LOCUS       NP_075373                796 aa            linear   ROD 09-OCT-2024
DEFINITION  vacuolar protein sorting-associated protein 35 [Mus musculus].
ACCESSION   NP_075373 NP_032608
VERSION     NP_075373.1
DBSOURCE    REFSEQ: accession NM_022997.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 796)
  AUTHORS   Fu,C., Yang,N., Chuang,J.Z., Nakajima,N., Iraha,S., Roy,N., Wu,Z.,
            Jiang,Z., Otsu,W., Radu,R.A., Yang,H.H., Lee,M.P., Worgall,T.S.,
            Xiong,W.C. and Sung,C.H.
  TITLE     Mutant mice with rod-specific VPS35 deletion exhibit retinal
            alpha-synuclein pathology-associated degeneration
  JOURNAL   Nat Commun 15 (1), 5970 (2024)
   PUBMED   39043666
  REMARK    GeneRIF: Mutant mice with rod-specific VPS35 deletion exhibit
            retinal alpha-synuclein pathology-associated degeneration.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 796)
  AUTHORS   Yuan,Y., Li,H., Sreeram,K., Malankhanova,T., Boddu,R., Strader,S.,
            Chang,A., Bryant,N., Yacoubian,T.A., Standaert,D.G., Erb,M.,
            Moore,D.J., Sanders,L.H., Lutz,M.W., Velmeshev,D. and West,A.B.
  TITLE     Single molecule array measures of LRRK2 kinase activity in serum
            link Parkinson's disease severity to peripheral inflammation
  JOURNAL   Mol Neurodegener 19 (1), 47 (2024)
   PUBMED   38862989
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 796)
  AUTHORS   Wang,X., Xie,Y., Fan,X., Wu,X., Wang,D. and Zhu,L.
  TITLE     Intermittent hypoxia training enhances Abeta endocytosis by plaque
            associated microglia via VPS35-dependent TREM2 recycling in murine
            Alzheimer's disease
  JOURNAL   Alzheimers Res Ther 16 (1), 121 (2024)
   PUBMED   38831312
  REMARK    GeneRIF: Intermittent hypoxia training enhances Abeta endocytosis
            by plaque associated microglia via VPS35-dependent TREM2 recycling
            in murine Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 796)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 796)
  AUTHORS   Shiraishi,T., Bono,K., Hiraki,H., Manome,Y., Oka,H., Iguchi,Y. and
            Okano,H.J.
  TITLE     The impact of VPS35 D620N mutation on alternative autophagy and its
            reversal by estrogen in Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 103 (2024)
   PUBMED   38409392
  REMARK    GeneRIF: The impact of VPS35 D620N mutation on alternative
            autophagy and its reversal by estrogen in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 796)
  AUTHORS   George,A., Leahy,H., Zhou,J. and Morin,P.J.
  TITLE     The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit
            canonical Wnt signaling
  JOURNAL   Neurobiol Dis 26 (1), 125-133 (2007)
   PUBMED   17239604
REFERENCE   7  (residues 1 to 796)
  AUTHORS   Kerr,M.C., Bennetts,J.S., Simpson,F., Thomas,E.C., Flegg,C.,
            Gleeson,P.A., Wicking,C. and Teasdale,R.D.
  TITLE     A novel mammalian retromer component, Vps26B
  JOURNAL   Traffic 6 (11), 991-1001 (2005)
   PUBMED   16190980
REFERENCE   8  (residues 1 to 796)
  AUTHORS   Collins,B.M., Skinner,C.F., Watson,P.J., Seaman,M.N. and Owen,D.J.
  TITLE     Vps29 has a phosphoesterase fold that acts as a protein interaction
            scaffold for retromer assembly
  JOURNAL   Nat Struct Mol Biol 12 (7), 594-602 (2005)
   PUBMED   15965486
REFERENCE   9  (residues 1 to 796)
  AUTHORS   Zhang,P., Yu,L., Gao,J., Fu,Q., Dai,F., Zhao,Y., Zheng,L. and
            Zhao,S.
