LOCUS       NM_126165               2136 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus vacuolar protein sorting 4A (Vps4a), mRNA.
ACCESSION   NM_126165
VERSION     NM_126165.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Yang,Y., Chen,H.L., Wu,S.F. and Bao,W.
  TITLE     CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane
            remodeling in endometrial carcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (1), 130497 (2024)
   PUBMED   37931722
  REMARK    GeneRIF: CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell
            membrane remodeling in endometrial carcinoma.
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Huang,X., Zhang,J., Wang,W., Huang,Z. and Han,P.
  TITLE     Vps4a Regulates Autophagic Flux to Prevent Hypertrophic
            Cardiomyopathy
  JOURNAL   Int J Mol Sci 24 (13), 10800 (2023)
   PUBMED   37445978
  REMARK    GeneRIF: Vps4a Regulates Autophagic Flux to Prevent Hypertrophic
            Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Rodger,C., Flex,E., Allison,R.J., Sanchis-Juan,A., Hasenahuer,M.A.,
            Cecchetti,S., French,C.E., Edgar,J.R., Carpentieri,G., Ciolfi,A.,
            Pantaleoni,F., Bruselles,A., Onesimo,R., Zampino,G., Marcon,F.,
            Siniscalchi,E., Lees,M., Krishnakumar,D., McCann,E., Yosifova,D.,
            Jarvis,J., Kruer,M.C., Marks,W., Campbell,J., Allen,L.E.,
            Gustincich,S., Raymond,F.L., Tartaglia,M. and Reid,E.
  CONSRTM   Genomics England Research Consortium
  TITLE     De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal
            Neurodevelopment
  JOURNAL   Am J Hum Genet 107 (6), 1129-1148 (2020)
   PUBMED   33186545
  REMARK    GeneRIF: De Novo VPS4A Mutations Cause Multisystem Disease with
            Abnormal Neurodevelopment.
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Azmi,I., Davies,B., Dimaano,C., Payne,J., Eckert,D., Babst,M. and
            Katzmann,D.J.
  TITLE     Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a
            conserved VSL region in Vta1
  JOURNAL   J Cell Biol 172 (5), 705-717 (2006)
   PUBMED   16505166
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Beyer,A., Scheuring,S., Muller,S., Mincheva,A., Lichter,P. and
            Kohrer,K.
  TITLE     Comparative sequence and expression analyses of four mammalian VPS4
            genes
  JOURNAL   Gene 305 (1), 47-59 (2003)
   PUBMED   12594041
REFERENCE   9  (bases 1 to 2136)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2136)
  AUTHORS   Finken-Eigen,M., Rohricht,R.A. and Kohrer,K.
  TITLE     The VPS4 gene is involved in protein transport out of a yeast
            pre-vacuolar endosome-like compartment
  JOURNAL   Curr Genet 31 (6), 469-480 (1997)
   PUBMED   9211789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV663224.1, AK159117.1, AC123868.4 and BU610346.1.
