LOCUS       NM_172620               3413 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus VPS52 GARP complex subunit (Vps52), transcript variant
            1, mRNA.
ACCESSION   NM_172620 XM_110209 XM_489781
VERSION     NM_172620.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3413)
  AUTHORS   Ibuchi,K., Fukaya,M., Shinohara,T., Hara,Y., Shiroshima,T.,
            Sugawara,T. and Sakagami,H.
  TITLE     The Vps52 subunit of the GARP and EARP complexes is a novel
            Arf6-interacting protein that negatively regulates neurite
            outgrowth of hippocampal neurons
  JOURNAL   Brain Res 1745, 146905 (2020)
   PUBMED   32473257
  REMARK    GeneRIF: The Vps52 subunit of the GARP and EARP complexes is a
            novel Arf6-interacting protein that negatively regulates neurite
            outgrowth of hippocampal neurons.
REFERENCE   2  (bases 1 to 3413)
  AUTHORS   Wei,J., Zhang,Y.Y., Luo,J., Wang,J.Q., Zhou,Y.X., Miao,H.H.,
            Shi,X.J., Qu,Y.X., Xu,J., Li,B.L. and Song,B.L.
  TITLE     The GARP Complex Is Involved in Intracellular Cholesterol Transport
            via Targeting NPC2 to Lysosomes
  JOURNAL   Cell Rep 19 (13), 2823-2835 (2017)
   PUBMED   28658628
REFERENCE   3  (bases 1 to 3413)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3413)
  AUTHORS   Schindler,C., Chen,Y., Pu,J., Guo,X. and Bonifacino,J.S.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   5  (bases 1 to 3413)
  AUTHORS   Sugimoto,M., Kondo,M., Hirose,M., Suzuki,M., Mekada,K., Abe,T.,
            Kiyonari,H., Ogura,A., Takagi,N., Artzt,K. and Abe,K.
  TITLE     Molecular identification of t(w5): Vps52 promotes pluripotential
            cell differentiation through cell-cell interactions
  JOURNAL   Cell Rep 2 (5), 1363-1374 (2012)
   PUBMED   23142660
  REMARK    GeneRIF: The Vps52 was responsible for the tw5 mutation, and
            revealed development-specific functions of this gene, which was
            formerly thought to be solely involved in retrograde endocytic
            transport.
REFERENCE   6  (bases 1 to 3413)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   7  (bases 1 to 3413)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   8  (bases 1 to 3413)
  AUTHORS   Walter,L. and Gunther,E.
  TITLE     Identification of a novel highly conserved gene in the centromeric
            part of the major histocompatibility complex
  JOURNAL   Genomics 52 (3), 298-304 (1998)
   PUBMED   9790748
REFERENCE   9  (bases 1 to 3413)
  AUTHORS   Vernet,C., Abe,K. and Artzt,K.
  TITLE     Genetic mapping of 10 microsatellites in the t complex region of
            mouse chromosome 17
  JOURNAL   Mamm Genome 9 (6), 472 (1998)
   PUBMED   9585437
REFERENCE   10 (bases 1 to 3413)
  AUTHORS   Artzt,K., McCormick,P. and Bennett,D.
  TITLE     Gene mapping within the T/t complex of the mouse. I. t-Lethal genes
            are nonallelic
  JOURNAL   Cell 28 (3), 463-470 (1982)
   PUBMED   7074682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5, AK052523.1, AK051732.1 and BE945926.1.
