LOCUS       NM_138582               4313 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus von Willebrand factor A domain containing 7 (Vwa7),
            transcript variant 1, mRNA.
ACCESSION   NM_138582 XM_994838
VERSION     NM_138582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4313)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4313)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   3  (bases 1 to 4313)
  AUTHORS   van Kooij,M., de Groot,K., van Vugt,H., Aten,J. and Snoek,M.
  TITLE     Genotype versus phenotype: conflicting results in mapping a lung
            tumor susceptibility locus to the G7c recombination interval in the
            mouse MHC class III region
  JOURNAL   Immunogenetics 53 (8), 656-661 (2001)
   PUBMED   11797099
REFERENCE   4  (bases 1 to 4313)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   5  (bases 1 to 4313)
  AUTHORS   Matthews,V.B., Christiansen,F.T. and Price,P.
  TITLE     A novel locus affecting serum levels of IgG2a maps to the murine H2
            region
  JOURNAL   Eur J Immunogenet 27 (3), 135-139 (2000)
   PUBMED   10940081
REFERENCE   6  (bases 1 to 4313)
  AUTHORS   Snoek,M., Albertella,M.R., van Kooij,M., Wixon,J., van Vugt,H., de
            Groot,K. and Campbell,R.D.
  TITLE     G7c, a novel gene in the mouse and human major histocompatibility
            complex class III region, possibly controlling lung tumor
            susceptibility
  JOURNAL   Immunogenetics 51 (4-5), 383-386 (2000)
   PUBMED   10803853
REFERENCE   7  (bases 1 to 4313)
  AUTHORS   Snoek,M., Teuscher,C. and van Vugt,H.
  TITLE     Molecular analysis of the major MHC recombinational hot spot
            located within the G7c gene of the murine class III region that is
            involved in disease susceptibility
  JOURNAL   J Immunol 160 (1), 266-272 (1998)
   PUBMED   9551980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF134318.1.
            
            On May 4, 2006 this sequence version replaced XM_994838.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF134319.1, BC137792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/Rij"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.55 cM"
     gene            1..4313
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /note="von Willebrand factor A domain containing 7"
                     /db_xref="GeneID:27762"
                     /db_xref="MGI:MGI:1306798"
     exon            1..189
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            190..438
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2880
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /note="corresponds to Mus musculus G7c mRNA sequence
                     presented in GenBank Accession Number AF134319; similar to
                     Homo sapiens G7c protein encoded by GenBank Accession
                     Number AJ245418; isoform 1 precursor is encoded by
                     transcript variant 1; protein G7c; von Willebrand factor A
                     domain-containing protein 7"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 7 isoform 1 precursor"
                     /protein_id="NP_613048.1"
                     /db_xref="CCDS:CCDS28672.1"
                     /db_xref="GeneID:27762"
                     /db_xref="MGI:MGI:1306798"
                     /translation="MLPVEVPLSHLGPPILLLLQLLLPPTSAFFPNIWSLLAAPGSVT
                     HQDLTEEAALNVTLVLFLEQPHPGRPRLHVEDYRGRTLLADDIFAAYFGPGFSSRRFR
                     AALGEVSRANAAQDFLPAFKSNPDLHFDAERLVQGRTRLVGALRETLVAARALEYTLA
                     RQRLGAALHALQDFYSHSNWVELGERQPHPHLLWPRQELWSLAQVGDPTCSDCEGLSC
                     PGNMLDSTLLTSGYFGMHPPKPPGKCSHGGHFDQSSSQPPRGGINKDSTSPSFSPHHK
