LOCUS       NM_177723               1814 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus V-set and immunoglobulin domain containing 8 (Vsig8),
            transcript variant 1, mRNA.
ACCESSION   NM_177723
VERSION     NM_177723.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Rice,R.H., Phillips,M.A. and Sundberg,J.P.
  TITLE     Localization of hair shaft protein VSIG8 in the hair follicle, nail
            unit, and oral cavity
  JOURNAL   J Invest Dermatol 131 (9), 1936-1938 (2011)
   PUBMED   21614015
  REMARK    GeneRIF: VSIG8 is found in the hair follicle, nails and oral
            cavity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037228.1, BC064106.1 and AW986342.1.
            
            On May 9, 2009 this sequence version replaced NM_177723.3.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1175              AK037228.1         2-1176
            1176-1800           BC064106.1         895-1519
            1801-1814           AW986342.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.95 cM"
     gene            1..1814
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /note="V-set and immunoglobulin domain containing 8"
                     /db_xref="GeneID:240916"
                     /db_xref="MGI:MGI:3642995"
     exon            1..183
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1388
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /note="V-set and immunoglobulin domain-containing protein
                     8"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 8 precursor"
                     /protein_id="NP_808391.2"
                     /db_xref="CCDS:CCDS15516.1"
                     /db_xref="GeneID:240916"
                     /db_xref="MGI:MGI:3642995"
                     /translation="MGVRGALHLLLVCLSPALLSAVRINGDGQEVMYLAEGDNVRLGC
                     PYLLDPEDLGTNSLDIEWMQVNSEPSHRENVFLTYQDKRIGHGNLPHLQQRVRFAASD
                     PSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMSKGN
                     DVVLKCFANGGSQPLSYKWAKISGHSHPYRAGAYHSQHSFHSELSYQESFHSTINQGL
                     GNGDLLLKGINADDDGLYQCTVANHVGYSVCVVEVKVSDSQRVGMIVGAVLGSLLMLA
                     CLALGIWGLICCCCGGGGAGGARGAFGYGVGGGVGGGACGDLASEIRVDAEAPGCKAS
                     GRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALVPRTASASCEAGPSPVYIKV
                     KSAEPADCADCAQVEQRSCKDGLLV"
     exon            184..359
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     exon            360..561
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     exon            562..783
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     exon            784..903
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1102
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1801
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /note="hexamer: AATAAA"
     polyA_site      1801
                     /gene="Vsig8"
                     /gene_synonym="A030011M19; EG240916"
                     /note="major polyA site"
ORIGIN      
        1 actcattgca tcttcctgcc accccgggca gtgtctgggc cctccgctcc ccctccctcc
       61 acctgcccct tccacccacc accaccagcc cactggagcc cagctcaggc ggaggaaaga
      121 ccaagcctag agacatggga gttcgaggag cactccatct tctacttgtg tgcctgagcc
      181 cagcactgtt gtctgctgta aggatcaacg gggatggcca ggaggtcatg tacctggcag
      241 aaggtgacaa tgtgaggcta ggctgtccct acctcctgga tcctgaggat ttgggtacca
      301 acagtctgga cattgagtgg atgcaagtca actcagagcc ctcacacagg gagaatgttt
      361 ttcttactta tcaagacaag aggataggtc atggcaacct cccccatctg cagcagaggg
      421 tccgctttgc agcctcagac cccagccagt acgatgcctc catcaacctc atgaacctgc
      481 aggtatctga cacagcaacc tatgagtgcc gggtgaagaa gaccaccatg gccaccagga
      541 aggtcattgt cactgtccaa gcacgtcctg cggtgcccat gtgttggacg gaaggccaca
      601 tgtcaaaggg caacgatgtg gtgctgaagt gctttgccaa cggaggctct cagcccctct
      661 cctacaagtg ggccaagatc agtgggcaca gtcaccccta ccgagctggg gcttaccact
      721 cacagcacag cttccactct gagctttctt accaagagtc attccacagc accatcaacc
      781 aaggcctggg caacggagac ctgctgttga agggcatcaa cgcagacgac gatgggctgt
      841 atcagtgcac agtggccaac catgtgggct acagcgtctg tgtggtagag gtgaaagtct
      901 cagactccca gcgagtaggc atgatcgttg gagcagtgct gggctctttg ctcatgctgg
      961 cctgcctggc actaggcatc tgggggctca tctgctgctg ctgcggaggc ggcggggccg
     1021 gtggtgcccg aggtgccttc ggctacgggg tcggcggcgg ggtcggcgga ggggcctgcg
     1081 gcgacttggc tagtgagatc agagtggacg ccgaggcgcc cgggtgtaag gccagcgggc
     1141 gcggcagccg cgtcacccac ctcctggggt acccgacgca gaacgtcagc cgctccctgc
     1201 gccgcaagta cgcgcctccg ccctgcggcg gccccgagga cgtggcccta gtgccccgca
     1261 ccgcctccgc ctcctgcgaa gcgggtccct cccccgtcta catcaaggtc aagagcgcgg
     1321 agccggccga ctgcgccgac tgtgcccagg tcgagcagcg ctcgtgcaag gacggcctct
     1381 tagtgtgagc gcacagcacc gggctgcgcc ccggctggga ggtggttcgg gggctctctg
     1441 cccgcagctg gggacaggtt cgggccagca gacctggctc tctcattggc cacctagcgg
     1501 tggtaaggaa atttccctct gagaagccaa gccgggcaga ccctcctccc ctgtagtggg
     1561 aggagaggcg ggggagacag aaaacagttc agagctctcc ctcacccctg gtttccaggg
     1621 agaggaaggg agaggagagc tgtcggtatc ccagaaccgc agaggtacaa cccagatgtc
     1681 cccagccaag gcgagggccc cccagccctg ggtaggtgga tgtcagggct gaattgctct
     1741 gtgtgtgaga tctgagctcc aaggcaacag tgttagcaca ataaagaaac ttaaagactg
     1801 aaaaaaaaaa aaaa
//
