LOCUS       NM_028732               4846 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus V-set immunoregulatory receptor (Vsir), transcript
            variant 1, mRNA.
ACCESSION   NM_028732
VERSION     NM_028732.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4846)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 4846)
  AUTHORS   Jin,S., Liu,W., He,X., Zhang,Y., Chen,W., Wu,Y. and Liu,J.
  TITLE     VISTA deficiency exerts anti-tumor effects in breast cancer through
            regulating macrophage polarization
  JOURNAL   Int Immunopharmacol 136, 112365 (2024)
   PUBMED   38820964
  REMARK    GeneRIF: VISTA deficiency exerts anti-tumor effects in breast
            cancer through regulating macrophage polarization.
REFERENCE   3  (bases 1 to 4846)
  AUTHORS   Tang,D., Zhao,L., Yan,F., Ren,C., Xu,K. and Zhao,K.
  TITLE     Expression of VISTA regulated via IFN-gamma governs endogenous
            T-cell function and exhibits correlation with the efficacy of CD19
            CAR-T cell treated B-malignant mice
  JOURNAL   J Immunother Cancer 12 (6), e008364 (2024)
   PUBMED   38925679
  REMARK    GeneRIF: Expression of VISTA regulated via IFN-gamma governs
            endogenous T-cell function and exhibits correlation with the
            efficacy of CD19 CAR-T cell treated B-malignant mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4846)
  AUTHORS   Ta,H.M., Roy,D., Zhang,K., Alban,T., Juric,I., Dong,J.,
            Parthasarathy,P.B., Patnaik,S., Delaney,E., Gilmour,C., Zakeri,A.,
            Shukla,N., Rupani,A., Phoon,Y.P., Liu,C., Avril,S., Gastman,B.,
            Chan,T. and Wang,L.L.
  TITLE     LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell
            responses
  JOURNAL   Sci Immunol 9 (95), eadi7418 (2024)
   PUBMED   38758807
  REMARK    GeneRIF: LRIG1 engages ligand VISTA and impairs tumor-specific
            CD8[+] T cell responses.
REFERENCE   5  (bases 1 to 4846)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4846)
  AUTHORS   Peng,Y., Clark,C., Luong,R., Tu,W.H., Lee,J., Johnson,D.T., Das,A.,
            Carroll,T.J. and Sun,Z.
  TITLE     The leucine zipper putative tumor suppressor 2 protein LZTS2
            regulates kidney development
  JOURNAL   J Biol Chem 286 (46), 40331-40342 (2011)
   PUBMED   21949185
REFERENCE   7  (bases 1 to 4846)
  AUTHORS   Flies,D.B., Wang,S., Xu,H. and Chen,L.
  TITLE     Cutting edge: A monoclonal antibody specific for the programmed
            death-1 homolog prevents graft-versus-host disease in mouse models
  JOURNAL   J Immunol 187 (4), 1537-1541 (2011)
   PUBMED   21768399
REFERENCE   8  (bases 1 to 4846)
  AUTHORS   Wang,L., Rubinstein,R., Lines,J.L., Wasiuk,A., Ahonen,C., Guo,Y.,
            Lu,L.F., Gondek,D., Wang,Y., Fava,R.A., Fiser,A., Almo,S. and
            Noelle,R.J.
  TITLE     VISTA, a novel mouse Ig superfamily ligand that negatively
            regulates T cell responses
  JOURNAL   J Exp Med 208 (3), 577-592 (2011)
   PUBMED   21383057
REFERENCE   9  (bases 1 to 4846)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 4846)
  AUTHORS   Aloia,L., Parisi,S., Fusco,L., Pastore,L. and Russo,T.
  TITLE     Differentiation of embryonic stem cells 1 (Dies1) is a component of
            bone morphogenetic protein 4 (BMP4) signaling pathway required for
            proper differentiation of mouse embryonic stem cells
  JOURNAL   J Biol Chem 285 (10), 7776-7783 (2010)
   PUBMED   20042595
  REMARK    GeneRIF: Results demonstrate that Dies1 is required for BMP4/Smad1
            signaling cascade.
            GeneRIF: Dies1 is a necessary factor of BMP4 signaling and its
            suppression sustains mESC self-renewal.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202363.1, AK014600.1 and AK142494.1.
