LOCUS       NM_001081041            2631 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus VPS51 GARP complex subunit (Vps51), mRNA.
ACCESSION   NM_001081041 XM_001004854
VERSION     NM_001081041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Wei,J., Zhang,Y.Y., Luo,J., Wang,J.Q., Zhou,Y.X., Miao,H.H.,
            Shi,X.J., Qu,Y.X., Xu,J., Li,B.L. and Song,B.L.
  TITLE     The GARP Complex Is Involved in Intracellular Cholesterol Transport
            via Targeting NPC2 to Lysosomes
  JOURNAL   Cell Rep 19 (13), 2823-2835 (2017)
   PUBMED   28658628
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Schindler,C., Chen,Y., Pu,J., Guo,X. and Bonifacino,J.S.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131692.5.
            
            On Feb 6, 2007 this sequence version replaced XM_001004854.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146211.1, AK137155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC131692.5         76648-76884
            238-367             AC131692.5         77343-77472
            368-514             AC131692.5         82127-82273
            515-734             AC131692.5         82350-82569
            735-1452            AC131692.5         82679-83396
            1453-1668           AC131692.5         83762-83977
            1669-1887           AC131692.5         84152-84370
            1888-2009           AC131692.5         84688-84809
            2010-2097           AC131692.5         84893-84980
            2098-2631           AC131692.5         85460-85993
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..2631
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /note="VPS51 GARP complex subunit"
                     /db_xref="GeneID:68505"
                     /db_xref="MGI:MGI:1915755"
     exon            1..237
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2358
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /note="protein fat-free homolog; vacuolar protein sorting
                     51 homolog"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 51
                     homolog"
                     /protein_id="NP_001074510.1"
                     /db_xref="CCDS:CCDS37894.1"
                     /db_xref="GeneID:68505"
                     /db_xref="MGI:MGI:1915755"
                     /translation="MAAAAAVGPGLGSGPGDSPEGPEADAPERRRKAHGMLKLYYGLS
                     EGEVAGHPAGPDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDS
                     DMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITNFSARISATLQDR
                     HERITKLAGVHALLRKLQFLFELPSRLTKCVELGAYGQAVRYQGRARAVLQQYQHLPS
                     FRAIQDDCQVITARLAQQLRQRFREGCSGAPEQAECVELLLALGEPAEELCEEFLAHA
                     RGRLEEELSSLEAELGPSPPAPDVLEFTDRGGNGFVGGLCQVAAAYQELFAAQGPAGA
                     EKLAAFAQELGGRYFALVERRLAQEQGGSDNSLLVRALDRFHRRLRAPGALLAAAGLS
                     ESATEIVERVARERLSHHLQGLKAAFLSSLTDVRQALAAPRLAGKEGPSLAELLANVA
                     SSILSHIKTSLASVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFIRSMCQTAQSF
                     CDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQSPVTPVSTLCA
                     EARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAID
                     VQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLF
                     SERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLW
                     RFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG"
     exon            238..367
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            368..514
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            515..734
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1452
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1668
