LOCUS       NM_016800               1296 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus vesicle transport through interaction with t-SNAREs 1B
            (Vti1b), transcript variant 1, mRNA.
ACCESSION   NM_016800
VERSION     NM_016800.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Bollmann,C., Schoning,S., Kotschnew,K., Grosse,J., Heitzig,N. and
            Fischer von Mollard,G.
  TITLE     Primary neurons lacking the SNAREs vti1a and vti1b show altered
            neuronal development
  JOURNAL   Neural Dev 17 (1), 12 (2022)
   PUBMED   36419086
  REMARK    GeneRIF: Primary neurons lacking the SNAREs vti1a and vti1b show
            altered neuronal development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Sokpor,G., Rosenbusch,J., Kunwar,A.J., Rickmann,M., Tuoc,T.,
            Rizzoli,S.O., Tarabykin,V., von Mollard,G.F., Krieglstein,K. and
            Staiger,J.F.
  TITLE     Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and
            Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex
  JOURNAL   Neuroscience 463, 303-316 (2021)
   PUBMED   33774122
  REMARK    GeneRIF: Ablation of Vti1a/1b Triggers Neural Progenitor Pool
            Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse
            Cortex.
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Sondermann,J.R., Barry,A.M., Jahn,O., Michel,N., Abdelaziz,R.,
            Kugler,S., Gomez-Varela,D. and Schmidt,M.
  TITLE     Vti1b promotes TRPV1 sensitization during inflammatory pain
  JOURNAL   Pain 160 (2), 508-527 (2019)
   PUBMED   30335684
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Emperador-Melero,J., Huson,V., van Weering,J., Bollmann,C., Fischer
            von Mollard,G., Toonen,R.F. and Verhage,M.
  TITLE     Vti1a/b regulate synaptic vesicle and dense core vesicle secretion
            via protein sorting at the Golgi
  JOURNAL   Nat Commun 9 (1), 3421 (2018)
   PUBMED   30143604
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Kuliyev,E., Gingras,S., Guy,C.S., Howell,S., Vogel,P. and
            Pelletier,S.
  TITLE     Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron
            Viability
  JOURNAL   J Neurosci 38 (10), 2615-2630 (2018)
   PUBMED   29437892
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Antonin,W., Fasshauer,D., Becker,S., Jahn,R. and Schneider,T.R.
  TITLE     Crystal structure of the endosomal SNARE complex reveals common
            structural principles of all SNAREs
  JOURNAL   Nat Struct Biol 9 (2), 107-111 (2002)
   PUBMED   11786915
  REMARK    GeneRIF: Crystal structure of the endosomal SNARE complex reveals
            common structural principles of all SNAREs
REFERENCE   7  (bases 1 to 1296)
  AUTHORS   Nakajima,K., Takei,Y., Tanaka,Y., Nakagawa,T., Nakata,T., Noda,Y.,
            Setou,M. and Hirokawa,N.
  TITLE     Molecular motor KIF1C is not essential for mouse survival and
            motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum
            transport
  JOURNAL   Mol Cell Biol 22 (3), 866-873 (2002)
   PUBMED   11784862
REFERENCE   8  (bases 1 to 1296)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   9  (bases 1 to 1296)
  AUTHORS   Fischer von Mollard,G. and Stevens,T.H.
  TITLE     A human homolog can functionally replace the yeast
            vesicle-associated SNARE Vti1p in two vesicle transport pathways
  JOURNAL   J Biol Chem 273 (5), 2624-2630 (1998)
   PUBMED   9446565
REFERENCE   10 (bases 1 to 1296)
  AUTHORS   Lupashin,V.V., Pokrovskaya,I.D., McNew,J.A. and Waters,M.G.
  TITLE     Characterization of a novel yeast SNARE protein implicated in Golgi
            retrograde traffic
  JOURNAL   Mol Biol Cell 8 (12), 2659-2676 (1997)
   PUBMED   9398683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY280269.1, CX239415.1 and BQ177030.1.
