LOCUS       NP_033216                444 aa            linear   ROD 01-JUN-2024
DEFINITION  vacuolar protein sorting-associated protein 4B [Mus musculus].
ACCESSION   NP_033216
VERSION     NP_033216.2
DBSOURCE    REFSEQ: accession NM_009190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 444)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   2  (residues 1 to 444)
  AUTHORS   Frey,N., Tortola,L., Egli,D., Janjuha,S., Rothgangl,T.,
            Marquart,K.F., Ampenberger,F., Kopf,M. and Schwank,G.
  TITLE     Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T
            cell-mediated killing
  JOURNAL   Nat Commun 13 (1), 1804 (2022)
   PUBMED   35379808
  REMARK    GeneRIF: Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T
            cell-mediated killing.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 444)
  AUTHORS   Tian,Q., Wang,Y.Y., Li,Q. and Chen,D.
  TITLE     Expressions of cytokeratin 14 and proliferating cell nuclear
            antigen in the Hertwig's epithelial root sheath of a Vps4b knockout
            mouse
  JOURNAL   Hua Xi Kou Qiang Yi Xue Za Zhi 39 (3), 274-278 (2021)
   PUBMED   34041875
  REMARK    GeneRIF: Expressions of cytokeratin 14 and proliferating cell
            nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b
            knockout mouse.
REFERENCE   4  (residues 1 to 444)
  AUTHORS   Chen,D., He,F., Lu,T., Huang,J., Li,M., Cai,D., Huang,C., Chen,D.
            and Xiong,F.
  TITLE     VPS4B deficiency causes early embryonic lethality and induces
            signal transduction disorders of cell endocytosis
  JOURNAL   Genesis 59 (4), e23415 (2021)
   PUBMED   33682352
  REMARK    GeneRIF: VPS4B deficiency causes early embryonic lethality and
            induces signal transduction disorders of cell endocytosis.
REFERENCE   5  (residues 1 to 444)
  AUTHORS   Pan,Y., Lu,T., Peng,L., Chen,Z., Li,M., Zhang,K., Xiong,F. and
            Wu,B.
  TITLE     Vacuolar protein sorting 4B regulates the proliferation and
            odontoblastic differentiation of human dental pulp stem cells
            through the Wnt-beta-catenin signalling pathway
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 2575-2584 (2019)
   PUBMED   31218890
  REMARK    GeneRIF: VPS4B, via Wnt-beta-catenin signalling, acts as a
            regulator of the proliferation and differentiation of hDPSCs
REFERENCE   6  (residues 1 to 444)
  AUTHORS   Yoshimori,T., Yamagata,F., Yamamoto,A., Mizushima,N., Kabeya,Y.,
            Nara,A., Miwako,I., Ohashi,M., Ohsumi,M. and Ohsumi,Y.
  TITLE     The mouse SKD1, a homologue of yeast Vps4p, is required for normal
            endosomal trafficking and morphology in mammalian cells
  JOURNAL   Mol Biol Cell 11 (2), 747-763 (2000)
   PUBMED   10679028
REFERENCE   7  (residues 1 to 444)
  AUTHORS   Bishop,N. and Woodman,P.
  TITLE     ATPase-defective mammalian VPS4 localizes to aberrant endosomes and
            impairs cholesterol trafficking
  JOURNAL   Mol Biol Cell 11 (1), 227-239 (2000)
   PUBMED   10637304
REFERENCE   8  (residues 1 to 444)
  AUTHORS   Scheuring,S., Bodor,O., Rohricht,R.A., Muller,S., Beyer,A. and
            Kohrer,K.
  TITLE     Cloning, characterisation, and functional expression of the Mus
            musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and
            the yeast VPS4 genes are orthologues and involved in intracellular
            protein trafficking
  JOURNAL   Gene 234 (1), 149-159 (1999)
   PUBMED   10393249
REFERENCE   9  (residues 1 to 444)
  AUTHORS   Finken-Eigen,M., Rohricht,R.A. and Kohrer,K.
  TITLE     The VPS4 gene is involved in protein transport out of a yeast
            pre-vacuolar endosome-like compartment
  JOURNAL   Curr Genet 31 (6), 469-480 (1997)
   PUBMED   9211789
REFERENCE   10 (residues 1 to 444)
  AUTHORS   Perier,F., Coulter,K.L., Liang,H., Radeke,C.M., Gaber,R.F. and
            Vandenberg,C.A.
  TITLE     Identification of a novel mammalian member of the
            NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in
            yeast
  JOURNAL   FEBS Lett 351 (2), 286-290 (1994)
   PUBMED   8082782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126089.1, AK151023.1 and AK034641.1.
            
            On Jan 15, 2008 this sequence version replaced NP_033216.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151023.1, BC003799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.1 cM"
     Protein         1..444
                     /product="vacuolar protein sorting-associated protein 4B"
                     /EC_number="3.6.4.6"
                     /note="suppressor of K(+) transport growth defect 1;
                     suppressor of K+ transport defect 1"
                     /calculated_mol_wt=49288
     Region          7..69
                     /region_name="MIT_VPS4"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in intracellular protein transport
                     proteins of the AAA-ATPase family. The molecular function
                     of the MIT domain is unclear; cd02678"
                     /db_xref="CDD:239141"
     Region          77..118
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46467.2)"
     Site            102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P46467.2)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75351; propagated from
                     UniProtKB/Swiss-Prot (P46467.2)"
     Region          128..298
                     /region_name="RecA-like_VPS4"
                     /note="ATPase domain of vacuolar protein
                     sorting-associated protein 4; cd19521"
                     /db_xref="CDD:410929"
     Site            order(129,148,152,155..156,160,164,176..177,181,185,196,
                     198,200..202,205,213,234..235,238,243,245,247..249,
                     251..253,256..257,280,283)
                     /site_type="other"
                     /note="hexamer interface [polypeptide binding]"
                     /db_xref="CDD:410929"
     Site            order(135..137,139,176..182,234,279)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410929"
     Region          325..366
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          381..441
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75351; propagated from
                     UniProtKB/Swiss-Prot (P46467.2)"
     CDS             1..444
                     /gene="Vps4b"
                     /gene_synonym="8030489C12Rik; Skd1"
                     /coded_by="NM_009190.2:279..1613"
                     /db_xref="CCDS:CCDS15211.1"
                     /db_xref="GeneID:20479"
                     /db_xref="MGI:MGI:1100499"
ORIGIN      
        1 mastntnlqk aidlaskaaq edkagnyeea lqlyqhavqy flhvvkyeaq gdkakqsira
       61 kcteyldrae klkeylkkke kkpqkpvkee qsgpvdekgn dsdgeaesdd pekkklqnql
      121 qgaivierpn vkwsdvagle gakealkeav ilpikfphlf tgkrtpwrgi llfgppgtgk
      181 sylakavate annstffsis ssdlvskwlg eseklvknlf qlarenkpsi ifideidslc
      241 gsrsenesea arrikteflv qmqgvgvdnd gilvlgatni pwvldsairr rfekriyipl
      301 peaharaamf rlhlgstqns lteadfqelg rktdgysgad isiivrdalm qpvrkvqsat
      361 hfkkvrgpsr adpncivndl ltpcspgdpg aiemtwmdvp gdkllepvvs mwdmlrslss
      421 tkptvneqdl lklkkftedf gqeg
//
