LOCUS       NM_009190               3272 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus vacuolar protein sorting 4B (Vps4b), mRNA.
ACCESSION   NM_009190
VERSION     NM_009190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Frey,N., Tortola,L., Egli,D., Janjuha,S., Rothgangl,T.,
            Marquart,K.F., Ampenberger,F., Kopf,M. and Schwank,G.
  TITLE     Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T
            cell-mediated killing
  JOURNAL   Nat Commun 13 (1), 1804 (2022)
   PUBMED   35379808
  REMARK    GeneRIF: Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T
            cell-mediated killing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Tian,Q., Wang,Y.Y., Li,Q. and Chen,D.
  TITLE     Expressions of cytokeratin 14 and proliferating cell nuclear
            antigen in the Hertwig's epithelial root sheath of a Vps4b knockout
            mouse
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 39 (3), 274-278 (2021)
   PUBMED   34041875
  REMARK    GeneRIF: Expressions of cytokeratin 14 and proliferating cell
            nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b
            knockout mouse.
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Chen,D., He,F., Lu,T., Huang,J., Li,M., Cai,D., Huang,C., Chen,D.
            and Xiong,F.
  TITLE     VPS4B deficiency causes early embryonic lethality and induces
            signal transduction disorders of cell endocytosis
  JOURNAL   Genesis 59 (4), e23415 (2021)
   PUBMED   33682352
  REMARK    GeneRIF: VPS4B deficiency causes early embryonic lethality and
            induces signal transduction disorders of cell endocytosis.
REFERENCE   5  (bases 1 to 3272)
  AUTHORS   Pan,Y., Lu,T., Peng,L., Chen,Z., Li,M., Zhang,K., Xiong,F. and
            Wu,B.
  TITLE     Vacuolar protein sorting 4B regulates the proliferation and
            odontoblastic differentiation of human dental pulp stem cells
            through the Wnt-beta-catenin signalling pathway
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 2575-2584 (2019)
   PUBMED   31218890
  REMARK    GeneRIF: VPS4B, via Wnt-beta-catenin signalling, acts as a
            regulator of the proliferation and differentiation of hDPSCs
REFERENCE   6  (bases 1 to 3272)
  AUTHORS   Yoshimori,T., Yamagata,F., Yamamoto,A., Mizushima,N., Kabeya,Y.,
            Nara,A., Miwako,I., Ohashi,M., Ohsumi,M. and Ohsumi,Y.
  TITLE     The mouse SKD1, a homologue of yeast Vps4p, is required for normal
            endosomal trafficking and morphology in mammalian cells
  JOURNAL   Mol Biol Cell 11 (2), 747-763 (2000)
   PUBMED   10679028
REFERENCE   7  (bases 1 to 3272)
  AUTHORS   Bishop,N. and Woodman,P.
  TITLE     ATPase-defective mammalian VPS4 localizes to aberrant endosomes and
            impairs cholesterol trafficking
  JOURNAL   Mol Biol Cell 11 (1), 227-239 (2000)
   PUBMED   10637304
REFERENCE   8  (bases 1 to 3272)
  AUTHORS   Scheuring,S., Bodor,O., Rohricht,R.A., Muller,S., Beyer,A. and
            Kohrer,K.
  TITLE     Cloning, characterisation, and functional expression of the Mus
            musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and
            the yeast VPS4 genes are orthologues and involved in intracellular
            protein trafficking
  JOURNAL   Gene 234 (1), 149-159 (1999)
   PUBMED   10393249
REFERENCE   9  (bases 1 to 3272)
  AUTHORS   Finken-Eigen,M., Rohricht,R.A. and Kohrer,K.
  TITLE     The VPS4 gene is involved in protein transport out of a yeast
            pre-vacuolar endosome-like compartment
  JOURNAL   Curr Genet 31 (6), 469-480 (1997)
   PUBMED   9211789
REFERENCE   10 (bases 1 to 3272)
  AUTHORS   Perier,F., Coulter,K.L., Liang,H., Radeke,C.M., Gaber,R.F. and
            Vandenberg,C.A.
