LOCUS       NM_001359143            2815 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus V-set and immunoglobulin domain containing 1 (Vsig1),
            transcript variant 3, mRNA.
ACCESSION   NM_001359143 XM_006528630
VERSION     NM_001359143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Jung,Y., Bang,H., Kim,Y.H., Park,N.E., Park,Y.H., Park,C.,
            Lee,S.R., Lee,J.W., Song,B.S., Kim,J.S., Sim,B.W., Seol,D.W.,
            Wee,G., Kim,S., Kim,S.U. and Kim,E.
  TITLE     V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly
            Expressed in Testicular Germ Cells, Is Dispensable for
            Spermatogenesis and Male Fertility in Mice
  JOURNAL   Animals (Basel) 11 (4), 1037 (2021)
   PUBMED   33916888
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Bernal,C., Silvano,M., Tapponnier,Y., Anand,S., Angulo,C. and Ruiz
            i Altaba,A.
  TITLE     Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq
            Is Shaped by Cancer Cell Interactions and Restricted by VSIG1
  JOURNAL   Cell Rep 33 (6), 108372 (2020)
   PUBMED   33176137
  REMARK    GeneRIF: Functional Pro-metastatic Heterogeneity Revealed by
            Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and
            Restricted by VSIG1.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Herriges,M.J., Tischfield,D.J., Cui,Z., Morley,M.P., Han,Y.,
            Babu,A., Li,S., Lu,M., Cendan,I., Garcia,B.A., Anderson,S.A. and
            Morrisey,E.E.
  TITLE     The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain
            lung development and homeostasis
  JOURNAL   Genes Dev 31 (9), 889-903 (2017)
   PUBMED   28546511
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Zhao,L., Svingen,T., Ng,E.T. and Koopman,P.
  TITLE     Female-to-male sex reversal in mice caused by transgenic
            overexpression of Dmrt1
  JOURNAL   Development 142 (6), 1083-1088 (2015)
   PUBMED   25725066
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Steyn,F.J., Ngo,S.T., Lee,J.D., Leong,J.W., Buckley,A.J.,
            Veldhuis,J.D., McCombe,P.A., Chen,C. and Bellingham,M.C.
  TITLE     Impairments to the GH-IGF-I axis in hSOD1G93A mice give insight
            into possible mechanisms of GH dysregulation in patients with
            amyotrophic lateral sclerosis
  JOURNAL   Endocrinology 153 (8), 3735-3746 (2012)
   PUBMED   22621959
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Oidovsambuu,O., Nyamsuren,G., Liu,S., Goring,W., Engel,W. and
            Adham,I.M.
  TITLE     Adhesion protein VSIG1 is required for the proper differentiation
            of glandular gastric epithelia
  JOURNAL   PLoS One 6 (10), e25908 (2011)
   PUBMED   21991385
  REMARK    GeneRIF: VSIG1 is required for the establishment of glandular
            versus squamous epithelia in the stomach.
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   Kim,E., Lee,Y., Kim,J.S., Song,B.S., Kim,S.U., Huh,J.W., Lee,S.R.,
            Kim,S.H., Hong,Y. and Chang,K.T.
  TITLE     Extracellular domain of V-set and immunoglobulin domain containing
            1 (VSIG1) interacts with sertoli cell membrane protein, while its
            PDZ-binding motif forms a complex with ZO-1
  JOURNAL   Mol Cells 30 (5), 443-448 (2010)
   PUBMED   20957455
  REMARK    GeneRIF: mouse VSIG1 interacts with Sertoli cells by heterophilic
            adhesion via its first Ig-like domain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132956.1 and BC145050.1.
            
            On Dec 22, 2017 this sequence version replaced XM_006528630.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145050.1, SRR5189685.138335.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK132956.1         2-45
            45-1452             BC145050.1         1-1408
            1453-2815           AK132956.1         1346-2708
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.62 cM"
     gene            1..2815
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="V-set and immunoglobulin domain containing 1"
                     /db_xref="GeneID:78789"
                     /db_xref="MGI:MGI:1926039"
     exon            1..119
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1399
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; V-set and immunoglobulin domain-containing
                     protein 1; glycoprotein A34; cell surface A33 antigen"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 1 isoform 3 precursor"
                     /protein_id="NP_001346072.1"
                     /db_xref="GeneID:78789"
                     /db_xref="MGI:MGI:1926039"
                     /translation="MMVFAFWKVFLILNCLAGQVSMVQVTIPDTFVNVTVGSNVTLLC
                     LYTTTEKSLEKLSIQWSFFHNKEMEEPISHVSHPKTEGMEEKAVSQCLKMMHARDARG
                     RCSWTSQIYYSEGGQASAIGQFKDRIIGATNPGNASITILHMQPADSGIYICDVNNPP
                     DFVGKNQGLLDVTVLVKPSKPFCTIQGRPEAGHPISLSCLSAFGTPSPLYYWYKIEGN