                     LHLQAAEVALLASIEAFSLLRSRLGDKAFSRLLDITPASSLSFVLDTTGSMGEEINAA
                     KIQARRIVEQRQGSPMEPVFYILVPFHDPGFGPVFTTSDPDSFWQKLNEIHALGGGDE
                     PEMCLSALELALLHTPPLSDIFVFTDASPKDALLTNRVESLTRERRCRVTFLVTEDPS
                     RTGGRRRREALSPLRFEPYEAIARASGGEVIFTKDQYIQDVAAIVGESMAGLVTLPLD
                     PPVFTPGEPCVFSVDSLLWQVTVRMHGDISSFWIKSPAGVSQGPEEGIGPLGHTRRFG
                     QFWTVTMTDPPRTGTWEIQVAAAGTPRVRVQAQTSLDFLFHFGISVEDGPHPGLYPLT
                     QPVAGLQTQLLVEVTGLTSRQKLVGGQPQFSHVVLRRVPEGTQLGRVSLEPVGPPVRG
                     LLAASLPPTLLSVSSPFSLELVGQGGGGESLRRTAPQPCSVAPVLLELSGPPDFLTPG
                     SKAPLSLHIVSFSGPQDLDLRTSVNPSFSLTSNLSRARLGLNESAWGRLWLEVPDSAA
                     PDSVVMVTVTAAGQGASQVPPTHAFLRLLVLAQSSKDQLDGPAHSAAPVLPPVSPALL
                     PSTLVTQGRAGGGMAGKAWWGTVGGVLFLLGCTSW"
     exon            439..720
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            721..817
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            818..928
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1124
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1294
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1407
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1524
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1710
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1843
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1996
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2089
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2391
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2531
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2706
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..4313
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4255..4260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /note="hexamer: AATAAA"
     polyA_site      4278
                     /gene="Vwa7"
                     /gene_synonym="C6orf27; D17H6S56E-3; G7c; NG37"
                     /note="major polyA site"
ORIGIN      
        1 cccggctttc gctacatctt gtggctctgg gttggcacga atggaagatg gccaggggct
       61 gcctgtcctc aatccccttg ctaagagcct ccctctcact ctactgaggc ccagttaatt
      121 ataactctga cctaagtgcc ctgtgacgcc acacccaggc cagcgctgcc caggagaccc
      181 agcttccagg tccatgcttc agccatgctc cctgtggagg tacccctgtc ccacctgggc
      241 cccccaatac tgcttctgct tcagctgctg ttgcccccaa catctgcctt ctttcccaac
      301 atctggagcc ttctggctgc ccctggctct gtcactcacc aagacctgac tgaggaggct
      361 gcactcaatg tcacccttgt gctctttctg gagcagccac acccaggccg accacgcctc
      421 catgtagagg actacagggg ccggaccctc ctcgccgatg acatctttgc tgcctacttt
      481 ggacctgggt tttcttcccg gcggttcagg gcagctttag gagaggtgtc tcgtgccaat
      541 gcagcccaag acttcctgcc agctttcaag agcaaccccg acctgcactt cgatgctgaa
      601 cggctggtcc aggggcgcac tcgcctggtg ggggcccttc gggaaaccct ggtggctgcc
      661 agagccctcg aatatacatt ggcccgccag cgcctagggg ctgcacttca tgccctgcag
      721 gatttctata gccacagcaa ctgggtggag ctgggggagc ggcagccaca ccctcacctc
      781 ctctggccaa ggcaggagct ctggagcctg gcacaagtgg gcgatcctac atgctctgac
      841 tgtgaggggc tgagctgccc tgggaatatg ctggactcga cactgctcac ctctggctac
      901 ttcggaatgc atccccccaa acctccaggg aaatgtagcc atgggggcca ttttgaccag
      961 agcagctccc agccaccccg gggaggcatc aacaaggaca gcacatcccc aagtttctcc
     1021 ccgcaccata agctgcacct ccaggctgca gaagtggcac tcctggcctc catcgaggcc
     1081 ttcagcctcc tgcgaagccg cctgggcgac aaggctttct ccaggctgct ggacatcacc
     1141 ccagcttcca gcctgagctt tgtcctggac accacaggca gtatgggcga ggaaatcaac
     1201 gcagccaaga tccaggctcg ccgcattgtg gagcagcgtc aaggcagccc catggagcct
     1261 gttttctata tcctagtgcc cttccacgac ccagggtttg gccccgtctt tacaaccagc
     1321 gacccggaca gcttttggca gaaactcaac gagatccatg ccttgggggg tggagatgag
