LOCUS       NP_081536                503 aa            linear   ROD 28-APR-2025
DEFINITION  serine/threonine-protein kinase VRK2 isoform 1 [Mus musculus].
ACCESSION   NP_081536 XP_909208
VERSION     NP_081536.2
DBSOURCE    REFSEQ: accession NM_027260.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Yin,M.Y., Guo,L., Zhao,L.J., Zhang,C., Liu,W.P., Zhang,C.Y.,
            Huo,J.H., Wang,L., Li,S.W., Zheng,C.B., Xiao,X., Li,M., Wang,C. and
            Chang,H.
  TITLE     Reduced Vrk2 expression is associated with higher risk of
            depression in humans and mediates depressive-like behaviors in mice
  JOURNAL   BMC Med 21 (1), 256 (2023)
   PUBMED   37452335
  REMARK    GeneRIF: Reduced Vrk2 expression is associated with higher risk of
            depression in humans and mediates depressive-like behaviors in
            mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Chen,J., Qiao,K., Zhang,C., Zhou,X., Du,Q., Deng,Y. and Cao,L.
  TITLE     VRK2 activates TNFalpha/NF-kappaB signaling by phosphorylating
            IKKbeta in pancreatic cancer
  JOURNAL   Int J Biol Sci 18 (3), 1288-1302 (2022)
   PUBMED   35173553
  REMARK    GeneRIF: VRK2 activates TNFalpha/NF-kappaB signaling by
            phosphorylating IKKbeta in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   He,W.R., Cao,L.B., Yang,Y.L., Hua,D., Hu,M.M. and Shu,H.B.
  TITLE     VRK2 is involved in the innate antiviral response by promoting
            mitostress-induced mtDNA release
  JOURNAL   Cell Mol Immunol 18 (5), 1186-1196 (2021)
   PUBMED   33785841
  REMARK    GeneRIF: VRK2 is involved in the innate antiviral response by
            promoting mitostress-induced mtDNA release.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Almarzooq,S., Kwon,J., Willis,A., Craig,J. and Morris,B.J.
  TITLE     Novel alternatively-spliced exons of the VRK2 gene in mouse brain
            and microglial cells
  JOURNAL   Mol Biol Rep 47 (7), 5127-5136 (2020)
   PUBMED   32583282
  REMARK    GeneRIF: Novel alternatively-spliced exons of the VRK2 gene in
            mouse brain and microglial cells.
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Wang,S., Yehya,N., Schadt,E.E., Wang,H., Drake,T.A. and Lusis,A.J.
  TITLE     Genetic and genomic analysis of a fat mass trait with complex
            inheritance reveals marked sex specificity
  JOURNAL   PLoS Genet 2 (2), e15 (2006)
   PUBMED   16462940
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Vega,F.M., Gonzalo,P., Gaspar,M.L. and Lazo,P.A.
  TITLE     Expression of the VRK (vaccinia-related kinase) gene family of p53
            regulators in murine hematopoietic development
  JOURNAL   FEBS Lett 544 (1-3), 176-180 (2003)
   PUBMED   12782311
  REMARK    GeneRIF: VRK genes play a role during embryonic development of
            hematopoiesis
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Agoulnik,A.I., Lu,B., Zhu,Q., Truong,C., Ty,M.T., Arango,N.,
            Chada,K.K. and Bishop,C.E.
  TITLE     A novel gene, Pog, is necessary for primordial germ cell
            proliferation in the mouse and underlies the germ cell deficient
            mutation, gcd
  JOURNAL   Hum Mol Genet 11 (24), 3047-3053 (2002)
   PUBMED   12417526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB852723.1, AF513620.1 and BE984366.1.
            
            On Nov 15, 2007 this sequence version replaced NP_081536.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154485.1, AK012664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 15.94 cM"
     Protein         1..503
                     /product="serine/threonine-protein kinase VRK2 isoform 1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase VRK2; vaccinia
                     virus BIR kinase related kinase 2"
                     /calculated_mol_wt=57988
     Region          16..314
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(35..38,41,43,59,61,101,121..124,166,170..171,173,
                     185..186)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          334..353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN21.2)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q86Y07; propagated from
                     UniProtKB/Swiss-Prot (Q8BN21.2)"
     Region          362..395
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN21.2)"
     Region          392..503
                     /region_name="Interaction with MAP3K7.
                     /evidence=ECO:0000250|UniProtKB:Q86Y07"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN21.2)"
     Site            482..502
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN21.2)"
     CDS             1..503
                     /gene="Vrk2"
                     /gene_synonym="2810003O05Rik"
                     /coded_by="NM_027260.3:337..1848"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24486.1"
                     /db_xref="GeneID:69922"
                     /db_xref="MGI:MGI:1917172"
ORIGIN      
        1 maprrkekyk lpvplpegki lddmegnrwa lgkmigsggf gliylafptn kpnkdarhvi
       61 kleyqengpl fselkfyqra akreciqkwi qqrkldylgi pvfygfgltd fkgrsyrfmv
      121 merlgidlqk lldqnggfkk ltvlqlgirm ldvleyihen eyvhgdikaa nllldftnpd
      181 rvyladygls yrycpngnhk qyqedprkgh ngtieftsld ahkgvapsrr sdveilgycm
      241 lhwlfgklpw eaklddpvav qtaktnllde lpesvlkwap sgsscselvk ylmyvhnlay
      301 ddkpdyqklk kilnpdgvpl gplefstkvq svhvrtpaqq kvdspkatrk panefpakfp
      361 kkvhretrar qreeqedsqp tmlqsrpaap ensrtrkihe ysdifsemqs lqqtpsymsf
      421 qgsyckpyld ctrrdpirkp rslpryrhtp tgnlgvtdle ssprfwpaif qltlseetka
      481 dvyyygitif cllifvflal yfl
//
