LOCUS       NM_022997               3196 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus VPS35 retromer complex component (Vps35), mRNA.
ACCESSION   NM_022997 NM_008582
VERSION     NM_022997.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3196)
  AUTHORS   Fu,C., Yang,N., Chuang,J.Z., Nakajima,N., Iraha,S., Roy,N., Wu,Z.,
            Jiang,Z., Otsu,W., Radu,R.A., Yang,H.H., Lee,M.P., Worgall,T.S.,
            Xiong,W.C. and Sung,C.H.
  TITLE     Mutant mice with rod-specific VPS35 deletion exhibit retinal
            alpha-synuclein pathology-associated degeneration
  JOURNAL   Nat Commun 15 (1), 5970 (2024)
   PUBMED   39043666
  REMARK    GeneRIF: Mutant mice with rod-specific VPS35 deletion exhibit
            retinal alpha-synuclein pathology-associated degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3196)
  AUTHORS   Yuan,Y., Li,H., Sreeram,K., Malankhanova,T., Boddu,R., Strader,S.,
            Chang,A., Bryant,N., Yacoubian,T.A., Standaert,D.G., Erb,M.,
            Moore,D.J., Sanders,L.H., Lutz,M.W., Velmeshev,D. and West,A.B.
  TITLE     Single molecule array measures of LRRK2 kinase activity in serum
            link Parkinson's disease severity to peripheral inflammation
  JOURNAL   Mol Neurodegener 19 (1), 47 (2024)
   PUBMED   38862989
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3196)
  AUTHORS   Wang,X., Xie,Y., Fan,X., Wu,X., Wang,D. and Zhu,L.
  TITLE     Intermittent hypoxia training enhances Abeta endocytosis by plaque
            associated microglia via VPS35-dependent TREM2 recycling in murine
            Alzheimer's disease
  JOURNAL   Alzheimers Res Ther 16 (1), 121 (2024)
   PUBMED   38831312
  REMARK    GeneRIF: Intermittent hypoxia training enhances Abeta endocytosis
            by plaque associated microglia via VPS35-dependent TREM2 recycling
            in murine Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3196)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3196)
  AUTHORS   Shiraishi,T., Bono,K., Hiraki,H., Manome,Y., Oka,H., Iguchi,Y. and
            Okano,H.J.
  TITLE     The impact of VPS35 D620N mutation on alternative autophagy and its
            reversal by estrogen in Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 103 (2024)
   PUBMED   38409392
  REMARK    GeneRIF: The impact of VPS35 D620N mutation on alternative
            autophagy and its reversal by estrogen in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3196)
  AUTHORS   George,A., Leahy,H., Zhou,J. and Morin,P.J.
  TITLE     The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit
            canonical Wnt signaling
  JOURNAL   Neurobiol Dis 26 (1), 125-133 (2007)
   PUBMED   17239604
REFERENCE   7  (bases 1 to 3196)
  AUTHORS   Kerr,M.C., Bennetts,J.S., Simpson,F., Thomas,E.C., Flegg,C.,
            Gleeson,P.A., Wicking,C. and Teasdale,R.D.
  TITLE     A novel mammalian retromer component, Vps26B
  JOURNAL   Traffic 6 (11), 991-1001 (2005)
   PUBMED   16190980
REFERENCE   8  (bases 1 to 3196)
  AUTHORS   Collins,B.M., Skinner,C.F., Watson,P.J., Seaman,M.N. and Owen,D.J.
  TITLE     Vps29 has a phosphoesterase fold that acts as a protein interaction
            scaffold for retromer assembly
  JOURNAL   Nat Struct Mol Biol 12 (7), 594-602 (2005)
   PUBMED   15965486
REFERENCE   9  (bases 1 to 3196)
  AUTHORS   Zhang,P., Yu,L., Gao,J., Fu,Q., Dai,F., Zhao,Y., Zheng,L. and
            Zhao,S.
