LOCUS       NM_054068               3579 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus visual system homeobox 1 (Vsx1), mRNA.
ACCESSION   NM_054068
VERSION     NM_054068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Debrulle,S., Baudouin,C., Hidalgo-Figueroa,M., Pelosi,B.,
            Francius,C., Rucchin,V., Ronellenfitch,K., Chow,R.L., Tissir,F.,
            Lee,S.K. and Clotman,F.
  TITLE     Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity
            during spinal cord development
  JOURNAL   Cell Mol Life Sci 77 (20), 4117-4131 (2020)
   PUBMED   31822965
  REMARK    GeneRIF: Vsx1 and Chx10 paralogs sequentially secure V2 interneuron
            identity during spinal cord development.
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Yamamoto,H., Kon,T., Omori,Y. and Furukawa,T.
  TITLE     Functional and Evolutionary Diversification of Otx2 and Crx in
            Vertebrate Retinal Photoreceptor and Bipolar Cell Development
  JOURNAL   Cell Rep 30 (3), 658-671 (2020)
   PUBMED   31968244
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Desiderio,S., Vermeiren,S., Van Campenhout,C., Kricha,S., Malki,E.,
            Richts,S., Fletcher,E.V., Vanwelden,T., Schmidt,B.Z.,
            Henningfeld,K.A., Pieler,T., Woods,C.G., Nagy,V., Verfaillie,C. and
            Bellefroid,E.J.
  TITLE     Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating
            the Expression of the NGF Receptor TrkA
  JOURNAL   Cell Rep 26 (13), 3522-3536 (2019)
   PUBMED   30917309
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Litke,A.M., Samuelson,S., Delaney,K.R., Sauve,Y. and Chow,R.L.
  TITLE     Investigating the Pathogenicity of VSX1 Missense Mutations and
            Their Association With Corneal Disease
  JOURNAL   Invest Ophthalmol Vis Sci 59 (15), 5824-5835 (2018)
   PUBMED   30535423
  REMARK    GeneRIF: Our results indicate that although VSX1 sequence variants
            can alter transcriptional activity, in the context of a mouse
            genetic model, at least one of these changes does not lead to
            corneal abnormalities. While we cannot exclude a role for VSX1 as a
            risk factor for corneal disease, on its own, it does not appear to
            play a major causative role.
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Kowalchuk,A.M., Maurer,K.A., Shoja-Taheri,F. and Brown,N.L.
  TITLE     Requirements for Neurogenin2 during mouse postnatal retinal
            neurogenesis
  JOURNAL   Dev Biol 442 (2), 220-235 (2018)
   PUBMED   30048641
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Knauer,S.K., Carra,G. and Stauber,R.H.
  TITLE     Nuclear export is evolutionarily conserved in CVC paired-like
            homeobox proteins and influences protein stability, transcriptional
            activation, and extracellular secretion
  JOURNAL   Mol Cell Biol 25 (7), 2573-2582 (2005)
   PUBMED   15767664
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Ohtoshi,A., Wang,S.W., Maeda,H., Saszik,S.M., Frishman,L.J.,
            Klein,W.H. and Behringer,R.R.
  TITLE     Regulation of retinal cone bipolar cell differentiation and
            photopic vision by the CVC homeobox gene Vsx1
  JOURNAL   Curr Biol 14 (6), 530-536 (2004)
   PUBMED   15043821
  REMARK    GeneRIF: Vsx1 is required for cone bipolar cell differentiation and
            regulates photopic vision perception.
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Chow,R.L., Volgyi,B., Szilard,R.K., Ng,D., McKerlie,C.,
            Bloomfield,S.A., Birch,D.G. and McInnes,R.R.
  TITLE     Control of late off-center cone bipolar cell differentiation and
            visual signaling by the homeobox gene Vsx1
  JOURNAL   Proc Natl Acad Sci U S A 101 (6), 1754-1759 (2004)
   PUBMED   14745032
  REMARK    GeneRIF: role in late differentiation and function of OFF-CB cells
            and is associated with a heritable OFF visual pathway-specific
            retinal defect
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Chow,R.L., Snow,B., Novak,J., Looser,J., Freund,C., Vidgen,D.,
            Ploder,L. and McInnes,R.R.
  TITLE     Vsx1, a rapidly evolving paired-like homeobox gene expressed in
            cone bipolar cells
  JOURNAL   Mech Dev 109 (2), 315-322 (2001)
   PUBMED   11731243
REFERENCE   10 (bases 1 to 3579)
  AUTHORS   Ohtoshi,A., Justice,M.J. and Behringer,R.R.
