LOCUS       NM_026955               1988 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus V-set and transmembrane domain containing 5 (Vstm5),
            mRNA.
ACCESSION   NM_026955 XM_134642
VERSION     NM_026955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Oludada,O.E., Idowu,T.O., Jeon,Y. and Choi,I.
  TITLE     VSTM5 is a novel immune checkpoint that promotes oral tolerance of
            cell-mediated and antibody responses
  JOURNAL   Biochem Biophys Res Commun 635, 283-290 (2022)
   PUBMED   36308908
  REMARK    GeneRIF: VSTM5 is a novel immune checkpoint that promotes oral
            tolerance of cell-mediated and antibody responses.
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Kim,H.R., Mun,Y., Lee,K.S., Park,Y.J., Park,J.S., Park,J.H.,
            Jeon,B.N., Kim,C.H., Jun,Y., Hyun,Y.M., Kim,M., Lee,S.M.,
            Park,C.S., Im,S.H. and Jun,C.D.
  TITLE     T cell microvilli constitute immunological synaptosomes that carry
            messages to antigen-presenting cells
  JOURNAL   Nat Commun 9 (1), 3630 (2018)
   PUBMED   30194420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Lee,A.R., Kim,S., Ko,K.W. and Park,C.S.
  TITLE     Differential effects of N-linked glycosylation of Vstm5 at multiple
            sites on surface expression and filopodia formation
  JOURNAL   PLoS One 12 (7), e0181257 (2017)
   PUBMED   28746350
  REMARK    GeneRIF: Data indicate that four N-linked glycosylation sites
            (Asn43, Asn87, Asn101, and Asn108) are predicted to be located in
            the extracellular N-terminus of V-set and transmembrane
            domain-containing protein 5 (Vstm5), but their functional roles may
            not be identical.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Lee,A.R., Ko,K.W., Lee,H., Yoon,Y.S., Song,M.R. and Park,C.S.
  TITLE     Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal
            Morphology and Migration in the Central Nervous System
  JOURNAL   J Neurosci 36 (39), 10181-10197 (2016)
   PUBMED   27683913
  REMARK    GeneRIF: In this study, we demonstrate for the first time that
            V-set and transmembrane domain-containing protein 5 (Vstm5), a
            putative cell adhesion membrane protein, modulates both the
            position and complexity of central neurons by altering their
            membrane morphology and dynamics.
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK034938.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026955.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034938.1, BC055786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1988              AK034938.1         2-1989
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.72 cM"
     gene            1..1988
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /note="V-set and transmembrane domain containing 5"
                     /db_xref="GeneID:69137"
                     /db_xref="MGI:MGI:1916387"
     exon            1..314
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..826
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /note="V-set and transmembrane domain-containing protein
                     5"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 5 precursor"
                     /protein_id="NP_081231.1"
                     /db_xref="CCDS:CCDS22833.1"
                     /db_xref="GeneID:69137"
                     /db_xref="MGI:MGI:1916387"
                     /translation="MRPLRCGERTQGIPLGLLAFWVTAARCLQSQGVSLYIPQSAINA
                     TVQQDILLSVDYICHGVPTIEWKYTPNWGVQRIVEWKPGTPANVSQSHRDRVCTFDNG
                     SIQLFNVSVKDSGYYIVTVTEHPGSSQSGTILLRVSEIRYEDLHFVAVFFALLAAVAV
                     VLISLMWVCNQCAYKFQRKRRYKLKESTTEEIEMKEVEC"
     exon            315..641
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            642..782
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1988
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1988
                     /gene="Vstm5"
                     /gene_synonym="2200002K05Rik"
                     /note="putative"
ORIGIN      
        1 ttccctctgt cctgggaact ggttgaacca gagtacaacc tgctcatctg cctctggcgg
       61 agcagctgca ggagctgaga cgtgctgagt tgcaagcaga gcagcagagc caaggcttgg
      121 gaggctaggc tggcgcgcta cgctgcgggg cgctgctgag ggcgagcatt ggaccggcca
      181 cctccccgag gcccatgcgg ggttctatac agcccgcggc tcgctcatga gaccactgcg
      241 gtgcggggag aggacccaag gcatcccgct ggggctgctc gcgttctggg tgactgctgc
      301 ccgctgtctg cagagccagg gggtgtcact gtacattcca cagtcggcca tcaacgccac
      361 tgtccaacaa gatatcctgt tgtcagtgga ctacatctgc catggcgtgc ccactattga
      421 gtggaagtac actcctaact ggggtgtgca gaggatcgtg gagtggaaac cagggacccc
      481 agccaatgtc tcccaaagcc acagagacag agtctgcacc tttgacaatg gctccatcca
      541 gcttttcaat gtgagtgtga aggattctgg ctactacatc gtcactgtca cagagcatcc
      601 ggggagcagc cagtctggca ccatcttgct gcgtgtgtct gagatccgct atgaagacct
      661 ccacttcgtt gctgtcttct ttgctctgct tgctgccgtg gctgtggtgc taatcagcct
      721 catgtgggtt tgcaatcagt gtgcgtataa attccaaagg aagaggaggt acaaactcaa
      781 agaaagcacc actgaggaga ttgagatgaa agaagttgag tgttagccaa gactgtgccc
      841 aattacattg ctacctcaag agaaaaacag tattttccag tcgaaggaac aaacagagcc
      901 catccttgct gcagctccca tacccctttc ccagtgagac agctggcaga taaagaagct
      961 gaccgtgggc ctggagggga tggcttactt atataagcca gttctaggag tcgcctgtag
     1021 ttcaaagcaa catctgagac tttcaaccag gaactttcct tggtttcagc ttcagggcca
     1081 tgctaaccct taaaacaggc aggcaccagc taccacactg cagtcccaca ttgccctgct
     1141 gaagcagcta ctgtctccag agccggcgtg tctgcagagg ggccgatgtg cagctttccg
     1201 tgcctctgtg ctcctgtcta atgtgcaaac ggtggcaccg tcctcctccc catgttatat
     1261 cccataaacg tgagcaagcc tgaggctctg acaatctgat gaggtaaagt gaactgtacc
     1321 tcacagggag cagttgagtg cacaaagggc ccagctctgg gcacagggag cagcaaacat
     1381 caatctcatc ctccctcata cgaagttacc tgagtagcct aaacttgggt tactatgaga
     1441 aaaaggtggc ttacgctgac cggggtagct ggatgggcag tacaccagta gaatctgtac
     1501 ggcttcatcc attcgatcag caacacttca ggtccccagt caggtcccag gcagaggagt
     1561 gtgtgctatt cacctacctc atatggcatc aggagaagcc agtattagcc tagatctctc
     1621 agaggcatta agcaaagcaa gcgagggctg gagagatgct ggctgttaaa ggctaggctc
     1681 acaatgaaaa atataagaaa agcatgcaaa ccattgaagg atctggaaag ttagttgaga
     1741 aagtgcaata ttgcataaca aaggttaaaa tgccctggga tgggactgga gagaaaggag
     1801 gctcagctcc taagagcact tgctgttctc ccagaggacc ctgactcaat tccatgaacc
     1861 acatggtata actccggttc cacagaatgc ctcgctcttc tggcccccat gggcattgca
     1921 tgcacacagt gcacacatat atgtgatggt aaaacattca tacatgtgaa aaataaaatt
     1981 taaaaatt
//
