LOCUS       NM_178594               3939 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus V-set domain containing T cell activation inhibitor 1
            (Vtcn1), transcript variant 1, mRNA.
ACCESSION   NM_178594
VERSION     NM_178594.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3939)
  AUTHORS   Yu,J., Yan,Y., Li,S., Xu,Y., Parolia,A., Rizvi,S., Wang,W.,
            Zhai,Y., Xiao,R., Li,X., Liao,P., Zhou,J., Okla,K., Lin,H., Lin,X.,
            Grove,S., Wei,S., Vatan,L., Hu,J., Szumilo,J., Kotarski,J.,
            Freeman,Z.T., Skala,S., Wicha,M., Cho,K.R., Chinnaiyan,A.M.,
            Schon,S., Wen,F., Kryczek,I., Wang,S., Chen,L. and Zou,W.
  TITLE     Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
  JOURNAL   Cell 187 (17), 4713-4732 (2024)
   PUBMED   38968937
REFERENCE   2  (bases 1 to 3939)
  AUTHORS   Liu,Y., John,P., Nishitani,K., Cui,J., Nishimura,C.D.,
            Christin,J.R., Couturier,N., Ren,X., Wei,Y., Pulanco,M.C.,
            Galbo,P.M. Jr., Zhang,X., Fu,W., Cui,W., Bartholdy,B.A., Zheng,D.,
            Lauvau,G., Fineberg,S.A., Oktay,M.H., Zang,X. and Guo,W.
  TITLE     A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune
            surveillance to drive breast cancer progression
  JOURNAL   Dev Cell 58 (23), 2700-2717 (2023)
   PUBMED   37963469
  REMARK    GeneRIF: A SOX9-B7x axis safeguards dedifferentiated tumor cells
            from immune surveillance to drive breast cancer progression.
REFERENCE   3  (bases 1 to 3939)
  AUTHORS   Cui,L., Wang,Y., Ren,L., Li,Z., Jiang,Y., Wang,C., Liu,X., Ren,Y.
            and Hu,X.
  TITLE     Effect of B7-H4 downregulation induced by Toxoplasma gondii
            infection on dysfunction of decidual macrophages contributes to
            adverse pregnancy outcomes
  JOURNAL   Parasit Vectors 15 (1), 464 (2022)
   PUBMED   36514159
  REMARK    GeneRIF: Effect of B7-H4 downregulation induced by Toxoplasma
            gondii infection on dysfunction of decidual macrophages contributes
            to adverse pregnancy outcomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3939)
  AUTHORS   Sun,X., Xie,H., Zhang,H., Li,Z., Qi,H., Yang,C., Liu,X., Ren,L.,
            Jiang,Y. and Hu,X.
  TITLE     B7-H4 reduction induced by Toxoplasma gondii infection results in
            dysfunction of decidual dendritic cells by regulating the
            JAK2/STAT3 pathway
  JOURNAL   Parasit Vectors 15 (1), 157 (2022)
   PUBMED   35505420
  REMARK    GeneRIF: B7-H4 reduction induced by Toxoplasma gondii infection
            results in dysfunction of decidual dendritic cells by regulating
            the JAK2/STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3939)
  AUTHORS   Peuker,K., Strigli,A., Tauriello,D.V.F., Hendricks,A., von
            Schonfels,W., Burmeister,G., Brosch,M., Herrmann,A., Kruger,S.,
            Nitsche,J., Juznic,L., Geissler,M.M., Hiergeist,A., Gessner,A.,
            Wirbel,J., Ponnudurai,R.P., Tunger,A., Wehner,R., Stange,D.E.,
            Weitz,J., Aust,D.E., Baretton,G.B., Schmitz,M., Rocken,C.,
            Hampe,J., Hinz,S., Zeller,G., Chavakis,T., Schafmayer,C., Batlle,E.
            and Zeissig,S.
  TITLE     Microbiota-dependent activation of the myeloid calcineurin-NFAT
            pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in
            colorectal cancer
  JOURNAL   Immunity 55 (4), 701-717 (2022)
   PUBMED   35364006
  REMARK    GeneRIF: Microbiota-dependent activation of the myeloid
            calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent
            anti-tumor immunity in colorectal cancer.
