LOCUS       NM_013841               2643 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus vacuolar protein sorting 45 (Vps45), mRNA.
ACCESSION   NM_013841
VERSION     NM_013841.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2643)
  AUTHORS   Frey,L., Zietara,N., Lyszkiewicz,M., Marquardt,B., Mizoguchi,Y.,
            Linder,M.I., Liu,Y., Giesert,F., Wurst,W., Dahlhoff,M.,
            Schneider,M.R., Wolf,E., Somech,R. and Klein,C.
  TITLE     Mammalian VPS45 orchestrates trafficking through the endosomal
            system
  JOURNAL   Blood 137 (14), 1932-1944 (2021)
   PUBMED   33512427
  REMARK    GeneRIF: Mammalian VPS45 orchestrates trafficking through the
            endosomal system.
REFERENCE   2  (bases 1 to 2643)
  AUTHORS   Roccisana,J., Sadler,J.B., Bryant,N.J. and Gould,G.W.
  TITLE     Sorting of GLUT4 into its insulin-sensitive store requires the
            Sec1/Munc18 protein mVps45
  JOURNAL   Mol Biol Cell 24 (15), 2389-2397 (2013)
   PUBMED   23741049
  REMARK    GeneRIF: A crucial role for mVps45 in the delivery of GLUT4 into
            its specialized, insulin-regulated compartment.
REFERENCE   3  (bases 1 to 2643)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   4  (bases 1 to 2643)
  AUTHORS   Mishra,V.S., Holt,S.M., Teodoro,J.M. and Kingsmore,S.F.
  TITLE     Genetic mapping of vacuolar protein sorting-45 (Vps45) on mouse
            chromosome 3
  JOURNAL   Mamm Genome 9 (1), 90-91 (1998)
   PUBMED   9434958
REFERENCE   5  (bases 1 to 2643)
  AUTHORS   Tellam,J.T., James,D.E., Stevens,T.H. and Piper,R.C.
  TITLE     Identification of a mammalian Golgi Sec1p-like protein, mVps45
  JOURNAL   J Biol Chem 272 (10), 6187-6193 (1997)
   PUBMED   9045632
REFERENCE   6  (bases 1 to 2643)
  AUTHORS   Pevsner,J., Hsu,S.C., Hyde,P.S. and Scheller,R.H.
  TITLE     Mammalian homologues of yeast vacuolar protein sorting (vps) genes
            implicated in Golgi-to-lysosome trafficking
  JOURNAL   Gene 183 (1-2), 7-14 (1996)
   PUBMED   8996080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39 and BC058528.1.
            
            On Jun 17, 2009 this sequence version replaced NM_013841.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058528.1, U66865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               AC092855.39        234771-235378       c
            609-2643            BC058528.1         1-2035
FEATURES             Location/Qualifiers
     source          1..2643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.65 cM"
     gene            1..2643
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /note="vacuolar protein sorting 45"
                     /db_xref="GeneID:22365"
                     /db_xref="MGI:MGI:891965"
     exon            1..774
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     CDS             682..2394
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /note="vacuolar protein sorting protein 45"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 45"
                     /protein_id="NP_038869.1"
                     /db_xref="CCDS:CCDS17628.1"
                     /db_xref="GeneID:22365"
                     /db_xref="MGI:MGI:891965"
                     /translation="MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEI
                     LQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVEYLIQELRRPKYSIYFIYFSNVI
                     SKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQ
                     GLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQVISKEYELFEFRRTEVPPLLLILDR
                     CDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNM
                     YLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTV
                     VGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVRLVMLYA
                     LHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITK
                     QFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTLRDRPQDIIVFIIG
                     GATYEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLASGLHSRSRESSQATSRS
                     ANRR"
     exon            775..909
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            910..970
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1050