            
            On Oct 25, 2017 this sequence version replaced NM_172620.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051732.1, AK042520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                CR974462.5         48972-49053
            83-2848             AK052523.1         2-2767
            2849-3344           AK051732.1         2838-3333
            3345-3413           BE945926.1         1-69                c
FEATURES             Location/Qualifiers
     source          1..3413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..3413
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /note="VPS52 GARP complex subunit"
                     /db_xref="GeneID:224705"
                     /db_xref="MGI:MGI:1330304"
     exon            1..383
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2465
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacuolar protein sorting-associated protein 52 homolog;
                     vacuolar protein sorting 52"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 52
                     homolog isoform 1"
                     /protein_id="NP_766208.2"
                     /db_xref="CCDS:CCDS37574.1"
                     /db_xref="GeneID:224705"
                     /db_xref="MGI:MGI:1330304"
                     /translation="MAAAATMAAAARELVLRAGASDVEEEEGPLGGGSGLQEPLQLGE
                     LDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDY
                     IQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISSEIRTLQEQSGAMNIRLRN
                     RQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEAMGTA
                     ACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQAALLKYRFFYQFLLGN
                     ERATAKEIRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFS
                     KPSLRSRNTIFTLGTRGTVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDN
                     SCREYLFICEFFIVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIV
                     LRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHY
                     ITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLIN
                     NYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIE
                     RGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLI
                     QLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF"
     exon            384..468
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            469..521
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            522..597
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            598..665
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            666..841
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..992
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1093
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1226
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1284
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1418
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1574
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1693
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1817
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1913
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2021
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2087
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2199
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2318
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..3398
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /note="hexamer: AATAAT"
     polyA_site      2849
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
                     /note="major polyA site"
     polyA_site      3395
                     /gene="Vps52"
                     /gene_synonym="ARE1; D130068D18; D430041K17Rik; SAC2;
                     Sacm2l; tclw5"
ORIGIN      
        1 gggaccggag ctataacttc cggttcggcc ttctctgtcg tcgtaccgtt cttgtgtggg
       61 cgcggagcga aggttccgga acagagttgt gttcgagacg ttcaccttcc tgtttgcact
      121 tgaccgaaat gatcaaagcc taaccggaga ggctggagcc gatcgcctta gctcaaatat
