LOCUS       NM_012038               1853 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus visinin-like 1 (Vsnl1), transcript variant 1, mRNA.
ACCESSION   NM_012038
VERSION     NM_012038.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Tyser,R.C.V., Ibarra-Soria,X., McDole,K., Arcot Jayaram,S.,
            Godwin,J., van den Brand,T.A.H., Miranda,A.M.A., Scialdone,A.,
            Keller,P.J., Marioni,J.C. and Srinivas,S.
  TITLE     Characterization of a common progenitor pool of the epicardium and
            myocardium
  JOURNAL   Science 371 (6533) (2021)
   PUBMED   33414188
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Desgrange,A., Le Garrec,J.F., Bernheim,S., Bonnelykke,T.H. and
            Meilhac,S.M.
  TITLE     Transient Nodal Signaling in Left Precursors Coordinates Opposed
            Asymmetries Shaping the Heart Loop
  JOURNAL   Dev Cell 55 (4), 413-431 (2020)
   PUBMED   33171097
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Giralt,A., Brito,V., Pardo,M., Rubio,S.E., Marion-Poll,L.,
            Martin-Ibanez,R., Zamora-Moratalla,A., Bosch,C., Ballesteros,J.J.,
            Blasco,E., Garcia-Torralba,A., Pascual,M., Pumarola,M., Alberch,J.,
            Gines,S., Martin,E.D., Segovia,J., Soriano,E. and Canals,J.M.
  TITLE     Helios modulates the maturation of a CA1 neuronal subpopulation
            required for spatial memory formation
  JOURNAL   Exp Neurol 323, 113095 (2020)
   PUBMED   31712124
  REMARK    GeneRIF: Our results demonstrated that...Helios has a specific and
            important role for a correct function of hippocampal
            calbindin-positive CA1 pyramidal neurons regulating
            spinogenesis...and that Visinin-like protein 1 (VSNL1) could play
            an important role in such processes
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   van Eif,V.W.W., Stefanovic,S., van Duijvenboden,K., Bakker,M.,
            Wakker,V., de Gier-de Vries,C., Zaffran,S., Verkerk,A.O.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     Transcriptome analysis of mouse and human sinoatrial node cells
            reveals a conserved genetic program
  JOURNAL   Development 146 (8) (2019)
   PUBMED   30936179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Magli,A., Schnettler,E., Swanson,S.A., Borges,L., Hoffman,K.,
            Stewart,R., Thomson,J.A., Keirstead,S.A. and Perlingeiro,R.C.
  TITLE     Pax3 and Tbx5 specify whether PDGFRalpha+ cells assume skeletal or
            cardiac muscle fate in differentiating embryonic stem cells
  JOURNAL   Stem Cells 32 (8), 2072-2083 (2014)
   PUBMED   24677751
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Mori,A.D., Zhu,Y., Vahora,I., Nieman,B., Koshiba-Takeuchi,K.,
            Davidson,L., Pizard,A., Seidman,J.G., Seidman,C.E., Chen,X.J.,
            Henkelman,R.M. and Bruneau,B.G.
  TITLE     Tbx5-dependent rheostatic control of cardiac gene expression and
            morphogenesis
  JOURNAL   Dev Biol 297 (2), 566-586 (2006)
   PUBMED   16870172
  REMARK    Erratum:[Dev Biol. 2007 Sep 15;309(2):386]
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Dai,F.F., Zhang,Y., Kang,Y., Wang,Q., Gaisano,H.Y.,
            Braunewell,K.H., Chan,C.B. and Wheeler,M.B.
  TITLE     The neuronal Ca2+ sensor protein visinin-like protein-1 is
            expressed in pancreatic islets and regulates insulin secretion
  JOURNAL   J Biol Chem 281 (31), 21942-21953 (2006)
   PUBMED   16731532
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Gonzalez Guerrico,A.M., Jaffer,Z.M., Page,R.E., Braunewell,K.H.,
            Chernoff,J. and Klein-Szanto,A.J.
  TITLE     Visinin-like protein-1 is a potent inhibitor of cell adhesion and
            migration in squamous carcinoma cells
  JOURNAL   Oncogene 24 (14), 2307-2316 (2005)
   PUBMED   15735716
  REMARK    GeneRIF: Decreased or absent VILIP-1 expression in SCC cell
            subpopulations may lead to a more advanced malignant phenotype
            characterized by changes in adhesive ability and increased cell
            motility, suggestive of a tumor suppressor function
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   10 (bases 1 to 1853)
  AUTHORS   Mathisen,P.M., Johnson,J.M., Kawczak,J.A. and Tuohy,V.K.
  TITLE     Visinin-like protein (VILIP) is a neuron-specific calcium-dependent
            double-stranded RNA-binding protein
  JOURNAL   J Biol Chem 274 (44), 31571-31576 (1999)
   PUBMED   10531361
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139207.10.
