LOCUS       NM_147776               3140 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus von Willebrand factor A domain containing 1 (Vwa1),
            mRNA.
ACCESSION   NM_147776
VERSION     NM_147776.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Hansen,U., Allen,J.M., White,R., Moscibrocki,C., Bruckner,P.,
            Bateman,J.F. and Fitzgerald,J.
  TITLE     WARP interacts with collagen VI-containing microfibrils in the
            pericellular matrix of human chondrocytes
  JOURNAL   PLoS One 7 (12), e52793 (2012)
   PUBMED   23300779
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Allen,J.M., Brachvogel,B., Farlie,P.G., Fitzgerald,J. and
            Bateman,J.F.
  TITLE     The extracellular matrix protein WARP is a novel component of a
            distinct subset of basement membranes
  JOURNAL   Matrix Biol 27 (4), 295-305 (2008)
   PUBMED   18314316
  REMARK    GeneRIF: identification of WARP as a component of a limited range
            of specialized basement membranes provides further evidence for the
            heterogeneous composition of basement membranes between different
            tissues
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Allen,J.M., Bateman,J.F., Hansen,U., Wilson,R., Bruckner,P.,
            Owens,R.T., Sasaki,T., Timpl,R. and Fitzgerald,J.
  TITLE     WARP is a novel multimeric component of the chondrocyte
            pericellular matrix that interacts with perlecan
  JOURNAL   J Biol Chem 281 (11), 7341-7349 (2006)
   PUBMED   16407285
  REMARK    GeneRIF: WARP forms macromolecular structures that interact with
            perlecan to contribute to the assembly and/or maintenance of
            'permanent' cartilage structures during development and in mature
            cartilages
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Fitzgerald,J. and Bateman,J.F.
  TITLE     Is there an evolutionary relationship between WARP (von Willebrand
            factor A-domain-related protein) and the FACIT and FACIT-like
            collagens?
  JOURNAL   FEBS Lett 552 (2-3), 91-94 (2003)
   PUBMED   14527666
  REMARK    GeneRIF: evolutionary relationship between von Willebrand factor
            A-domain-related protein (WARP), and the fibril-associated collagen
            with interrupted triple helix (FACIT) and FACIT-like subfamilies of
            collagens
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Fitzgerald,J., Tay Ting,S. and Bateman,J.F.
  TITLE     WARP is a new member of the von Willebrand factor A-domain
            superfamily of extracellular matrix proteins
  JOURNAL   FEBS Lett 517 (1-3), 61-66 (2002)
   PUBMED   12062410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX210560.1, AK077240.1 and AK030019.1.
            
            On Jun 19, 2009 this sequence version replaced NM_147776.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030019.1, AY030094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CX210560.1         1-33
            34-2295             AK077240.1         5-2266
            2296-3140           AK030019.1         2250-3094
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.31 cM"
     gene            1..3140
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="von Willebrand factor A domain containing 1"
                     /db_xref="GeneID:246228"
                     /db_xref="MGI:MGI:2179729"
     exon            1..132
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1307
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="von Willebrand factor A domain-containing protein
                     1; von Willebrand factor A domain-related protein"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 1 precursor"
                     /protein_id="NP_680085.3"
                     /db_xref="CCDS:CCDS19039.1"
                     /db_xref="GeneID:246228"
                     /db_xref="MGI:MGI:2179729"
                     /translation="MLFWTAFSMALSLRLALARSSIERGSTASDPQGDLLFLLDSSAS
                     VSHYEFSRVREFVGQLVATMSFGPGALRASLVHVGSQPHTEFTFDQYSSGQAIQDAIR
                     VAPQRMGDTNTGLALAYAKEQLFAEEAGARPGVPKVLVWVTDGGSSDPVGPPMQELKD
                     LGVTIFIVSTGRGNLLELLAAASAPAEKHLHFVDVDDLPIIARELRGSITDAMQPQQL
                     HASEVLSSGFRLSWPPLLTADSGYYVLELVPSGKLATTRRQQLPGNATSWTWTDLDPD
                     TDYEVSLLPESNVHLLRPQHVRVRTLQEEAGPERIVISHARPRSLRVSWAPALGPDSA
                     LGYHVQLGPLQGGSLERVEVPAGQNSTTVQGLTPCTTYLVTVTAAFRSGRQRALSAKA
                     CTASGARTRAPQSMRPEAGPREP"
     exon            133..690
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /inference="alignment:Splign:2.1.0"
