LOCUS       NM_011707               1763 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus vitronectin (Vtn), mRNA.
ACCESSION   NM_011707
VERSION     NM_011707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Zhang,C., Liu,Y., Jiang,J., Chen,C., Duan,Z., Su,H., Wang,S.,
            Tian,B., Shi,Y., Xiang,R. and Luo,Y.
  TITLE     Targeting tumor cell-to-macrophage communication by blocking
            Vtn-C1qbp interaction inhibits tumor progression via enhancing
            macrophage phagocytosis
  JOURNAL   Theranostics 14 (7), 2757-2776 (2024)
   PUBMED   38773982
  REMARK    GeneRIF: Targeting tumor cell-to-macrophage communication by
            blocking Vtn-C1qbp interaction inhibits tumor progression via
            enhancing macrophage phagocytosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Gu,X., Chen,X., Zhang,X., Liu,K., Li,J.J., Lv,W., Zeng,L., Wu,M.,
            Zhou,W., Wang,W., Shi,S., Deng,Y., Li,Y., Gao,X., Ju,R., Dubrac,A.,
            Liu,X. and Zhang,F.
  TITLE     Macrophage-induced integrin signaling promotes Schlemm's canal
            formation to prevent intraocular hypertension and glaucomatous
            optic neuropathy
  JOURNAL   Cell Rep 43 (2), 113799 (2024)
   PUBMED   38367239
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Jia,C., Lovins,C., Malone,H.M., Keasey,M.P. and Hagg,T.
  TITLE     Female-specific neuroprotection after ischemic stroke by
            vitronectin-focal adhesion kinase inhibition
  JOURNAL   J Cereb Blood Flow Metab 42 (10), 1961-1974 (2022)
   PUBMED   35702047
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Nakashima,N., Miyazaki,K., Ishikawa,M., Yatohgo,T., Ogawa,H.,
            Uchibori,H., Matsumoto,I., Seno,N. and Hayashi,M.
  TITLE     Vitronectin diversity in evolution but uniformity in ligand binding
            and size of the core polypeptide
  JOURNAL   Biochim Biophys Acta 1120 (1), 1-10 (1992)
   PUBMED   1372829
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Seiffert,D., Keeton,M., Eguchi,Y., Sawdey,M. and Loskutoff,D.J.
  TITLE     Detection of vitronectin mRNA in tissues and cells of the mouse
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9402-9406 (1991)
   PUBMED   1719529
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Preissner,K.T., Grulich-Henn,J., Ehrlich,H.J., Declerck,P.,
            Justus,C., Collen,D., Pannekoek,H. and Muller-Berghaus,G.
  TITLE     Structural requirements for the extracellular interaction of
            plasminogen activator inhibitor 1 with endothelial cell
            matrix-associated vitronectin
  JOURNAL   J Biol Chem 265 (30), 18490-18498 (1990)
   PUBMED   1698787
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Ehrlich,H.J., Gebbink,R.K., Keijer,J., Linders,M., Preissner,K.T.
            and Pannekoek,H.
  TITLE     Alteration of serpin specificity by a protein cofactor. Vitronectin
            endows plasminogen activator inhibitor 1 with thrombin inhibitory
            properties
  JOURNAL   J Biol Chem 265 (22), 13029-13035 (1990)
   PUBMED   1695900
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Kolb,W.P. and Muller-Eberhard,H.J.
  TITLE     The membrane attack mechanism of complement. Isolation and subunit
            composition of the C5b-9 complex
  JOURNAL   J Exp Med 141 (4), 724-735 (1975)
   PUBMED   47885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK617609.1, AK090325.1 and AI173462.1.