            
            On Mar 13, 2020 this sequence version replaced NM_012038.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144454.1, AJ489331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC139207.10        223376-223597       c
            223-389             AC139207.10        173834-174000       c
            390-605             AC139207.10        119020-119235       c
            606-1853            AC139207.10        112276-113523       c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 5.58 cM"
     gene            1..1853
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /note="visinin-like 1"
                     /db_xref="GeneID:26950"
                     /db_xref="MGI:MGI:1349453"
     exon            1..222
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..389
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..803
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /note="NVL-1; NVP-1; neural visinin-like protein 1"
                     /codon_start=1
                     /product="visinin-like protein 1"
                     /protein_id="NP_036168.1"
                     /db_xref="CCDS:CCDS25816.1"
                     /db_xref="GeneID:26950"
                     /db_xref="MGI:MGI:1349453"
                     /translation="MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLN
                     LEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN
                     WAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDK
                     NKDDQITLDEFKEAAKSDPSIVLLLQCDIQK"
     exon            390..605
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1853
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /note="hexamer: AATAAA"
     polyA_site      1853
                     /gene="Vsnl1"
                     /gene_synonym="VILIP; Vnsl1"
                     /note="major polyA site"
ORIGIN      
        1 aatctgcagc agagattcac ccgagcgtgt tgcagcggcc gctgggcttg cagggcgcaa
       61 tccaagagag atttaagcag cccggagctc ctagaaaagg agcgagagag aaccactcgc
      121 agagacggtt tagccgttag cctgaattaa atatatatat tttttgaaag aactgttgag
      181 ttttatcatt ttccttaagt gacggtgcac agcgctataa ctgcaaaatg gggaaacaga
      241 atagcaaact ggccccagaa gtcatggagg acctggtgaa gagcactgag ttcaatgagc
      301 atgagcttaa gcagtggtac aagggcttcc tcaaggactg tccgagcggg aggctgaacc
      361 tcgaggagtt ccagcagctc tatgtgaagt tcttccccta tggagatgcc tccaagttcg
      421 cgcagcacgc cttccgcacc ttcgacaaga acggtgatgg caccatcgat ttccgagagt
      481 tcatctgtgc cctgtccatc acctccagag gtagctttga gcagaaactg aactgggctt
      541 tcaacatgta tgatctggac ggtgacggca agatcacccg agtggagatg ctggagatta
      601 tcgaggctat ctacaaaatg gtgggcaccg tgatcatgat gaaaatgaat gaggatggcc
      661 tgacgcctga acagcgggtg gacaagattt tcagcaagat ggataagaac aaagatgacc
      721 agattacact ggatgaattc aaagaagctg caaaaagcga cccttccatt gtattacttc
      781 tgcagtgtga cattcagaaa tgagctgatg tcgatgctat ggactgcaca caagtcttga
      841 tgttccattc agtctgcagc tacacacaca cacacacaca cacacacaca caccacaccc
      901 cacaccccac accccacacc ccacacaatt gcttggacta cctataaatg gacttgcttc
      961 ttgtgtttga aacacttgtg tgcatgagaa tgtcatttgc taatgaattt taaaagcata
     1021 tattataaaa caaatctgac aacctgccac aatgtgatat gtgtaatatc atttcattaa
     1081 aatacatctt cctccaaagc ctgggcagaa gcgtgctgca aagaattcta tgatttcttg
     1141 tacatgtttt gctaatgctt gtgtcccttg attatataat attagtagca ctgagaccct
     1201 tcccccacgg taatgtaact tattatgggc tgcgtcacca ttctcctgta aaatagtact
     1261 ggacagacac acaggaggag cccttggctc cctgtctggc ccacacacag cttgtattat
     1321 cagtgaatat aaatatacta tatttgcatg ccttttgggt ttgccttaat tcttacctca
     1381 tttgtaacct ctcaatctgg aaagagctgt tttggatgaa tgcagtatac aacttaaaaa
     1441 tcctgctcaa ctactcatta agtataacta catatctata gacacaaagg tattatttat
     1501 tgaaagtaaa aacataataa tgggaatgta ttgatttctg tttgacgttt caaaggcttc
     1561 cagaaaggtg gcaatagatg tcccaaataa atttctaata gtcgatttac ttccctaatt
     1621 attaatttat agttttcagc tcagtgttca taggggtcag ctagccataa cttactaatc
     1681 taccctggaa tttgcagaat gactggaagt ggggaaagtc actgtccaac ttatcatcca
     1741 gcccctcctt ccccaaagat caatatggca tgtaatattt aaagaaaaca ggagatttgt
     1801 tcattctgga aaacaatgct cattatgtga caataaactt tatctcagtg tga
//
