LOCUS       NM_016862               4599 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus vesicle transport through interaction with t-SNAREs 1A
            (Vti1a), transcript variant 2, mRNA.
ACCESSION   NM_016862
VERSION     NM_016862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4599)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4599)
  AUTHORS   Bollmann,C., Schoning,S., Kotschnew,K., Grosse,J., Heitzig,N. and
            Fischer von Mollard,G.
  TITLE     Primary neurons lacking the SNAREs vti1a and vti1b show altered
            neuronal development
  JOURNAL   Neural Dev 17 (1), 12 (2022)
   PUBMED   36419086
  REMARK    GeneRIF: Primary neurons lacking the SNAREs vti1a and vti1b show
            altered neuronal development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4599)
  AUTHORS   Sokpor,G., Rosenbusch,J., Kunwar,A.J., Rickmann,M., Tuoc,T.,
            Rizzoli,S.O., Tarabykin,V., von Mollard,G.F., Krieglstein,K. and
            Staiger,J.F.
  TITLE     Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and
            Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex
  JOURNAL   Neuroscience 463, 303-316 (2021)
   PUBMED   33774122
  REMARK    GeneRIF: Ablation of Vti1a/1b Triggers Neural Progenitor Pool
            Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse
            Cortex.
REFERENCE   4  (bases 1 to 4599)
  AUTHORS   Liu,Y., Sugiura,Y., Sudhof,T.C. and Lin,W.
  TITLE     Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not
            Spontaneous Neurotransmitter Release at Neuromuscular Synapses
  JOURNAL   J Neurosci 39 (31), 6049-6066 (2019)
   PUBMED   31160536
REFERENCE   5  (bases 1 to 4599)
  AUTHORS   Emperador-Melero,J., Huson,V., van Weering,J., Bollmann,C., Fischer
            von Mollard,G., Toonen,R.F. and Verhage,M.
  TITLE     Vti1a/b regulate synaptic vesicle and dense core vesicle secretion
            via protein sorting at the Golgi
  JOURNAL   Nat Commun 9 (1), 3421 (2018)
   PUBMED   30143604
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4599)
  AUTHORS   Wang,Y. and Tang,B.L.
  TITLE     SNAREs in neurons--beyond synaptic vesicle exocytosis (Review)
  JOURNAL   Mol Membr Biol 23 (5), 377-384 (2006)
   PUBMED   17060155
  REMARK    Review article
REFERENCE   7  (bases 1 to 4599)
  AUTHORS   Xu,Y., Wong,S.H., Tang,B.L., Subramaniam,V.N., Zhang,T. and Hong,W.
  TITLE     A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor
            attachment protein receptor (Vti1-rp2) implicated in protein
            trafficking in the secretory pathway
  JOURNAL   J Biol Chem 273 (34), 21783-21789 (1998)
   PUBMED   9705316
REFERENCE   8  (bases 1 to 4599)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   9  (bases 1 to 4599)
  AUTHORS   Fischer von Mollard,G. and Stevens,T.H.
  TITLE     A human homolog can functionally replace the yeast
            vesicle-associated SNARE Vti1p in two vesicle transport pathways
  JOURNAL   J Biol Chem 273 (5), 2624-2630 (1998)
   PUBMED   9446565
REFERENCE   10 (bases 1 to 4599)
  AUTHORS   Lupashin,V.V., Pokrovskaya,I.D., McNew,J.A. and Waters,M.G.
  TITLE     Characterization of a novel yeast SNARE protein implicated in Golgi
            retrograde traffic
  JOURNAL   Mol Biol Cell 8 (12), 2659-2676 (1997)
   PUBMED   9398683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133100.5, AK028646.1, BC089321.1 and BB767664.1.