  TITLE     Cloning and characterization of human VPS35 and mouse Vps35 and
            mapping of VPS35 to human chromosome 16q13-q21
  JOURNAL   Genomics 70 (2), 253-257 (2000)
   PUBMED   11112353
REFERENCE   10 (bases 1 to 3196)
  AUTHORS   Hwang,S., Benjamin,L.E., Oh,B., Rothstein,J.L., Ackerman,S.L.,
            Beddington,R.S., Solter,D. and Knowles,B.B.
  TITLE     Genetic mapping and embryonic expression of a novel, maternally
            transcribed gene Mem3
  JOURNAL   Mamm Genome 7 (8), 586-590 (1996)
   PUBMED   8678978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134854.3 and AC159275.6.
            
            On Jun 14, 2018 this sequence version replaced NM_022997.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167421.1, AK167594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC134854.3         102664-102726
            64-162              AC134854.3         107224-107322
            163-259             AC134854.3         112379-112475
            260-383             AC134854.3         114362-114485
            384-566             AC134854.3         115658-115840
            567-780             AC134854.3         117975-118188
            781-864             AC134854.3         120257-120340
            865-974             AC134854.3         120836-120945
            975-1071            AC134854.3         123125-123221
            1072-1220           AC134854.3         123329-123477
            1221-1428           AC134854.3         127154-127361
            1429-1584           AC134854.3         128554-128709
            1585-1694           AC134854.3         131366-131475
            1695-1707           AC159275.6         195022-195034       c
            1708-1887           AC159275.6         188473-188652       c
            1888-2127           AC159275.6         187640-187879       c
            2128-2271           AC159275.6         186324-186467       c
            2272-3196           AC159275.6         184714-185638       c
FEATURES             Location/Qualifiers
     source          1..3196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.61 cM"
     gene            1..3196
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /note="VPS35 retromer complex component"
                     /db_xref="GeneID:65114"
                     /db_xref="MGI:MGI:1890467"
     exon            1..63
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            64..162
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..259
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..383
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..566
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..780
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..864
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..974
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1071
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1220
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1428
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1584
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1707
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1887
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2127
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2271
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..3196
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /note="major polyA site"
ORIGIN      
        1 acctgacggc gggcggctcc ggcggggtag gcgctgctgc ttgtggtccc cggagtcgcc
       61 atgcctacaa cacagcagtc accccaggat gagcaggaaa aacttttgga tgaagccatc
      121 caggctgtga aggttcagtc attccagatg aaaagatgcc tggacaaaaa caagctgatg
      181 gatgctctga agcatgcctc caatatgctt ggagagctcc ggacctctat gctgtcacca