            
            On Apr 22, 2009 this sequence version replaced NM_028732.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079734.1, AK033393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BY202363.1         2-73
            73-4469             AK014600.1         1-4397
            4470-4846           AK142494.1         2316-2692
FEATURES             Location/Qualifiers
     source          1..4846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 30.26 cM"
     gene            1..4846
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /note="V-set immunoregulatory receptor"
                     /db_xref="GeneID:74048"
                     /db_xref="MGI:MGI:1921298"
     exon            1..253
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            254..679
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            680..730
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            731..838
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            839..866
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1063
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..4846
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4475
                     /gene="Vsir"
                     /gene_synonym="4632428N05Rik; Dies1; PD-1H; VISTA"
ORIGIN      
        1 gggggcgctg ctgggcgggg agcttgctcg gccgcctgcc tcgccttggg ctcagcattc
       61 actctagcga gcgagcggcg tgtacagccg gctccctggg ctcctggagt cccgcttgct
      121 ccaagcgcac tccagcagtc tctttctgct cttgcccggc tcgacggcga catgggtgtc
      181 cccgcggtcc cagaggccag cagcccgcgc tggggaaccc tgctccttgc tattttcctg
      241 gctgcatcca gaggtctggt agcagccttc aaggtcacca ctccatattc tctctatgtg
      301 tgtcccgagg gacagaatgc caccctcacc tgcaggattc tgggccccgt gtccaaaggg
      361 cacgatgtga ccatctacaa gacgtggtac ctcagctcac gaggcgaggt ccagatgtgc
      421 aaagaacacc ggcccatacg caacttcaca ttgcagcacc ttcagcacca cggaagccac
      481 ctgaaagcca acgccagcca tgaccagccc cagaagcatg ggctagagct agcttctgac
      541 caccacggta acttctctat caccctgcgc aatgtgaccc caagggacag cggcctctac
      601 tgctgtctag tgatagaatt aaaaaaccac cacccagaac aacggttcta cgggtccatg
      661 gagctacagg tacaggcagg caaaggctcg gggtccacat gcatggcgtc taatgagcag
      721 gacagtgaca gcatcacggc tgcggccctg gccaccggcg cctgcatcgt gggaatcctc
      781 tgcctccccc ttatcctgct gctggtctat aagcagagac aggtggcctc tcaccgccgt
      841 gcccaggagt tggtgaggat ggacagcagc aacacccaag gaatcgaaaa cccaggcttc
      901 gagaccactc cacccttcca ggggatgcct gaggccaaga ccaggccgcc actgtcctat
      961 gtggcccagc ggcaaccttc ggagtcagga cggtacctgc tctctgaccc cagcacacct
     1021 ctgtcgcctc caggccctgg ggacgtcttt ttcccatccc tagatccagt ccctgactcc
     1081 cctaactctg aagccatcta aaccagctgg ggaaccatga accatggtac ctgggtcagg
     1141 gatatgtgca cttgatctat ggctggccct tggacagtct tttaggcact gactccagct
     1201 tccttgctcc tgctctgagc ctagactctg cttttacaag atgcacagac cctcccctat
     1261 ctctttcaga cgctacttgg ggggcaggga gaagatgttg gattgctcat tgctgttctc
     1321 aagatcttgg gatgctgagt tctccctaga gacttgactt cgacagccac agatgtcaga
     1381 tgacctgcat cctatgaacg tccggcttgg caagagcctt tcttcatgga aaccagtagc
     1441 ccggagggga tgaggtaggc accttgccac cctcccggga gagagacaca agatgtgaga
     1501 gactcctgct cactgtgggg gtgtggctgg cctgcttgtt tgcctgagga tgctcctctg
     1561 ttggactgac tctatccccc tggattctgg agcttggctg gcctatgtcc caccagagga
     1621 gcatctcagc agccttccac cagcaacctg agggcctgcc agcttcgtgg ctctgggctc
     1681 tcattacctg tatggccgtc cacagagctc agtggccaga ggctttgaaa caggaagtac
     1741 atgtcaggtt caggaaccac tgtgagctca ttagtgtctt gagcaatgtg aggcctggac
     1801 cagtggacac ggagggaggg tggcgagagg atgatgggga tgatgagggg aacacgctcc
     1861 cttcctgtcc ttgtcatcca ccactaccac tattcagtgt ggagcagtgg caaaggtgac
