LOCUS       NM_001419153            1594 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus vaccinia related kinase 3 (Vrk3), transcript variant
            2, mRNA.
ACCESSION   NM_001419153
VERSION     NM_001419153.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Eltokhi,A., Santuy,A., Merchan-Perez,A. and Sprengel,R.
  TITLE     Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations
            in Schizophrenia and Autism Spectrum Disorder: Evidence from Human
            and Rodent Studies
  JOURNAL   Int J Mol Sci 22 (1), 59 (2020)
   PUBMED   33374598
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Kang,M.S., Choi,T.Y., Ryu,H.G., Lee,D., Lee,S.H., Choi,S.Y. and
            Kim,K.T.
  TITLE     Autism-like behavior caused by deletion of vaccinia-related kinase
            3 is improved by TrkB stimulation
  JOURNAL   J Exp Med 214 (10), 2947-2966 (2017)
   PUBMED   28899869
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Park,N., Song,J., Jeong,S., Thi Tran,T., Ko,H.W. and Kim,E.Y.
  TITLE     Vaccinia-related kinase 3 (VRK3) sets the circadian period and
            amplitude by affecting the subcellular localization of clock
            proteins in mammalian cells
  JOURNAL   Biochem Biophys Res Commun 487 (2), 320-326 (2017)
   PUBMED   28412365
  REMARK    GeneRIF: Finally, downregulation of hvrk3 using siRNA reduced the
            amplitude and lengthened the period of the cellular bioluminescence
            rhythm. Taken together, these data suggest that VRK3 plays a role
            in setting the amplitude and period length of circadian rhythms in
            mammalian cells.
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Song,H., Kim,W., Choi,J.H., Kim,S.H., Lee,D., Park,C.H., Kim,S.,
            Kim,D.Y. and Kim,K.T.
  TITLE     Stress-induced nuclear translocation of CDK5 suppresses neuronal
            death by downregulating ERK activation via VRK3 phosphorylation
  JOURNAL   Sci Rep 6, 28634 (2016)
   PUBMED   27346674
  REMARK    GeneRIF: Stress-induced nuclear translocation of CDK5 suppresses
            neuronal death by downregulating ERK activation via VRK3
            phosphorylation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Vega,F.M., Gonzalo,P., Gaspar,M.L. and Lazo,P.A.
  TITLE     Expression of the VRK (vaccinia-related kinase) gene family of p53
            regulators in murine hematopoietic development
  JOURNAL   FEBS Lett 544 (1-3), 176-180 (2003)
   PUBMED   12782311
  REMARK    GeneRIF: VRK genes play a role during embryonic development of
            hematopoiesis
REFERENCE   8  (bases 1 to 1594)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1594)
  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
            Varki,A.
  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
            signaling molecule that can interact with SHP-1 and SHP-2 and is
            expressed by tissue macrophages, including brain microglia
  JOURNAL   J Biol Chem 277 (27), 24466-24474 (2002)
   PUBMED   11986327
REFERENCE   10 (bases 1 to 1594)
  AUTHORS   Rennie,P.S., Bruchovsky,N., Akakura,K., Goldenberg,S.L., Otal,N.,
            Akakura,S., Wong,P. and Tenniswood,M.