  TITLE     Identification of a novel mammalian member of the
            NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in
            yeast
  JOURNAL   FEBS Lett 351 (2), 286-290 (1994)
   PUBMED   8082782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126089.1, AK151023.1 and AK034641.1.
            
            On Jan 15, 2008 this sequence version replaced NM_009190.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151023.1, BC003799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY126089.1         5-51
            48-2902             AK151023.1         2-2856
            2903-3272           AK034641.1         1561-1930
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.1 cM"
     gene            1..3272
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /note="vacuolar protein sorting 4B"
                     /db_xref="GeneID:20479"
                     /db_xref="MGI:MGI:1100499"
     exon            1..305
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1613
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /EC_number="3.6.4.6"
                     /note="suppressor of K(+) transport growth defect 1;
                     suppressor of K+ transport defect 1"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4B"
                     /protein_id="NP_033216.2"
                     /db_xref="CCDS:CCDS15211.1"
                     /db_xref="GeneID:20479"
                     /db_xref="MGI:MGI:1100499"
                     /translation="MASTNTNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHV
                     VKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKKKEKKPQKPVKEEQSGPVDEKGNDS
                     DGEAESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLF
                     TGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKN
                     LFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLG
                     ATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQELGRKTD
                     GYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAI
                     EMTWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFGQEG"
     exon            306..417
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..574
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..642
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..762
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..919
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1068
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1150
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1370
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1511
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..3272
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2885..2890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /note="hexamer: AGTAAA"
     polyA_site      2903
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /note="major polyA site"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /note="hexamer: ATTAAA"
     polyA_site      3131
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
ORIGIN      
        1 ctgggtgact ggttagcgcg tgtgcggatg acgaagcgga agtgcccggg ccagaggcgg
       61 gaccagagcc ctaaggggct cgaaattacg gaagttttgt gcggagggtc gggtggctgc
      121 tggagttcct gctggattta cggctccgga gctggggctg ccgctggggg ggtctcagag
      181 ccgccagcct ccgcacggtt tgcggtggtg acccgggcgc gactcgacgg cgctgctgcg
      241 ggccttgtct gtagtagggg acccctcgga tctccaccat ggcgtccacg aacaccaacc
      301 tgcagaaagc aatagatctt gcaagcaaag cagcccagga agacaaagct gggaactatg
      361 aggaagctct tcaactctac caacatgctg tgcagtattt tctccatgtt gttaaatatg