            
            On Jun 13, 2014 this sequence version replaced NM_016862.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028646.1, AK004751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC133100.5         12476-12769         c
            295-3699            AK028646.1         1-3405
            3700-4447           BC089321.1         3428-4175
            4448-4599           BB767664.1         378-529
FEATURES             Location/Qualifiers
     source          1..4599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.35 cM"
     gene            1..4599
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /note="vesicle transport through interaction with t-SNAREs
                     1A"
                     /db_xref="GeneID:53611"
                     /db_xref="MGI:MGI:1855699"
     exon            1..488
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1048
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vesicle transport v-SNARE protein Vti1-like 2; vesicle
                     transport through interaction with t-SNAREs 1 homolog;
                     vesicle transport through interaction with t-SNAREs
                     homolog 1A"
                     /codon_start=1
                     /product="vesicle transport through interaction with
                     t-SNAREs homolog 1A isoform 2"
                     /protein_id="NP_058558.1"
                     /db_xref="CCDS:CCDS29910.1"
                     /db_xref="GeneID:53611"
                     /db_xref="MGI:MGI:1855699"
                     /translation="MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQ
                     LEEARELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNE
                     LLGDAGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKI
                     QRARDRLRDADANLGKSSRILTGMLRRIIQNRILLVILGIIVVIAILTAIAFFVKGH"
     exon            489..547
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..658
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..736
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..821
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..892
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..954
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..4599
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
     regulatory      4425..4430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /note="hexamer: ATTAAA"
     polyA_site      4447
                     /gene="Vti1a"
                     /gene_synonym="1110014F16Rik; 1110018K19Rik;
                     4921537J05Rik; MVti1; MVti1a; Vti1; Vti1-rp2"
                     /note="major polyA site"
ORIGIN      
        1 cttccctcgg aaagcccgcg cctgcaactt agagtttggg ggcgctccag ccgtttctct
       61 ggagctgcag tgtgggggac gtgtattctg tgatacccga gagcatgtgg gctttcgtag
      121 tctttttttt tttttagggg tcaccgaaag tgaacttttt ctttagtttt acgttcgaag
      181 atttgggtgg aaaggaaaag gcgcaggcag cgcagtttcc ggaggacaag gactgcgtag
      241 agcaaccagg aagcggcagg gctgggagtt gttcccggtt cccgctgtgc tgtggagact
      301 tcttcacagg gtccctgcgc cgaggccggg cgcccttggc gagtcccgct ctgagcgcta
      361 gaacccggct ccggccggcc gtgcccgagc tgccatgtct tccgacttcg aagggtacga
      421 gcaggacttc gcagtgctca ctgctgagat caccagcaag attgcaaggg tccctcggct
      481 ccctcccgat gagaagaagc aaatggttgc caatgtggag aaacagcttg aagaggccag
      541 agaactgctt gaacagatgg atttggaagt tcgagaaatt ccaccccaaa gtcgaggaat
      601 gtatagcaac aggatgagaa gctacaagca agaaatgggg aaactggaaa cggattttaa
      661 aaggtcacgg atcgcctaca gtgacgaagt acggaatgag ctcctagggg atgctgggaa
      721 ttcctccgag aaccagaggg cacatctgct ggataacacg gagaggctgg aaaggtcgtc
      781 tcggagacta gaggctgggt accagatagc agtggagact gagcaaatcg gccaagagat
      841 gttggaaaac ctgagtcatg acagagaaaa gatacagcgg gcacgtgacc gactccggga
      901 cgcagatgca aacctgggga agagctctcg gattctgacg gggatgctgc gaagaatcat
      961 ccagaaccgt atcctgctcg tcatcttggg gatcatcgtg gtcatcgcca tcctgacggc
     1021 catcgcgttt ttcgtcaaag gacactgatg catctggtcc cccttgataa acagtgatct
     1081 tggcttgttc cgagtaatta agacaaaatg gtcacatgaa tcattctttc gtgctgacag
     1141 gccccgagtg accctctgtc tctcccttag cactgttgag ctgagtgcag agagtgtaaa
     1201 agcatctttc tattcctgtc tgcatgtggg ttggtttcct ttctgaggtt ggtctttgcc
