LOCUS       NM_027260               1906 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus vaccinia related kinase 2 (Vrk2), transcript variant
            1, mRNA.
ACCESSION   NM_027260 XM_904115
VERSION     NM_027260.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Yin,M.Y., Guo,L., Zhao,L.J., Zhang,C., Liu,W.P., Zhang,C.Y.,
            Huo,J.H., Wang,L., Li,S.W., Zheng,C.B., Xiao,X., Li,M., Wang,C. and
            Chang,H.
  TITLE     Reduced Vrk2 expression is associated with higher risk of
            depression in humans and mediates depressive-like behaviors in mice
  JOURNAL   BMC Med 21 (1), 256 (2023)
   PUBMED   37452335
  REMARK    GeneRIF: Reduced Vrk2 expression is associated with higher risk of
            depression in humans and mediates depressive-like behaviors in
            mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Chen,J., Qiao,K., Zhang,C., Zhou,X., Du,Q., Deng,Y. and Cao,L.
  TITLE     VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating
            IKKbeta in pancreatic cancer
  JOURNAL   Int J Biol Sci 18 (3), 1288-1302 (2022)
   PUBMED   35173553
  REMARK    GeneRIF: VRK2 activates TNFalpha/NF-kappaB signaling by
            phosphorylating IKKbeta in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   He,W.R., Cao,L.B., Yang,Y.L., Hua,D., Hu,M.M. and Shu,H.B.
  TITLE     VRK2 is involved in the innate antiviral response by promoting
            mitostress-induced mtDNA release
  JOURNAL   Cell Mol Immunol 18 (5), 1186-1196 (2021)
   PUBMED   33785841
  REMARK    GeneRIF: VRK2 is involved in the innate antiviral response by
            promoting mitostress-induced mtDNA release.
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Almarzooq,S., Kwon,J., Willis,A., Craig,J. and Morris,B.J.
  TITLE     Novel alternatively-spliced exons of the VRK2 gene in mouse brain
            and microglial cells
  JOURNAL   Mol Biol Rep 47 (7), 5127-5136 (2020)
   PUBMED   32583282
  REMARK    GeneRIF: Novel alternatively-spliced exons of the VRK2 gene in
            mouse brain and microglial cells.
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Wang,S., Yehya,N., Schadt,E.E., Wang,H., Drake,T.A. and Lusis,A.J.
  TITLE     Genetic and genomic analysis of a fat mass trait with complex
            inheritance reveals marked sex specificity
  JOURNAL   PLoS Genet 2 (2), e15 (2006)
   PUBMED   16462940
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Vega,F.M., Gonzalo,P., Gaspar,M.L. and Lazo,P.A.
  TITLE     Expression of the VRK (vaccinia-related kinase) gene family of p53
            regulators in murine hematopoietic development
  JOURNAL   FEBS Lett 544 (1-3), 176-180 (2003)
   PUBMED   12782311
  REMARK    GeneRIF: VRK genes play a role during embryonic development of
            hematopoiesis
REFERENCE   10 (bases 1 to 1906)
  AUTHORS   Agoulnik,A.I., Lu,B., Zhu,Q., Truong,C., Ty,M.T., Arango,N.,
            Chada,K.K. and Bishop,C.E.
  TITLE     A novel gene, Pog, is necessary for primordial germ cell
            proliferation in the mouse and underlies the germ cell deficient
            mutation, gcd
  JOURNAL   Hum Mol Genet 11 (24), 3047-3053 (2002)
   PUBMED   12417526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB852723.1, AF513620.1 and BE984366.1.
