LOCUS       NP_077222                964 aa            linear   ROD 23-JUL-2024
DEFINITION  syndetin isoform 1 [Mus musculus].
ACCESSION   NP_077222
VERSION     NP_077222.4
DBSOURCE    REFSEQ: accession NM_024260.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 964)
  AUTHORS   Ahumada-Marchant,C., Ancaten-Gonzalez,C., Haensgen,H., Brauer,B.,
            Merino-Veliz,N., Droste,R., Arancibia,F., Horvitz,H.R.,
            Constantine-Paton,M., Arriagada,G., Chavez,A.E. and Bustos,F.J.
  TITLE     Deletion of VPS50 protein in mouse brain impairs synaptic function
            and behavior
  JOURNAL   BMC Biol 22 (1), 142 (2024)
   PUBMED   38926759
  REMARK    GeneRIF: Deletion of VPS50 protein in mouse brain impairs synaptic
            function and behavior.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 964)
  AUTHORS   Paquin,N., Murata,Y., Froehlich,A., Omura,D.T., Ailion,M.,
            Pender,C.L., Constantine-Paton,M. and Horvitz,H.R.
  TITLE     The Conserved VPS-50 Protein Functions in Dense-Core Vesicle
            Maturation and Acidification and Controls Animal Behavior
  JOURNAL   Curr Biol 26 (7), 862-871 (2016)
   PUBMED   26948874
  REMARK    GeneRIF: An evolutionarily conserved C. elegans protein, VPS-50,
            that is required for animals to assume the well-fed behavioral
            state. Both VPS-50 and its murine homolog mVPS50 are expressed in
            neurons, are associated with synaptic and dense-core vesicles, and
            control vesicle acidification and hence synaptic function, likely
            through regulation of the assembly of the V-ATPase complex.
REFERENCE   3  (residues 1 to 964)
  AUTHORS   Schindler,C., Chen,Y., Pu,J., Guo,X. and Bonifacino,J.S.
  TITLE     EARP is a multisubunit tethering complex involved in endocytic
            recycling
  JOURNAL   Nat Cell Biol 17 (5), 639-650 (2015)
   PUBMED   25799061
REFERENCE   4  (residues 1 to 964)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   5  (residues 1 to 964)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (residues 1 to 964)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY100563.1, AK129458.1 and AI551221.1.
            
            On Nov 17, 2009 this sequence version replaced NP_077222.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075898.1, SRR1660821.43384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     Protein         1..964
                     /product="syndetin isoform 1"
                     /note="coiled-coil domain-containing protein 132;
                     coiled-coil domain containing 132; EARP/GARPII complex
                     subunit VPS50; bcl2-like protein blm; syndetin"
                     /calculated_mol_wt=111043
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CI71.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q96JG6; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JG6; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Region          54..345
                     /region_name="Vps54_N"
                     /note="Vacuolar-sorting protein 54, of GARP complex;
                     pfam10475"
                     /db_xref="CDD:431303"
     Site            494
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JG6; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Site            498
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96JG6; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Region          532..563
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CI71.2)"
     Site            559
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Site            561
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CI71.2)"
     Region          723..957
                     /region_name="DUF2451"
                     /note="Protein of unknown function C-terminus (DUF2451);
                     pfam10474"
                     /db_xref="CDD:463103"
     CDS             1..964
                     /gene="Vps50"
                     /gene_synonym="1700034M03Rik; 8430415E05Rik; BLM; Ccdc132;
                     mKIAA1861"
                     /coded_by="NM_024260.5:131..3025"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39415.1"
                     /db_xref="GeneID:73288"
                     /db_xref="MGI:MGI:1920538"
ORIGIN      
        1 mqkikslmtr qglksppesl ndlgafeslr vpgkeefrel reqpsdpqae qelinsieqv
       61 yfsadpfdiv kyeleklppv lnlqeleeyr dklkqqqsav skkvadlile kqpayvkele
      121 rvtslqtglq laavictngr rhlniakegf tqaslgllan qrkrqlligl lkslrtiktl
      181 qrtdirlsem leeedypgai qlclecqkaa stfkhyscis elnsklqdtl eqieeqldva
      241 lskicknfdi nhytkvqqay rllgktqtam dqlhmhftqa ihntvfqvvl gyvelcagnt
      301 dtkfqklqyk dlcthvtpds yipcladlck alwevmlsyy rtmewhekhd neetaaaaeg
      361 snvmsteeat fdrgyvkkkl ehgltriwqd vqlkvktyll gtdlsifkyd dfifvldivs
      421 rlmqvgeefc gsksevlqes irkqsvnyfk nhhrirldel rmflenetwe lcpvksnfsi
      481 lqlhefkfle qsrspsvsps kqpsatsskp vtlfeqycsg gnpfeiqadh kdeetedvla
      541 sngyesdeqe ksayqdydsd sdvpeelkrd yvdeqtgdvp vksvsretlk srkksdysln
      601 kvnapiltnt tlnvirlvgk ymqmmnilkp iafdvihfms qlfdyylyai ytffgrndsl
      661 estglglsss rlkttlnriq eslidlegsa dptatltaae erkekvpsph lnqlviltsg
      721 dtlyglaerv vateslvfla eqfeflqphl davmpavkkp flqqfysqtv staselrkpi
      781 ywivagkaid yeqmlllmmn vkwdvkeims qhniyvdall kefeqfnkrl nevskrvrip
      841 lpvsnilweh cirlanrtiv egyanvkkcs negralmqld fqqflmklek ltdirpipdk
      901 efvetyikay yltendmerw ikehreystk qltnlvnvcl gshinkkarq kllaaideid
      961 rpkr
//