            
            On Jan 17, 2019 this sequence version replaced NM_126165.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018368.1, AK047821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DV663224.1         1-32
            33-1416             AK159117.1         2-1385
            1417-1417           AC123868.4         69203-69203
            1418-1854           AK159117.1         1387-1823
            1855-1855           AC123868.4         69641-69641
            1856-2131           AK159117.1         1825-2100
            2132-2136           BU610346.1         791-795
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.53 cM"
     gene            1..2136
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /note="vacuolar protein sorting 4A"
                     /db_xref="GeneID:116733"
                     /db_xref="MGI:MGI:1890520"
     exon            1..223
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1516
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /EC_number="3.6.4.6"
                     /note="vacuolar protein sorting protein 4a"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4A"
                     /protein_id="NP_569053.1"
                     /db_xref="CCDS:CCDS40463.1"
                     /db_xref="GeneID:116733"
                     /db_xref="MGI:MGI:1890520"
                     /translation="MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIK
                     YEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGD
                     NPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW
                     RGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQ
                     HKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWV
                     LDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADI
                     SIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDV
                     PGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES"
     exon            224..335
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            336..483
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            484..545
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..665
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            666..822
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..971
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1053
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1273
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1414
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2136
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2132
                     /gene="Vps4a"
                     /gene_synonym="4930589C15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgtgac tcgggctggg ccgctctggg ccgcgctcct cgttcaccct cggactcggc
       61 tcccactgct agtggcagct ctgcccgcgc cgagagccga cctgccgggc tcctaagcgg
      121 cggacccacc acctcggctc ctccgagccg gaccgaggcc gcaagcagca ccgcggggtg
      181 tggggcggac ccaggatatg aaatgacaac gtcaaccctc cagaaagcca tcgatctggt
      241 gacaaaagcc acagaagagg ataaagccaa gaactacgag gaggcactcc gtctctacca
      301 gcatgctgtg gagtatttcc tccacgccat caaatatgaa gcacacagtg acaaggccaa
      361 ggagagcatt cgagcaaagt gcatgcagta cctagacaga gcggagaagc tgaaggatta
      421 tttacgaaac aaagagaaac atggcaagaa gccagtcaaa gagaaccaga gtgaaggcaa
      481 gggtagtgac agtgacagtg aaggggataa tccagagaaa aagaagttac aagaacaatt
      541 gatgggtgct gttgtgatgg agaagccgaa catacggtgg aatgatgtag ctggactgga
      601 gggggctaaa gaggctctca aagaagctgt gattttgcca attaaattcc cacacttatt
      661 cacaggcaaa cgcactcctt ggcgaggcat actcctcttt gggcccccag gcacaggcaa
      721 gtcctacctg gccaaagccg tggcaacaga agccaacaac tctaccttct tctctgtgtc
      781 ctcctcggat ctgatgtcta agtggttggg ggaaagcgag aagctagtca agaacctgtt
      841 tgagctggcc cggcagcata agccttccat catcttcatt gatgaggtag attccctctg
      901 tgggtcacgg aatgaaaatg agagtgaagc cgctcgtagg atcaaaacag agttcttggt
      961 ccagatgcaa ggagtgggga ataataatga tggaactctt gttcttggtg ccacaaacat
     1021 cccctgggtg ttggattcag ccatcaggag gaggtttgaa aagcgaattt atatcccatt
     1081 gccagaggaa gcggcccgtg cccaaatgtt tcggttacat ctgggaagca cacctcacaa
     1141 cctcacagat gctaacattc acgagctggc ccgcaagaca gaaggctact caggagcaga
     1201 tatcagcatc attgtgcggg actccctcat gcagccagtc agaaaagtac agtcagcaac
     1261 acacttcaag aaggtgtgtg gcccttctcg aaccaaccct agcgttatga ttgatgatct
     1321 tctgacccca tgttctccgg gagatccagg ggccatagag atgacttgga tggatgtccc
     1381 tggtgataaa ctcttagagc ctgtggtttg catgtctgac atgctccggt ctttggccac
     1441 tacccggccc acagtgaatg cagacgacct cctgaaagta aagaaattct ctgaggactt
     1501 tggacaggag agttaaagct tcatgtgata atgaaattga gagtctgact ggagaaaatt
     1561 catgggactt cgtacaccag tggccaggca gggcctgaag tcgtgaagtc aatagtattt
     1621 cctctactgc ctggctgtca acctagtagg atgaagaagg ggcctcccca gctgcagaga
     1681 tgcttcacca tgtaggacac ttgagactgg ctctgcatac ttcactactg gatgctcaca
     1741 ctccttgccc tgatctgttt ttgtctaact tttgttcccc taaattaatg ccgctttgat
     1801 ttctgtcttg tttataaata aagagaaaag tcatctggaa atgttaagga gtgggagctg
     1861 ccaggcccct gctttcactc cttgcctctt aactttggct acttgtgagc tgactgtggt
     1921 aaagtaggaa aagccatccc actctcctaa gcttgcatct ggagcttcag gtcctccttg
     1981 caggagctga cagcttctgt gaacacgatg ccgtttccat caggagagac ggcaaacagg
     2041 caggtcttta tcgctgcctt cacctgagaa ctgagcccag cctctgctgg tcctgtcctg
     2101 gagatgtcta ataaaccctt ttcccttatt gagcta
//
