LOCUS       NM_177164               4545 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus von Willebrand factor C domain-containing protein
            2-like (Vwc2l), transcript variant 1, mRNA.
ACCESSION   NM_177164
VERSION     NM_177164.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4545)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4545)
  AUTHORS   Machado,C.B., Kanning,K.C., Kreis,P., Stevenson,D., Crossley,M.,
            Nowak,M., Iacovino,M., Kyba,M., Chambers,D., Blanc,E. and
            Lieberam,I.
  TITLE     Reconstruction of phrenic neuron identity in embryonic stem
            cell-derived motor neurons
  JOURNAL   Development 141 (4), 784-794 (2014)
   PUBMED   24496616
  REMARK    Erratum:[Development. 2014 Mar 15;141(6):1416]
REFERENCE   3  (bases 1 to 4545)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   4  (bases 1 to 4545)
  AUTHORS   Ohyama,Y., Katafuchi,M., Almehmadi,A., Venkitapathi,S., Jaha,H.,
            Ehrenman,J., Morcos,J., Aljamaan,R. and Mochida,Y.
  TITLE     Modulation of matrix mineralization by Vwc2-like protein and its
            novel splicing isoforms
  JOURNAL   Biochem Biophys Res Commun 418 (1), 12-16 (2012)
   PUBMED   22209847
REFERENCE   5  (bases 1 to 4545)
  AUTHORS   Miwa,H., Miyake,A., Kouta,Y., Shimada,A., Yamashita,Y.,
            Nakayama,Y., Yamauchi,H., Konishi,M. and Itoh,N.
  TITLE     A novel neural-specific BMP antagonist, Brorin-like, of the Chordin
            family
  JOURNAL   FEBS Lett 583 (22), 3643-3648 (2009)
   PUBMED   19852960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129933.13 and AC130481.11.
            
            On Nov 10, 2022 this sequence version replaced NM_177164.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094541.1, SRR1660819.131377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-614               AC129933.13        121472-122085       c
            615-1084            AC129933.13        118742-119211       c
            1085-1214           AC129933.13        96844-96973         c
            1215-4545           AC130481.11        59341-62671
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 35.46 cM"
     gene            1..4545
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /note="von Willebrand factor C domain-containing protein
                     2-like"
                     /db_xref="GeneID:320460"
                     /db_xref="MGI:MGI:2444069"
     exon            1..614
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /inference="alignment:Splign:2.1.0"
     exon            615..1084
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /inference="alignment:Splign:2.1.0"
     CDS             695..1363
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Brorin-like"
                     /codon_start=1
                     /product="von Willebrand factor C domain-containing
                     protein 2-like isoform 1 precursor"
                     /protein_id="NP_796138.2"
                     /db_xref="CCDS:CCDS15028.1"
                     /db_xref="GeneID:320460"
                     /db_xref="MGI:MGI:2444069"
