LOCUS       NM_001364374            1222 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus vesicle transport through interaction with t-SNAREs 1B
            (Vti1b), transcript variant 2, mRNA.
ACCESSION   NM_001364374 XM_006516088
VERSION     NM_001364374.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1222)
  AUTHORS   Bollmann,C., Schoning,S., Kotschnew,K., Grosse,J., Heitzig,N. and
            Fischer von Mollard,G.
  TITLE     Primary neurons lacking the SNAREs vti1a and vti1b show altered
            neuronal development
  JOURNAL   Neural Dev 17 (1), 12 (2022)
   PUBMED   36419086
  REMARK    GeneRIF: Primary neurons lacking the SNAREs vti1a and vti1b show
            altered neuronal development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1222)
  AUTHORS   Sokpor,G., Rosenbusch,J., Kunwar,A.J., Rickmann,M., Tuoc,T.,
            Rizzoli,S.O., Tarabykin,V., von Mollard,G.F., Krieglstein,K. and
            Staiger,J.F.
  TITLE     Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and
            Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex
  JOURNAL   Neuroscience 463, 303-316 (2021)
   PUBMED   33774122
  REMARK    GeneRIF: Ablation of Vti1a/1b Triggers Neural Progenitor Pool
            Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse
            Cortex.
REFERENCE   3  (bases 1 to 1222)
  AUTHORS   Sondermann,J.R., Barry,A.M., Jahn,O., Michel,N., Abdelaziz,R.,
            Kugler,S., Gomez-Varela,D. and Schmidt,M.
  TITLE     Vti1b promotes TRPV1 sensitization during inflammatory pain
  JOURNAL   Pain 160 (2), 508-527 (2019)
   PUBMED   30335684
REFERENCE   4  (bases 1 to 1222)
  AUTHORS   Emperador-Melero,J., Huson,V., van Weering,J., Bollmann,C., Fischer
            von Mollard,G., Toonen,R.F. and Verhage,M.
  TITLE     Vti1a/b regulate synaptic vesicle and dense core vesicle secretion
            via protein sorting at the Golgi
  JOURNAL   Nat Commun 9 (1), 3421 (2018)
   PUBMED   30143604
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1222)
  AUTHORS   Kuliyev,E., Gingras,S., Guy,C.S., Howell,S., Vogel,P. and
            Pelletier,S.
  TITLE     Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron
            Viability
  JOURNAL   J Neurosci 38 (10), 2615-2630 (2018)
   PUBMED   29437892
REFERENCE   6  (bases 1 to 1222)
  AUTHORS   Antonin,W., Fasshauer,D., Becker,S., Jahn,R. and Schneider,T.R.
  TITLE     Crystal structure of the endosomal SNARE complex reveals common
            structural principles of all SNAREs
  JOURNAL   Nat Struct Biol 9 (2), 107-111 (2002)
   PUBMED   11786915
  REMARK    GeneRIF: Crystal structure of the endosomal SNARE complex reveals
            common structural principles of all SNAREs
REFERENCE   7  (bases 1 to 1222)
  AUTHORS   Nakajima,K., Takei,Y., Tanaka,Y., Nakagawa,T., Nakata,T., Noda,Y.,
            Setou,M. and Hirokawa,N.
  TITLE     Molecular motor KIF1C is not essential for mouse survival and
            motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum
            transport
  JOURNAL   Mol Cell Biol 22 (3), 866-873 (2002)
   PUBMED   11784862
REFERENCE   8  (bases 1 to 1222)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   9  (bases 1 to 1222)
  AUTHORS   Fischer von Mollard,G. and Stevens,T.H.
  TITLE     A human homolog can functionally replace the yeast
            vesicle-associated SNARE Vti1p in two vesicle transport pathways
  JOURNAL   J Biol Chem 273 (5), 2624-2630 (1998)
   PUBMED   9446565
REFERENCE   10 (bases 1 to 1222)
  AUTHORS   Lupashin,V.V., Pokrovskaya,I.D., McNew,J.A. and Waters,M.G.
  TITLE     Characterization of a novel yeast SNARE protein implicated in Golgi
            retrograde traffic
  JOURNAL   Mol Biol Cell 8 (12), 2659-2676 (1997)
   PUBMED   9398683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154585.2.