  TITLE     Isolation and characterization of Vsx1, a novel mouse CVC
            paired-like homeobox gene expressed during embryogenesis and in the
            retina
  JOURNAL   Biochem Biophys Res Commun 286 (1), 133-140 (2001)
   PUBMED   11485319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057647.1.
            
            On Dec 20, 2003 this sequence version replaced NM_054068.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057647.1, AK044393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.74 cM"
     gene            1..3579
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="visual system homeobox 1"
                     /db_xref="GeneID:114889"
                     /db_xref="MGI:MGI:1890816"
     exon            1..622
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1269
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="homeodomain protein RINX; transcription factor
                     VSX1; retinal inner nuclear layer homeobox protein; visual
                     system homeobox 1 homolog"
                     /codon_start=1
                     /product="visual system homeobox 1"
                     /protein_id="NP_473409.1"
                     /db_xref="CCDS:CCDS16860.1"
                     /db_xref="GeneID:114889"
                     /db_xref="MGI:MGI:1890816"
                     /translation="MTGRDGLSDARSRSRALAPGCPPTGSRLRSFAINDLLGLEADLP
                     TPAEPGLRSNSGDPAEAIGSGPGPGPGLCGSCPARGALPLGLGLLCGFGAQPPSAAAA
                     ARARCLLLADLRLLPSAGPEPAVAQGPVHPPPALGSQQRSESVSTSDGDSPSEEKNDP
                     KMSLILGKRKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAAKTELPEDRIQVW
                     FQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCAPWLLG
                     MHKKSTGMRKPESEDKLAGLWEFDHLKKGANKDEDGPERGPDETTQNPENSLEDVAID
                     LSSSSRQETKKMPPGSSTQLPQPPQVGAS"
     exon            623..701
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /inference="alignment:Splign:2.1.0"
     exon            702..825
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1003
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3568
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="hexamer: AATAAA"
     polyA_site      1384
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="major polyA site"
     regulatory      2250..2255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="hexamer: AATAAA"
     polyA_site      2277
                     /gene="Vsx1"
                     /gene_synonym="CHX10-like"
                     /note="major polyA site"
ORIGIN      
        1 tgaacctgct ggtgggagct tggatgcgtc tgctccctgc tgattggcgc cttctaggct
       61 gtctaggtct cagggacagc ttctccagca taaaaggggt cgcctagagc tagcctcttc
      121 tgcacaggtg gccagagagg actcaactcc ggctcctagc ctagaggact gagaagcatg
      181 actggacggg atgggctttc ggatgcgcgc tccaggagta gagccctggc gccaggctgt
      241 cctcccaccg gctctcgcct tcgaagcttt gccatcaatg acctgctggg attggaggca
      301 gacctgccaa ctccggcgga gcctgggcta agatccaaca gcggagatcc agcggaggca
      361 atagggtcgg gaccgggacc ggggccagga ctctgcggct cctgccctgc tcgcggggct
      421 ctcccgctgg gcctggggct cctctgcggc ttcggggcgc agcccccttc cgctgccgcc
      481 gccgctcgtg cgcgctgcct gctcctcgcc gacctgcggc ttctgccatc tgcaggaccc
      541 gagcctgctg tcgcccaggg cccggtccac ccgccgcctg cgctcggcag ccagcagcgc
      601 agcgagagcg tctccacgtc ggatggggac agtccatctg aagaaaagaa tgacccgaag
      661 atgtccctta tcctgggcaa aaggaagaag cggaggcaca ggacggtttt cactgcccat
      721 caactcgaag aactggagaa ggcctttggt gaggcccact accctgacgt gtacgctcgg
