LOCUS       NM_172840               3885 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus von Willebrand factor A domain containing 2 (Vwa2),
            mRNA.
ACCESSION   NM_172840
VERSION     NM_172840.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3885)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3885)
  AUTHORS   Esho,T., Kobbe,B., Tufa,S.F., Keene,D.R., Paulsson,M. and
            Wagener,R.
  TITLE     The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form
            Anchoring Cords in the Absence of AMACO at the Dermal-Epidermal
            Junction of Mouse Skin
  JOURNAL   Int J Mol Sci 24 (7), 6782 (2023)
   PUBMED   37047755
  REMARK    GeneRIF: The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can
            Form Anchoring Cords in the Absence of AMACO at the
            Dermal-Epidermal Junction of Mouse Skin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3885)
  AUTHORS   Richardson,R.J., Gebauer,J.M., Zhang,J.L., Kobbe,B., Keene,D.R.,
            Karlsen,K.R., Richetti,S., Wohl,A.P., Sengle,G., Neiss,W.F.,
            Paulsson,M., Hammerschmidt,M. and Wagener,R.
  TITLE     AMACO is a component of the basement membrane-associated Fraser
            complex
  JOURNAL   J Invest Dermatol 134 (5), 1313-1322 (2014)
   PUBMED   24232570
  REMARK    GeneRIF: Our data suggest that AMACO represents a member of the
            Fraser complex.
REFERENCE   4  (bases 1 to 3885)
  AUTHORS   Gebauer,J.M., Keene,D.R., Olsen,B.R., Sorokin,L.M., Paulsson,M. and
            Wagener,R.
  TITLE     Mouse AMACO, a kidney and skin basement membrane associated
            molecule that mediates RGD-dependent cell attachment
  JOURNAL   Matrix Biol 28 (8), 456-462 (2009)
   PUBMED   19651211
  REMARK    GeneRIF: Murine AMACO localizes subjacent to the basement membrane
            in kidney and skin. AMACO supports beta1 integrin-mediated adhesion
            of a keratinocyte-like cell line, HaCaT, and a fibroblast cell
            line, Wi26, in an RGD-dependent manner.
REFERENCE   5  (bases 1 to 3885)
  AUTHORS   Sengle,G., Kobbe,B., Morgelin,M., Paulsson,M. and Wagener,R.
  TITLE     Identification and characterization of AMACO, a new member of the
            von Willebrand factor A-like domain protein superfamily with a
            regulated expression in the kidney
  JOURNAL   J Biol Chem 278 (50), 50240-50249 (2003)
   PUBMED   14506275
  REMARK    GeneRIF: AMACO is a new member of the von Willebrand factor A-like
            domain protein superfamily with a regulated expression in the
            kidney
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ536329.1, AK029297.1 and BX631538.1.
            
            On Feb 23, 2004 this sequence version replaced NM_172840.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ536329.1, AK160971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2653              AJ536329.1         1-2653
            2654-3062           AK029297.1         2599-3007
            3063-3681           AK029297.1         3009-3627
            3682-3885           BX631538.1         1-204               c
FEATURES             Location/Qualifiers
     source          1..3885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 52.02 cM"
     gene            1..3885
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /note="von Willebrand factor A domain containing 2"
                     /db_xref="GeneID:240675"
                     /db_xref="MGI:MGI:2684334"
     exon            1..163
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            164..225
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2549
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /note="VWA-like domains, matrilins and collagens; von