            
            On Jun 15, 2018 this sequence version replaced XM_006516088.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002290.1, BI246400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC154585.2         128184-128422       c
            240-431             AC154585.2         120912-121103       c
            432-605             AC154585.2         116373-116546       c
            606-667             AC154585.2         113812-113873       c
            668-1222            AC154585.2         111981-112535       c
FEATURES             Location/Qualifiers
     source          1..1222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1222
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="vesicle transport through interaction with t-SNAREs
                     1B"
                     /db_xref="GeneID:53612"
                     /db_xref="MGI:MGI:1855688"
     exon            1..239
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..431
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..764
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Soluble N-ethylmaleimide-sensitive factor-attachment
                     protein receptor; vesicle transport through interaction
                     with t-SNAREs homolog 1B; A novel SNARE; vesicle transport
                     v-SNARE protein Vti1-like 1; vesicle transport through
                     interaction with t-SNAREs 1B homolog"
                     /codon_start=1
                     /product="vesicle transport through interaction with
                     t-SNAREs homolog 1B isoform 2"
                     /protein_id="NP_001351303.1"
                     /db_xref="GeneID:53612"
                     /db_xref="MGI:MGI:1855688"
                     /translation="MEEELRYAPLTFRNPMMSKLRNYRKDLAKLHREVRSTPLTAAPG
                     GRGDLKYGTYTLENEHLNRLQSQRALLLQGTESLNRATQSIERSHRIATETDQIGTEI
                     IEELGEQRDQLERTKSRLVNTNENLSKSRKILRSMSRKVITNKLLLSVIILLELAILV
                     GLVYYKFFRHH"
     exon            432..605
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..667
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1222
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      954..959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATAAA"
     polyA_site      981
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="major polyA site"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATACA"
     regulatory      1061..1066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
                     /note="hexamer: AATAGA"
     polyA_site      1062
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
     polyA_site      1084
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
     polyA_site      1218
                     /gene="Vti1b"
                     /gene_synonym="GES30; MVti1b; SNARE; Vti1-rp1"
ORIGIN      
        1 ggaagcgcct gattccggga ggccgaggtg cggctgcagt gatggcttcg gggctgggca
       61 gctgattgct gaggtgggag tgggcccagc gcccggtggc cgcagctcac gcgcaacctg
      121 cgccatggcc gcctccgccg cctcctccga gcatttcgag aagctgcacg agatcttccg
      181 cggcctcctt gaagacttac aaggggtgcc ggagcggctg ctggggaccg cggggacagt
      241 tggcagagat ggaggaagaa ctacgatatg cacccctgac tttccgtaac cccatgatgt
      301 ctaagctgag aaactaccgg aaggaccttg ctaaactcca ccgtgaggtg agaagtacac
      361 ctctgacagc cgctcctgga ggccgaggag acctgaagta tggcacgtat accttggaga
      421 acgagcattt gaatcgacta cagtctcaaa gagcattact cctacaaggc actgaaagcc
      481 tgaaccgggc tacccaaagc attgagcgtt ctcatcggat tgccacagaa actgatcaaa
      541 ttggtacaga aatcatagaa gagttggggg agcaacgaga ccagttggaa cgtactaaga
      601 gcagactggt aaatacaaat gaaaatttga gcaaaagccg gaagattctt cgctcaatgt
      661 ccagaaaagt gataaccaac aagttgctgc tctccgtcat catcttgctg gagctagcca
      721 tcctggtcgg tctggtgtat tacaaattct ttcgacacca ttgaacttct gtagggaaag
      781 ccttgtggac cagcatctta ctctgaatga atggttttac ataggaatat gtgttgctgc
      841 tgtgggctaa cagttcaaga atgtattgtc ttgtcagact atgggaggga gggcaatgga
      901 aaacctcgaa aatgtgaagg aacagcaaca agaccagtat gatatactaa ggtaataaat
      961 gttgtttatg actccttcaa acttacatgt ataacattaa tagcttgtaa acttcaaaaa
     1021 caacaaaaaa tacatttaca gtaatagtgt tggtgaccaa aatagagaag ggagttttac
     1081 agttgtgaga gtgcacagat gttctcatta aggcaatatt gatccagaca gccatttcat
     1141 atctgtccct tcgaatgcct tgcaactctg taatgctgtt gtgaaaggtg ccagagtaca
     1201 gtatttccta aattctcaca ca
//