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1119
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1257
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1368
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1503
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1617
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1785
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1944
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2052
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2174
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2306
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2626
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2596..2601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="Vps45"
                     /gene_synonym="mVps45"
                     /note="major polyA site"
ORIGIN      
        1 cgcagtccca gcggtcctga gtagggggcg ggtggaagct ccgcgccttc ctggggtctc
       61 taaggtctac aacatctcta aatagcgttc ccattgtttc ttcattcaac aaacgtgatg
      121 aatttcagct ccccttctct ctttaggaaa cccagttgag tctcattcta tgacctacca
      181 aatacaaaat gccgtctctt gatgctactt tgtttggata ctttagaaaa ccggggctgc
      241 ctctgtaacc tagcctgggc tatcagagaa cttgctatgc agtacagacc tgggaccccg
      301 ctgccccagc ctgcccagtg ctacgatgac gtgcgagggc ttcagaaaag atgctcagca
      361 aacagtgtcc gagagagctg tatcccgcgg tgcgccaagc gcttccctac tcaggaccag
      421 aagccagcac agcgcgggtt cggggaaaca ggctgccttc cactccctac cgagaagcgt
      481 cgggaatggc accgtcgctt agctgctgag tctgagtccc ggactccacg gaggaactac
      541 aattcccagt atcggagcta cccggactcc cggaagccga ggctttggcg accggaagca
      601 gctgagaccc aacaggcctg aggttaattc agccaggaaa gtgggtggga agggctgtgg
      661 ggcacctgtc aattcgccac catgaatgtg gtctttgctg tgaagcagta tatttccaaa
      721 atgatagagg acagcgggcc gggcatgaag gtacttctca tggataaaga aacgactggt
      781 atagtgagta tggtctacac acagtcagag attcttcaga aggaagtata cctcttcgaa
      841 cgaattgatt ctcaaaatcg agagatcatg aaacacctaa aagcaatttg tttccttcga
      901 cccacaaagg agaatgtgga atatctgatc caggagctcc gaagacccaa gtacagcata
      961 tattttattt atttcagtaa tgtgatcagc aagagtgacg tgaagtcact ggctgaagct
     1021 gacgagcagg aagttgtggc tgaagttcag gaattttatg gtgattacat tgcggtgaat
     1081 ccacatttgt tttctctcaa tattttgggt tgctgtcagg gtcgaaattg ggatccagcc
     1141 cagctatcaa gaacgactca agggctgaca gctctccttt tgtctctgaa gaagtgcccc
     1201 atgattcgtt atcagctttc atcagaggct gcaaagagac tgggagaatg tgttaagcaa
     1261 gtgataagta aagagtacga actctttgaa ttccggcgga cagaggttcc tccgctactt
     1321 ctcattctgg atcgctgcga tgacgccatt accccgctgc tcaaccagtg gacatatcag
     1381 gccatggtcc atgaactact gggcataaac aacaaccgga ttgatctttc cagagtgcca
     1441 ggaatcagca aagacttaag agaggtggtc ctgtccgctg aaaatgatga attctatgct
     1501 aataacatgt acctgaactt tgccgagatt ggtagcaata taaagaatct catggaagac
     1561 ttccagaaga agagaccaaa agagcagcaa aagctggaat ccatagcaga catgaaggcc
     1621 tttgttgaaa attatccaca gttcaaaaag atgtctggga ctgtctcaaa gcacgtgaca
     1681 gtggtcgggg aactgtctcg gttggtcagt gagcggaatc tgctggaggt ttcagaagtt
     1741 gagcaagaac tggcctgtca gaatgaccat tctagtgctc ttcagaatgt gaagagactc
     1801 ctgcagaatc cgaaagtcac agaatttgat gcagttcgcc tggtgatgct ttatgctcta
     1861 cattacgagc gccacagcag caacagcctg ccaggactca tagtggacct caggagtaaa
     1921 ggtgttgctg agaagtatcg gaagcttgtg tcggcagttg ttgaatatgg tggtaaacgg
     1981 gttagaggaa gtgacctctt cagtcccaaa gatgctgtgg ctattaccaa gcagtttctc
     2041 aaaggactga agggagtgga aaatgtgtat acacagcacc agcctttcct gcatgagacc
     2101 ctggatcatc tcatcaaagg aaggcttaag gaaaacctct atccttattt aggccccagc
     2161 acactcagag acaggcctca ggatatcatc gtgtttatta ttggaggagc cacctatgaa
     2221 gaggctctga cagtctataa cctgaaccgc accactcctg gagtgaggat cgttctggga
     2281 ggaacaacaa tacacaacac aaaaagcttc ctagaggaag tcctggcttc tgggctgcac
     2341 agccgcagca gggagagctc gcaggccacc tcaaggtcag caaacagaag atgagatggc
     2401 agtggagagc ggcgagaatg tcatggcctc ctcttacctg cctcggccct tccctgctga
     2461 ccaggggctt tggggctggc ccttgtgttt gctctgactc actccaggta accccgattc
     2521 ctggactgct ggaacagacc ccgggactgc gagccgacga tgagcccacc ccgacccact
     2581 tgtgattgtg tatggaataa acacactctt tgtgtatttg acagcaaaaa aaaaaaaaaa
     2641 aaa
//