                     Willebrand factor A domain-containing protein 2; a
                     domain-containing protein similar to matrilin and
                     collagen"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 2 precursor"
                     /protein_id="NP_766428.2"
                     /db_xref="CCDS:CCDS29923.1"
                     /db_xref="GeneID:240675"
                     /db_xref="MGI:MGI:2684334"
                     /translation="MPPLLLLPAIYMLLFFRVSPTISLQEVHVNRETMGKIAVASKLM
                     WCSAAVDILFLLDGSHSIGKGSFERSKRFAIAACDALDISPGRVRVGALQFGSTPHLE
                     FPLDSFSTRQEVKESIKGIVFKGGRTETGLALKRLSRGFPGGRNGSVPQILIIVTDGK
                     SQGPVALPAKQLRERGIVVFAVGVRFPRWDELLTLASEPKDRHVLLAEQVEDATNGLL
                     STLSSSALCTTADPDCRVEPHPCERRTLETVRELAGNALCWRGSRQADTVLALPCPFY
                     SWKRVFQTHPANCYRTICPGPCDSQPCQNGGTCIPEGVDRYHCLCPLAFGGEVNCAPK
                     LSLECRIDVLFLLDSSAGTTLGGFRRAKAFVKRFVQAVLREDSRARVGIASYGRNLMV
                     AVPVGEYQHVPDLIRSLDSIPFSGGPTLTGSALLQVAEHGFGSASRTGQDRPRRVVVL
                     LTESRSQDEVSGPAAHARARELLLLGVGSEILQAELVKITGSPKHVMVHTDPQDLFSQ
                     IPELQRRLCSQPRPGCQAQSLDLVFLLDASASVGRENFAQMQSFIRKCTLRFDVNPDV
                     TQVGLVVYGSRVQTAFGLDTHPTRAAVLRAMSQAPYLGGVGSAGTALLHIEDKVMTVQ
                     RGARPGVPKAVVMLTGGSGAEDAAVPAQKLRGNGISVLVMSVGAVLREAVRRLAGPRD
                     SLIHVAAYTDLPYHQDMLIEWLCREARLPVNLCKPSPCMNEGTCVLKNGSYRCECRGG
                     WEGPHCENRILRGDAPMARSFHQEPAGLQGPTPSQQAPKHLRIGKALSSAK"
     exon            226..300
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            301..434
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            435..544
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            545..736
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            737..870
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1003
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1059
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1167
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1740
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2292
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2418
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..3882
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3861..3866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="Vwa2"
                     /gene_synonym="Amaco"
                     /note="major polyA site"
ORIGIN      
        1 ttgccagtga gcgagcgagc gtgtggaacc ccaggcctga gcccgcgccc ctacctgccc
       61 agccaagccg agtgccgccg gctttgttcg ctttgtcctc gcgcacctaa gcggccggcc
      121 tggaagaacg ccatcccgga gagcgcacgc ggcgtcgcac caggtctaac aacatgcctc
      181 cacttctgct tctaccagcc atctacatgc tcctgttctt cagagtgtcc ccgaccatct
      241 ctcttcagga agtgcatgtg aaccgggaga ccatggggaa gatcgctgtg gccagcaaat
      301 taatgtggtg ctcagccgcg gtcgacatcc tgtttctgtt agatggctct cacagcatcg
      361 ggaaggggag cttcgagagg tccaagcgct tcgccatcgc tgcctgtgat gccctggaca
      421 tcagccctgg cagggtcaga gtcggagcct tgcagtttgg ttccactcct catctggaat
      481 tccccttgga ctccttctca actcgacagg aagtgaagga aagcatcaag gggatagttt
      541 tcaaaggtgg gcgcaccgag acgggcctag ccctgaaacg cctgagcaga gggttccccg
      601 gaggcagaaa tggctctgtg ccccagattc ttatcatcgt cacggatggc aagtcccagg
      661 ggcccgtggc tctcccggct aagcagctga gagaaagggg catcgtcgtg tttgccgtag
      721 gagtccgttt tcccaggtgg gacgagctgc tcacgctggc cagtgagccg aaggaccggc
      781 atgtgctgtt ggctgagcaa gtggaggatg ccaccaatgg cctcctcagc accctcagca
      841 gctccgcact ctgcaccact gctgatccag actgcagggt ggaacctcat ccctgtgagc
      901 ggaggacgct ggagaccgtc agggagctcg ctggcaatgc cttgtgctgg agaggatcaa