                     /translation="MALHIHEACILLLVIPGLVTSAAISHEDYPADEGDQASSNDNLI
                     FDDYRGKGCVDDSGFVYKLGERFFPGHSNCPCVCALDGPVCDQPECPKIHPKCTKVEH
                     NGCCPECKEVKNFCEYHGKNYKILEEFKPSPCEWCRCEPSNEVHCVVADCAVPECVNP
                     IYEPEQCCPVCKNGPNCFAGTTIIPAGIEVKVDDCNICHCHNGDWWKPAQCSKRECQG
                     KQTV"
     exon            1085..1214
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..4545
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgcaaa ctgctcacag cgatgccaaa ccccagttaa agttgcgcct ttgcttcaca
       61 tccacagtta gaatcttctg gtgtgtgagg agggattcag tcaacatact gtggacgatg
      121 ctgatgcttc tgctggtgga gtgggcttta agcttcagta tgctgtttct gtttgtgatc
      181 ctcagagcct agccaagtca cctctactgc cgtagcaaac actgtgtaag tgaactcatg
      241 tgtggaggag gcgtaatcag ccaggaaatt tcatagaagg atctaagaaa atgctaaaaa
      301 taagttcaac atgattctgc taccagggtc cggatttcca caggaccagc attgcttctt
      361 gctttgaatt ctgaagacag gtccaaagca tatttcttat gtgtgtctgc tgtgtttctc
      421 tctggaaggg tgggagactg cttcttggct gtgttttgaa atgggaaata gagaggatgg
      481 attgccttta attcatgcct gaaaatgcat tctttgggtg actaaagagg accggcttac
      541 ctaagagata cctgaccttt aagttcagat tggtctgtga cccccagcac caccgttaac
      601 ctcagagtga ctagcccacc cctcttgcat tcccatggaa ggagctgagt gtgtttaata
      661 ttaggagaac atccagaagt ctgtgaggag ggggatggct cttcatattc atgaagcttg
      721 catacttcta ttggtcatcc ctggattggt cacctctgct gccatcagtc acgaagacta
      781 tcctgctgat gaaggtgacc aggcttccag taatgacaat ctgatctttg atgactatcg
      841 agggaaaggg tgtgtggatg acagcggctt tgtatacaag ttgggagaac ggtttttccc
      901 ggggcattcc aactgtccgt gtgtctgtgc cctagatgga cctgtctgtg accagccaga
      961 atgccctaaa attcatccga aatgtacaaa ggtggaacac aatggatgct gtcccgaatg
     1021 taaagaagtg aaaaactttt gtgaatatca tgggaaaaat tacaaaatct tggaggaatt
     1081 taagccctct ccatgtgaat ggtgtcgctg tgagcccagc aatgaagttc actgtgttgt
     1141 agcagactgc gcagttcctg agtgtgtcaa cccaatctat gaaccagagc aatgttgtcc
     1201 tgtctgcaaa aatggtccaa actgctttgc aggaactaca ataattccag ctggcattga
     1261 agtgaaagtg gacgactgta acatctgtca ctgtcacaac ggggactggt ggaaacctgc
     1321 tcagtgttca aagcgcgaat gccaaggcaa gcagactgtg tagggtagat tcccgaccag
     1381 tgacttgttc taggagggga tgctatggct tctacactgc acatgtatcg cgctcaacag
     1441 aatgagcaaa ccaacccctg ccagctacaa cagggtcacc agcaaaacct tctggggttg
     1501 acaaaagtga atattttacg aagaggaaat ctctctctct ttctcttgct atataaaata
     1561 tacatagcat atagctatct acaccacttt tgtaattgcc aatgcttgat ggtaactaga
     1621 caaccaagct ttcttggaca agaaagaaag aaaacagcct tggacaggct ccttcccagg
     1681 tgatgtctct gacctgccgc ctcacatccc ttgatttact ccatctttcc tctgatgtgc
     1741 accctacatt tctctattgt atgttttcta cctttggaat ctaaaggggt cagattggac
     1801 tacatggtaa agttttgtgt tttcatgaga agtgtttgat aaagaaactt tgtgggaaaa
     1861 tatccttcca gagggggaag attgaagagt atccaagtct tggctctctt gggggtagtt
     1921 atgtttgtag gctaacaaat agaaaggtaa actgggccct ctgacaatca ggtaaggaat
     1981 gggtattttg accaatatgt tggggctcac tgttgattct tacagaccac gcattttaca
     2041 cataaaattt tgaaactgcc tatcagaacc aagtaggtga gcgagaacac catgtgttga