  TITLE     Effect of tumour progression on the androgenic regulation of the
            androgen receptor, TRPM-2 and YPT1 genes in the Shionogi carcinoma
  JOURNAL   J Steroid Biochem Mol Biol 50 (1-2), 31-40 (1994)
   PUBMED   8049130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150895.2 and AC158231.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.10721864.1,
                                           SRR17253014.185538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC150895.2         21895-21921         c
            28-89               AC150895.2         18370-18431         c
            90-229              AC150895.2         16591-16730         c
            230-379             AC150895.2         12651-12800         c
            380-574             AC150895.2         10652-10846         c
            575-639             AC150895.2         9604-9668           c
            640-706             AC150895.2         7489-7555           c
            707-791             AC150895.2         6337-6421           c
            792-897             AC150895.2         5658-5763           c
            898-990             AC150895.2         3332-3424           c
            991-1123            AC150895.2         1971-2103           c
            1124-1244           AC150895.2         893-1013            c
            1245-1303           AC158231.2         43563-43621
            1304-1594           AC158231.2         49921-50211
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.9 cM"
     gene            1..1594
                     /gene="Vrk3"
                     /note="vaccinia related kinase 3"
                     /db_xref="GeneID:101568"
                     /db_xref="MGI:MGI:2182465"
     exon            1..27
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            28..89
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            90..229
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1329
                     /gene="Vrk3"
                     /EC_number="2.7.11.22"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serine/threonine-protein kinase VRK3; inactive
                     serine/threonine-protein kinase VRK3;
                     serine/threonine-protein pseudokinase VRK3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase VRK3 isoform 2"
                     /protein_id="NP_001406082.1"
                     /db_xref="GeneID:101568"
                     /db_xref="MGI:MGI:2182465"
                     /translation="MISFCPVCGKSVKVSFKFCPYCGKALPVEEDGGTQSAVTPHVSS
                     VPGSRRDLNSSFETSPKKVKCSHTVTSLPLSRHSDCDSSGSDNTLTSPDRATGTRSRP
                     LTPKGSPLSNRQSPQTLKRTRVTTSLQALATGTELTDQNGKHWTLGALQIRDDQGILY
                     EAEPTSAVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFLLPLL
                     AIPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYL
                     HENEYVHGNLTAENVFVNPEDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPHDGDLE
                     FISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPER
                     LVGLCGRWNKASELPTCSLK"
     exon            230..379
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            380..574
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..639
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..706
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..791
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            792..897
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            898..990
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1123
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1244
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1303
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1594
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtttct gcggggcaac tgtaaaggct ggtgtcgaga tggagtgtct aacccagtaa
       61 tccaaggacc agaccccgag gccacaaagc atgatctcct tctgtccagt ctgtggcaaa
      121 agtgtcaagg tatcattcaa gttctgccct tactgtggca aggccctgcc tgtagaggag
      181 gatggaggca cccagtctgc cgtgacgcct catgtgtcat ccgttccagg ctccaggaga
      241 gacctgaact ccagttttga aacctctccc aagaaagtga aatgctcaca cactgtcact
      301 tctctcccac tctcccgcca ctctgactgt gacagttctg ggtcagacaa caccttgact
      361 tctcctgaca gggccacagg cacccggagc agacccctga cccccaaagg cagcccactt
      421 tccaacaggc agagccctca gactctgaag cggacccggg tgaccacctc actccaggct
      481 ctagccacag gaacagagct gacagaccag aatgggaaac actggaccct gggggccctg
      541 cagatccggg atgaccaagg cattctctat gaagctgagc ctacttctgc cgtcccctct
      601 gaatcaagga cccagaagtg gagattctca ctcaaactgg actccaagga tgggcgcctt
      661 ttcaatgagc agaacttctt tcagagagta gccaagcctc tgcaagtgaa caaatggaag
      721 aagcagttct tgctcccgct cctggccatc cccacctgta tcggctttgg cattcaccag
      781 gacaagtaca ggttcctagt attccccagc ctggggagga gccttcagtc agccctggat
      841 gacaacccaa agcatgtggt atcagagaga tgtgtgcttc aggtggcctg caggctgctg
      901 gatgctctgg agtatctcca tgaaaatgag tatgttcacg ggaacctgac agctgagaat
      961 gtctttgtga atccagagga tctgagccag gtgaccctgg tgggctatgg cttcacctac
     1021 cgatactgcc caggtggcaa acacgtggcc tacaaagaag gcagcaggag tccacacgat
     1081 ggggacttgg agttcattag catggacctg cacaagggat gcggaccctc ccgccgcagc
     1141 gatctccaga ccttgggcta ctgtatgctc aagtggcttt atgggtccct gccatggaca
     1201 aattgccttc ccaacaccga aaagataact aggcagaagc agaagtatct ggacagcccc
     1261 gagcgcctcg tgggactgtg tggccgctgg aacaaggcct cagagcttcc gacttgcagc
     1321 ttgaagtaga acatgaagta gtgtgactgg aggcctgttt gaactcatag ctcctaaaag
     1381 aatcccttga atgtgcattc tcaccgctcc cttaggacat atgaatcagc acttgtgttg
     1441 gggaacctga gtcatgtcat gtaatgtgaa actcctccct gtctcagctc tggcagctgt
     1501 ggatggaggt aagtggatgc tggcggcggc ggcggcagca gccactccac tccctatggc
     1561 atttctgtga tggcataata aactgttttt aatc
//