REFERENCE   6  (bases 1 to 3939)
  AUTHORS   Sedy,J.R., Gavrieli,M., Potter,K.G., Hurchla,M.A., Lindsley,R.C.,
            Hildner,K., Scheu,S., Pfeffer,K., Ware,C.F., Murphy,T.L. and
            Murphy,K.M.
  TITLE     B and T lymphocyte attenuator regulates T cell activation through
            interaction with herpesvirus entry mediator
  JOURNAL   Nat Immunol 6 (1), 90-98 (2005)
   PUBMED   15568026
REFERENCE   7  (bases 1 to 3939)
  AUTHORS   Choi,I.H., Zhu,G., Sica,G.L., Strome,S.E., Cheville,J.C., Lau,J.S.,
            Zhu,Y., Flies,D.B., Tamada,K. and Chen,L.
  TITLE     Genomic organization and expression analysis of B7-H4, an immune
            inhibitory molecule of the B7 family
  JOURNAL   J Immunol 171 (9), 4650-4654 (2003)
   PUBMED   14568939
  REMARK    GeneRIF: Genomic DNA of mouse B7-H4 is mapped on chromosome 3
            comprised of six exons and five introns spanning 66 kb.
REFERENCE   8  (bases 1 to 3939)
  AUTHORS   Zang,X., Loke,P., Kim,J., Murphy,K., Waitz,R. and Allison,J.P.
  TITLE     B7x: a widely expressed B7 family member that inhibits T cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10388-10392 (2003)
   PUBMED   12920180
REFERENCE   9  (bases 1 to 3939)
  AUTHORS   Prasad,D.V., Richards,S., Mai,X.M. and Dong,C.
  TITLE     B7S1, a novel B7 family member that negatively regulates T cell
            activation
  JOURNAL   Immunity 18 (6), 863-873 (2003)
   PUBMED   12818166
  REMARK    GeneRIF: novel negative costimulator and regulates the threshold of
            T cell activation
REFERENCE   10 (bases 1 to 3939)
  AUTHORS   Sica,G.L., Choi,I.H., Zhu,G., Tamada,K., Wang,S.D., Tamura,H.,
            Chapoval,A.I., Flies,D.B., Bajorath,J. and Chen,L.
  TITLE     B7-H4, a molecule of the B7 family, negatively regulates T cell
            immunity
  JOURNAL   Immunity 18 (6), 849-861 (2003)
   PUBMED   12818165
  REMARK    GeneRIF: May participate in negative regulation of cell-mediated
            immunity in peripheral tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691436.7 and AL669872.8.
            
            On Jul 21, 2022 this sequence version replaced NM_178594.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145664.1, AK143276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL691436.7         48009-48140
            133-197             AL669872.8         24239-24303
            198-545             AL669872.8         33223-33570
            546-824             AL669872.8         37642-37920
            825-997             AL669872.8         42027-42199
            998-3939            AL669872.8         44776-47717
FEATURES             Location/Qualifiers
     source          1..3939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.78 cM"
     gene            1..3939
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="V-set domain containing T cell activation inhibitor
                     1"
                     /db_xref="GeneID:242122"
                     /db_xref="MGI:MGI:3039619"
     exon            1..132
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..952
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immune costimulatory protein B7-H4; t cell
                     costimulatory molecule B7x; B7 homolog 4"
                     /codon_start=1
                     /product="V-set domain containing T-cell activation
