LOCUS       NM_001029844            3680 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus vaccinia related kinase 1 (Vrk1), transcript variant
            3, mRNA.
ACCESSION   NM_001029844
VERSION     NM_001029844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Fan,Z., Wang,X., Cheng,H. and Pan,M.
  TITLE     VRK1 promotes DNA-induced type I interferon production
  JOURNAL   Mol Biol Rep 51 (1), 453 (2024)
   PUBMED   38536553
  REMARK    GeneRIF: VRK1 promotes DNA-induced type I interferon production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Garcia-Gonzalez,R., Morejon-Garcia,P., Campillo-Marcos,I.,
            Salzano,M. and Lazo,P.A.
  TITLE     VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16
            Acetylation in Response to DNA Damage
  JOURNAL   Cancers (Basel) 12 (10), 2986 (2020)
   PUBMED   33076429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Liu,T., Zuo,L., Guo,D., Chai,X., Xu,J., Cui,Z., Wang,Z. and Hou,C.
  TITLE     Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer
            cells by activating VRK1/P53BP1 pathway
  JOURNAL   Biomed Pharmacother 120, 109483 (2019)
   PUBMED   31629252
  REMARK    GeneRIF: Ginsenoside Rg3 upregulate VRK1 expression and P53BP1 foci
            formation in response to DNA damage.
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Boyle,K.A. and Traktman,P.
  TITLE     Members of a novel family of mammalian protein kinases complement
            the DNA-negative phenotype of a vaccinia virus ts mutant defective
            in the B1 kinase
  JOURNAL   J Virol 78 (4), 1992-2005 (2004)
   PUBMED   14747564
  REMARK    GeneRIF: can perform the functions of B1 kinase required for
            vaccinia virus genome replication, most likely due to overlapping
            specificity for cellular and/or viral substrates
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Vega,F.M., Gonzalo,P., Gaspar,M.L. and Lazo,P.A.
  TITLE     Expression of the VRK (vaccinia-related kinase) gene family of p53
            regulators in murine hematopoietic development
  JOURNAL   FEBS Lett 544 (1-3), 176-180 (2003)
   PUBMED   12782311
  REMARK    GeneRIF: VRK genes play a role during embryonic development of
            hematopoiesis
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Zelko,I., Kobayashi,R., Honkakoski,P. and Negishi,M.
  TITLE     Molecular cloning and characterization of a novel nuclear protein
            kinase in mice
  JOURNAL   Arch Biochem Biophys 352 (1), 31-36 (1998)
   PUBMED   9521809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY130767.1, AK032344.1 and AV567830.1.
            
            On Jun 15, 2018 this sequence version replaced NM_001029844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3016441.1,
                                           SRR17784643.244425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY130767.1         1-29
            30-1260             AK032344.1         1-1231
            1261-3664           AK032344.1         1292-3695
            3665-3680           AV567830.1         78-93
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 56.37 cM"
     gene            1..3680
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="vaccinia related kinase 1"
                     /db_xref="GeneID:22367"
                     /db_xref="MGI:MGI:1261847"
     exon            1..96
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            97..261
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1292
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /EC_number="2.7.11.1"