      421 aagcacaagg tgataaagcc aagcaaagta tcagggccaa gtgtacagaa tatctcgata
      481 gagcagaaaa actaaaggaa tatctgaaga aaaaggagaa gaaaccacag aagcctgtga
      541 aagaggaaca gtcaggccca gttgatgaga aggggaatga cagtgatggg gaagcagaat
      601 ctgatgatcc tgaaaaaaag aaactgcaga atcaacttca aggtgccatt gttatagagc
      661 gaccaaatgt gaagtggagt gatgttgctg gtctcgaagg agccaaagaa gctcttaaag
      721 aggctgtgat tctgcctatt aagtttcctc atctgtttac aggaaagcgg acaccttgga
      781 gaggaatcct attatttgga ccaccaggaa caggaaaatc ttatttggct aaagctgttg
      841 caacggaagc aaacaactca acatttttct caatatcttc ctctgacctt gtgtctaagt
      901 ggctggggga aagcgaaaaa ctggttaaga acttattcca gcttgccaga gagaacaagc
      961 cttctatcat cttcatcgat gagattgatt ctctgtgtgg ttccagaagt gagaatgaga
     1021 gcgaggctgc acggagaatt aagacggagt tcctggttca aatgcaagga gttggtgtgg
     1081 acaatgatgg cattttggtt ctgggagcta caaatatacc ctgggttctg gattctgcaa
     1141 ttaggcgaag atttgagaaa cgtatttata ttcctttgcc cgaagcccat gcccgagcag
     1201 ccatgtttag actgcacttg ggcagcactc agaacagcct cacagaagca gacttccaag
     1261 aacttgggag gaagacggat ggctattcag gagcagatat aagtatcatt gtacgggatg
     1321 cacttatgca gcctgtgaga aaagttcagt cagctactca cttcaaaaag gttcgaggac
     1381 cctcaagagc tgatcctaac tgcattgtaa atgacctgct gacaccctgc tctccgggag
     1441 accctggggc tattgaaatg acatggatgg atgttcctgg agataaactc ttggagccag
     1501 ttgtttccat gtgggatatg ctgcggtccc tgtccagcac aaagccaaca gtcaatgagc
     1561 aggacttgtt gaagctgaag aagtttacag aagattttgg ccaggaaggc taacacaaag
     1621 acagcaagaa catgtttatg ctgcatttct tctcttttgt aggtattttg cctttcttgg
     1681 atgacattca gattatttcc agcaaaactc gtttacccag ggaaacatac atgtcacttg
     1741 agtgttccta aagtctgtgt tgtccttttc cttcactgtc tgttaaattc tctaattcac
     1801 aaacattgtc gaattgtaag gaaagcaaca atggtatgag gaacagcaga gtggggacat
     1861 cgaggagcct cgcccggctt catggacagc agctaggatt ctcatgagta cttgttcaaa
     1921 gagcaaggcc ttttttcttt tcctaaaaat gaaattgaaa cggggctaaa gctaatggta
     1981 tataaatgtc ttgaaaaatc tttaagcatt ttatcaatgt aaacttactg ctttattaaa
     2041 aattaatggt agaatcttta ctctcaggga tgggcagcaa aacgcagagc actgatgaat
     2101 ttggggtttg tggcacagcc agtgctcctg ttgagtttct agtgggctgg tttctcctgt
     2161 atagattaaa gtgattcctt taaagcagtg ggcttttata actccatgac tccttccact
     2221 gtgcactcga gactttctaa atcagtagtc atctttgcct tgtctacgca gtgtctttta
     2281 tagccaagat tgaccaaaag aggtagcaaa caagtatgca tttttcgaga attgtcatga
     2341 aatactgtaa tgggaaactt taataagaaa atgactttct tctggacttt gggatgtttc
     2401 ctgtggatga tgtgggtatg tgtgtacata tatatacata atttttaaaa tattagcgag
     2461 agtcatgtct ttcactttta agttcaggga gcagtttgtt ctaaccacac aaacattctc
     2521 agtgtggtat ttcatggagc tttagagaca aactaatgtc tcattacata atgaaatatg
     2581 aacataccat cgtgttattt caatgtcttc aaatacatga tctgagggtg tatgtcacat
     2641 acttgtgtac caactcttag ttgtgccttg gacatttgca ttgcctacct gcaaacaatt
     2701 actaggttaa ctagaattgc tatgcagttc taccttgcga gtgctacacg gtaattgcat
     2761 tttaaagtat atttgcacat tttacatgct atgctatatg attgcctttg ggttttgtgt
     2821 acagactatt tttgttgata ttcaatgaaa attataggct tgaaataata ctgttcctat
     2881 gtgaagtaaa ttgctataac ctacttttgg cttttatatg tttttttttt ttttattttg
     2941 gaaccttcta cataggagaa aatgtcttaa gttggttaga taaaaagaaa taatttatat
     3001 ttattaatga gcatatatga aagattcaag ggtagaagtg cacacctata atctcaggac
     3061 ttcaaagcta gtctagtttc cataacaaga cactgttttt taaaagaaca ttaaaattct
     3121 gctcttccac agctactgtg tgaaagctgt aagttatatt ggcagaataa tactgaattt
     3181 tttctaaatg aattaatttg tgtagcatct tagttgttga attagatttt aattaataga
     3241 tcctacttcc agcctcagtg cttaacattc cc
//
