LOCUS       NM_001368871            5485 bp    mRNA    linear   ROD 10-FEB-2024
DEFINITION  Mus musculus von Willebrand factor D and EGF domains (Vwde),
            transcript variant 1, mRNA.
ACCESSION   NM_001368871
VERSION     NM_001368871.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5485)
  AUTHORS   Iwata,K., Kawarabayashi,K., Yoshizaki,K., Tian,T., Saito,K.,
            Sugimoto,A., Kurogoushi,R., Yamada,A., Yamamoto,A., Kudo,Y.,
            Ishimaru,N., Fukumoto,S. and Iwamoto,T.
  TITLE     von Willebrand factor D and EGF domains regulate ameloblast
            differentiation and enamel formation
  JOURNAL   J Cell Physiol 237 (3), 1964-1979 (2022)
   PUBMED   34957547
  REMARK    GeneRIF: von Willebrand factor D and EGF domains regulate
            ameloblast differentiation and enamel formation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158682.8.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849379
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC158682.8         24637-24808
            173-357             AC158682.8         29522-29706
            358-589             AC158682.8         33802-34033
            590-655             AC158682.8         41208-41273
            656-912             AC158682.8         43609-43865
            913-1002            AC158682.8         44532-44621
            1003-1147           AC158682.8         53478-53622
            1148-1362           AC158682.8         56309-56523
            1363-1436           AC158682.8         56960-57033
            1437-1710           AC158682.8         58846-59119
            1711-1916           AC158682.8         61584-61789
            1917-2866           AC158682.8         61930-62879
            2867-3003           AC158682.8         64405-64541
            3004-3159           AC158682.8         67844-67999
            3160-3264           AC158682.8         68105-68209
            3265-3379           AC158682.8         69597-69711
            3380-3630           AC158682.8         71699-71949
            3631-3850           AC158682.8         72939-73158
            3851-3988           AC158682.8         75272-75409
            3989-4552           AC158682.8         77375-77938
            4553-4648           AC158682.8         79400-79495
            4649-4744           AC158682.8         79579-79674
            4745-4840           AC158682.8         80873-80968
            4841-4936           AC158682.8         81555-81650
            4937-5032           AC158682.8         83200-83295
            5033-5128           AC158682.8         86729-86824
            5129-5224           AC158682.8         86945-87040
            5225-5320           AC158682.8         88635-88730
            5321-5424           AC158682.8         91450-91553
            5425-5485           AC158682.8         93102-93162
FEATURES             Location/Qualifiers
     source          1..5485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.64 cM"
     gene            1..5485
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /note="von Willebrand factor D and EGF domains"
                     /db_xref="GeneID:232585"
                     /db_xref="MGI:MGI:2685313"
     exon            1..172
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..5424
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; von Willebrand factor D and EGF
                     domain-containing protein"
                     /codon_start=1
                     /product="von Willebrand factor D and EGF
                     domain-containing protein isoform 1 precursor"
                     /protein_id="NP_001355800.1"
                     /db_xref="CCDS:CCDS90028.1"
                     /db_xref="GeneID:232585"
                     /db_xref="MGI:MGI:2685313"