      781 gaaatgctgg ctgcgaaaac agagctcccg gaagaccgaa tacaggtctg gttccagaac
      841 cggagggcca agtggcgtaa gcgagagaag cgctggggtg gcagcagtgt gatggctgag
      901 tacgggctct acggagccat ggtgcgccac tgcattccac tgccggacag cgtgctcaac
      961 tctgcagata gcctgcaggg ctcctgtgca ccctggcttc tggggatgca taaaaagtcc
     1021 acagggatga gaaaaccaga aagtgaagac aagttggcag gactctggga gtttgaccat
     1081 ctcaaaaagg gtgctaataa ggatgaggat ggacctgaga gggggccaga cgaaacaacc
     1141 cagaaccctg agaatagctt ggaggatgtg gccattgacc tgtccagctc ttccaggcag
     1201 gagactaaga aaatgccccc agggtccagt actcagctgc cccagccccc acaggtggga
     1261 gcctcatgag actgacagat tgcgtccccc aaagctggac aaacaccttc agtttgattt
     1321 tctctctgaa atgtctggat aaaaagcaac actacaacac tgaataaaca atgacgtagg
     1381 gaaagttccc tttagttcta gagtggggaa cattcatacc acctctcaag ccagtcagtt
     1441 tggtctaaaa tcttgttttt ccttagtgga atctgaacat ggaaggtttg aagttcaaag
     1501 aaaattttag ggatggggta tgacgtcgct tagttaatag tacacaagaa ggcctggatt
     1561 caatacccgg caccactcaa accagataca gtagcacgca cctgcaatcc cagcactcag
     1621 ggggcggaga caagagatca gatgttcaag agcatcccag agagagagag agagagagag
     1681 agagagagag agattattac tccctagcat tatttaagat gtggttcagt cattaaagag
     1741 ggctggtctg acctcctcac tctaagttag aatatttggt ttggttttgg ttgaaatggg
     1801 ttcttgctgt gcagcccagg ctcgcttcat tttcatgatc tcctgcctca gtctctctag
     1861 tgctgggtta caagtgtgaa tataattgtt ataccatctc taggcttcag aggagtgaat
     1921 gaatgaatga atgaatgact gctatattac cattccttga gctgggtcta ggacatctct
     1981 gtctttgtga taggtgataa ttttgtgttc tcagtcactt gatgggcctt gaatattcga
     2041 ggtataaaca acaaagaaag ccacaagccc ctccttctct gaagtcacct ggagccatgt
     2101 ttaagcaatt gttaaatatc tggagactgt ctgaaggtca gacccaactt cttggtcttt
     2161 ttgaatttat gtttgaaagc actttagtaa cttggattca tgaatgttgt cttccctgta
     2221 tttcttttgc catttatttg ttatttaaaa ataaatgtgt cgtgtgtctg gctcaaagct
     2281 acttcctggc ccctcagtag gctctcccct tatgccccgt tttagtctgg aaacatgccg
     2341 agcaagctgt ctttcagccc gcagaactta gcacagggtc tgtgtcatgt actgtgtggc
     2401 agtagccctg gcttttggag ttcagaggct gaagaagggt tgtctgtttt gggcagcttc
     2461 ctctgcagat tatctcagga acccatcaag ttaggctgtc cccaccttca ccctagtctc
     2521 tttagataag aaaacgggca gtctcttcct ttagtctagg tttgtcctat gttagttcca
     2581 tagtgttaca ctctatatca atgaagtatt aaccctgtga gatgatggtg aaatgttgct
     2641 aggtgagaag cccttagagg gggaaagaga taagaggaaa taaagatgtt taaagtacac
     2701 tgaaaataaa ataaataata ttcgacaact ggttcgaaat aaacatgtga acaatgggca
     2761 aaagtctctg aaacattcta aggaaaacag agataacaaa aatggtgtgg ggcatatgta
     2821 acagatgtgc agctgggtct tcacgtggga ctcctaaagc aggagcaggg gccgtctctg
     2881 acctcattgc cgtcctttgg attccccctc ccctaactgc acctcagctc actgcagctc
     2941 agcgtgccaa gcctggctga tatccatgtg aggtgtcccc tcttctgaga agaaggggaa
     3001 ggggctgggg gtggggaggg gagaggaaag ggaggaactg ggggggggga gagaagctct
     3061 cgatcaggat gtaaagtaaa ttaataagta atgggaaaat ggtgtgagaa aagaggaaag
     3121 ctatatattt gtgtgtgtgt atatatatat atgtatatat atttttcttt ttttcccttg
     3181 acttttgcta tgttacccaa ccagcgatcc ctctgcccca acctccacag tagctggacc
     3241 acagttttgt gccactgtga tcccgcagct aaaactgtgt taaatatgta agaaaagcac
     3301 tatagctcag tgtgctggta tttgggaggc tgggccagag gacctcaagt tccaggttag
     3361 cctttgctac agagtgagat ttttttttcc tcccaagaca ggacctcact atagagctcc
     3421 ggttgtctta gaactcactg tgtaccaggc tggcctctgc ttggcctttg cttcttaagt
     3481 gctgcgatca aaggcctggc catgagatct tgttttttaa aaaaaaaaaa aaaacaaata
     3541 aaataaaaat cactattcac aactaaaaaa aaaaaaaaa
//