     1381 ccagagatgt gcctgtctgc cctggagcta gccctgttgc acacccctcc cctctctgac
     1441 atctttgtct tcactgatgc ctcacccaag gatgctcttc ttaccaaccg ggtggaatcc
     1501 ctgactcggg agaggcgctg cagggtgaca tttctagtaa ctgaagaccc atcgaggact
     1561 gggggtcgac gacggcgaga ggccttgtct cctctgcgtt ttgaaccata tgaagcaata
     1621 gcccgggcat cagggggaga ggtgatcttc accaaagacc agtacatcca ggatgtggct
     1681 gccattgttg gggagagcat ggctggtctg gtgactcttc ccctggatcc ccctgtcttc
     1741 acccctgggg agccgtgtgt gttttctgtg gacagtctgc tctggcaggt cacagtccgg
     1801 atgcacgggg acatcagtag cttctggatc aagagccctg caggggtgtc ccagggccca
     1861 gaggagggca taggtcctct gggtcacact cgtcgctttg ggcaattctg gacggtgacc
     1921 atgactgacc ctcctcggac agggacttgg gagatccagg tagcagctgc gggaaccccc
     1981 cgggtgagag tacaagccca gacctctctg gacttcctct ttcatttcgg tatctctgtg
     2041 gaggatggac cccaccctgg cctctacccc ctgactcagc cagttgcagg tctccagacc
     2101 cagctgctgg tagaagtgac agggctcacc tctagacaga agcttgtggg tggccagcca
     2161 cagttttccc atgttgtcct tcgaagggtc ccagagggca ctcagctggg ccgggtgtcc
     2221 ttggagcccg tgggaccccc cgttcgaggc ctccttgctg cctctctacc acccacactg
     2281 ctgtcagtct cttctccctt ctccctggag ctggtcggcc agggtggagg gggagagagc
     2341 ctgcggagga ctgcgcccca gccttgcagt gtggcccccg tgcttctgga gctgagtggc
     2401 cctccagatt tcttgactcc gggcagcaag gcccctctca gcctccacat cgtcagcttc
     2461 tctggccccc aggatcttga tcttaggaca tcggtgaacc ctagcttctc cctcacctcc
     2521 aacctctcca gggctcgcct gggactgaat gagtctgcct ggggacgcct gtggctagag
     2581 gtcccagatt cagcagcccc tgacagtgtg gtgatggtga ctgtgactgc agcaggtcag
     2641 ggagccagcc aggtgccccc aacccatgcc ttcctccggc tgctggtgct ggcccagtcc
     2701 tcgaaggacc agctggacgg ccctgcccac tctgctgccc ctgtgctgcc cccggtcagc
     2761 cctgccttgc ttccttccac tttggtgact cagggcagag ctgggggagg gatggcaggc
     2821 aaagcctggt ggggaacagt tggaggggtg ctgttcctgc taggctgcac ttcctggtaa
     2881 cacaggaaca ggacatcaag ccccattttc agtctgccct atgggtggga tggtcacgtg
     2941 gattcagggc cctgccctgc ctacctggtt tggggatttt tcttccatca catttgtccc
     3001 tcctctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt
     3061 ctagatttat ttatttatta tatgtaagtg cactgtggct gtcttcagac acaccagaag
     3121 aggggggcat cagatctcat tacagatggt tatgagcaac catgtggttg ctgggaattg
     3181 aactcatgac ctttggaaga gcagtcaggt ccctttatct ttctttagac caggctggcc
     3241 tcacagagat ctacttgcct ctgtgtgtct tcctactgct ggaatcaaag gcatgcacca
     3301 ccgctgcccg gctcccttat ctttctaaaa tgagtagatt ggcataacca ggtggtacct
     3361 acctgtcgcc cctgtaacag ggaggactgc tgctgtgagt tcaaggccag cctgagctat
     3421 gagaccctag ctcaaaatcc acatcaacca aaaccagaag attgggatgg agggtgatgg
     3481 gtttcccttg gggtgctttt cctaacccca acaggagcca aaccaaaggc tttttttttt
     3541 ttttttttaa taaggaagct gctgtttatt ccagaagcag agcaggacac agggcacaga
     3601 gcagcacaca gggcaccaga tggtgcagtt ttcactctaa gttccagggc agctgcttta
     3661 gcttagtttt gcttcagctg aaggcgagtc tcagtgatca cgccttctca ccggatacac
     3721 tggggaaaga cggttgttgt gcacgatgaa ggggagagcg agggcaaggg gcatggagaa
     3781 ggagctgtgg acactttgta ccaagctgtc tgaatttctc agcctggagc cccctggctg
     3841 ctgagttaag atgaaatcgg ggtggggagg ggcaggagta ttctgactcc aaccccaccc
     3901 cttactcacc agtgcaggga ggggagggtc tcctgtctac acaagggtag gcccctttgg
     3961 ccctggggga gcctggctga ccacctctcc cgtggactgg gtgactcctt tccgatgctt
     4021 tgacaactcc taaaagagag agaatccgcc ctgccctgca ccgtccccca ccctgtgggt
     4081 ttgtcagcca gggctcaacc cctgtcagtt cacccattgc caccagaagt tctcttgccc
     4141 tgacattccc tcctggtcct ggactgtgtg ggagtcagcc agtgcatatg gacgaggcta
     4201 aatcagtacg actccaaaag ccccgtccgt ccccgaagtc tagaaattaa aactaataaa
     4261 ctcaccttgt gaatcagact gtgcagacaa gcattcacct tttgaatccg ggt
//