                     inhibitor 1 isoform 1 precursor"
                     /protein_id="NP_848709.2"
                     /db_xref="CCDS:CCDS17677.1"
                     /db_xref="GeneID:242122"
                     /db_xref="MGI:MGI:3039619"
                     /translation="MASLGQIIFWSIINIIIILAGAIALIIGFGISGKHFITVTTFTS
                     AGNIGEDGTLSCTFEPDIKLNGIVIQWLKEGIKGLVHEFKEGKDDLSQQHEMFRGRTA
                     VFADQVVVGNASLRLKNVQLTDAGTYTCYIRTSKGKGNANLEYKTGAFSMPEINVDYN
                     ASSESLRCEAPRWFPQPTVAWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVT
                     INNTYSCMIENDIAKATGDIKVTDSEVKRRSQLQLLNSGPSPCVFSSAFVAGWALLSL
                     SCCLMLR"
     exon            133..197
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     exon            198..545
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     exon            546..824
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     exon            825..997
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     exon            998..3939
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="hexamer: ATTAAA"
     polyA_site      1373
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="major polyA site"
     regulatory      2700..2705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="hexamer: AATAAA"
     polyA_site      2727
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="major polyA site"
     regulatory      3918..3923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="hexamer: AATAAA"
     polyA_site      3939
                     /gene="Vtcn1"
                     /gene_synonym="B7h4; B7s1; B7x"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtcaca acacccagga gggcagcagc aggcaggcag ctccactcac caaaatctgg
       61 ccccacacac agcaggactg tgggaaggaa ctccctctcc atggcttcct tggggcagat
      121 catcttttgg agtattatta acatcatcat catcctggct ggggccatcg cactcatcat
      181 tggctttggc atttcaggca agcacttcat cacggtcacg accttcacct cagctggaaa
      241 cattggagag gacgggaccc tgagctgcac ttttgaacct gacatcaaac tcaacggcat
      301 cgtcatccag tggctgaaag aaggcatcaa aggtttggtc cacgagttca aagaaggcaa
      361 agacgacctc tcacagcagc atgagatgtt cagaggccgc acagcagtgt ttgctgatca
      421 ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg cagctcacgg atgctggcac
      481 ctacacatgt tacatccgca cctcaaaagg caaagggaat gcaaaccttg agtataagac
      541 cggagccttc agtatgccag agataaatgt ggactataat gccagttcag agagtttacg
      601 ctgcgaggct cctcggtggt tcccccagcc cacagtggcc tgggcatctc aagtcgacca
      661 aggagccaat ttctcagaag tctccaacac cagctttgag ttgaactctg agaatgtgac
      721 catgaaggtc gtatctgtgc tctacaatgt cacaatcaac aacacatact cctgtatgat
      781 tgaaaacgac attgccaaag ccaccgggga catcaaagtg acagattcag aggtcaaaag
      841 gcgaagtcag ctgcagttgc tgaactctgg gccttccccg tgtgtttttt cttctgcctt
      901 tgtggctggc tgggcactcc tatctctctc ctgttgcctg atgctaagat gaggggccct
      961 ggctacacaa aagcatgcaa cgttgctggt ccaacagaat cccggagaac tacagaaata
     1021 ttttcctcaa gacatgacct agttttatat ttctagaaga agatgaaatc atgtctagaa
     1081 gtctggagag agcagacagg aacaagatgt ggaaggaaaa caaaagtaac ccacagacac
     1141 ccccgatcgg aacaagatgg acctagaaaa taattcaacc aaactagagt atactaagtg
     1201 tgctgttaca atgtgtgtag ggtaggtgtc ctcccacatc tcaggggcct cccctggtcc
     1261 accagctcct gagttaggat gggctgttat gatgtcactc tgaaggttcc tggatggttc