                     TIVPVKESFNTATGVLVIGNLTNFEQGYYQCTAINSLGNSSCEIDLTSSHPEVGIIIG
                     ALVGALIGAAVIICVVYFARNKVKSKQQKNLNSSTELEPMTKVHHPQQSEAISADGVQ
                     LEGTLPSSIHAGHNTEPTTTAVLEPEYEPNPPLETTTQPDPEPEGSVPVLAPEAEIQP
                     HPELDPETETEPEPEPEPKPEPEPEPELEPDPQSGVIIEPLSKAGEDTVKA"
     exon            120..286
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            287..394
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..593
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..749
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..869
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1008
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..2815
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1546..1551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1572
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="major polyA site"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2304
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="major polyA site"
     regulatory      2453..2458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
                     /note="hexamer: AATAAT"
     polyA_site      2474
                     /gene="Vsig1"
                     /gene_synonym="1700062D20Rik; 4930405J24Rik"
ORIGIN      
        1 aatttgaaac tcagcctagt tcaggcagcc ttcggactgg cacctgctgc tccaagcgac
       61 tttcagcatg atggtgtttg cattttggaa ggtctttctg atcttaaact gccttgcagg
      121 tcaggtcagt atggtgcaag tgaccatccc agacactttc gtgaatgtga ctgttggatc
      181 taatgttact cttctctgcc tctataccac caccgagaag tccctggaaa agctttcaat
      241 tcaatggtct ttcttccaca ataaggaaat ggaggagcca atatctcatg tctcgcaccc
      301 caaaactgag ggtatggagg aaaaggcagt cagtcagtgt ctaaaaatga tgcatgcaag
      361 agacgctcgg ggaagatgta gctggacctc tcagatctac tactctgaag gtggacaggc
      421 ttcagctatt gggcaattca aagaccgaat aattggggct actaatcccg gtaatgcatc
      481 tatcaccata ttgcatatgc agccagcaga cagtggaatt tacatctgtg atgtcaacaa
      541 tcctccagat tttgtgggca aaaaccaagg cctccttgac gtcactgtct tagtcaaacc
      601 ttccaagccc ttttgtacca tccaaggaag accagaagca ggccatccta tttccttgtc
      661 ttgcctttct gcctttggaa caccgtctcc tttgtattac tggtataaga ttgaggggaa
      721 caccattgtg ccagtaaaag aaagtttcaa cacggccact ggagttttag ttattggaaa
      781 tctaacaaat tttgaacaag gttattacca gtgtactgcc atcaacagtc ttggcaatag
      841 ttcctgtgaa attgacttaa cgtcttcaca tccagaagtt gggatcatca tcggagcttt
      901 ggtcggtgcc ctgataggag ctgctgttat catctgtgtg gtgtactttg ccaggaacaa
      961 agttaaatcc aagcagcaga agaatttaaa ttccagcaca gaacttgagc caatgacaaa
     1021 ggtacaccat ccccaacaaa gtgaggcaat ttcagctgat ggcgtccagc tagaaggaac
     1081 tctgccatct tccatccatg ctggccacaa caccgaacct actactacag cagtcttgga
     1141 gccagaatat gagcctaatc ctccactgga aactaccaca cagcctgacc ctgaaccaga
     1201 gggttcagtg ccagtgctag cacctgaggc agagattcaa ccacacccag agctggaccc
     1261 ggagactgag acagagcctg agcctgagcc tgagcctaag cctgagcctg agccggaacc
     1321 tgagcttgag cctgatcccc agtctggagt aataattgag cctctgagca aggcgggaga
     1381 ggatacagtt aaggcataaa taggcacggc atttagtatg gcaattccca ctaaagaacc
     1441 cattcccggc ttttaaaatt tggttgactt aaccagcccc cagtttgtcc gtccatcata
     1501 gacaaccctc atctatcaac gtattcattc caaccattaa tccaaaataa aaaaatcaag
     1561 gcaactactg aagaaatgcc gtgatttctg cctttttagt atagggctta cttaaaactg
     1621 tactaatatg taacataaca aaggccaagg ccaagacacg tggtttattt ctaatttact
     1681 tggaagaata tttgcaaaag tatataacgc attttatagt tatttttttt gtcatggatc
     1741 acctgtaaat atcataagat agggttaatt tgattgaata ttaattttat gattggttgt
     1801 ctttcctgtt cattttcttt tgtatttacc actgagaaaa aagttggcac cattggccca
     1861 taaattagaa aaaaaataat ttcctccaaa taaggtatgt atcaattggt acatataatt
     1921 taaaactaag taagtcttat aatttatcat attaggtctt taataaatca cctcagcgtg
     1981 caacatttga gcatagcatt tttgtaactt ttttttttca ctaccaaata gtgtacaaga
     2041 aaacaattta gaataaacct tttctttggt gagcataaag tgttggtatt ggaggcgatt
     2101 cagagtaaac ctttgactaa gctatgatgt tattactgtc ggatgctatg tggttttggc
     2161 accagactgg gatggttttc cagatgaaca ctttggtcta ctttagataa tctaaactgg
     2221 ccatttaaat actctgtatt actgtgtctg tagtccatgt taatggaaat atcactctta
     2281 aataaatgat aagcagtaag taaatacatt gataaaatcc tttcttcact ttaaaatgct
     2341 ttttcatggt catatatcac tgatatccca ctctgaagaa atttacatgg agatttactt
     2401 tttaaaacat atgtaatcaa tcataaatga aatataattt taaggctcaa taaataatcc
     2461 ttaatgaaat ctcatttagt gactactaag ataaattctt taataagtaa ttttattgtc
     2521 atataattta tgcattataa gctctatcca tttaaactgt ataatttgat gagttttgac
     2581 agttgcatac acccatgaaa ccaccatacc tatgtagaag tagatggttt ccaccatccc
     2641 aaagtgcttc tttgttccct tttataatcc cattgtgccc tggaccaaga tgtccactga
     2701 tctgttttac atttctaaat gttagctttt tcttttcctg accttttata caaatgttat
     2761 cctatagtat atacttttgt gtctgacttt cttctcaagt aaatattttt cagtg
//