     2101 cccaagaacc cacagagaca ggtatttaaa actgtagcat ttaatcatcg gacttcttca
     2161 tgatgccagc cttgagtctg gtttataatt aaacacacag caaagcccac cttgtcatcg
     2221 ggcgatataa ataccagaac cagggtgagt agccccactg tgaatcaatc tttctaaaca
     2281 tttctgactt tcaagtacca gtttggctga aagccacagc agtttttatg gttcaggact
     2341 gtgttttcca tgttacagta acaaccactc agccctaaat ctaaaatcca gattcaggac
     2401 actctttcca ccttaagtgc tgatgtaaat taaagattag ggtagagtga gtcttgcaca
     2461 atacaatttc attagttgaa cattttttta atgtatatat aatagatact aaacgattaa
     2521 agagaacttt tgaagcgtct caaggttgcc ctggtaatgc tgctagtcta ataatggaaa
     2581 atattaataa taaaagaaat acacagggta tctgatgcca cctctagtca agtgcaaaat
     2641 tcccagctct gagaccacat ggcctagttc actctctgtc ctaaaaacct tggtgcagat
     2701 ttgataagat ccttaggaaa cttcaaagtt ttcttcatct ccagttgtct ttctttttcc
     2761 tgttttcggc tcccacccgt aatatacact tcatgtggct tctgtgaagg atcgcattgc
     2821 atagaaagat atctcagtgt cagtttctga tatttggggc tagattggta gggagtgtgc
     2881 tgcccgctct tatgatacta agcgacattc ttagatttca tgccctaggt agcaggaata
     2941 cccaactagt tatatcaacc aaatgtcccc agacatagcc taaagtcatc aacgggtgtg
     3001 gctagggaac aaaatgtcac ctggctaagg agctgtgtca tgcagctata tcatgtgtgc
     3061 catataatga tctgggcagc ttcgactgcc cacatatggc tttgttgagc ccttgagccc
     3121 tttggatcat gcacaaacag taactccaag ggtcagtctc ctccctgtca agtggtgttt
     3181 ctaacaccca ctctccggac accagtttct ttagtctcat aaattagttt tctcattcaa
     3241 aattgtcagc ctctccttcc tggaagcact gcctgtcatc aagaaagagt tgtcatttcc
     3301 aaaattaatg tgctgacgag ccagacctga cactttttac acacagtgtg cttgtgttat
     3361 gatacaaata accatcctgg tgccatccga ggaagaacac ccagccgcct tcctttagaa
     3421 caccaatttg ctgcgaggtt ggtgcctttc agttcccact atggatacat catagagaca
     3481 gccatgaatc attcatgagc aattctgcat gatttatgcc tacactcaaa agcaaaggca
     3541 ctccatactt cagtccatgt ctagacagag ttgtactata cagttttctt tgccctgagg
     3601 ttgcctaatg ccagttccaa aaactcacat tcttggaaag aaataataat attaattatt
     3661 attataataa atgacaggaa taaggtttaa aactgagaaa aatatcgcta ctagagagag
     3721 ccatgtagcc tagacccttc tctattatta aggagctact acgtccttgt tagagatggg
     3781 atgtgcagct tggaagggaa gatacagaga ttttgcatca aagtctgagc ccactgacat
     3841 tcccagcaag gattcggtag gctagagtgt aacaaccatc aagactcttc agacagttcg
     3901 cagctgccag cggatcaata gtggcctctg tgacaaactt gagaagggga tttttatcat
     3961 tgtttgtgtc aggtttgggc ttggtttctt ttgtgtgttt gttatgttct tttggttgtt
     4021 cagtttcact acagcatgtc ctttatcact ccgaagcacc aatgttttcc cacctttagg
     4081 aagagacaaa gcagaatttc tgtggcagga tttctcataa atggataaac attcaacaat
     4141 ttcctactac caggtcactg agaaattctt tccaagctca gacatcagag ttcttctgat
     4201 ctaaccattt tattattgtt gtttcttttt aaggctttga ttgcagccac agttacctct
     4261 gttaccattt ctcctctgcc tttggctctc ggctttaaat tcaactatgt ttaaataagg
     4321 gatcagtatc tggtttgtca gctaatgcct gttaaactga ttcagtttct aaaacctttg
     4381 aaaaatggtg tgcctgaaaa ctagtgagag agagagacaa aacaaaacaa aaaaaccact
     4441 aaatactaaa ctgtacaaaa agggattcta gcaacaatat ttgatgtgta aaagaatata
     4501 ttattaaaaa attattttgt taaatataaa gtgtgttaac cagtg
//
