LOCUS       NM_172767               4157 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus von Willebrand factor A domain containing 5A (Vwa5a),
            transcript variant 1, mRNA.
ACCESSION   NM_172767 NM_026372
VERSION     NM_172767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4157)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4157)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4157)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   4  (bases 1 to 4157)
  AUTHORS   Martin,E.S., Cesari,R., Pentimalli,F., Yoder,K., Fishel,R.,
            Himelstein,A.L., Martin,S.E., Godwin,A.K., Negrini,M. and
            Croce,C.M.
  TITLE     The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor
            suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (20), 11517-11522 (2003)
   PUBMED   14504409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856505.1, AK054497.1, AK136934.1 and AY366502.1.
            
            On Mar 21, 2009 this sequence version replaced NM_172767.2.
            
            Transcript Variant: This variant represents the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY366502.1, AK136934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB856505.1         3-30
            29-2844             AK054497.1         2-2817
            2845-3408           AK136934.1         2818-3381
            3409-4157           AY366502.1         3373-4121
FEATURES             Location/Qualifiers
     source          1..4157
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.89 cM"
     gene            1..4157
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="von Willebrand factor A domain containing 5A"
                     /db_xref="GeneID:67776"
                     /db_xref="MGI:MGI:1915026"
     exon            1..120
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            121..196
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            197..254
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2593
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="loss of heterozygosity, 11, chromosomal region 2,
                     gene A homolog"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 5A"
                     /protein_id="NP_766355.3"
                     /db_xref="CCDS:CCDS23024.1"
                     /db_xref="GeneID:67776"
                     /db_xref="MGI:MGI:1915026"
                     /translation="MEHHCGLITSNKETVPLKNISVTLSINEFVAAVVATLNYENEEK
                     VPLEATFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKAHSEYEEALSQGHQAYLLEE
                     DDYSRDVFSCNVGNLQPGAKVAVTLRYVQELPLETDGALRYLLPAILNPRYQLSEQSA
                     NSCLNIQKPTVPLEDLPYTLNMTATITSQHGIERVQSNCSLSPIQYLTDDKTSAQVSL
                     TEGHKFDRDVELLIYYNEVHSPSVAVEMGMLDMKPDSLMGAPSAMVSFYPDIPEVEAS
                     KACGEFVFLMDRSGSMDSPMSTENNSQLRIEAAKETLLLLLKSLPMGCYFNIYGFGSS
                     YEKFFPESVKYTQDTMEDAVKRVKALKANLGGTEILTPLCNIYKASSIPGHPLQLFVF
                     TDGEVSDTFSVIREVKLNSKKHRCFSFGIGQGASTSLIKNIARVSGGTAVFITGKDRM
                     QTKALGSLKFALQCAVDNISLSWDLPPGLSVKMLSPEQLTIFRGQRLIIYAQLTGLMP
                     QVESTGAVCLKHILQGRSLENRVTFSLQPKANDNFTIHRLAAKSLIQTKDFGSQEASK
                     EEKEDVMNISLQSGVLSSFTAFIAINKELNKPVQGPLAHRVIPRPVMAGSSSMRFYSS
                     FSGGFKGPQPRSLRVPAYDLCSAESANLVLKKSACSAIQKKKTNSSTNKSNLKKEHKA
                     FGENAVVQLISLQKANGSWELDEDLTKILGTKSKDIKAANPAKHEDPSAWSTVLAVVW
                     LHANGTDLKCEWELLERKAVAWLHDHAGSSIPMLVQAANSLLKLSVNPAVFGV"
     exon            255..457
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            458..680