     1261 cagatttgcc gtttttttat aggtaaaggt gaatgcttac ttgcctttag gtaacttcat
     1321 ctgctgtcca aaatagcttt ggtagcatcc ttccttgcct tgtggacatg cctggggtca
     1381 cggtctgaga ggggccgtga tgactcagtc acagtagctt ctttgtgtca tgtacctctc
     1441 cttaccagac agtccttctg tgctgtccat ggacaaaatg ccagaaaaat cagaggccag
     1501 agatcagctc caggccagcc tagccctttc ccagcacaat gagcttggcc atcctgcctg
     1561 tgcaacttca ttgccaaggg gcagatttac tgtctcttgt ccagagaaat aacttggccc
     1621 tttccctaga tgtttattgc atacatatgt atgtgtatgt atattttgcc cacacatgtg
     1681 tatgtgtatg tatattttgc ccaagagttt tggttttggt tttggttttt gccgaagctg
     1741 cccaatgcct acttttccca gctttggtta ctggcaacaa gaaatattcc ctcgccttcc
     1801 ccaaaagcca ttctccccag aacttgctgg cagcgtgaga attggcacag aatttaattg
     1861 tgaccgcatc tcccctggcc tgtttctgta tcctctcggt tttaagatga gctcagtcaa
     1921 cagcggccct cgtataagca aaaggtcaga ggttctcgcc acatcccttc ctgtacggaa
     1981 agagagcctg agcagggttt gctcctgtga cgtgtgcaat gtgggaataa aatgggcggg
     2041 accactagga aaacacaaac aagcaagcaa gcaaacagag accctctgtg ggggcccact
     2101 gacctctttc aaagaatgag gaactgcaga cagctaccca agaaccactc atttttagag
     2161 acagccgttt agcaaagcct gcctcagttc tccacgcatt caaacctcta acacactcca
     2221 tcattttctt ccctttcttt ttgtctgagg taactgggaa ttgtgttcaa aattagttca
     2281 tttgtgatca ggctttaaag ttcccaagct gaggtcattt cccctctagt catgaagcaa
     2341 atgtgttctt cttaagactt ggtaggccct tgcagcgctg cacgcactat ctttttaata
     2401 taattggcag ctttgaattc ttgaaaagcc aacctgctct ctttataaaa aatgctaacc
     2461 acctgtgctc atgtgagtaa gatcatgctg cagttgatct cctaacacac acacacacag
     2521 acgcacactc atatacacac tcacatacac actcacacac acagacatgc acacactcaa
     2581 aagagaacca ttatagagta gagaagaaat acaaaatcca cgagaggact tgtgcccgtg
     2641 gaaacaggca gggcctatat gtgctcagat gaatcattta ttattgtgta aataaaggtg
     2701 tagtctcagt tttggaagga tggcgtgggg tttgggctga acaaagtagg acagcagagg
     2761 agacaggctg gaagctgcgc cacctttcct gtcagcgaaa gggacagctt agtgagaacc
     2821 ttttatcctg ataactgaat tctggccatc ctaaatgtat caaagaaacc attaaaaagc
     2881 aaagaggcaa cctcagtctg ccgtgctgat gctggggaag gaaatcgagg ccccggtggc
     2941 ctctttggga atactggttc atagttcaga gcagacctga gtcctgagcc gtctctccca
     3001 cctccctccg tcctcccaag tcacatcttc ccaagaccac ctaacaggtg aagcactggc
     3061 tcttgctggc ccctaaggag ttcaccagaa cccacgttga ctctgaagcc gatgaaatga
     3121 gaagaaggaa gggaggcacc tgccactcac ctttcatgac tctctctgct tggtgctttc
     3181 cttgctatcg ccagtgatgt tggcccagct caactgtggg agtggaaatc tgtgactcta
     3241 tagcccttgg cctaagggct ccctcacatc ccctggatag tggacacccc attcaccaag
     3301 ggtggggact ggtctgaatg tccctggtcg gccctctggc ctcctgatgt catgggaaga
     3361 acaaggaaga gccctaggcc agggcgatac ctttcccacc tccctaccca ccacggaagg
     3421 gagaaagcac acagctctga agcaggtgtc tctgtgtgga aggttctagg ttcttattat
     3481 gcagacctcg gttgttgagc atttgtgaag ctgggagcct ttgtttaaaa gtgtgtggga
     3541 ggtggggggc gaaatgacgg catgggggag gaggaagagg aggaagccct caccatataa
     3601 aattcatgca gactaaacag tttctctgac ggcataaata aagcggaaac aaccctgctc
     3661 cagaatcaaa agcaatttaa ttaaagtctc ttaagttgta aagagtttta aatgttccgt
     3721 gttgaaggcg gatgcctgca gatgcagcgc gcctgacgtc agcgggcagg cctgggctgc
     3781 ggggccattt gcgattctct ttcaggctgg ctggattgtc ttattttgga accagcttgg
     3841 tggggggttt gctttgctac tgcttctgag cccggagctt caaaggctga aattaatggc
     3901 gaacaaaatt gtgcggctct ggccgtccca tgcggggcga gcccattgag ggttatcatt
     3961 aagtaaagaa ataaagaggg ggaaaagcct gcctgctcca aaaacctcat cagataatga
     4021 cctccgtgat tgggttttca ttaccaaaca gcatccagag attaccaact cgtggaagaa
     4081 gggaggaggg agggaaagga agacgagcca ctgtctttct ctctctccct ctccctctct
     4141 ctctctctct gtctctctct cttttgcaca tcttttcttt aaaactgtca gatcatttca
     4201 gtatttcaaa tccgaggaaa acagcctgcc tgctgctgta tttgaagttg taatggtgtc
     4261 aaaaagtcac gactgactga cagccgtcag tcccagaggg gctcattaaa tcataaaaac
     4321 ttgacaagga aataattgcg cacggccagc gacttggcgc ctgtttagac ggttttattg
     4381 tctttcatta tcagtccccg ccattacgtt cattaacaaa ttgcattaaa caactgttaa
     4441 gggctaatga tttgtttatc gctttttttt attattatta tttaaacatt agctgtgtca
     4501 tgtggtaccc cagcagcctc ttgccatcat ctgactgaat attttttcca ctccgagccc
     4561 tgggtactgt tggaatatga aatagattat tcattactc
//