     1321 ctactgccat atactcattt tatattcagc acattaaacc atagtgaatg ctatgaaaag
     1381 ctgctaatca gctgccactc cgagattcgg aggtggcaac gtctgagtga caggtccagt
     1441 gattcgcttc tccttaggat gcttttacaa gctctttggc gtctcctccc acctggcaaa
     1501 tgccaaatgc ataggggagg gtgatcatca ttctagggca aacaaaatag ttgagggatg
     1561 ctgatttccc aaatcatccg aatcacttct cccttgagca aacaagcgcc ctgttatttc
     1621 tcaaatgctg ctttgtgaat cagtccaggg caaggcgctc tcctcatccc gctatgtggc
     1681 cttaagtcat cgtaaggttt gaagtttcta ctttcgatcc tgcatggaga gctataatct
     1741 cagctccccc gcccccccca cacacacctc tgcacacaca ccccccccca acactgggag
     1801 taaaccagga tgatgtccgt cttctcattc cccatgtgac cgttggcagt gtagagagac
     1861 tgattgtcac agctaaagga agagggacaa cagggtcact ggtgtctaca gagattatat
     1921 tctacgtgtc tcactgaatt tacacaactc caagtgccaa ccacatcaag gtcaggaaat
     1981 cctgaactgg aataagaaag acccagaaga tgaatgtgaa cagatccatt tgcttcccga
     2041 cagtgggcac agacttcagt ctctggctac tgttccaaga cccagggctc tgcaattgtg
     2101 tgacatcctt cagtgaaccc acatgggaaa ttctccatgg aattatcttc agcccactgt
     2161 acttctgaat ccctcttcct tccttctgtg ccacacagca agtctggctt aaatgctgcc
     2221 tgatctccat ttcaagtttt ctgcctctgg atttttagat ctcaagacca tggacgaaac
     2281 atcagttaca gcaacaaaag tgaattttcc gtgcagagac ttctaggggt tctgtttgtt
     2341 ttcagggtgc tagagatcac actcagatgc tcatatatgt taggtaaatg ttctcccact
     2401 gagttacagc ccagctcaca cagagacttc taaaagaaaa tacggccatg ctctttgaaa
     2461 tggagcattg agggatgaag tttggatggc gaagaaaact tctcaccagc tctctcccca
     2521 cattcgtgcc aagcactgcc tccctagact tcgggtcacc atatctgtac tacgttttga
     2581 tacagaaggc tcgagaccat tcaagagaat tatttagtac acattcccta tgctgctgtc
     2641 cgcctggtct gtcaccaaag gtgaaaacga agagatggat gaaaggatag aggaagtgta
     2701 ataaagagga atgcctccca cagaaaatag gccttccacg agggttagtt gcataagtgg
     2761 gaatgagtgg gagtctgtat gggctgaatg cctaagtcta ggtacgcaag aaaattcctc
     2821 caggtttata ctagccttgc ctgttcctat cagggaaaac agttattgct cttaatttgt
     2881 gatagatatt tcaggggaac atatacaatt gtatgcacta gtattataag agacaattcg
     2941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgtgtgtaga
     3001 tggggtctct atatagccct tgctggtcgg aaactctctc tgtagaccag gctggcgtcg
     3061 aactcacaga gatccaacta cctctgcttc ccaagtgctg ggattaaaga catcaccatc
     3121 aagaaaactc ttactactga ggaattaaca agttttagat ctggaagaac ctcaaaatta
     3181 tctttaagtc tttttatcat tcatataaag atccaggggc caatggtgaa gttcaggtca
     3241 ccagtcagtc tcagattaca tactttctat tagtagctgg tgggaaaatg atatcgacag
     3301 aggaagaatt tccaaggaac cttagaccct ctcccttcct gcattcccat ctgggcccca
     3361 atatatctta cacagaaagg actgtaggct ttctgtcaca tgacataaca gctaaaatga
     3421 gacaaaggag gaaggatgaa tcttgttcaa tcttaggggt cttgggacat ggttggttgg
     3481 gacatggctg gttggtgcct ttgctttggt cctgcagtga tgtgagtttg ttgcagggag
     3541 cattcagcaa agcaaagcca ctcacatcat aatgacagaa gcagaaggag acatgagcag
     3601 tgacccttca aggtcatact tctaagggct taaattcctc tcccttggag ctatctccaa
     3661 agccttctct actggctcca aaggctggag agtaagtttt tattgaatgc atggatctct
     3721 gcttatattt cagaatcaga gaccaaaggt gactcaagct gtaacatata aatattcctg
     3781 tcttgttcat gtgtacacac tgcacatgca gtagacagca gatatgtatg ttacaaacca
     3841 gaatatggtg tggaccacaa acacctataa ctgttcaaat ctaaatgcta aagctagagc
     3901 taaagtacat ttaagggaat aaaccatccg accttcaaa
//