  TITLE     Cloning and characterization of human VPS35 and mouse Vps35 and
            mapping of VPS35 to human chromosome 16q13-q21
  JOURNAL   Genomics 70 (2), 253-257 (2000)
   PUBMED   11112353
REFERENCE   10 (residues 1 to 796)
  AUTHORS   Hwang,S., Benjamin,L.E., Oh,B., Rothstein,J.L., Ackerman,S.L.,
            Beddington,R.S., Solter,D. and Knowles,B.B.
  TITLE     Genetic mapping and embryonic expression of a novel, maternally
            transcribed gene Mem3
  JOURNAL   Mamm Genome 7 (8), 586-590 (1996)
   PUBMED   8678978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134854.3 and AC159275.6.
            
            On Nov 4, 2002 this sequence version replaced NP_032608.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167421.1, AK167594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.61 cM"
     Protein         1..796
                     /product="vacuolar protein sorting-associated protein 35"
                     /note="maternal embryonic message 3; vesicle protein
                     sorting 35"
                     /calculated_mol_wt=91582
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96QK1; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Region          15..752
                     /region_name="Vps35"
                     /note="Vacuolar protein sorting-associated protein 35;
                     pfam03635"
                     /db_xref="CDD:427414"
     Region          25..44
                     /region_name="Interaction with SNX3.
                     /evidence=ECO:0000250|UniProtKB:Q96QK1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Region          205..215
                     /region_name="Interaction with SNX3.
                     /evidence=ECO:0000250|UniProtKB:Q96QK1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Region          438..796
                     /region_name="Interaction with SLC11A2.
                     /evidence=ECO:0000250|UniProtKB:Q96QK1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Region          500..693
                     /region_name="Interaction with IGF2R cytoplasmic domain.
                     /evidence=ECO:0000250|UniProtKB:Q96QK1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Region          776..796
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Site            783
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH3.1)"
     Site            791
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660,
                     ECO:0007744|PubMed:19131326; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH3.1)"
     CDS             1..796
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /coded_by="NM_022997.5:61..2451"
                     /db_xref="CCDS:CCDS40421.1"
                     /db_xref="GeneID:65114"
                     /db_xref="MGI:MGI:1890467"
ORIGIN      
        1 mpttqqspqd eqeklldeai qavkvqsfqm krcldknklm dalkhasnml gelrtsmlsp
       61 ksyyelymai sdelhylevy ltdefakgrk vadlyelvqy agniiprlyl litvgvvyvk
      121 sfpqsrkdil kdlvemcrgv qhplrglflr nyllqctrni lpdegeptde ettgdisdsm
      181 dfvllnfaem nklwvrmqhq ghsrdrekre rerqelrilv gtnlvrlsql egvnverykq
      241 ivltgileqv vncrdalaqe ylmeciiqvf pdefhlqtln pflracaelh qnvnvkniii
      301 alidrlalfa hredgpgipa eiklfdifsq qvatviqsrq dmpsedvvsl qvslinlamk
      361 cypdrvdyvd kvlettveif nklnlehiat ssavskeltr llkipvdtyn niltvlklkh
      421 fhplfeyfdy esrksmscyv lsnvldynte ivsqdqvdsi mnlvstliqd qpdqpvedpd
      481 pedfadeqsl vgrfihllrs ddpdqqylil ntarkhfgag gnqrirftlp plvfaayqla
      541 frykensqmd dkwekkcqki fsfahqtisa likaelaelp lrlflqgala ageigfenhe
      601 tvayefmsqa fslyedeisd skaqlaaitl iigtfermkc fseenheplr tqcalaaskl
      661 lkkpdqgrav stcahlfwsg rntdkngeel hggkrvmecl kkalkianqc mdpslqvqlf
      721 ieilnryiyf yekendavti qvlnqliqki redlpnless eeteqinkhf hntlehlrsr
      781 respesegpi yeglil
//
