LOCUS       NM_177789               1434 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4),
            mRNA.
ACCESSION   NM_177789 XM_905545
VERSION     NM_177789.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Cai,P., Wang,J., Xu,J., Zhang,M., Yin,X., He,S. and Zhuang,J.
  TITLE     V-set and immunoglobulin domain containing 4 inhibits oxidative
            stress, mitochondrial dysfunction, and inflammation to attenuate
            Parkinson's disease progression by activating the JAK2/STAT3
            pathway
  JOURNAL   J Neuroimmunol 391, 578345 (2024)
   PUBMED   38759519
  REMARK    GeneRIF: V-set and immunoglobulin domain containing 4 inhibits
            oxidative stress, mitochondrial dysfunction, and inflammation to
            attenuate Parkinson's disease progression by activating the
            JAK2/STAT3 pathway.
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Peiseler,M., Araujo David,B., Zindel,J., Surewaard,B.G.J.,
            Lee,W.Y., Heymann,F., Nusse,Y., Castanheira,F.V.S., Shim,R.,
            Guillot,A., Bruneau,A., Atif,J., Perciani,C., Ohland,C., Ganguli
            Mukherjee,P., Niehrs,A., Thuenauer,R., Altfeld,M., Amrein,M.,
            Liu,Z., Gordon,P.M.K., McCoy,K., Deniset,J., MacParland,S.,
            Ginhoux,F., Tacke,F. and Kubes,P.
  TITLE     Kupffer cell-like syncytia replenish resident macrophage function
            in the fibrotic liver
  JOURNAL   Science 381 (6662), eabq5202 (2023)
   PUBMED   37676943
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Gao,H., Wang,K., Suarez,J.A., Jin,Z., Rocha,K.C.E., Zhang,D.,
            Farrell,A., Truong,T., Tekin,Y., Tan,B., Jung,H.S., Kempf,J.,
            Mahata,S.K., Dillmann,W.H., Suarez,J. and Ying,W.
  TITLE     Gut lumen-leaked microbial DNA causes myocardial inflammation and
            impairs cardiac contractility in ageing mouse heart
  JOURNAL   Front Immunol 14, 1216344 (2023)
   PUBMED   37520546
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Wang,Y., Zhang,Y., Li,J., Li,C., Zhao,R., Shen,C., Liu,W., Rong,J.,
            Wang,Z., Ge,J. and Shi,B.
  TITLE     Hypoxia Induces M2 Macrophages to Express VSIG4 and Mediate Cardiac
            Fibrosis After Myocardial Infarction
  JOURNAL   Theranostics 13 (7), 2192-2209 (2023)
   PUBMED   37153746
  REMARK    GeneRIF: Hypoxia Induces M2 Macrophages to Express VSIG4 and
            Mediate Cardiac Fibrosis After Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Gorgani,N.N., He,J.Q., Katschke,K.J. Jr., Helmy,K.Y., Xi,H.,
            Steffek,M., Hass,P.E. and van Lookeren Campagne,M.
  TITLE     Complement receptor of the Ig superfamily enhances
            complement-mediated phagocytosis in a subpopulation of tissue
            resident macrophages
  JOURNAL   J Immunol 181 (11), 7902-7908 (2008)
   PUBMED   19017980
  REMARK    GeneRIF: CRIg thus identifies a subset of tissue resident
            macrophages capable of increased phagocytosis of complement
            C3-coated particles, a function critical for immune clearance
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Kim,D.D., Miwa,T., Kimura,Y., Schwendener,R.A., van Lookeren
            Campagne,M. and Song,W.C.
  TITLE     Deficiency of decay-accelerating factor and complement receptor
            1-related gene/protein y on murine platelets leads to
            complement-dependent clearance by the macrophage phagocytic
            receptor CRIg
  JOURNAL   Blood 112 (4), 1109-1119 (2008)
   PUBMED   18524992
  REMARK    GeneRIF: Antibody blocking or gene ablation of the newly identified
            complement receptor CRIg, but not complement receptor 3 (CR3),
            rescued DAF/Crry-deficient platelets from complement-dependent
            elimination.
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Katschke,K.J. Jr., Helmy,K.Y., Steffek,M., Xi,H., Yin,J., Lee,W.P.,
            Gribling,P., Barck,K.H., Carano,R.A., Taylor,R.E., Rangell,L.,
            Diehl,L., Hass,P.E., Wiesmann,C. and van Lookeren Campagne,M.
  TITLE     A novel inhibitor of the alternative pathway of complement reverses
            inflammation and bone destruction in experimental arthritis
  JOURNAL   J Exp Med 204 (6), 1319-1325 (2007)
   PUBMED   17548523
  REMARK    GeneRIF: A soluble form of complement receptor of the
            immunoglobulin superfamily (CRIg) reversed inflammation and bone
            loss in two experimental models of arthritis by inhibiting the
            alternative pathway of complement in the joint.
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
  REMARK    GeneRIF: The specific expression of VSIG4 on resting macrophages
            suggests that VSIG4 may be important for the maintenance of T cell
            unresponsiveness in healthy tissues.