     exon            691..969
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /inference="alignment:Splign:2.1.0"
     exon            970..3140
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="hexamer: AATACA"
     polyA_site      2292
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="major polyA site"
     regulatory      2309..2314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="hexamer: ATTAAA"
     polyA_site      2335
                     /gene="Vwa1"
                     /gene_synonym="4932416A11Rik; WARP"
                     /note="major polyA site"
ORIGIN      
        1 gtaggagggc aagttagcag ccagctgtgg tcgatcaaga gcccgccact ccaggcgcga
       61 tgctgttctg gactgcgttc agcatggctt tgagtctgcg gttggcattg gcgcggagca
      121 gcatagagcg cggttccaca gcatcagacc cccaggggga cctgttgttc ctgttggaca
      181 gctcagccag cgtgtcacac tatgagttct caagagttcg ggaatttgtg gggcagctgg
      241 tggctacgat gtctttcgga cccggggctc tgcgtgctag tctggtgcac gtgggcagcc
      301 agcctcacac agagtttact tttgaccagt acagttcagg ccaggctata caggatgcca
      361 tccgtgttgc accccaacgt atgggtgata ccaacacagg cctggcactg gcttatgcca
      421 aagaacaatt gtttgctgag gaagcaggtg cccggccagg ggttcccaag gtgctggtgt
      481 gggtgacaga tggtggctcc agcgaccccg tgggcccccc tatgcaggag ctcaaggacc
      541 tgggtgtcac catcttcatt gtcagcactg gccgaggcaa cctgttggag ctgttggcag
      601 ctgcctcggc tcctgccgag aagcacctac actttgtgga tgtggatgat cttcctatca
      661 ttgcccggga gctgcggggc tccataactg atgcgatgca gccacaacag cttcatgcct
      721 cggaggttct gtccagtggc ttccgcctgt cctggccgcc cctgctgaca gcggactctg
      781 gttactacgt gctggaattg gtacctagcg gcaaactggc aaccacaaga cgccaacagc
      841 tgcccgggaa tgctaccagc tggacctgga cagatctcga cccggacaca gactatgaag
      901 tatcactgct gcctgagtcc aacgtgcacc tcctgaggcc gcagcacgtg cgagtacgca
      961 cactgcaaga ggaggccggg ccagaacgca tcgtcatctc gcatgcgagg ccgcgcagcc
     1021 tccgcgtaag ctgggccccc gcgcttggcc cggactccgc tctcggctac catgtacagc
     1081 tcggacctct gcagggcggg tccctagagc gcgtggaggt gccagcaggc cagaacagca
     1141 ctaccgtcca gggcctgacg ccctgcacca cttacctggt gactgtgact gccgccttcc
     1201 gctccggccg ccagagggcg ctgtcggcta aggcctgtac ggcctctggc gcgcggaccc
     1261 gtgctccgca gtccatgcgg ccggaggctg gaccgcggga gccctgaact gcctgcctgc
     1321 tcgtccaccc gggggccctc ttccctagcc cggagagaga gacactgctg ctcgtgggtt
     1381 ttcttgtgga tggagtcggg tggggagatg ggatgccggt cctgcctttg accagcgtta
     1441 attcctttcg tcgtttcccc actggtcatc gccgcccttg cctgacttcc gggaaacccg
     1501 ggtagcctca cgcgcaatgg cggtcctctc cggttgccag tggagttgag cacacggtgg
     1561 tccttgggca actcttggcg aggggatgga cagtgtctga ggtcaggttg aggacataag
     1621 acccaggaca agccttcagg agaggaggcc acagagtttc caacctgtgc caaaggctgg
     1681 gccctctggt ggcagggact acgcatggct ttgaggaggc gttcaggacc atccaggtcc
     1741 tgcctgggcc tagaaagtgg gtaggagaaa gggaagagag actagtgtag acaggattcc
     1801 cgaaaacttc ctcaaggaaa ggaaagatag ggaggtatgc tgggaggctg atgatgtggc
     1861 attggttttc atcaagatgt cctgccagcc tagaggccgg gatctgtcag ggtcactgac
     1921 tctgccttcc tgcccaggac ctgcactggg ccctcgatca gtgccaagga tgcagtcttt
     1981 tcacaggaat gggacgagac cttggcattt agggcctcag ggataggaga gccgcactat
     2041 gacagattct aagggagcct cctgctttag tgtagggagc aaggtgtcat gcaggtgggc
     2101 tacctcctgc catcaccatt accctggggc atctgacaga tacctaaggg tggtcaggaa
     2161 caggtttcct ctcaagtccc tatgtaggcc tctcctctcc tctcagaatc atttgcctta
     2221 tcccaagctt actccatctc ttccccacta atgacccgga ctctaacaac aatacagtca
     2281 gacagacata aactgtgcct gcagtctcat taaaatgctg tatttttcgt caaaactctc
     2341 cccagctgtg gtactcgtgt gggcagcatg aaaggttgga cgtacagggt ttattacgtt
     2401 tggggagtag gggaagcagg tctgcagcat ccgtacacgg atcattcagg ctcctgtccc
     2461 tccatgttcc ctgccagctt cataccaggg cctcacttct gcagcccgcg agcgatccag
     2521 tgtctgcagt aggtcaagtt gttgctgcta caactcagag ggcaggaggc tttacagggg
     2581 tgtccccacc accgcctgtg ctgtactaca cactgctcgg ccctcttctt acatgttttc
     2641 cttacactac tttggctgca agtgagatcc aggagctaag tattgagaga ggtggggtag
     2701 actttgggta tggagagagc agaggtggct ttcctgagac tttgccctct accatttccc
     2761 gagaagctga aggagcacgg tagggctcat cctggacacc caaaggagca ctggccatgc
     2821 accgaacgtg ttgtgttggt gggaggtggc tgtttgtgtg acgatggctt gagatacaag
     2881 gccctagccg gctcatggag cagaagccat tggggtatgt gtgtttggga ggggggggcc
     2941 ctctccatgt gtccttgtca gggcagtaag cctatgtgtg cacttacagg tttcatgttt
     3001 cacctgttga tcaaaagttg gagctcagat acttcctgtg atgtcagttt ccaggccaga
     3061 ggctgaggcc atctgcatcc aggacagatg taggtttggt atgttggcct cacattcccc
     3121 taaaatatgg aagttcctcc
//