     1921 cgacctccac aatgtcctag tgatgctgga ccatttctaa gtgtgaaaga gatgctatta
     1981 aaaacagtat gtggcaatgg ctgccaacag ctgagtggac tggaggcact ggctttaagg
     2041 ccctggaggt gcagggcccg gtatggggat agggatggga gtttcagtga gggcctaggg
     2101 atcactccgc ttctgaccac tcttcttctg agcctcacct cagggtgacc ttcaggcaca
     2161 cagaagagct tgcccctggt ccgatactac tcttggctct catctccagg gtttggcatg
     2221 acctgggcac acagggggag tcttcagaaa ggattttaaa gcatgaaaag aaagggtagt
     2281 tcttgtgagg tagggatggg cagctgatgt ttgagagtga ggagggatac ggctgggcag
     2341 atcactctcc agtctctaga gggaaagtag ctctaagtct gggagagcag cagcccagtg
     2401 gtaccatatg tcttcttgca gcttccactg gctgggctga actgggcatg ggtaggaaag
     2461 ctcctgttct gggcctgcag ccagggagaa ccccattcat tccctgagga cagatgggtg
     2521 gggagagaag agagagtttc aggccgggaa gcagcaataa gctatctgct ggggacccag
     2581 acaagttgtc tgatgaggtc caagatgtgg gatgccagtt atacctgggg cttggggatc
     2641 cttagaggct ttgtatcatc atcataggag tgtcggggtg gccagggcat caaagccatg
     2701 acccctgttt tatcctcagg gtccactctt ctgcaccatc cattgctcta gatctatgca
     2761 gttactatag acagaatgtg ttgttctgtt tggctttggg gataatggcc tggcgaactg
     2821 ccagctgttc agtggcaggg ctgtgaggcc agtcaaagac tagaacccac agaccagctg
     2881 aacgatgagt atagcctgtc ccctggggga gcctgacctg tctccagccc taagcttcag
     2941 acctcaccac tcagatgact tctaagaatt tgcctgtggg gacccctgca tggctgcagc
     3001 tccgtggaaa ggagaggagg cccccagcag aagaaccact cgcttcctgc ccagcttcct
     3061 cctgtagggc tctaagtctc ttcttcttgg gaccctgcaa gcaaaggcat gtcagcttgg
     3121 tggtttcctg ttttgggtga agttttgtgt ggtccgggtt ctgtctacat ccatgaactt
     3181 gggtgctacc accttgctgc tgctgtagag acagctgcag gatcttaggg tggaaaatgg
     3241 aggtgccctg aggtgctagc ccttggggca aaagatgggg tggcaatgag acacagtggg
     3301 gaactgagtt ccccaagagg agggaggagc cctgtagcct caagggccat attgggttcc
     3361 tggtaccagc aaaagcctag agagcgaagt ctgtattttg aggaggtaat tgatccttac
     3421 ggaatccatc agaaatttgg agcgggtgct ttatctatct ctggagggtc tctacctatc
     3481 tccgatgaag ctctccctgg gcctgggatg ggagaaacca ggaggaaagg tgtctgataa
     3541 agcaggggct tcttgacaag ccaaagggcc actggtagct gttgtggacc gagctgaccc
     3601 tgctgaagta ttgtagtgtg ccttggacca acttctcaaa agagcaaccc cggggctacc
     3661 ctacttctgc caggaagagg cggagaaggg gctgagaggc ctggaagggg ctagctcctt
     3721 ctttgagaac tgctccccgg aggacttgga ggaggcggct aggctacggg ctgctgaggg
     3781 ccctttgtct ttcctaacct gggcactgtt aggatgctcc ctcctggaaa aggctttcct
     3841 gggtgtgagc tagagcagtg tccatgccag cgctgaacct gccatggtgg gagctgaact
     3901 aaaaatttct cagggaacta aaataggcaa aagaggaact gggggaggag ggtgccaggc
     3961 aggatggggg gaagggaggg cagtgcaaaa gtctcttgaa acacagacag cccagctgag
     4021 tgccagtccc agatcacaga gaatacggct catctggctc atgttctgca tgcttgctgc
     4081 tttaccctgg cactttcctt ctccaccatg agtgcgagtc ctgggagtcc tgggagggtg
     4141 aggattaatg ccagcctggg gagcagatag ctgacagagt ccttgggtaa ctggcttgaa
     4201 ccaggacctc aggattccac tctggggatc tagctttgtc tgggccagtg aagatctcta
     4261 taatggcatt attgccaggg gataaacatt tcactgggtt ctgatctgtt gggtgtggct
     4321 tcctggaaaa tatggtgaga ggaattctgc taaggataca gttgataaga aagttctgag
     4381 attgattagt aatgcctgcc ttggactcag gaagggaagt ggcagtatga atgccatgtc
     4441 ttaatcattt tggttaaaat atgcttccca aaagatttcc acgtgtgttc ttgtttattt
     4501 gacatctgtc tccatatcag tcttgaaagc ctttctgtgt gtatatatat gatgtttgcg
     4561 tgtatatatg tttttgtgtg tgcatatgga agtcagaaat cactgggtgt cttcctccat
     4621 tcctttgcaa tgtatgtttt tttttttttt acgatttatt tactatatga atgttttgcc
     4681 tgaatacatg cataggtgtc acgtacatgc ctgctggaac gcttggaact ggagttacag
     4741 gtggctatga gctacagtgt gagcactggg aatcaaacct gggtcttctg caagagcaac
     4801 aaattaaaag tcagctctta actacttgag ctatttttcc aactcc
//