                     /note="isoform c is encoded by transcript variant 3;
                     serine/threonine-protein kinase VRK1;
                     serine/threonine-protein kinase 51PK"
                     /codon_start=1
                     /product="serine/threonine-protein kinase VRK1 isoform c"
                     /protein_id="NP_001025015.1"
                     /db_xref="CCDS:CCDS26158.1"
                     /db_xref="GeneID:22367"
                     /db_xref="MGI:MGI:1261847"
                     /translation="MPRVKAAQAGRPGPAKRRLAEQFAAGEVLTDMSRKEWKLGLPIG
                     QGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT
                     HKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR
                     ILDILEYIHEHEYVHGDIKASNLLLSHKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPK
                     RCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKI
                     RYRDNVAALMEKCFPEKNKPGEIAKYMESVKLLEYTEKPLYQNLRDILLQGLKAIGSK
                     DDGKLDFSAVENGSVKTRPASKKRKKEAEESAVCAVEDMECSDTQVQEAAQTRSRTRK
                     KAQK"
     exon            262..317
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            318..387
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            388..475
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            476..584
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            585..677
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            678..810
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            932..990
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1169
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1260
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3680
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1428..1433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="hexamer: ATTAAA"
     polyA_site      1454
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="major polyA site"
     regulatory      1630..1635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="major polyA site"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="hexamer: GATAAA"
     polyA_site      2865
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
                     /note="hexamer: CATAAA"
     polyA_site      3680
                     /gene="Vrk1"
                     /gene_synonym="51PK; Gm40568; Gm46378"
ORIGIN      
        1 ggggtgtgga ggggacggcg ccgtgggtag gtcgcgagtc tagggaagcg gcgggaagtt
       61 cgtactacgc tgtggaccgc gagttggccg ctctggtgaa gatgccccgt gtaaaagcag
      121 ctcaggctgg aagacccgga cctgcgaaga ggcgcctcgc agagcagttt gccgctggag
      181 aggtcctaac cgacatgtct aggaaggagt ggaaactagg attgcccatt ggccaaggtg
      241 gctttggctg catctatctg gcggacacaa attcttccaa accggttggc agtgacgcgc
      301 cctgtgttgt gaaagtggaa cccagtgaca atggacctct tttcacggaa ttaaagttct
      361 accagagggc tgctaaacca gagcaaattc agaaatggat tcgtacacat aaattgaagt
      421 accttggtgt tcctaagtat tggggatctg gtctacatga taaaaatgga aaaagttaca
      481 ggtttatgat aatggaccgc tttgggagtg accttcagaa aatatatgaa gcaaatgcca
      541 aaaggttttc tcggaaaact gtattgcagc taagcttaag aattctggat atcctggagt
      601 acatccatga gcatgagtac gtgcacgggg acatcaaggc ctccaacctg ctcctgagtc
      661 acaagaaccc tgaccaggta tatttggtag actatggcct tgcttatcgg tactgcccag
      721 atggagttca taaagagtac aaggaagatc ccaaaaggtg ccatgacggc accctggagt
      781 tcaccagcat cgacgctcac aaaggcgtgg ccccatcaag acgtggtgat ttggaaatac
      841 ttggttattg catgatccag tggctcagcg gctgtcttcc ttgggaagat aacttgaaag