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Helmy,K.Y., Katschke,K.J. Jr., Gorgani,N.N., Kljavin,N.M.,
            Elliott,J.M., Diehl,L., Scales,S.J., Ghilardi,N. and van Lookeren
            Campagne,M.
  TITLE     CRIg: a macrophage complement receptor required for phagocytosis of
            circulating pathogens
  JOURNAL   Cell 124 (5), 915-927 (2006)
   PUBMED   16530040
  REMARK    GeneRIF: Results report the identification and characterization of
            a Complement Receptor of the Immunoglobulin superfamily, CRIg, that
            binds complement fragments C3b and iC3b.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831708.9.
            
            On Jul 27, 2018 this sequence version replaced NM_177789.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025105.1, AK041014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL831708.9         97796-97920         c
            126-482             AL831708.9         94972-95328         c
            483-539             AL831708.9         74038-74094         c
            540-617             AL831708.9         73537-73614         c
            618-722             AL831708.9         54357-54461         c
            723-744             AL831708.9         52696-52717         c
            745-1434            AL831708.9         51683-52372         c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.69 cM"
     gene            1..1434
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /note="V-set and immunoglobulin domain containing 4"
                     /db_xref="GeneID:278180"
                     /db_xref="MGI:MGI:2679720"
     exon            1..125
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..913
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /note="complement receptor of the immunoglobulin
                     superfamily"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 4 precursor"
                     /protein_id="NP_808457.1"
                     /db_xref="CCDS:CCDS30288.1"
                     /db_xref="GeneID:278180"
                     /db_xref="MGI:MGI:2679720"
                     /translation="MEISSGLLFLGHLIVLTYGHPTLKTPESVTGTWKGDVKIQCIYD
                     PLRGYRQVLVKWLVRHGSDSVTIFLRDSTGDHIQQAKYRGRLKVSHKVPGDVSLQINT
                     LQMDDRNHYTCEVTWQTPDGNQVIRDKIIELRVRKYNPPRINTEAPTTLHSSLEATTI
                     MSSTSDLTTNGTGKLEETIAGSGRNLPIFAIIFIISLCCIVAVTIPYILFRCRTFQQE
                     YVYGVSRVFARKTSNSEETTRVTTIATDEPDSQALISDYSDDPCLSQEYQITIRSTMS
                     IPAC"
     exon            126..482
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            483..539
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            540..617
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            618..722
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            723..744
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1434
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1410..1415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="Vsig4"
                     /gene_synonym="A530061A11; CRIg; Z39IG"
                     /note="major polyA site"
ORIGIN      
        1 agctaccagc acttccaggt tcttcagcag caagaggatg gaaggatgaa tagaagtagc
       61 ttcaaatagg atggagatct catcaggctt gctgttcctg ggccacctaa tagtgctcac
      121 ctatggccac cccaccctaa aaacacctga gagtgtgaca gggacctgga aaggagatgt
      181 gaagattcag tgcatctatg atcccctgag aggctacagg caagttttgg tgaaatggct
      241 ggtaagacac ggctctgact ccgtcaccat cttcctacgt gactccactg gagaccatat
      301 ccagcaggca aagtacagag gccgcctgaa agtgagccac aaagttccag gagatgtgtc
      361 cctccaaata aataccctgc agatggatga caggaatcac tatacatgtg aggtcacctg
      421 gcagactcct gatggaaacc aagtaataag agataagatc attgagctcc gtgttcggaa
      481 atataatcca cctagaatca atactgaagc acctacaacc ctgcactcct ctttggaagc
      541 aacaactata atgagttcaa cctctgactt gaccactaat gggactggaa aacttgagga
      601 gaccattgct ggttcaggga ggaacctgcc aatctttgcc ataatcttca tcatctccct
      661 ttgctgcata gtagctgtca ccatacctta tatcttgttc cgctgcagga cattccaaca
      721 agagtatgtc tatggagtga gcagggtgtt tgccaggaag acaagcaact ctgaagaaac
      781 cacaagggtg actaccatcg caactgatga accagattcc caggctctga ttagtgacta
      841 ctctgatgat ccttgcctca gccaggagta ccaaataacc atcagatcaa caatgtctat
      901 tcctgcctgc tgaacacagt ttccagaaac taagaagttc ttgctactga agaaaataac
      961 atctgctaaa atgcccctac taagtcaagg tctactggcg taattacctg ttacttattt
     1021 actacttgcc ttcaacatag ctttctccct ggcttccttt cttcttagac aacctaaagt
     1081 atctatctag tctgccaatt ctggggccat tgagaaatcc tgggtttggc taagaatata
     1141 ctacatgcac ctcaagaaat ctagcttctg ggcttcaccc agaacaattt tcttcctagg
     1201 gccttcacaa ctcttctcca aacagcagag aaattccata gcagtagagg ttctttatca
     1261 tgcctccaga cagcgtgagt ctcagtccta caaactcaga caagcacatg ggtctaggat
     1321 tactcctctt tctctagggc cagatgactt ttaattgata ttactattgc tacattatga
     1381 atctaatgca catgtattct tttgttgtta ataaatgttt aatcatgaca tcaa
//