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1887
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2009
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2097
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2631
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="Vps51"
                     /gene_synonym="1110014N23Rik; 3110057M17Rik; Ffr"
                     /note="major polyA site"
ORIGIN      
        1 gttggagcta tggcggctgc ggcagctgtg gggcctggcc tagggtccgg gcctggagac
       61 tccccagaag gtcccgaggc ggacgctccg gagcgtcggc ggaaggctca cgggatgctg
      121 aagctttact acggcctctc ggagggggag gtggcggggc atcccgcagg gcctgaccct
      181 ctggacccaa ccgatctcaa tggggcgcac ttcgacccgg aagtttatct tgacaagctg
      241 cgtagagaat gtcctctggc ccagctgatg gacagtgaga cggacatggt acggcagatc
      301 cgggctctag acagcgacat gcagaccctg gtctatgaga actacaacaa gttcatctca
      361 gctacagaca ccattcgaaa gatgaagaat gacttccgga agatggaaga tgagatggac
      421 cggctggcca ccaacatggc agtgatcacc aacttcagcg cacggatcag cgccacgcta
      481 caggaccgac acgagcgcat caccaagcta gcaggggtac atgcactact gcggaagctg
      541 cagttccttt ttgagctgcc ttcgcgcctc accaagtgtg tggagctggg tgcctatggg
      601 caggcagtgc gctatcaggg tcgtgccagg gccgtgctgc agcagtacca gcacctgccc
      661 tccttccgtg ccatacagga tgactgccag gtcatcacag ctcgcttggc ccagcagctg
      721 cggcagcgct tcagggaagg ctgctcaggt gccccggagc aggccgagtg tgtggagctg
      781 ctgctggccc tgggcgagcc agctgaggag ctgtgcgagg agttcctggc gcatgcgcgg
      841 ggacggctgg aggaagaact gagcagcctg gaggccgaac tggggccctc ccctccagca
      901 cctgatgtgt tagagttcac cgaccgtggt ggcaatggtt ttgtaggtgg cctctgccag
      961 gtggcagcag cctaccaaga gctgtttgct gctcagggcc ctgctggtgc ggagaagctg
     1021 gcagcctttg cgcaggagct gggcggccgc tactttgcac tggttgagcg gcggctggca
     1081 caggagcagg gtggtagtga caactcactg ctggtgcggg cactagatcg cttccaccgg
     1141 cgcctgcgag cacctggggc cctgctggcc gctgctgggc tttcagagtc agccacagag
     1201 attgtggagc gagtggcccg ggagcgcctg agccaccatc tgcagggtct gaaggctgcc
     1261 ttcctgagct ccctgacgga tgttcgccag gccctggcag cacctcgcct agcggggaag
     1321 gagggcccca gcctggctga gttgctggcc aatgtggcca gctccatcct aagccacatc
     1381 aagacgtcac tggcttctgt gcatctcttt accgccaagg aggtgtcctt ctccaataag
     1441 ccctacttca ggggcgagtt ctgcagccag ggagttcgtg agggcctcat cgtgggtttc
     1501 atccgctcca tgtgccagac agcccagagc ttctgtgaca gccctggaga aaagggaggt
     1561 gccacgccgc ctgccctgct cctgctgctc tctcgcctct gcctggatta tgagacagcc
     1621 accatctcct acatcctcac actcactgat gaacagtttc tggtgcagga ccagtctccc
     1681 gttacacccg tgagcacact gtgtgcagag gccagagaga cagcacggcg gctgctgact
     1741 cactatgtga aggtgcaagg cctggtcata tcccagatgc tacgtaagag tgtggagacc
     1801 cgggactggc tcagtactct ggagcctagg aacgtgcgtg ctgtcatgaa gcgtgtggtg
     1861 gaggacacta cagctattga tgtccaggtg gggctcctgt atgaagaggg tgtccggaag
     1921 gcccagagca gtgactcaag caaaaggact ttctctgtgt acagcagctc ccggcagcag
     1981 ggccgctatg cacccagcta cacacccagt gctcccatgg acacaaacct cctgagcaat
     2041 attcagaagc tgttctctga acggatcgat gtgttcagcc ccgtggaatt caacaaggtg
     2101 tcggtgctga ctggcatcat taagatcagc ttgaagacac tactggagtg tgtgcgccta
     2161 cgcacctttg ggcgctttgg gctgcagcag gtgcaggtgg actgccactt cctgcagctt
     2221 tacttgtggc gctttgtggc tgatgaggag ctagtgcacc tgctgctgga cgaagtagta
     2281 gcctcagctg ctctgcgctg tcccgaccca gtgcccatgg aacctagtgt tgtcgaggtc
     2341 atctgcgagc gcggctagaa tctgccaacg agtcgcgtag tagccctatc gccctgtcct
     2401 ccctgtgccc tgttctcatc ctagaggccc ttccccgctg gcgggttcat ggatccttct
     2461 aataaactta tgtgtcctcc tccttcctct tgcctgcagg ggcgggaccc gcccgggttg
     2521 ggtttcagtg ccgaagcttc tgaggcgcca gcatggggcc cgcctcccag cgctgattgg
     2581 ctactgtgct gggcccaggg tgggcagagg gcgcgtccat ttaaagatca a
//
