tgccccatgg gctatcggga agagaagagc
     8161 cagggtgaat gctgtgggag atgcttgcct acagcttgca ctattcagct aagaggagga
     8221 cggatcatga ccctgaagca agatgagaca ttccaggatg gctgtgacag tcatttgtgc
     8281 agggtcaacg agagaggaga gtacatctgg gagaagaggg tcacgggctg cccaccattt
     8341 gatgaacaca agtgtctggc tgaaggaggc aaaatcgtga aaattccagg cacctgctgt
     8401 gacacatgtg aggagcctga ttgcaaagac atcacagcca aggtgcagta catcaaagtg
     8461 ggagattgta agtcccaaga ggaagtggac attcattact gccagggaaa gtgtgccagc
     8521 aaagctgtgt actccattga catcgaggat gtgcaggagc aatgctcctg ctgcctgccc
     8581 tcgaggacgg agcccatgcg cgtgcccttg cactgcacca atggctctgt cgtgtaccac
     8641 gaggtcatca acgccatgca gtgcaggtgt tctccccgga actgcagcaa gtgaggcctg
     8701 tgcagctaca gcggattcct actgataccc atgctatgac ctggctatcc agaaaaccag
     8761 atccctccct tgggcctcct gacctttgtg ccctcctggg cccacaataa aggccaagtt
     8821 ctcatcttaa ccaa
//
