LOCUS       NM_001290539            3489 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus V-set and transmembrane domain containing 2A (Vstm2a),
            transcript variant 1, mRNA.
ACCESSION   NM_001290539 XM_006514605
VERSION     NM_001290539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3489)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3489)
  AUTHORS   Al Dow,M., Silveira,M.A.D., Poliquin,A., Tribouillard,L.,
            Fournier,E., Trebaol,E., Secco,B., Villot,R., Tremblay,F.,
            Bilodeau,S. and Laplante,M.
  TITLE     Control of adipogenic commitment by a STAT3-VSTM2A axis
  JOURNAL   Am J Physiol Endocrinol Metab 320 (2), E259-E269 (2021)
   PUBMED   33196296
  REMARK    GeneRIF: Control of adipogenic commitment by a STAT3-VSTM2A axis.
REFERENCE   3  (bases 1 to 3489)
  AUTHORS   Secco,B., Camire,E., Briere,M.A., Caron,A., Billong,A., Gelinas,Y.,
            Lemay,A.M., Tharp,K.M., Lee,P.L., Gobeil,S., Guimond,J.V.,
            Patey,N., Guertin,D.A., Stahl,A., Haddad,E., Marsolais,D.,
            Bosse,Y., Birsoy,K. and Laplante,M.
  TITLE     Amplification of Adipogenic Commitment by VSTM2A
  JOURNAL   Cell Rep 18 (1), 93-106 (2017)
   PUBMED   28052263
  REMARK    GeneRIF: VSTM2A is produced to preserve and amplify the adipogenic
            capability of adipose precursors.
REFERENCE   4  (bases 1 to 3489)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3489)
  AUTHORS   Rolfe,R.A., Nowlan,N.C., Kenny,E.M., Cormican,P., Morris,D.W.,
            Prendergast,P.J., Kelly,D. and Murphy,P.
  TITLE     Identification of mechanosensitive genes during skeletal
            development: alteration of genes associated with cytoskeletal
            rearrangement and cell signalling pathways
  JOURNAL   BMC Genomics 15, 48 (2014)
   PUBMED   24443808
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3489)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033048.1, BM963943.1, AK134954.1 and AK137363.1.
            
            On May 19, 2018 this sequence version replaced NM_001290539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.65205.1,
                                           SRR1660825.160519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AK033048.1         21-345
            326-971             BM963943.1         4-649
            972-1718            AK134954.1         365-1111
            1719-1719           AK137363.1         1779-1779
            1720-3489           AK134954.1         1113-2882
FEATURES             Location/Qualifiers
     source          1..3489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 8.89 cM"
     gene            1..3489
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="V-set and transmembrane domain containing 2A"
                     /db_xref="GeneID:211739"
                     /db_xref="MGI:MGI:2384826"
     exon            1..345
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1025
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; V-set and transmembrane domain-containing
                     protein 2A"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 2A isoform 1 precursor"
                     /protein_id="NP_001277468.1"
                     /db_xref="GeneID:211739"
                     /db_xref="MGI:MGI:2384826"
                     /translation="MMGIFLASVGFMFFSVLYVQQGLSSQAKFTELPRNVTATEGQNV
                     EMSCAFQSGSASVYLEIQWWFLRGPEDLEQGTEAAGSQVELLPDRDPDNDGTKISTVK
                     VQGNDISHKLQISKVRKKDEGLYECRVTDANYGELQEHKAQAYLKVNANSHARRMQAF
                     EASPMWLQDTKPRKNASSVVPSSVHNSANQRMHSTSSPQAVAKIPKQSPQSAKSKSPV
                     KSTERTAKLTLYSKHHSAPLYSSYLHKEHQLPEA"
     exon            346..512
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..563
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..900
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..3489
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="major polyA site"
     regulatory      3106..3111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="hexamer: AATAAA"
     polyA_site      3137
                     /gene="Vstm2a"
                     /gene_synonym="Vstm2"
                     /note="major polyA site"
ORIGIN      
        1 aggtagcgga agcagccagc cggcggcgga gacacttcac ggcgtggcaa cccgggtctg
