LOCUS       NP_796138                222 aa            linear   ROD 02-MAY-2024
DEFINITION  von Willebrand factor C domain-containing protein 2-like isoform 1
            precursor [Mus musculus].
ACCESSION   NP_796138
VERSION     NP_796138.2
DBSOURCE    REFSEQ: accession NM_177164.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 222)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 222)
  AUTHORS   Machado,C.B., Kanning,K.C., Kreis,P., Stevenson,D., Crossley,M.,
            Nowak,M., Iacovino,M., Kyba,M., Chambers,D., Blanc,E. and
            Lieberam,I.
  TITLE     Reconstruction of phrenic neuron identity in embryonic stem
            cell-derived motor neurons
  JOURNAL   Development 141 (4), 784-794 (2014)
   PUBMED   24496616
  REMARK    Erratum:[Development. 2014 Mar 15;141(6):1416]
REFERENCE   3  (residues 1 to 222)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   4  (residues 1 to 222)
  AUTHORS   Ohyama,Y., Katafuchi,M., Almehmadi,A., Venkitapathi,S., Jaha,H.,
            Ehrenman,J., Morcos,J., Aljamaan,R. and Mochida,Y.
  TITLE     Modulation of matrix mineralization by Vwc2-like protein and its
            novel splicing isoforms
  JOURNAL   Biochem Biophys Res Commun 418 (1), 12-16 (2012)
   PUBMED   22209847
REFERENCE   5  (residues 1 to 222)
  AUTHORS   Miwa,H., Miyake,A., Kouta,Y., Shimada,A., Yamashita,Y.,
            Nakayama,Y., Yamauchi,H., Konishi,M. and Itoh,N.
  TITLE     A novel neural-specific BMP antagonist, Brorin-like, of the Chordin
            family
  JOURNAL   FEBS Lett 583 (22), 3643-3648 (2009)
   PUBMED   19852960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129933.13 and AC130481.11.
            
            On Jul 15, 2005 this sequence version replaced NP_796138.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094541.1, SRR1660819.131377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 35.46 cM"
     Protein         1..222
                     /product="von Willebrand factor C domain-containing
                     protein 2-like isoform 1 precursor"
                     /note="Brorin-like"
                     /calculated_mol_wt=22302
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2244
     mat_peptide     22..222
                     /product="von Willebrand factor C domain-containing
                     protein 2-like. /id=PRO_0000348062"
                     /note="propagated from UniProtKB/Swiss-Prot (Q505H4.1)"
                     /calculated_mol_wt=22302
     Region          116..171
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; cl17735"
                     /db_xref="CDD:450195"
     CDS             1..222
                     /gene="Vwc2l"
                     /gene_synonym="A830006F12Rik; Brl"
                     /coded_by="NM_177164.4:695..1363"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15028.1"
                     /db_xref="GeneID:320460"
                     /db_xref="MGI:MGI:2444069"
ORIGIN      
        1 malhiheaci lllvipglvt saaishedyp adegdqassn dnlifddyrg kgcvddsgfv
       61 yklgerffpg hsncpcvcal dgpvcdqpec pkihpkctkv ehngccpeck evknfceyhg
      121 knykileefk pspcewcrce psnevhcvva dcavpecvnp iyepeqccpv ckngpncfag
      181 ttiipagiev kvddcnichc hngdwwkpaq cskrecqgkq tv
//
