LOCUS       NP_742118                853 aa            linear   ROD 28-APR-2025
DEFINITION  vacuolar protein sorting-associated protein 41 homolog [Mus
            musculus].
ACCESSION   NP_742118
VERSION     NP_742118.3
DBSOURCE    REFSEQ: accession NM_172120.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 853)
  AUTHORS   Jain,S., Yee,A.G., Maas,J., Gierok,S., Xu,H., Stansil,J.,
            Eriksen,J., Nelson,A.B., Silm,K., Ford,C.P. and Edwards,R.H.
  TITLE     Adaptor protein-3 produces synaptic vesicles that release phasic
            dopamine
  JOURNAL   Proc Natl Acad Sci U S A 120 (42), e2309843120 (2023)
   PUBMED   37812725
REFERENCE   2  (residues 1 to 853)
  AUTHORS   Wang,T., Yan,L., Wang,L., Sun,J., Qu,H., Ma,Y., Song,R., Tong,X.,
            Zhu,J., Yuan,Y., Gu,J., Bian,J., Liu,Z. and Zou,H.
  TITLE     VPS41-mediated incomplete autophagy aggravates cadmium-induced
            apoptosis in mouse hepatocytes
  JOURNAL   J Hazard Mater 459, 132243 (2023)
   PUBMED   37562348
  REMARK    GeneRIF: VPS41-mediated incomplete autophagy aggravates
            cadmium-induced apoptosis in mouse hepatocytes.
REFERENCE   3  (residues 1 to 853)
  AUTHORS   Burns,C.H., Yau,B., Rodriguez,A., Triplett,J., Maslar,D., An,Y.S.,
            van der Welle,R.E.N., Kossina,R.G., Fisher,M.R., Strout,G.W.,
            Bayguinov,P.O., Veenendaal,T., Chitayat,D., Fitzpatrick,J.A.J.,
            Klumperman,J., Kebede,M.A. and Asensio,C.S.
  TITLE     Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due
            to Defects in Insulin Secretion
  JOURNAL   Diabetes 70 (2), 436-448 (2021)
   PUBMED   33168621
  REMARK    GeneRIF: Pancreatic beta-Cell-Specific Deletion of VPS41 Causes
            Diabetes Due to Defects in Insulin Secretion.
REFERENCE   4  (residues 1 to 853)
  AUTHORS   Lorincz,P., Kenez,L.A., Toth,S., Kiss,V., Varga,A., Csizmadia,T.,
            Simon-Vecsei,Z. and Juhasz,G.
  TITLE     Vps8 overexpression inhibits HOPS-dependent trafficking routes by
            outcompeting Vps41/Lt
  JOURNAL   Elife 8, e45631 (2019)
   PUBMED   31194677
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 853)
  AUTHORS   Barry,A.O., Boucherit,N., Mottola,G., Vadovic,P., Trouplin,V.,
            Soubeyran,P., Capo,C., Bonatti,S., Nebreda,A., Toman,R.,
            Lemichez,E., Mege,J.L. and Ghigo,E.
  TITLE     Impaired stimulation of p38alpha-MAPK/Vps41-HOPS by LPS from
            pathogenic Coxiella burnetii prevents trafficking to microbicidal
            phagolysosomes
  JOURNAL   Cell Host Microbe 12 (6), 751-763 (2012)
   PUBMED   23245320
  REMARK    GeneRIF: Lack of Coxiella burnetii targeting to degradative
            compartments involves an antagonistic engagement of TLR4 by
            lipopolysaccharides, lack of p38alpha-MAPK-driven phosphorylation,
            and block in recruitment of the Vps41 to
            lipopolysaccharide-containing vesicles.
REFERENCE   6  (residues 1 to 853)
  AUTHORS   Aoyama,M., Agari,K., Sun-Wada,G.H., Futai,M. and Wada,Y.
  TITLE     Simple and straightforward construction of a mouse gene targeting
            vector using in vitro transposition reactions
  JOURNAL   Nucleic Acids Res 33 (5), e52 (2005)
   PUBMED   15784610
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 853)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   8  (residues 1 to 853)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 853)
  AUTHORS   Loebel,D.A., O'Rourke,M.P., Steiner,K.A., Banyer,J. and Tam,P.P.
  TITLE     Isolation of differentially expressed genes from wild-type and
            Twist mutant mouse limb buds
  JOURNAL   Genesis 33 (3), 103-113 (2002)
   PUBMED   12124942
REFERENCE   10 (residues 1 to 853)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB028843.1 and AI851542.1.
            
            On Dec 29, 2009 this sequence version replaced NP_742118.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028843.1, AK164177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 6.75 cM"
     Protein         1..853
                     /product="vacuolar protein sorting-associated protein 41
                     homolog"
                     /note="VAM2 homolog; vacuolar protein sorting 41"
                     /calculated_mol_wt=98471
     Region          1..539
                     /region_name="Interaction with ARL8B.
                     /evidence=ECO:0000250|UniProtKB:P49754"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KU39.1)"
     Region          1..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KU39.1)"
     Region          87..131
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          567..711
                     /region_name="CHCR"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5KU39.1)"
     Region          570..707
                     /region_name="CLH"
                     /note="Clathrin heavy chain repeat homology; smart00299"
                     /db_xref="CDD:128594"
     Region          786..840
                     /region_name="RING-H2_Vps41"
                     /note="RING finger, H2 subclass, found in vacuolar protein
                     sorting-associated protein 41 (Vps41) and similar
                     proteins; cd16690"
                     /db_xref="CDD:438351"
     CDS             1..853
                     /gene="Vps41"
                     /gene_synonym="mVam2; Vam2"
                     /coded_by="NM_172120.4:25..2586"
                     /db_xref="CCDS:CCDS26257.1"
                     /db_xref="GeneID:218035"
                     /db_xref="MGI:MGI:1929215"
ORIGIN      
        1 maeaeeqete sleestdese eeseeepklk yerlsngvte ilqkdaascm tvhdkflalg
       61 thygkvylld vqgnitqkfd vspvkinqis lddsgehmgv csedgklqvf glysgeefhe
      121 tfdcpikiia vhpqfvrssc kqfvtggkkl llfertwmnr wkssvlhege gnirsvkwrg
      181 hliawannmg vkvfditskq risnvprddi slrpdmypcs lcwkdnvtli igwgtsikic
      241 svkerhasem rdlpsryvei vsqfetefyi sglaplcdql vvlsyvkevs ektereycar
      301 prldiiqplp etceeissda ltvrgfqene crdyhleyse geslfyvvsp rdvvvakerd
      361 qddhidwlle kkkyeealma aeisqrnikr hkildiglay vnhlvergey dmaarkcqki
      421 lgknaslwey evykfkeigq lkaispylpr gdpvlkpliy emilhefles dyegfatlir
      481 ewpgdlynns vivqavrdhl kkdsqnktll ktlaelytyd knygnaleiy ltlrhkdvfq
      541 lihkhnlfss ikdkivllmd fdsekavdml ldnedkisik kvveeledrp elqhvylhkl
      601 fkrdhhkgqr yhekqislya eydrpnllpf lrdsthcple kaleicqqrn fveetvylls
      661 rmgnsrsalk mimeelhdvd kaiefakeqd dgelwedlil ysidkppfit gllnnigthv
      721 dpillihrik egmeipnlrd slvkilqdyn lqillregck kilvadslsl lkkmhrtqmk
      781 gvlvdeenic esclspilpt daakpfsvvv fhcrhmfhke clpmpsmnap aqycnicsak
      841 nrgpgsaile mkk
//