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            681..856
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            857..971
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1141
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1230
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1375
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1455
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1570
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1735
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1836
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2090
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2156
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2255
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2386
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2513
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..4157
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: ATTAAA"
     polyA_site      3404
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="major polyA site"
     regulatory      3563..3568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: TATAAA"
     polyA_site      3587
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: TATAAA"
     polyA_site      3748
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
     regulatory      3788..3793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: TATAAA"
     polyA_site      3814
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
     regulatory      3862..3867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: AATAGA"
     polyA_site      3884
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
     regulatory      3933..3938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
                     /note="hexamer: AATAAT"
     polyA_site      3937
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
     polyA_site      3966
                     /gene="Vwa5a"
                     /gene_synonym="5830475I06Rik; BCSC-1; E130119J22;
                     Loh11cr2a"
ORIGIN      
        1 gggtcttcct ggaagttctg ctttagttac tttcactttt aaagctgcgg agactttagg
       61 aggtttgcga ttgctctact ctgctctctc tgggaagaat cctactgatc cctctaaaag
      121 cttcctgcag tagccaaagc aagcctgaga tctctgctgt cagacataat ctgtccttca
      181 gcattgctgc tcctagaagc gtgcaatcac catggagcat cactgtggtc taatcactag
      241 caacaaagag acagtaccac tgaaaaatat ctcagtaaca ttgtccatca atgaatttgt
      301 ggctgctgtg gtggcaacct taaattacga gaatgaggag aaagtcccat tagaggcgac
      361 ctttgtgttt cctatggatg aagactctgc tgtctacagc tttgaagcct tggtggatgg
      421 gaagaaaatt gtggcagagt tgcaggataa gatgaaggct cacagcgagt atgaggaagc
      481 cctctcccag ggccaccaag catacttatt ggaagaggat gactattcca gagatgtctt
      541 ttcttgcaac gtggggaacc tgcagcctgg agctaaggtt gcagttaccc tgaggtatgt
      601 gcaggaactg cccttggaaa cagatggggc cctgcgctac ctgctcccag caatcttgaa
      661 tccaagatat cagctctctg aacagtcagc aaacagttgc ttgaacatcc agaaacccac
      721 agtccctttg gaagacctgc cttacacact caacatgact gccaccatca cttcccagca
      781 tggtattgaa agggtccagt ccaactgctc tttgagccct attcagtacc ttacagatga
      841 caagacttct gctcaggttt ccttgactga agggcacaag tttgaccggg atgtggaact
      901 cctgatttac tacaatgaag tgcacagccc cagtgtagct gtggaaatgg ggatgctgga
      961 catgaagcca gacagtttga tgggagctcc ttctgcaatg gtgagtttct acccagatat
     1021 cccagaagtg gaagcctcaa aggcctgtgg agaatttgtg tttctcatgg accgttcagg
     1081 aagtatggac tcccccatga gcacagagaa caattctcag ctacgcatcg aggctgccaa
     1141 ggaaactctg ttgctgttgc tgaagagttt gcctatgggt tgttatttta atatctatgg
     1201 atttggatct tcctatgaga aattctttcc ggagagtgtg aagtacactc aggatacaat