                     /translation="MRGGAWARLVTALMLLVQGKCQQAQECSPGGHRILQSPYRSVHF
                     DSVYLQYSAVQDLICDHSLSPGWYRFLIFDRPAEMPTKCVEMNHCGTQAPIWLSLSDS
                     EALPLPGEMKKLTACATWQFLFSTEKDCCLFQIPVSVRNCGDFFVYLLQPTQGCMGYC
                     AEAISDVKLHTCGPGETENEGGCVGQLSMAQPPAPPAPPGRPKISVELLGSLVFCRCT
                     FDVSPTNTSVGFLIAWSRLSSQEIKEELRQESTLQAFSLLELDGINLRLGDTIFCSAA
                     VFYLEKPDVQSIAVESQEFFAGIKLKPELDTISEDGKEYQLKIESTIPIVCSEFSELD
                     QGCKISLKLKTIEQGKEHLGLNLALSSCHVDLHQNSCANGICSQAVLYYTAVTDFSRD
                     GDRVTDIIVEPIVNDVFLWDRYAPDSIQIKVKDVPSAYCYSFTDPHIITFDGRVYDNF
                     KTGTFVLYKSMSRDFEIHVRQWNCGSLHYSVSCNCGFVAKEEGDIVTFDMCSGQLHES
                     PSYLFVKNQESSSSNIRITESYLGRKITIWFSSGAFIRADLSEWGMSITLRVPSLDYR
                     STLGLCGTFDENPENDFHDKNGIKIDHDDNYIAFINEWRLQPGRSMFDKVPASSRFPA
                     KPSYCSCWLGTAMHHLLSHHLDSRSHLEMASGCKGIKHLQFSSLIPDLDITSEYINSE
                     ALAGKLSPHVPREENNLNFLLQKNAHPNLSKLDLNLPHPGNKILNPPAYLSDERHTQD
                     QEMRKSLQNRWKRQNVKDFHPVYIFQSLGQGNLEEFSYFFPEDHTEDSQPEFAPSWPT
                     ASGLTEFSVLAICQQTLANSSIGRLCLPFLGRTLNHVVDMCVKDVLLKDDVNWAEGGV
                     ALLENECERRVLEDGKRNVEENRKTVEGILEVLKCPNLCSGHGECMGWGCVCSPGYSS
                     YDCSHSYEIAPEIAEVENAGFCDIQKKNCATVRVFGQGFKESLSITCEVTKLEYNGSK
                     WVLETSVYTQAVFQSSRVVDCQLFPNGQHFDTIDLTAEKPLAKLQLKVSNDGYTFSNS
                     KIMIIYDGTCQVCGPYENDSCTIKNNICIIDDFCYTDGDKNPTSSCLICRPQTSNSTW
                     SVLDDNQPPMIQTLQDKLEAFYGEDFEYHFMAWDPEGSEIRFTLDSGPDGAAVSSEGL
                     LTWKTESQTPQTFTLRLKDDCEAKSTVTVEVTVKSCDCLNGGSCVPDRKFPPGSGAYL
                     CDCLPGFYGDLCESEARECQSNPCGLGKCIRGSHSYSCDCPPELTGKNCEKDVDECES
                     WPCFPGLECINVFGSYHCGPCPEGFQGDGTTCNDLSFQPPSMEPLLTNPSFTQRPATT
                     FNEFLNSIGASHLSVKSVTTQMDNGKKGVSHQTPTYEYVDHVLSPDLTVDELEVPAHN
                     GSFASINPNNSFDQVDPVQSTFPTETGGLSTQISKPFQNFSGQEFISLTTKGAITTLP
                     EKNGSTKISNCIESSCFQGVSCVSTTGGHFKCGRCPFGYYGDGITCRAFCRHSCGRNR
                     ECVAPNTCKCKPGYTGSNCQTAICHPVCKKHGKCIKPNICACPPGHGGATCDEEHCSP
                     PCEHGGTCLSGNLCTCPYGFVGPRCETLVCNRHCENGGECVAPDICQCKSGWYGPTCS
                     TALCDPICLNGGSCYKPNTCLCPGGFFGTQCQNAVCHPPCKNGGLCMRNNVCSCPGGY
                     TGKRCQTSICEPMCMNGGKCVGPNICSCASGWSGKQCNTPICLQKCKNGGECIAPSMC
                     HCPSTWEGVQCQKPICTQKCLYGGRCAFPGVCSCRTGYSGAKCEKKI"
     exon            173..357
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            358..589
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            590..655
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            656..912
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1002
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1147
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1362
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1436
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1710
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1916
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2866
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3003
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3159
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3264
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3379
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3630
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3850
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3988
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4552
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            4553..4648
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..4744
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4840