      901 atcctaacta cgttagggat tccaaaatta gatacagaga caacgtcgca gctttgatgg
      961 agaaatgctt tcctgagaaa aataagccag gtgagatcgc taagtacatg gagtctgtga
     1021 aactactgga atacaccgaa aaacctctct atcaaaacct acgtgatatc cttttacaag
     1081 gactaaaagc tataggaagt aaagacgacg gcaaactgga ttttagtgct gtggagaacg
     1141 gaagtgtgaa gacaagacca gcctcaaaga agcggaagaa agaagcagaa gaaagcgcgg
     1201 tgtgcgctgt ggaggacatg gagtgctcag acacacaggt gcaagaggcc gcacagaccc
     1261 gttcacgaac cagaaagaaa gcccagaagt aaacgagatt ccaggaacca tcttctctgc
     1321 ctattcattt gatttttttt ctccttttct gatttctgtt ttattttcat gtgagtcttc
     1381 tggggtgtta gtaataattg agtggctatt ttttaaaaaa acactttatt aaaatgaatt
     1441 ttttgtgtac tttactgaag ggtaatttat aaaattctga atctttagtc gtcataaccc
     1501 atgtggtctg gggctcaggc tgctgtgcga ttcccagact ggacagagtg ctcagcaggc
     1561 tccttgcttt taaggaatga agaaccttta ggtctctttt gctcgatgta gtatacaagt
     1621 cgttgtgaca ataaagtctg gtctacatgg attccggtct tttacacaag cgtttattga
     1681 atgcgtgctg tgtgcactaa ggaagaaaga gcacagtaag gtatggcctg tctgagagca
     1741 gccccacagt ctaaagtcag aagcaaggat gagaagcggc agggtgccct tcaggggagt
     1801 cctgtcagta gggggcagag cctcccccac ttagattttt tgtttttata agtttattta
     1861 agagaaatga taatttgtaa aactcaagtt ctctagagat gtttgttttt gttttttgtt
     1921 ttgttttggc ttttggggat ttgttttttt ggttttctca gtctgacttg tatagaccaa
     1981 gtgttctcaa actcctggcc tgcctgtgtc tgcctcccaa aggcagtagc tgagggattg
     2041 cggctatgct ctgcacgaga gcagaagtga ttacagtctg tatgacatcc tagctgcaga
     2101 ggttacatgc accccacact agctgcagat atgatagctg tgcaccccat attagctaca
     2161 ggggttacag ctgtgcacct tgcactacct ggagatattg caggctcaca cctcacacta
     2221 gaagcaggga ttatcatgtg taccccttac acatggttgg aaaacaagat acacagagta
     2281 ttttccaact cttttggaaa taaagctcag aaaatttagc atgtttatga acaatttcaa
     2341 gagaccttcc tcaaaaatta ctcttagagc aatcagggtt gggcaaatgg gtaagcaagt
     2401 tggctgctgg caccgtgtgt attgtgtttt tgggcagccg tggtgtgttc agaatatacc
     2461 tcacacggcc taggacaggc ctgaagtcgt cacctcagta cttaagagac tggttgcttt
     2521 gaagacagtt ctgtgtaaac cattgtgtga tggacaggag cagcaactgt gactggctcc
     2581 gcccgtggac tgttgagtca tcacgtgacg tggaataagg cgcagtcaga agcggatcga
     2641 gctgcgctgt ggccccagag gctacttttc tcagcgtccc agacttcccg tgggccctag
     2701 gagaaggggc ctagagactt ctgtttcctt tagaatatag gggggttgta gtacagagta
     2761 gtgtgtcggt tggtcccaag tgtatttgtg acacctaaaa tcaactccca agttctgttt
     2821 taaacatatt cctgcttaaa ataggataaa atgtgtgtga tacggttttg tctgtatact
     2881 gtagcctttt tttaaaattt ttttaaaaca caaaacagca caacctgttg gttaaatatt
     2941 aagaaaacaa atatttcctc acatattgtt ttaaacaagt gctgacattt tctcaaatgt
     3001 tactatattg gcagggctac ataaattagt taaaagctac tagccagcag tagcctggtt
     3061 ggtcgtcagc tgggctcctt gttctgctgc gttttcagtc cctacggagg gagcgtggtt
     3121 cttcctgggc cagccgcggc agcgcccaca gttgttgctg atttctgccc tttgcagttc
     3181 catgagttta tcttcttgcc agttcctgag cgagtgtgct tgcatccgct cttctccctc
     3241 gtcatggtgg tgcccttcct gacctgatgt gctctgactc ttctgtcagg cacagggtcc
     3301 agcaatggta accagcagcc cagctctcca tgttctccga tggcggtggt ttcttaagac
     3361 aacaccatta aaccagagcc ataaacacac tcattttctt gaactgctga gttagctgtg
     3421 cccatataga ctgaagttgc atagcatggc ctcagtgtgc cctttgtctc cgtgtgcccg
     3481 ggtacataag ctgtagagta ttgtattttt gtttttaata tgtattatga ctgggggttt
     3541 ttaataatac actgcccttg ttgaagattt aaaagataca gaaagatgtt gtaactacca
     3601 ctctcagcac atagttcata gtcacacttt gtattttata ctttatttta aagcttcata
     3661 aaccactcca cgatctcttc
//