     1261 ggaggacgca gtgaaaagag tgaaggcttt aaaagccaac ttagggggta ctgaaatctt
     1321 gacacccctc tgcaacattt acaaggcatc ctccattcct ggtcatcccc tacagctctt
     1381 tgtcttcacg gatggagaag tgagtgacac atttagtgtc attagagaag ttaagttaaa
     1441 cagcaagaaa cacagatgtt tctcttttgg aattggacaa ggagcctcga ccagtttaat
     1501 caaaaatatc gcccgggtat cagggggtac tgcagtgttt atcacaggca aggacaggat
     1561 gcagaccaag gctcttgggt ctctcaagtt tgctctacag tgtgcagtgg ataacatctc
     1621 tctaagttgg gatttgcctc ctggtttgtc tgttaaaatg ctttctccag agcaacttac
     1681 catctttagg ggtcagaggt taatcatcta tgcacaactg actgggctta tgcctcaagt
     1741 ggagagcaca ggagcagtgt gcctcaagca catcctccag ggtaggagtc tggaaaacag
     1801 ggtgacattt tccctgcaac ccaaggcaaa tgacaatttc accattcatc ggttggctgc
     1861 aaagtccttg attcagacta aggattttgg atcccaggag gcctcaaaag aagaaaaaga
     1921 agatgtgatg aacatcagcc ttcagtctgg agtccttagc tccttcacag ccttcattgc
     1981 cataaacaag gagctgaaca aaccagtgca ggggcctctg gcccacagag tgattcctag
     2041 gccagtgatg gctggatcta gtagtatgcg gttctactcc agtttctctg gtggctttaa
     2101 aggcccacag ccaagaagtt tacgtgtacc agcatatgat ttatgttcag cagaaagtgc
     2161 taatcttgtc ctcaaaaaat ctgcgtgttc tgctatacag aagaaaaaga caaattcttc
     2221 taccaataaa agcaacttga aaaaggaaca caaagcattt ggagagaatg ctgtggtgca
     2281 gctgatttct ctccaaaagg caaatggctc ctgggagcta gatgaagatt tgaccaagat
     2341 cctgggcact aagtcaaaag acatcaaggc tgcaaaccct gccaagcatg aggacccctc
     2401 agcctggtcc acagtgctgg ctgtggtctg gttgcatgcc aacggcacag acttaaagtg
     2461 tgaatgggag cttctggaaa ggaaggctgt ggcctggctt catgaccatg caggttcctc
     2521 catccccatg cttgtgcaag ctgccaatag tctcctgaaa ttatctgtga atcctgctgt
     2581 ctttggcgtc taaacatgtc acccatgaaa ggaaagcctt ttctggcgac cactgagtcc
     2641 cttattttct atccctatca tttcttttgt cagaagttaa catagtctcc caacatgttt
     2701 tcttctttga ggattttatt ttattcatat gcagaatgac acacggagtt tcgagaccat
     2761 ttacaatata attacaatat aatgattggc atgagatcta tagtaagcat gcagcattaa
     2821 ccatgagcaa tgcttaaatt aataccctgc attattgtta tccattctct atgcagagcc
     2881 atgtagtatg gtcaacaaat ggctttaaac tcatagaata gccctaccag ttagcacaga
     2941 catgatggat gctcctcagt tgaggcagta ctactaggac tatgtgtcct gagtacctca
     3001 tgctgttatg aatttttgcc ctgcccattg ccttcacatc cctcttaatc taaggattgt
     3061 atgaaaagtc taaagtggct tccagcccct cactggggag tatcattgac attaaacaat
     3121 aataatgcct gatatctttt aggcattgtt gctggagcag attagtgatc caagtactac
     3181 cataggaaag aacttaaaaa gatgtggatt ttcagcaatg ttcaccatcc ttaaaacctt
     3241 tatttggaaa aacaaagttt ttagtaagcc tatgttaaga tttttttttt gattgtttgt
     3301 tattgatact gttttaaaaa atcttagtga acattttgaa cttctgtaat gcacacacat
     3361 attcattaaa ctatggacat ttcatggtca gagaacaaga aaaatggcaa cattggctaa
     3421 catgaatctc actgaggctg gactgctcct gattgacttg ttatgtctag ttttgccctc
     3481 agctttctga tatgatttaa taagaattgc tgatgtctag gtaaaccttc ttagtattta
     3541 aagtagttaa gactgacttt tatataaaag ttcagatttg tgactcattg gagatttttg
     3601 tatgactact cttaaagata aacacaataa ttagtccttc cttcgtaagt gcaaattgct
     3661 gcctgagagt aagaggagct ggctgagaaa actcctttgc ttactcacac tttttaaatc
     3721 tataaaaagt tgcttagtta tgaatgcaca tgggttcttg ggaatacttt cttttattta
     3781 cctgtactat aaaatgttat ttcttgtaaa gatattatat aacatcctgg aaattttttc
     3841 atagtcagtc actagaagga aaatagaaag tactaaaact gtaattttat actgtctaaa
     3901 aggtttttct gggatatata agagatggga aaaataatgt tgaaactttg cttcttccac
     3961 ctccaagtat gtgtgtatat atttatacat gtgcttgtat gtatgtatat gtgtaaagtt
     4021 tgtgaattgg aactttgttc catctatcaa atttatatgt atgttatatg taaagcttgt
     4081 gtgggtatgt gttggagctt attccaacca actgtgtata tatgtgtgga tatgtgcaaa
     4141 atgcttttga gcctgct
//