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4936
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            4937..5032
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            5033..5128
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5224
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5320
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            5321..5424
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
     exon            5425..5485
                     /gene="Vwde"
                     /gene_synonym="Gm467"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgacctg caacaaactc tgagaaagtc cagggagtag aggactgggg tcaggttttc
       61 ccgatctgtg atacgggcag tgacccgtgc acaaccctag caatgagggg cggagcctgg
      121 gcacggctgg tgactgcgct gatgctcctg gtccagggaa aatgccagca agctcaggag
      181 tgctctcctg ggggccaccg gattcttcag agtccttaca gaagtgttca ctttgactca
      241 gtctatctcc agtattcagc tgttcaagac ctgatctgtg accattctct ctcccctggt
      301 tggtaccgat ttcttatctt tgacagaccc gctgagatgc caaccaagtg tgttgagatg
      361 aaccactgcg ggactcaggc ccccatctgg ctgtctctga gtgattcaga agctctgcct
      421 cttcctggag agatgaagaa actgacagct tgtgccactt ggcagttttt atttagcact
      481 gaaaaagact gctgcctctt tcaaatccct gtgtctgtaa gaaactgtgg ggattttttt
      541 gtttacttac tgcaacccac tcagggatgt atgggctact gtgctgaagc tatttctgat
      601 gtgaagttac acacatgtgg ccctggagaa acagaaaacg aaggtggctg tgttggccag
      661 ctctccatgg cacagcctcc tgctcctcct gctcctccag gcaggcccaa gatctcagtg
      721 gagctcctgg gctccctggt gttttgtagg tgtacttttg atgtttcccc cacaaacacc
      781 tcagtaggat ttctgatagc ctggtctagg ctttcttccc aagaaatcaa agaagagctg
      841 agacaggaga gcactcttca ggcgttctcg cttttagagc ttgatggcat aaatctcaga
      901 cttggagata cgatattctg cagtgctgcc gtcttttact tggagaaacc agatgtgcaa
      961 agtatagcgg tggaaagcca ggaatttttt gctggaatta agttaaaacc tgaactggac
     1021 actatatcag aagatggaaa ggaataccag ctgaagatag agagtacaat tcctattgtt
     1081 tgctcggagt ttagtgagct tgatcaagga tgcaaaatct cattaaaact gaaaaccatt
     1141 gaacaaggta aagaacacct tggtttaaat ttggcattgt cttcctgcca tgtggatctt
     1201 caccagaact cttgtgccaa tggaatatgc agccaggctg tattgtacta cactgctgtg
     1261 acagactttt cccgggatgg agacagagtt acagacatca ttgtggaacc tatagtcaat
     1321 gatgttttcc tgtgggacag atacgctcca gacagcatcc agatcaaagt caaggatgtg
     1381 ccatctgctt actgctattc atttactgac ccacacataa ttacctttga tggcagagta
     1441 tatgacaact tcaagactgg aacatttgtc ctttataaga gcatgtcacg tgattttgaa
     1501 atccatgtac gtcagtggaa ctgtgggagc cttcactatt ctgtgtcatg caactgtggc
     1561 tttgttgcaa aagaagaagg tgacatcgtt acttttgata tgtgcagtgg ccagttacat
     1621 gaatccccgt catatttatt tgtaaagaac caagagtcat catcaagcaa tatcagaata
     1681 actgaatctt atttaggaag aaaaatcacg atttggtttt cctctggagc gttcatccgc
     1741 gctgacctca gtgagtgggg tatgagtata acactccgag tccctagttt agattacaga
     1801 agcacattag gactttgtgg caccttcgat gaaaacccag aaaatgattt ccatgacaag
     1861 aacgggatca aaattgatca cgacgacaat tatattgctt ttatcaatga atggaggctt
     1921 caaccaggaa gaagcatgtt tgacaaagta ccggcttcct cacggtttcc tgcaaaacca
     1981 tcctactgca gctgctggtt gggtactgcc atgcatcatc tactttctca ccatctggac
     2041 agcagatctc acttagaaat ggcttccggc tgcaaaggca tcaagcacct tcagttctct
     2101 tccttgatac cagacctaga tatcacctct gaatatatca attccgaagc tcttgctgga
     2161 aaactaagcc ctcatgtacc tagagaagaa aataatttga atttcttact acagaaaaat
     2221 gcccacccaa acctatccaa actggactta aatttaccgc atcctggtaa taagatacta
     2281 aatcctcctg catatttaag tgatgagagg catacacagg accaggaaat gaggaagagt
     2341 ctacaaaaca gatggaaacg acaaaatgtg aaggactttc atcccgtcta tattttccag
     2401 agtcttggac aaggcaacct ggaagagttt tcttattttt tccctgagga ccacactgag
     2461 gacagccagc cggagtttgc cccctcgtgg cccacagcat cgggcctcac tgaattcagc