            
            On Jul 16, 2009 this sequence version replaced NM_011707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011736.1, AK090325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               CK617609.1         64-209
            147-1738            AK090325.1         2-1593
            1739-1763           AI173462.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1763
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /note="vitronectin"
                     /db_xref="GeneID:22370"
                     /db_xref="MGI:MGI:98940"
     exon            1..294
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1667
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /note="S-protein; serum-spreading factor"
                     /codon_start=1
                     /product="vitronectin precursor"
                     /protein_id="NP_035837.1"
                     /db_xref="CCDS:CCDS25106.1"
                     /db_xref="GeneID:22370"
                     /db_xref="MGI:MGI:98940"
                     /translation="MAPLRPFFILALVAWVSLADQESCKGRCTQGFMASKKCQCDELC
                     TYYQSCCADYMEQCKPQVTRGDVFTMPEDDYWSYDYVEEPKNNTNTGVQPENTSPPGD
                     LNPRTDGTLKPTAFLDPEEQPSTPAPKVEQQEEILRPDTTDQGTPEFPEEELCSGKPF
                     DAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKT
                     YLFKGSQYWRFEDGVLDPGYPRNISEGFSGIPDNVDAAFALPAHRYSGRERVYFFKGK
                     QYWEYEFQQQPSQEECEGSSLSAVFEHFALLQRDSWENIFELLFWGRSSDGAREPQFI
                     SRNWHGVPGKVDAAMAGRIYVTGSLSHSAQAKKQKSKRRSRKRYRSRRGRGHRRSQSS
                     NSRRSSRSIWFSLFSSEESGLGTYNNYDYDMDWLVPATCEPIQSVYFFSGDKYYRVNL
                     RTRRVDSVNPPYPRSIAQYWLGCPTSEK"
     exon            295..414
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            415..756
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            757..896
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1053
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1206
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1557
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1745
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="Vtn"
                     /gene_synonym="Vn"
                     /note="major polyA site"
ORIGIN      
        1 gggttttctg tttcccagct ctcctggggc tggggttctg ggaatgtgac cctttgctgc
       61 agctgtgttt ggaggagggc aatggggctg ggccagagga tgagcaaata aagggcagaa
      121 acccagggaa ctaggaactc ttcttcagtc tgcttctttt ttcaggcagg acagcgagat
      181 tccagaagct ccgcgcccag cttgccaagg ccctgggcta gaggcctgcc atggcacccc
      241 tgaggccctt tttcatacta gccctggtgg catgggtttc tctggctgac caagagtcat
      301 gcaagggccg ctgcactcag ggtttcatgg ccagcaagaa gtgtcagtgt gacgagcttt
      361 gcacttacta tcagagctgc tgtgccgact acatggagca gtgcaagccc caagtaacgc
      421 ggggggacgt gttcactatg ccagaggatg attattggag ctatgactac gtggaggagc
      481 ccaagaacaa taccaacacc ggtgtgcaac ccgagaacac ctctccaccc ggtgacctaa
      541 atcctcggac ggacggcact ctaaagccga cagccttcct agatcctgag gaacagccaa
      601 gcaccccagc gcctaaagtg gagcaacagg aggagatcct aaggcccgac accactgatc
      661 aagggacccc tgagtttcca gaggaagaac tgtgcagtgg aaagcccttt gacgccttca
      721 cggatctcaa gaatgggtcc ctctttgcct tccgagggca gtactgctat gagctagatg
      781 agacggcagt gaggcctggg taccccaaac ttatccaaga tgtctggggc attgagggcc
      841 ccatcgatgc tgccttcact cgcatcaact gtcaggggaa gacctacttg ttcaagggta
      901 gtcagtactg gcgctttgag gatggggtcc tggaccctgg ttatccccga aacatctccg
      961 aaggcttcag tggcatacca gacaatgttg atgcagcgtt cgcccttcct gcccaccgtt
     1021 acagtggccg ggaaagggtc tacttcttca aggggaagca gtactgggag tacgaatttc
     1081 agcagcaacc cagccaggag gagtgcgaag gcagctctct gtcagccgtg tttgagcact
     1141 ttgccttgct tcagcgggac agctgggaga acattttcga actcctcttc tggggcagat
     1201 cctctgatgg agccagagaa ccccaattca tcagccggaa ctggcatggt gtgccaggga
     1261 aagtggacgc tgctatggcc ggccgcatct acgtcactgg ctccttatcc cactctgccc
     1321 aagccaaaaa acagaagtct aagcgtagaa gccgaaagcg ctatcgttca cgccgagggc
     1381 gtggccacag acgcagccag agctcgaact cccgtcgttc atcacgttca atctggttct
     1441 ctttgttctc cagcgaggag agtgggctag gaacctacaa caactatgat tatgatatgg
     1501 actggcttgt acctgccacc tgcgagccca ttcagagcgt ctatttcttc tctggagaca
     1561 aatactaccg agtcaacctt agaacccggc gagtggactc tgtgaatcct ccctacccac
     1621 gctccattgc tcagtattgg ctgggctgcc cgacctctga gaagtaggaa tcagagccca
     1681 ctcggctgag cttcaggagc ctcatctctt tctcccagcc caataaaaag tctgttggct
     1741 acgagaaaaa aaaaaaaaaa aaa
//