      181 ctgggaccct tttttgctcc atagaagaca ttccaggact tgtagctttg cttcgggaaa
      241 cggactttct gagactgaca gctgccggaa gtcggaagtg aagctgcggg ggaatggcag
      301 ccgcagcgac catggcggcc gctgcccggg agctggtgtt gcgggctggg gcctcagatg
      361 tagaggagga ggagggcccg ctgggggggg gttctggact ccaagaaccc ctacaacttg
      421 gagagttgga catcacctct gatgaattca tcttggatga agtggatgtt cacatccagg
      481 caaacctgga ggatgagtta gtgaaggaag ctctcaaaac gggtgtggat cttcgacact
      541 attcaaagca ggtggagctg gagctgcagc agattgagca gaagtcaatc cgggactata
      601 tccaagagag tgaaaacata gcgtctctgc acaatcagat cacggcctgt gacgccgtcc
      661 tggagcgcat ggaacagatg ctgggagctt ttcagagcga tctcagctcc atcagctctg
      721 agatccgaac cctgcaggag cagtcggggg ccatgaacat ccgacttcgt aaccgacagg
      781 cagttcgggg gaaacttggg gaacttgtgg atgggctggt ggtgccctct gctctggtca
      841 cagcaattct ggaagctcca gtgaccgagc ccaggttcct ggagcagcta caggagctgg
      901 atgccaaggc agccgcggtg agagagcagg aggctatggg caccgctgcc tgtgctgacg
      961 tcagaggcgt gctggaccgg ctccgggtca aggcagtgac gaagatccgg gagtttattc
     1021 tccagaagat ctactccttc agaaagccca tgaccaacta ccagatcccc caggcggccc
     1081 tgctgaagta caggtttttc tatcagttcc tgctgggtaa tgagcgtgct acagccaagg
     1141 agatcaggga tgagtacgta gagacgctga gcaagatcta cctgtcctac taccgatcct
     1201 atgtggggcg gctcatgaaa gtgcagtacg aggaagttgc tgagaaagac gacctaatgg
     1261 gtgttgaaga cacagcaaag aaaggcttct tctcgaagcc gtccctccga agcaggaaca
     1321 ccatctttac ccttggcact cgtggtactg tcatctcacc ggccgagctg gaggccccca
     1381 tcctagtgcc ccatactgcc caacgtggag agcagaggta tccattcgaa gcgctcttcc
     1441 gcagccagca ctatgccctc ctcgacaatt cttgccgtga atatcttttc atctgtgaat
     1501 ttttcatcgt gtctggcccg gctgcacatg acctgttcca cgccgtcatg ggccgcacgc
     1561 tctccatgac gctgaaacac ctggagtcct acctggctga ctgctacgat gccattgctg
     1621 tttttctctg tatccacatt gttctccggt tccgcaacat tgcagcgaag agggacgtcc
     1681 ctgccctgga caggtactgg gagcaggtgc ttgccttgct gtggcctcgg tttgagctga
     1741 tcctggagat gaatgtccag agtgtccgca gcactgaccc ccagcgcctt gggggactgg
     1801 acactcggcc ccactatatc acacgccgct atgctgagtt ctcctctgca cttgtcagca
     1861 tcaaccagac gatccccaat gaacgcacgc tgcagctcct gggacagctc caggtggagg
     1921 tggagaattt tgtcctccga gtggctgcag agttctcctc caggaaggag cagcttgtgt
     1981 ttctgatcaa caactatgac atgatgctcg gggtgctgat ggagcgggct gctgatgaca
     2041 gcaaagaggt ggaaagtttc cagcagctgc tcaatgctcg gacacaggag ttcattgagg
     2101 agctgctgtc tccccccttc gggggtctgg tggcattcgt gaaggaggct gaagccttga
     2161 ttgagcgtgg gcaggctgag cggctccgag gggaggaagc ccgagtcact cagctgatcc
     2221 gtggctttgg tagttcctgg aaggcatcag tggagtccct gagtcaggat gtaatgcgaa
     2281 gttttaccaa cttccgaaat ggaaccagca tcatccaggg ggcgctgacc cagctgatcc
     2341 agctctacca tcgcttccac cgggtgctgt ctcagcccca gctccgcgca ctcccggcca
     2401 gggccgagct catcaacatc catcacctca tggtggagct gaagaaacac aagccgaact
     2461 tctgattcag acccccctcc cccgccccta agctcctgtg tactctgtgt gtcacacatt
     2521 ttcacctggg acccctttcc catccctttt atctctatgg cttccacact cccctctcag
     2581 cctccattgc caggactctg cctcaacaga gtgcgttcaa ggccactccc tgggtttctg
     2641 agtgaggtga ccttcatttc cagtccggtc agctcctctg ctgttcactc acagcctgtg
     2701 agcttccacc gccccaggct ctgactgacc ctcagctctt agggcagagc actgcaggcc
     2761 accctgtagc tgatctgtgg gctctgctgg aacagtgaca tcacctcgtg gtgggtctca
     2821 ctatgtggca ataataagta ctaacagtgc tgggaccgtg tcctctcctt tgtccctggg
     2881 cctctaaatt ctccagcatg tgtttattgt agacctagtc tgttcctggt gggcatcagg
     2941 aagagggtgt gatagtaccc caaggtctgt tgctgcttct ggcccagggg tggcatagat
     3001 gctcaggagg ggactgtttg tagctctcca ggagggtggc acttgtcgca aggcctggga
     3061 atgtggtagc tttgggtgct gtcctgaggg ataccatggg aatagtccac acagcctctg
     3121 agattgtgtc agccactaag tggctgttac agctcctttg aggatggagg gcctataaca
     3181 cctgcagcca tgcatcaagg caggggtgga cctggctcca aaacagatcc tgtcattttc
     3241 atgtgaccca gacccttccc gctgccctct gcctcacctc tgtaaggagt ttgcagactc
     3301 cagagcagtg gttctcaacc ttcctaatac tgcaacgctt taacacagtt ccttgtgctg
     3361 accccaacct taaagttatt ttcattgtta cttcataaaa aaaaaaaaaa aaa
//