            
            On Nov 15, 2007 this sequence version replaced NM_027260.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154485.1, AK012664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               BB852723.1         3-451
            450-1870            AF513620.1         114-1534
            1871-1906           BE984366.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 15.94 cM"
     gene            1..1906
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /note="vaccinia related kinase 2"
                     /db_xref="GeneID:69922"
                     /db_xref="MGI:MGI:1917172"
     exon            1..331
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..472
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1848
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase VRK2; vaccinia virus BIR
                     kinase related kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase VRK2 isoform 1"
                     /protein_id="NP_081536.2"
                     /db_xref="CCDS:CCDS24486.1"
                     /db_xref="GeneID:69922"
                     /db_xref="MGI:MGI:1917172"
                     /translation="MAPRRKEKYKLPVPLPEGKILDDMEGNRWALGKMIGSGGFGLIY
                     LAFPTNKPNKDARHVIKLEYQENGPLFSELKFYQRAAKRECIQKWIQQRKLDYLGIPV
                     FYGFGLTDFKGRSYRFMVMERLGIDLQKLLDQNGGFKKLTVLQLGIRMLDVLEYIHEN
                     EYVHGDIKAANLLLDFTNPDRVYLADYGLSYRYCPNGNHKQYQEDPRKGHNGTIEFTS
                     LDAHKGVAPSRRSDVEILGYCMLHWLFGKLPWEAKLDDPVAVQTAKTNLLDELPESVL
                     KWAPSGSSCSELVKYLMYVHNLAYDDKPDYQKLKKILNPDGVPLGPLEFSTKVQSVHV
                     RTPAQQKVDSPKATRKPANEFPAKFPKKVHRETRARQREEQEDSQPTMLQSRPAAPEN
                     SRTRKIHEYSDIFSEMQSLQQTPSYMSFQGSYCKPYLDCTRRDPIRKPRSLPRYRHTP
                     TGNLGVTDLESSPRFWPAIFQLTLSEETKADVYYYGITIFCLLIFVFLALYFL"
     exon            473..522
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            523..592
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            593..680
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..786
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..879
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1012
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1133
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1192
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1359
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1506
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1892
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1892
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcagaactg gtacaggaag ggttcagttc ttctgtaagc gctggcccag tttactaccc
       61 ccaggttaat ctgcaggctc ttcagacagg ccttggcagg gtccggtgct tggaaactct
      121 aaccctctct ctcggtaccg cccctccacc gctgcagcct ctgccactgg gcggcctctg
      181 ccactgggcg gcctccgcca gactctgggg ctcccagggc tggctgccgg gaggcggccc
      241 acaggctcgc ccggcccctg ggaggagccc ggagaggccc acctggctgc gaggccttag
      301 gagaccagcg ctgtggggac tccggcggca gatgtgatgg caccaagaag aaaagagaaa
      361 tataagcttc cggttccact cccagaaggc aaaattctgg atgatatgga aggaaaccgg
      421 tgggcactgg gcaagatgat cggctctgga gggtttggac tgatatactt agctttcccc
      481 acaaataaac caaacaaaga tgcaagacat gtcataaagc tggagtatca agaaaatggc
      541 ccattatttt cagagcttaa attttatcag agagctgcaa aaagagaatg tatccaaaag
      601 tggatacaac agaggaaact tgattattta ggaattcctg tattttatgg atttggtctg
      661 actgatttca aaggaagaag ttacagattc atggtaatgg aaagacttgg aatagattta
      721 cagaaactcc tggaccagaa tggtggtttt aaaaaattaa ccgtcctaca acttggcatc
      781 aggatgctgg atgtactgga atatatacat gaaaatgagt atgttcatgg tgatataaaa
      841 gccgcaaatc tactgttgga ttttacaaat ccagaccggg tttatcttgc agactatgga
      901 ctttcctaca gatattgtcc caatgggaac cacaaacagt atcaggaaga tcccagaaag
      961 ggccataatg ggacaataga gtttacaagt ttggatgcac acaaaggagt ggccccgtcc
     1021 aggaggagtg atgttgaaat ccttggttac tgcatgctgc actggctctt cgggaagctt
     1081 ccttgggaag caaagctgga cgaccctgtg gctgtccaga ctgctaaaac caacctgctg
     1141 gatgaactcc cagagtcggt gcttaagtgg gctccttctg gaagcagttg cagtgaactt
     1201 gtcaagtact tgatgtatgt tcataattta gcttatgatg acaagccaga ctatcagaag
     1261 ctcaagaaaa ttttgaatcc agatggagta cctttagggc cactggaatt ttccactaaa
     1321 gtacagagtg tccatgtgcg gactccagcc caacaaaaag ttgattcacc aaaggctaca
     1381 agaaaaccag ccaatgagtt cccagctaag ttcccaaaga aagtccacag ggagacaaga
     1441 gcaaggcaga gagaggagca ggaagacagc cagcccacaa tgctgcagag caggccggca
     1501 gcaccggaaa actcaaggac aaggaaaata catgaatatt ctgatatttt cagtgagatg
     1561 cagagtcttc aacaaacacc cagctatatg agtttccaag gttcatattg caagccctat
     1621 ctggactgca ctagaagaga tcccatcagg aagccaagat ccctgcctcg gtacagacac
     1681 acgcccacgg gtaatctggg agtcacagac ttggaaagtt ctccaaggtt ttggcctgca
     1741 atttttcagt tgactctgag tgaagagaca aaggcagatg tgtattacta tgggatcact
     1801 atattctgtc tgctgatatt tgtatttctt gctttgtatt ttctctgaag tcatcaaata
     1861 aattggtttt tgcttttgtt tttattttta aaaaaaaaaa aaaaaa
//