            
            On Aug 14, 2009 this sequence version replaced NM_016800.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002289.1, SRR1660819.78009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY280269.1         2-24
            24-781              CX239415.1         1-758
            782-1296            BQ177030.1         1-515               c
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1296
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="vesicle transport through interaction with t-SNAREs
                     1B"
                     /db_xref="GeneID:53612"
                     /db_xref="MGI:MGI:1855688"
     exon            1..239
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..823
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Soluble N-ethylmaleimide-sensitive factor-attachment
                     protein receptor; vesicle transport through interaction
                     with t-SNAREs homolog 1B; A novel SNARE; vesicle transport
                     v-SNARE protein Vti1-like 1; vesicle transport through
                     interaction with t-SNAREs 1B homolog"
                     /codon_start=1
                     /product="vesicle transport through interaction with
                     t-SNAREs homolog 1B isoform 1"
                     /protein_id="NP_058080.2"
                     /db_xref="CCDS:CCDS26008.1"
                     /db_xref="GeneID:53612"
                     /db_xref="MGI:MGI:1855688"
                     /translation="MAASAASSEHFEKLHEIFRGLLEDLQGVPERLLGTAGTEEKKKL
                     VRDFDEKQQEANETLAEMEEELRYAPLTFRNPMMSKLRNYRKDLAKLHREVRSTPLTA
                     APGGRGDLKYGTYTLENEHLNRLQSQRALLLQGTESLNRATQSIERSHRIATETDQIG
                     TEIIEELGEQRDQLERTKSRLVNTNENLSKSRKILRSMSRKVITNKLLLSVIILLELA
                     ILVGLVYYKFFRHH"
     exon            240..298
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..490
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..664
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..726
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1281
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATAAA"
     polyA_site      1040
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="major polyA site"
     regulatory      1088..1093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATACA"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATAGA"
     polyA_site      1121
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
     polyA_site      1143
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
     polyA_site      1277
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
ORIGIN      
        1 ggaagcgcct gattccggga ggccgaggtg cggctgcagt gatggcttcg gggctgggca
       61 gctgattgct gaggtgggag tgggcccagc gcccggtggc cgcagctcac gcgcaacctg
      121 cgccatggcc gcctccgccg cctcctccga gcatttcgag aagctgcacg agatcttccg
      181 cggcctcctt gaagacttac aaggggtgcc ggagcggctg ctggggaccg cggggacaga
      241 agagaagaag aagctggtca gagattttga tgaaaagcaa caggaagcaa atgaaacgtt
      301 ggcagagatg gaggaagaac tacgatatgc acccctgact ttccgtaacc ccatgatgtc
      361 taagctgaga aactaccgga aggaccttgc taaactccac cgtgaggtga gaagtacacc
      421 tctgacagcc gctcctggag gccgaggaga cctgaagtat ggcacgtata ccttggagaa
      481 cgagcatttg aatcgactac agtctcaaag agcattactc ctacaaggca ctgaaagcct
      541 gaaccgggct acccaaagca ttgagcgttc tcatcggatt gccacagaaa ctgatcaaat
      601 tggtacagaa atcatagaag agttggggga gcaacgagac cagttggaac gtactaagag
      661 cagactggta aatacaaatg aaaatttgag caaaagccgg aagattcttc gctcaatgtc
      721 cagaaaagtg ataaccaaca agttgctgct ctccgtcatc atcttgctgg agctagccat
      781 cctggtcggt ctggtgtatt acaaattctt tcgacaccat tgaacttctg tagggaaagc
      841 cttgtggacc agcatcttac tctgaatgaa tggttttaca taggaatatg tgttgctgct
      901 gtgggctaac agttcaagaa tgtattgtct tgtcagacta tgggagggag ggcaatggaa
      961 aacctcgaaa atgtgaagga acagcaacaa gaccagtatg atatactaag gtaataaatg
     1021 ttgtttatga ctccttcaaa cttacatgta taacattaat agcttgtaaa cttcaaaaac
     1081 aacaaaaaat acatttacag taatagtgtt ggtgaccaaa atagagaagg gagttttaca
     1141 gttgtgagag tgcacagatg ttctcattaa ggcaatattg atccagacag ccatttcata
     1201 tctgtccctt cgaatgcctt gcaactctgt aatgctgttg tgaaaggtgc cagagtacag
     1261 tatttcctaa attctcacac aaaaaaaaaa aaaaaa
//