     2521 gtcttggcaa tctgtcagca gactctagcc aactccagca ttggaaggct ctgtcttccc
     2581 tttctcggca ggacactgaa ccatgttgtg gacatgtgtg tgaaggatgt tctgttaaag
     2641 gatgacgtga actgggcaga gggaggagtg gccttgttag aaaatgaatg tgagagacgc
     2701 gttttagaag atggaaaacg caatgtagaa gaaaacagga agacagtaga aggcattctg
     2761 gaagtgttaa aatgtcccaa tttatgcagt ggacatggag agtgtatggg ctggggctgt
     2821 gtgtgttctc caggctacag ttcctatgac tgcagtcatt cgtatgaaat agctcctgaa
     2881 attgccgagg ttgagaatgc tggattctgt gatattcaga agaagaactg tgccacagtg
     2941 agggtttttg gtcaaggctt caaagagtca ttgtccatca cgtgtgaagt tactaaactg
     3001 gagtataacg gcagtaagtg ggtgcttgaa acaagtgtct acacacaggc agtctttcaa
     3061 agtagcagag tggttgactg tcagctgttc ccaaatggcc aacattttga taccatagat
     3121 ctgacagcag agaaaccctt ggcaaagttg caattaaagg tatctaatga tggttacaca
     3181 ttcagtaatt ccaagataat gatcatatat gatggcactt gtcaagtttg tggcccctat
     3241 gaaaatgatt catgcactat aaagaataat atttgtatta ttgatgattt ctgctacact
     3301 gatggagaca aaaatcctac cagctcttgt ttgatttgta gacctcaaac ttcaaattct
     3361 acttggtcag ttttagatga taaccagccc cccatgattc aaacactgca agacaaatta
     3421 gaggcatttt atggtgaaga ctttgaatac catttcatgg cctgggatcc agaaggctct
     3481 gagatacgtt ttacattgga ttctggtcct gatggagcag ctgtttcctc tgagggactt
     3541 cttacatgga aaacagagtc acagactcct cagacgttca ctctccgcct gaaggacgat
     3601 tgtgaggcta aatctacagt cacagtggag gtgactgtga agtcttgtga ctgcttgaac
     3661 ggtggatcat gtgtgcctga tagaaaattc cctccaggaa gcggagccta cctttgtgac
     3721 tgcttgcctg gtttttatgg tgatctttgc gagtccgaag ccagggagtg ccagtccaac
     3781 ccttgtggcc ttggcaaatg tattagaggc tcacacagtt actcctgtga ctgtcctcct
     3841 gagctcacag gcaagaactg tgagaaggat gtagatgagt gtgaatcctg gccttgtttc
     3901 ccaggtttgg aatgcatcaa tgtttttggt tcctatcatt gtggtccatg tccagaaggg
     3961 tttcaaggtg atgggaccac atgcaatgac ctgagctttc aaccaccatc aatggagcct
     4021 ttactgacga acccaagctt tactcagagg cctgcaacaa ctttcaatga gttcttaaac
     4081 tcaataggcg catcccacct gtcagtaaaa tcagttacca ctcaaatgga caatgggaag
     4141 aaaggtgttt ctcatcagac accaacttat gagtatgtgg atcatgttct cagtccagat
     4201 cttactgttg atgagcttga agttccagca cacaatggta gttttgcaag catcaaccct
     4261 aacaattctt ttgaccaggt agatcctgtc cagagcacat ttccaacaga gacaggagga
     4321 cttagtactc aaattagcaa acctttccaa aatttctctg ggcaagagtt tatatcattg
     4381 actactaaag gagcaatcac taccttgcca gaaaaaaatg gatcaaccaa aatatcaaac
     4441 tgcatagaat catcttgttt ccagggtgtt tcctgtgtgt caaccacagg tggtcacttc
     4501 aagtgtggac gctgcccctt tgggtattac ggagatggta tcacttgtag agcattttgt
     4561 agacactcct gtggaagaaa cagagaatgt gttgccccaa atacatgcaa atgtaaacca
     4621 ggttatactg gttccaactg ccaaactgcc atctgtcacc ctgtttgcaa aaagcatgga
     4681 aaatgcatta agcctaacat ctgtgcatgt cctccagggc atggtggagc aacctgcgat
     4741 gaagaacatt gtagccctcc ttgtgaacat gggggcacat gcttgtctgg caatctctgc
     4801 acttgtcctt atggctttgt aggaccaagg tgtgaaacac tggtctgtaa caggcattgt
     4861 gaaaatggag gcgaatgtgt tgcaccagat atttgtcagt gcaagtctgg ctggtatgga
     4921 cccacctgta gtacagctct atgcgatcct atttgcctca acggtggttc ctgttataag
     4981 ccaaacacgt gcctttgtcc tggtggattc tttggaacac agtgccagaa tgctgtctgt
     5041 caccctccct gtaaaaatgg tggcctgtgc atgagaaata acgtatgcag ttgtcctggc
     5101 ggatacaccg gaaagagatg ccagacaagc atctgtgagc ctatgtgcat gaatggtgga
     5161 aaatgtgtgg gaccgaatat ttgttcctgt gcttctggct ggagtgggaa acagtgtaac
     5221 acacccatct gccttcagaa atgtaaaaat gggggtgaat gcatagctcc cagcatgtgt
     5281 cattgtccct ccacctggga aggagtgcag tgtcagaaac ccatttgtac tcaaaagtgc
     5341 ctttatggag gaagatgtgc atttcctggt gtatgttctt gccgcactgg atattctgga
     5401 gccaaatgtg aaaagaagat atagatgaaa catcattaag aaacatattt acaagcctct
     5461 atcattagat atgcagtttt attca
//