      241 aagagttact atgaacttta tatggctatt tctgatgaac tgcactactt ggaggtctac
      301 ctgactgatg aatttgctaa aggaagaaag gtggcagatc tctatgaact tgtacagtac
      361 gcgggaaaca ttattccaag gctttatctc ttgatcacag ttggagttgt atatgtcaag
      421 tcatttcctc aatccaggaa agatattttg aaagatttgg tagaaatgtg ccgtggtgtg
      481 cagcatccgc taaggggttt gtttcttcga aattaccttc ttcagtgtac taggaacatt
      541 ttacctgatg aaggagagcc aacagatgaa gaaacaactg gtgatatcag tgattccatg
      601 gattttgtac tactcaactt tgcagaaatg aataagctct gggtgcggat gcagcatcaa
      661 ggacatagtc gagatagaga aaaaagagaa cgagagagac aagaactgag aattttagtg
      721 ggaacaaatt tggtgcgcct tagtcagttg gaaggtgtaa atgtggaacg ttacaaacag
      781 attgttctaa caggcattct ggagcaggtt gtgaattgta gggatgctct ggctcaggag
      841 tatctcatgg agtgcatcat tcaggttttt cctgatgagt ttcatcttca gactttgaat
      901 ccttttctta gagcttgtgc tgaattacac caaaatgtaa atgtgaaaaa cataatcatt
      961 gctttaattg acagattagc tttatttgct catcgtgaag atggacccgg aattccagct
     1021 gagattaaac tttttgacat attttcacaa caggtggcta cagtcataca gtccagacaa
     1081 gacatgccat cagaggatgt tgtatcttta caagtctctc tcattaatct tgctatgaaa
     1141 tgttaccctg atcgtgtgga ctacgtcgat aaagttctag aaacaacagt ggagatattc
     1201 aataagctta accttgaaca tattgctacc agtagtgcag tttcaaagga gcttaccaga
     1261 cttttgaaga tacctgttga tacttacaac aatatcttaa cagtattaaa gttaaagcat
     1321 ttccacccac tttttgagta ctttgactac gagtccagaa agagcatgag ctgttatgtg
     1381 cttagtaatg ttctggatta taacacagaa atcgtctctc aggaccaggt agattccata
     1441 atgaatttgg tgtccacatt gattcaggat cagccagacc aacctgtaga agaccctgat
     1501 ccagaagact tcgctgatga acagagcctt gttggccgat ttattcatct gctacgttct
     1561 gatgatcctg accagcagta tttgattttg aatacggcac gaaaacattt tggggctggt
     1621 ggaaatcagc ggattcgctt cacactgcca cctttggtat ttgcagctta ccagttggct
     1681 tttcgataca aagagaattc ccaaatggat gacaagtggg aaaagaaatg ccagaagata
     1741 ttttcatttg ctcaccagac tatcagtgct ttgattaaag ctgagctggc tgaattacca
     1801 ctgagacttt ttcttcaagg agcattagct gctggagaaa ttggctttga aaatcatgaa
     1861 acagtagcat atgaatttat gtcccaggca ttttctctat atgaagatga aatcagtgat
     1921 tctaaagcac agctggctgc tatcaccttg atcatcggta cttttgagag gatgaaatgc
     1981 ttcagtgaag agaatcatga acccttgaga actcagtgtg cacttgctgc atcaaaactt
     2041 ctgaaaaaac cagatcaagg ccgagccgtg agcacatgtg cgcatctctt ttggtctggc
     2101 cgaaacacag acaaaaatgg ggaagagctt catggaggta aaagggtcat ggagtgccta
     2161 aagaaggcac taaaaatagc aaatcagtgc atggacccct ctctacaagt tcagctcttt
     2221 atagagattc tgaacaggta catctatttc tatgaaaaag aaaatgatgc ggtaaccatt
     2281 caagtcttga accaacttat tcaaaagatt cgagaagatc tcccaaatct tgagtccagt
     2341 gaagaaacag aacaaataaa caagcatttt cacaacacat tggagcactt gcgctcaaga
     2401 cgggaatcac cagagtctga ggggccaatc tatgaaggtc tcatccttta aaagaagaca
     2461 gctcagcata ctcctttcta cacatcagaa agggcttaac taggtctccc ttccatagat
     2521 tgtgcctttc agaaatgctg aggtaggttt cccattcctt acctgtgatg tgtttaccca
     2581 gcacctccag acaccttcag gaccttaact cacttcataa ttgtttaagt ctgtctgatc
     2641 acccaagtag catgactgat ctgctcttta aacttctgtg atctgtgaaa attgaaagca
     2701 aaacccactt attctggcta ctaatggagc tctcctttct tatttttatt ttgatgaatt
     2761 gttgattgtg tattttcttc attaatgagg aatactaacc caaacatact tgtttcttcg
     2821 ttctctggtc ctatgtgaga ttactttaga ggacaggagt actgtgcgtg aaattcagcg
     2881 tgggctttcc ctgaatgcaa gataaagcct atgtgtaata tattccctac aactagaata
     2941 tattaatgca tgttgaagaa ttttaaagca ccatggtcag aagcagaagc tatattttgc
     3001 atatttggac tcagctatcc attaagaact atgccattat ctggatacat caaagtaatt
     3061 tgattctata aaatagaaat tttgtgactt aatgtaattt atgtataacc tccactattg
     3121 taaatttatg tgaaatgcat cacaactaca actttttcat cagtggaata ataaagttgc
     3181 tgttaacaat tttgga
//