      961 ggcaagcaga cactgtgctg gctctgccct gtcccttcta cagctggaag agagtgttcc
     1021 agacacaccc tgccaactgc tacagaacca tctgtccagg cccctgtgac tcccagccct
     1081 gccaaaatgg aggcacgtgc attccagaag gtgtggatag gtaccactgt ctctgcccac
     1141 tggcattcgg aggggaagtc aactgtgccc cgaagctgag cctggaatgc agaatcgatg
     1201 tcctcttcct gctggacagt tctgcaggca ccacattggg gggcttccgg agggccaagg
     1261 cctttgtcaa gcgctttgtg caggccgtgc tgagggagga ctcccgagcc cgcgttggga
     1321 tagccagtta tggcaggaat ctaatggtgg cggtgcccgt cggggagtac cagcatgtgc
     1381 cggacctgat caggagcctt gacagcattc ccttcagcgg tggcccgacc ctaaccggga
     1441 gtgccttgct ccaggtggca gagcacggct ttgggagtgc cagcaggact ggtcaggaca
     1501 ggccacgcag agtagtagtt ctgctcactg aatcacgctc ccaggatgag gtgtctgggc
     1561 cagcagctca cgcaagggct cgggagctac tcctcctggg cgtgggcagt gagatcctgc
     1621 aggcggagct ggtgaagatc accggtagcc cgaagcatgt gatggtccac acagaccctc
     1681 aggacctgtt cagccaaatc ccagagctgc agaggaggct atgcagccag ccacggccag
     1741 gctgccaggc acagtcactg gacctggtct tcctgttgga tgcctctgcc tctgtgggac
     1801 gtgagaactt tgcccaaatg cagagcttca tcaggaaatg caccctccgg tttgatgtga
     1861 atcctgatgt gacacaggtt ggcctggtgg tatatggcag ccgggtgcag actgccttcg
     1921 ggctagacac ccatcccacc cgggctgccg tgttgcgggc catgagccag gctccctacc
     1981 tagggggtgt gggttctgct ggtacagcct tgctgcacat tgaggacaag gtgatgacgg
     2041 tccagagggg tgcccgcccc ggtgtcccca aggccgtggt gatgctcaca ggcgggagtg
     2101 gggcagaaga tgcagctgtc cctgcccaga agctgagagg caatggcatc tcagtcttgg
     2161 ttatgagcgt gggagccgtc ctcagggagg cagtacggag gcttgccggt ccacgcgact
     2221 ccctgatcca tgtggcagct tacacagacc ttccgtacca tcaggacatg ctcatcgagt
     2281 ggctatgtag agaagccagg ctgccagtca acctctgcaa gccgagccca tgcatgaatg
     2341 aaggcacctg tgtcctgaag aacggcagtt accgatgcga gtgccggggt ggctgggaag
     2401 gcccccactg tgagaaccgc atcttgagag gagatgcccc catggcacgt agcttccacc
     2461 aagagcctgc aggactacaa gggccaaccc cctcgcagca agctcccaag catcttagaa
     2521 tcggaaaggc cctgtcctcc gccaagtaaa tctcccgggg gccctggagc atcagcttcc
     2581 agctctgcca caggggacac tgcttgggac agtagcagct gtcgctatgg tgatgttggg
     2641 aacgactact gcgtcagcat ttatcccctg aatccgtttg taccttgctg aggtaagctg
     2701 cctgtcattt ttcctgagga taagaggcag gccagagaga tctgacgacc tgcttgaggg
     2761 tcatcacaga tgctagacag atgttcctga ggtggtagcg ctttgaagaa gactctgtca
     2821 gagctcaccg cctggtgatt ggtgcaaaaa gtgggtttct ccctgttcca aaagacagct
     2881 cctgtggatt tcatttgcaa agggattatg tgtcatttgt gacgttttct ggtgaccaga
     2941 tctgtgtgtg ggagagacct gggaaggtct cagacagcca tttgaccaat tactcagttt
     3001 gcacgtaggg gagggacatg tgtgaacagc cgtgtacgat tggtctgggc gctgagcaac
     3061 ggcctccaga ggggcttcct ttcagagatt actcaggaga gagtggcagt gagtgctgcc
     3121 ctcctcttag tggtggcaat gatgggcaga cttctcaaac tcagcaaggg agggatgagg
     3181 ggttgcccag gaggtttgct ttcaaagctt actgtgctgc tctgttttaa tgtgcatctc
     3241 acgcccactc ggtaatgtct caagacagat tggttggttg ttcgtccatc aggactgtat
     3301 ccgctggcaa cgaggcttct ttggaatatc tttgggaaac taggtactta actgcagcgc
     3361 taacacatca gtctcccccc acaccccttc cccaccctgc ccctttcttg tgctgtttga
     3421 agctgggttt tcagaagaag ccatgtgtag cgctctggga gatgagaagc attggtaagg
     3481 gtgtgtatct ttgtgcagcc aatgctgtaa actctgtttg tgttctgtgt gccaggctgg
     3541 ctggctgagg tgctactcca cgtctgcagg atgctctccc cgtctctgac ccacattttc
     3601 ttccttcaca tttatacact ggggatgtaa actttacgta ttgttatatt tcaatcatcg
     3661 aaccaatatg tagacattgt cacagcagaa tagtgctgat gtcttcgtgg aacaccagga
     3721 cttcccaaac acccgtgcag ctgtagtcac agtaccttcc tgtaaactcc tgtcctggtc
     3781 tgttatattc tactttactc tgggttgtca gtaccatgtt caaggagtca gaatttggtc
     3841 ttgatggttt ttaaacataa aataaaacat ttatgtcctt aaaaa
//