       61 tgccttgaag cctccggatc gcagccagct cggtccatcc ctcactagtc gcaatcccct
      121 gtgtccaagc tactctttgc tatgagcggc agcatgcgtg cagtatcgcg ccccaggctc
      181 tgagagcagc ctgcggacac gcttgcctat ctgtcttttt aggttttggg gctctgggct
      241 acacggatgt gccccactcc cttggcatga tggggatctt tttggcgtct gttggattta
      301 tgttcttttc cgtgttatat gtacaacaag ggctttcttc tcaagcaaaa tttaccgagt
      361 tgccgagaaa tgtgactgct accgaagggc aaaatgtgga gatgtcctgt gctttccaaa
      421 gcggctctgc ttcagtgtac ctggagatcc agtggtggtt ccttcggggg ccagaggacc
      481 tggagcaagg cacggaggct gcaggctcgc aggtggagct cttacccgac agagacccgg
      541 acaacgatgg gaccaagatt agtacagtga aagtccaagg caatgatatc tcccacaagc
      601 ttcagatatc caaagtgaga aaaaaggatg aaggtttata cgagtgcagg gtgactgacg
      661 ctaactacgg ggagcttcag gaacacaagg cccaggccta tctgaaagtc aatgccaaca
      721 gccatgctcg gaggatgcag gcctttgaag cctcacctat gtggctgcaa gacacgaagc
      781 ctcgaaagaa cgcatcatcg gtggttccca gcagcgtcca caactctgcc aaccaacgaa
      841 tgcactccac ctccagccct caagcggtag ccaaaatccc caagcaaagt ccacaatcag
      901 caaagagcaa atcgcctgta aaatctacgg agcggacagc aaagttgacc ctatactcca
      961 agcaccattc tgcacccctg tactctagtt atctacacaa ggagcatcag cttccggaag
     1021 cataagtgaa gacactgtca cacgctttat tgataatatt ttctttggga agttgctgat
     1081 cttttatttc aagagaatta atgggaagag ataggacatt ttccaattac aagaccaatt
     1141 tttttccttt tatttcaaca aataaaacct gcatttcact gactgctcag gagttggcct
     1201 gaatgacatc agtatactaa atatttccat ggattccacc aatttcctaa cgagggacac
     1261 ctaatcttca agaagcaaac aaagatggaa aacctaagaa ccacaaactg tctcatacag
     1321 caccccagct gaggaacaaa acaaatagct aaatgctgac catggcaaat caacatcaga
     1381 caactttatt ttacatatgg aataatcaaa gaaagttttt ttttacttcc tttttgcccc
     1441 ctggaattta tcttggagtt tccctttttt ccttgattgc cgttttcgtt caatggtagc
     1501 aagtgccaat tatggccaat ccttgtcaat cctggaaggt ttatattcat atacattgag
     1561 tgtggtatat atcaatgtat tttaattcat ttggcaattt ctgtataggc aaacctggca
     1621 aattctgtaa attgcttata gtatgtgtga tatgacttca aggtagatag gctatgatgc
     1681 tcatgcaagc tgactttctt cattctatat acaaatatat tcatgagcat atattaggcc
     1741 accaacttct tttcctaaag aattattttt catttgtacc tcatgtattt tgtgaatttt
     1801 gtagtatatt tctctgttcc actagtttga ccgctacagt ttgtctctgt tgtcctctac
     1861 ttccttctgg aaaaatttaa aattgtgtat gtctctgata aatgaattaa ttttgttgtg
     1921 tgtatgctat gttggaattt gctgtgttct tttaaacatg tatttattaa ggtttgggga
     1981 tcttgagttg agtctgaaga atgcacacct ggtttttgac agagttcctc atgttaccaa
     2041 tattctatct cagagaaaga aagacaccaa gtgggaaaac taagaagaca ttttgacttc
     2101 ccaagatcct ggaagagcac ttcacactct gactaaataa tgttgctttt tttgttcttc
     2161 aagacttttt tgtagctttg tctttctgtt agttgctgct aattatattt taatgtctac
     2221 taattaaaaa ttaaaatgtg attgttggct gaatacaata tgcaaatgac tgcaaagccc
     2281 atactgaaga aaatagatgt ttaatcttca ctcaataatt ataattttaa atagttcatc
     2341 attatttttt gaccttatga tattttgttt agacctgttc taattacatc tttctctggc
     2401 aaagaaagat agaacaatca atacattccc tcttacagta tggaatggtt gtggcttaag
     2461 aaagaatgca tccagatggt cttccagaga gattatttta ttttcattat aaaaccagaa
     2521 accatatatg taggaatggt tcattcctaa tgtaaggcca taaattgtag cttgaaggca
     2581 aggaatacat ttgttttttt atggtaaagg actggcctct gacatgcact tataagcaat
     2641 gtgaatattt tcataatatg cttgacattc tcctttaaca aatattgttt tatggtaaat
     2701 ctttccttgc cattttcctt ctttcatttg attcattatt tcattctaat gaagaaaata
     2761 aaggtttaat tatgatactt tattaacata caaatgtatt ttctttctaa gttaaatatc
     2821 tgaaagttgt ataaaatgat ggtagagaaa tattactcat tcggtttctt tgagctttaa
     2881 gaatcccata cattgcagta tatattagaa tactgattta acatcaaact gggggggaaa
     2941 atcatgtatt atacttttac tcaatgtcta ggtaatgaat tcagctaatt ttacagcaag
     3001 ccaaatgtgt acccgtatca gtaatgttca ccatgcttgt aataaaaggg tatatgctag
     3061 ttttggaaga atgctcatta gattcattgt atcagtgtcc aaaataataa agacctgttt
     3121 atcactgtgt gaccaaagtc caccccaccc tccactttgt aaaaagaata ccgcaaacca
     3181 cctgtttgct ccaaactcca aaagagtatg gaactttaaa tattagagca gaaaatacag
     3241 cagatcaata tgcttggata ctccattata ttcctttggg aatataactt tttatgtaac
     3301 catgacaatg gaagtggata gaaatgcaaa ggagaagtat ctggctttct caaccttgtt
     3361 ttcaagttta tacagtattt tttttataag agagacttat agaaagctga aattgcttac
     3421 tttgtttctt aaagacttat agacagccta aaaagcaaag aaagcaaata aaaatactcc
     3481 tgaacaaag
//
